Dhfr (dihydrofolate reductase) - Rat Genome Database

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Gene: Dhfr (dihydrofolate reductase) Ictidomys tridecemlineatus
Analyze
Symbol: Dhfr
Name: dihydrofolate reductase
RGD ID: 12451390
Description: ENCODES a protein that exhibits dihydrofolate reductase activity (ortholog); dihydrofolic acid binding (ortholog); folic acid binding (ortholog); INVOLVED IN axon regeneration (ortholog); dihydrofolate metabolic process (ortholog); negative regulation of translation (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; dopa responsive dystonia pathway; folate cycle metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); autistic disorder (ortholog); Breast Neoplasms (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,542,580 - 182,561,929 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493646967,962 - 83,116 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
mitochondrion  (IEA)
nucleus  (IEA,ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dhfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,542,580 - 182,561,929 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493646967,962 - 83,116 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38580,626,226 - 80,654,983 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl580,626,226 - 80,654,983 (-)EnsemblGRCh38hg38GRCh38
GRCh37579,922,045 - 79,950,802 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,957,801 - 79,986,556 (-)NCBINCBI36Build 36hg18NCBI36
Build 34579,957,803 - 79,986,572NCBI
Celera575,825,049 - 75,854,857 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef575,130,997 - 75,159,721 (-)NCBIHuRef
CHM1_1579,355,281 - 79,384,046 (-)NCBICHM1_1
T2T-CHM13v2.0581,111,116 - 81,139,892 (-)NCBIT2T-CHM13v2.0
Dhfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,491,291 - 92,525,561 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,491,234 - 92,525,561 (+)EnsemblGRCm39 Ensembl
GRCm381392,354,783 - 92,389,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,354,726 - 92,389,053 (+)EnsemblGRCm38mm10GRCm38
MGSCv371393,124,738 - 93,159,008 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361393,455,536 - 93,489,806 (+)NCBIMGSCv36mm8
Celera1395,961,012 - 95,994,907 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.64NCBI
Dhfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8225,320,895 - 25,346,004 (+)NCBIGRCr8
mRatBN7.2223,585,876 - 23,611,199 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl223,586,031 - 23,613,713 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,620,446 - 30,644,695 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,720,807 - 28,745,052 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,548,630 - 23,573,162 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0221,931,887 - 21,958,927 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl221,931,493 - 21,962,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0241,137,784 - 41,149,417 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0241,162,308 - 41,162,496 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,607,093 - 22,828,487 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1222,527,461 - 22,748,856 (+)NCBI
Celera219,675,965 - 19,700,103 (+)NCBICelera
Cytogenetic Map2q12NCBI
Dhfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541829,274,170 - 29,283,028 (+)NCBIChiLan1.0ChiLan1.0
DHFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2434,653,369 - 34,681,917 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1532,806,994 - 32,835,542 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0534,663,210 - 34,689,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1534,938,548 - 34,967,003 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl534,938,548 - 34,967,003 (+)Ensemblpanpan1.1panPan2
DHFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,521,214 - 26,556,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,762,458 - 27,797,614 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0326,441,764 - 26,476,948 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1326,381,985 - 26,417,256 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,356,657 - 26,413,875 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,636,300 - 26,671,702 (+)NCBIUU_Cfam_GSD_1.0
DHFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1289,230,660 - 89,255,830 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2291,077,865 - 91,102,076 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1474,787,292 - 74,811,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl474,787,629 - 74,810,960 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604923,650,277 - 23,674,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhfr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247431,446,643 - 1,461,863 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247431,446,643 - 1,462,319 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_040273429   ⟹   XP_040129363
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213182,542,648 - 182,561,929 (+)NCBI
RefSeq Acc Id: XM_040273430   ⟹   XP_040129364
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213182,542,648 - 182,561,929 (+)NCBI
RefSeq Acc Id: XM_040273431   ⟹   XP_040129365
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213182,542,580 - 182,561,929 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040129363 (Get FASTA)   NCBI Sequence Viewer  
  XP_040129364 (Get FASTA)   NCBI Sequence Viewer  
  XP_040129365 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000018453.1
GenBank Protein KAG3266432 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_040129365   ⟸   XM_040273431
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040129363   ⟸   XM_040273429
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040129364   ⟸   XM_040273430
- Peptide Label: isoform X2
- UniProtKB: I3N257 (UniProtKB/TrEMBL)
Protein Domains
DHFR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028494 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000022578.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.430.10 UniProtKB/TrEMBL
InterPro DHFR UniProtKB/TrEMBL
  DHFR-like_dom_sf UniProtKB/TrEMBL
  DHFR_CS UniProtKB/TrEMBL
  DHFR_dom UniProtKB/TrEMBL
NCBI Gene Dhfr ENTREZGENE
PANTHER DIHYDROFOLATE REDUCTASE UniProtKB/TrEMBL
  PTHR48069 UniProtKB/TrEMBL
Pfam DHFR_1 UniProtKB/TrEMBL
PRINTS DHFR UniProtKB/TrEMBL
PROSITE DHFR_1 UniProtKB/TrEMBL
  DHFR_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53597 UniProtKB/TrEMBL
UniProt I3N257 ENTREZGENE, UniProtKB/TrEMBL