Herc1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1) - Rat Genome Database

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Gene: Herc1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1) Ictidomys tridecemlineatus
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Symbol: Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
RGD ID: 12448305
Description: ENCODES a protein that exhibits ubiquitin-protein transferase activity (inferred); INVOLVED IN autophagy (ortholog); brain development (ortholog); cerebellar Purkinje cell differentiation (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1, transcript variant X1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1, transcript variant X2; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1, transcript variant X3; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1, transcript variant X4; probable E3 ubiquitin-protein ligase HERC1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647124,141,928 - 24,330,967 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647124,142,227 - 24,330,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Herc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647124,141,928 - 24,330,967 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647124,142,227 - 24,330,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HERC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381563,608,618 - 63,833,948 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1563,608,618 - 63,833,948 (-)EnsemblGRCh38hg38GRCh38
GRCh371563,900,817 - 64,126,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,687,870 - 61,913,200 (-)NCBINCBI36Build 36hg18NCBI36
Build 341561,687,870 - 61,913,141NCBI
Celera1540,780,251 - 41,005,485 (-)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1540,725,245 - 40,950,861 (-)NCBIHuRef
CHM1_11564,020,042 - 64,245,382 (-)NCBICHM1_1
T2T-CHM13v2.01561,415,858 - 61,641,183 (-)NCBIT2T-CHM13v2.0
Herc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39966,257,694 - 66,416,057 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl966,257,732 - 66,416,057 (+)EnsemblGRCm39 Ensembl
GRCm38966,350,412 - 66,508,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl966,350,450 - 66,508,775 (+)EnsemblGRCm38mm10GRCm38
MGSCv37966,198,257 - 66,356,582 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36966,148,456 - 66,309,055 (+)NCBIMGSCv36mm8
Celera963,584,587 - 63,742,741 (+)NCBICelera
Cytogenetic Map9CNCBI
cM Map935.86NCBI
Herc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8875,796,347 - 75,965,347 (+)NCBIGRCr8
mRatBN7.2866,857,169 - 67,070,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,856,935 - 67,070,312 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0872,029,550 - 72,198,363 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl872,029,489 - 72,198,358 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0871,696,247 - 71,866,080 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4870,642,670 - 70,811,822 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1870,685,007 - 70,830,421 (+)NCBI
Celera866,287,307 - 66,455,898 (+)NCBICelera
Cytogenetic Map8q24NCBI
Herc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545011,525,246 - 11,719,992 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545011,525,245 - 11,719,992 (+)NCBIChiLan1.0ChiLan1.0
HERC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21652,856,563 - 53,087,506 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11557,032,688 - 57,262,796 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01542,555,131 - 42,785,228 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11560,848,030 - 61,017,273 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1560,848,493 - 61,017,244 (-)Ensemblpanpan1.1panPan2
HERC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13028,195,296 - 28,379,343 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3028,195,673 - 28,379,444 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3028,116,109 - 28,299,721 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03028,369,387 - 28,553,435 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3028,369,389 - 28,553,406 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13028,306,763 - 28,490,386 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03028,368,982 - 28,552,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03028,607,198 - 28,791,048 (-)NCBIUU_Cfam_GSD_1.0
HERC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1108,205,580 - 108,403,862 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11108,206,172 - 108,404,149 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,362,017 - 119,560,531 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HERC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12619,713,780 - 19,930,807 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2619,713,617 - 19,930,937 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048121,468,297 - 121,687,435 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Herc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247818,745,780 - 8,907,701 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247818,694,044 - 8,907,701 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000016079   ⟹   ENSSTOP00000014391
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647124,141,928 - 24,330,967 (-)Ensembl
RefSeq Acc Id: XM_021727300   ⟹   XP_021582975
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640106,294,169 - 106,482,872 (-)NCBI
SpeTri2.0NW_00493647124,142,231 - 24,330,966 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040274880   ⟹   XP_040130814
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBI
RefSeq Acc Id: XM_040274881   ⟹   XP_040130815
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640106,294,164 - 106,482,474 (-)NCBI
RefSeq Acc Id: XM_040274882   ⟹   XP_040130816
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBI
RefSeq Acc Id: XM_040274883   ⟹   XP_040130817
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBI
RefSeq Acc Id: XM_040274884   ⟹   XP_040130818
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBI
RefSeq Acc Id: XM_040274885   ⟹   XP_040130819
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBI
RefSeq Acc Id: XM_040274886   ⟹   XP_040130820
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBI
RefSeq Acc Id: XM_040274887   ⟹   XP_040130821
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBI
RefSeq Acc Id: XM_040274888   ⟹   XP_040130822
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640106,294,164 - 106,482,872 (-)NCBI
RefSeq Acc Id: XP_021582975   ⟸   XM_021727300
- Peptide Label: isoform X9
- UniProtKB: I3MQV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040130820   ⟸   XM_040274886
- Peptide Label: isoform X6
RefSeq Acc Id: XP_040130822   ⟸   XM_040274888
- Peptide Label: isoform X8
RefSeq Acc Id: XP_040130821   ⟸   XM_040274887
- Peptide Label: isoform X7
RefSeq Acc Id: XP_040130816   ⟸   XM_040274882
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040130819   ⟸   XM_040274885
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040130818   ⟸   XM_040274884
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040130817   ⟸   XM_040274883
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040130814   ⟸   XM_040274880
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040130815   ⟸   XM_040274881
- Peptide Label: isoform X1
Ensembl Acc Id: ENSSTOP00000014391   ⟸   ENSSTOT00000016079
Protein Domains
B30.2/SPRY   HECT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000016063 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000016079.3 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  2.130.10.30 UniProtKB/TrEMBL
  2.60.120.920 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/TrEMBL
  Reg_chr_condens UniProtKB/TrEMBL
  Signaling_Regulatory_Domain UniProtKB/TrEMBL
  SPRY_dom UniProtKB/TrEMBL
  SPRY_HERC1 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene Herc1 ENTREZGENE
PANTHER BTK-BINDING PROTEIN-RELATED UniProtKB/TrEMBL
  HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER 1 UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  RCC1 UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PRINTS RCCNDNSATION UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  RCC1_2 UniProtKB/TrEMBL
  RCC1_3 UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
  SSF50985 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt I3MQV8 ENTREZGENE, UniProtKB/TrEMBL