Fmo4 (flavin containing dimethylaniline monoxygenase 4) - Rat Genome Database

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Gene: Fmo4 (flavin containing dimethylaniline monoxygenase 4) Ictidomys tridecemlineatus
Analyze
Symbol: Fmo4
Name: flavin containing dimethylaniline monoxygenase 4
RGD ID: 12441014
Description: ENCODES a protein that exhibits flavin adenine dinucleotide binding (inferred); monooxygenase activity (inferred); N,N-dimethylaniline monooxygenase activity (inferred); INVOLVED IN energy homeostasis (ortholog); negative regulation of fatty acid oxidation (ortholog); xenobiotic catabolic process (ortholog); ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); autism spectrum disorder (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN endoplasmic reticulum (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dimethylaniline monooxygenase [N-oxide-forming] 4; flavin containing monooxygenase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934497,890,880 - 97,920,616 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648115,737,491 - 15,767,344 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fmo4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934497,890,880 - 97,920,616 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648115,737,491 - 15,767,344 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FMO4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,314,183 - 171,342,084 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,314,183 - 171,342,084 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,283,322 - 171,311,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,550,110 - 169,577,847 (+)NCBINCBI36Build 36hg18NCBI36
Build 341168,015,143 - 168,042,880NCBI
Celera1144,392,833 - 144,420,570 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,506,623 - 142,533,609 (+)NCBIHuRef
CHM1_11172,705,588 - 172,733,342 (+)NCBICHM1_1
T2T-CHM13v2.01170,670,481 - 170,698,383 (+)NCBIT2T-CHM13v2.0
Fmo4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,620,757 - 162,643,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,620,757 - 162,641,541 (-)EnsemblGRCm39 Ensembl
GRCm381162,793,188 - 162,816,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,793,188 - 162,813,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,724,014 - 164,742,680 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,630,558 - 164,649,224 (-)NCBIMGSCv36mm8
Celera1165,240,967 - 165,259,585 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
Fmo4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,687,909 - 77,706,100 (-)NCBIGRCr8
mRatBN7.21375,154,683 - 75,172,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,154,684 - 75,172,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,725,727 - 77,750,997 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,033,318 - 79,051,533 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,293,187 - 76,311,402 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,685,385 - 80,703,575 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,685,325 - 80,703,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,580,299 - 85,598,234 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,476,211 - 78,494,458 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,490,398 - 78,508,646 (-)NCBI
Celera1374,892,262 - 74,910,106 (-)NCBICelera
Cytogenetic Map13q22NCBI
Fmo4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540611,967,003 - 11,988,887 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540611,967,045 - 11,987,105 (+)NCBIChiLan1.0ChiLan1.0
FMO4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,416,496 - 78,444,472 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1178,090,686 - 78,118,661 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,806,413 - 146,834,315 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,520,375 - 150,548,270 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,520,375 - 150,548,270 (+)Ensemblpanpan1.1panPan2
FMO4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,529,034 - 27,596,467 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,568,438 - 27,596,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,049,840 - 27,117,469 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,329,955 - 27,397,773 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,369,360 - 27,397,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,181,116 - 27,248,502 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,215,669 - 27,283,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,457,952 - 27,525,372 (-)NCBIUU_Cfam_GSD_1.0
FMO4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,908,868 - 63,934,982 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1963,908,846 - 63,934,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,202,685 - 70,224,674 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMO4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,729,381 - 57,755,940 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,728,614 - 57,755,259 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605559,371,043 - 59,396,968 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005319878   ⟹   XP_005319935
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934497,890,880 - 97,920,616 (-)NCBI
SpeTri2.0NW_00493648115,737,491 - 15,767,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040277581   ⟹   XP_040133515
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934497,890,880 - 97,920,616 (-)NCBI
RefSeq Acc Id: XM_040277582   ⟹   XP_040133516
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934497,892,937 - 97,920,616 (-)NCBI
RefSeq Acc Id: XM_040277583   ⟹   XP_040133517
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934497,896,225 - 97,920,616 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005319935 (Get FASTA)   NCBI Sequence Viewer  
  XP_040133515 (Get FASTA)   NCBI Sequence Viewer  
  XP_040133516 (Get FASTA)   NCBI Sequence Viewer  
  XP_040133517 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000015432.2
GenBank Protein KAG3258751 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005319935   ⟸   XM_005319878
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_040133515   ⟸   XM_040277581
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040133516   ⟸   XM_040277582
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040133517   ⟸   XM_040277583
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028302 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000025877.2 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  Flavin_mOase UniProtKB/TrEMBL
  Flavin_mOase-like UniProtKB/TrEMBL
  Flavin_mOase_4 UniProtKB/TrEMBL
NCBI Gene Fmo4 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/TrEMBL
  DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 4 UniProtKB/TrEMBL
Pfam FMO-like UniProtKB/TrEMBL
PRINTS FMOXYGENASE UniProtKB/TrEMBL
  FMOXYGENASE4 UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
UniProt I3MTI7_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-30 Fmo4  flavin containing dimethylaniline monoxygenase 4    flavin containing monooxygenase 4  Symbol and/or name change 5135510 APPROVED