Arhgap12 (Rho GTPase activating protein 12) - Rat Genome Database

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Gene: Arhgap12 (Rho GTPase activating protein 12) Ictidomys tridecemlineatus
Analyze
Symbol: Arhgap12
Name: Rho GTPase activating protein 12
RGD ID: 12440448
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); INVOLVED IN actin filament organization (inferred); morphogenesis of an epithelial sheet (inferred); negative regulation of small GTPase mediated signal transduction (inferred); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); phagocytic cup (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Rho GTPase activating protein 12, transcript variant X1; Rho GTPase activating protein 12, transcript variant X2; Rho GTPase activating protein 12, transcript variant X3; Rho GTPase activating protein 12, transcript variant X4; Rho GTPase activating protein 12, transcript variant X5; rho GTPase-activating protein 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934410,908,185 - 11,015,502 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936574407,639 - 506,950 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936574407,639 - 514,268 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Arhgap12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934410,908,185 - 11,015,502 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936574407,639 - 506,950 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936574407,639 - 514,268 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381031,805,398 - 31,928,876 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1031,805,398 - 31,928,876 (-)EnsemblGRCh38hg38GRCh38
GRCh371032,094,326 - 32,217,804 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361032,135,231 - 32,257,776 (-)NCBINCBI36Build 36hg18NCBI36
Build 341032,135,230 - 32,257,776NCBI
Celera1031,860,349 - 31,982,898 (-)NCBICelera
Cytogenetic Map10p11.22NCBI
HuRef1031,814,718 - 31,938,300 (-)NCBIHuRef
CHM1_11032,094,260 - 32,217,738 (-)NCBICHM1_1
T2T-CHM13v2.01031,836,817 - 31,960,265 (-)NCBIT2T-CHM13v2.0
Arhgap12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,024,448 - 6,136,102 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,024,427 - 6,136,098 (-)EnsemblGRCm39 Ensembl
GRCm38186,024,448 - 6,136,098 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,024,427 - 6,136,098 (-)EnsemblGRCm38mm10GRCm38
MGSCv37186,024,446 - 6,136,096 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36186,025,215 - 6,135,887 (-)NCBIMGSCv36mm8
Celera186,070,257 - 6,182,214 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.46NCBI
Arhgap12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81756,284,282 - 56,397,630 (+)NCBIGRCr8
mRatBN7.21751,588,810 - 51,702,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1751,588,842 - 51,702,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1754,762,309 - 54,875,839 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01758,765,245 - 58,878,772 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01752,903,659 - 53,017,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01754,280,815 - 54,394,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1754,280,851 - 54,394,634 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01751,975,184 - 52,089,094 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41759,797,507 - 59,910,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11759,808,198 - 59,920,795 (+)NCBI
Celera1747,599,059 - 47,712,148 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
Arhgap12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542923,450,268 - 23,560,948 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542923,452,880 - 23,560,948 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2844,453,350 - 44,581,617 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11044,457,833 - 44,586,941 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01031,932,294 - 32,061,450 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11032,526,466 - 32,630,370 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1032,527,838 - 32,628,690 (-)Ensemblpanpan1.1panPan2
ARHGAP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1214,959,556 - 15,114,710 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl214,976,416 - 15,115,194 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha212,447,199 - 12,602,262 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0213,195,757 - 13,350,836 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl213,195,744 - 13,346,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1212,635,843 - 12,790,873 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0212,527,046 - 12,681,618 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0212,800,653 - 12,955,754 (+)NCBIUU_Cfam_GSD_1.0
ARHGAP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1042,454,646 - 42,577,345 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11042,458,115 - 42,577,351 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21047,054,190 - 47,173,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1931,124,281 - 31,249,546 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl931,123,727 - 31,249,524 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605640,095,774 - 40,220,663 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248054,283,213 - 4,383,718 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248054,283,213 - 4,383,737 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000003613   ⟹   ENSSTOP00000003237
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936574407,639 - 506,950 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000038970   ⟹   ENSSTOP00000027362
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936574407,639 - 504,410 (-)Ensembl
RefSeq Acc Id: XM_005330812   ⟹   XP_005330869
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934410,908,185 - 11,015,501 (-)NCBI
SpeTri2.0NW_004936574407,639 - 514,268 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013360989   ⟹   XP_013216443
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934410,908,185 - 11,004,915 (-)NCBI
SpeTri2.0NW_004936574407,639 - 504,416 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021730185   ⟹   XP_021585860
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934410,908,185 - 11,015,500 (-)NCBI
SpeTri2.0NW_004936574407,639 - 514,268 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021730186   ⟹   XP_021585861
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934410,908,185 - 11,015,501 (-)NCBI
SpeTri2.0NW_004936574407,639 - 514,268 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040276717   ⟹   XP_040132651
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934410,908,704 - 11,015,501 (-)NCBI
RefSeq Acc Id: XM_040276718   ⟹   XP_040132652
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934410,908,704 - 11,015,501 (-)NCBI
RefSeq Acc Id: XM_040276719   ⟹   XP_040132653
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934410,908,704 - 11,015,501 (-)NCBI
RefSeq Acc Id: XM_040276720   ⟹   XP_040132654
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934410,908,704 - 11,015,502 (-)NCBI
RefSeq Acc Id: XM_040276722   ⟹   XP_040132656
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934410,908,704 - 11,015,501 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005330869   ⟸   XM_005330812
- Peptide Label: isoform X3
- UniProtKB: I3M2L7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013216443   ⟸   XM_013360989
- Peptide Label: isoform X9
- UniProtKB: A0A287D1G1 (UniProtKB/TrEMBL),   I3M2L7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021585861   ⟸   XM_021730186
- Peptide Label: isoform X7
- UniProtKB: I3M2L7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021585860   ⟸   XM_021730185
- Peptide Label: isoform X5
- UniProtKB: I3M2L7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040132654   ⟸   XM_040276720
- Peptide Label: isoform X6
- UniProtKB: I3M2L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040132656   ⟸   XM_040276722
- Peptide Label: isoform X8
- UniProtKB: I3M2L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040132653   ⟸   XM_040276719
- Peptide Label: isoform X4
- UniProtKB: I3M2L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040132652   ⟸   XM_040276718
- Peptide Label: isoform X2
- UniProtKB: I3M2L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040132651   ⟸   XM_040276717
- Peptide Label: isoform X1
- UniProtKB: I3M2L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000003237   ⟸   ENSSTOT00000003613
RefSeq Acc Id: ENSSTOP00000027362   ⟸   ENSSTOT00000038970
Protein Domains
PH   Rho-GAP   SH3   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003596 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003613.3 UniProtKB/TrEMBL
  ENSSTOT00000038970.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  2.20.70.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro ARHGAP12_SH3 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene Arhgap12 ENTREZGENE
PANTHER RHO GTPASE-ACTIVATING PROTEIN 12 UniProtKB/TrEMBL
  RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3-WW_linker UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
UniProt A0A287D1G1 ENTREZGENE, UniProtKB/TrEMBL
  I3M2L7 ENTREZGENE, UniProtKB/TrEMBL