Pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) - Rat Genome Database

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Gene: Pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) Ictidomys tridecemlineatus
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Symbol: Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
RGD ID: 12439077
Description: ENCODES a protein that exhibits 6-phosphofructo-2-kinase activity (ortholog); fructose-2,6-bisphosphate 2-phosphatase activity (ortholog); INVOLVED IN carbohydrate phosphorylation (inferred); fructose 2,6-bisphosphate metabolic process (inferred); fructose metabolic process (inferred); PARTICIPATES IN glycolysis pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 1 (ortholog); genetic disease (ortholog); Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ortholog); FOUND IN cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, transcript variant X1; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, transcript variant X2; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, transcript variant X3; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, transcript variant X4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, transcript variant X5; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, transcript variant X6; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,543,590 - 63,585,774 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529303,843 - 342,935 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529304,090 - 346,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pfkfb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,543,590 - 63,585,774 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529303,843 - 342,935 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529304,090 - 346,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKFB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,517,684 - 48,563,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,517,684 - 48,562,015 (-)EnsemblGRCh38hg38GRCh38
GRCh37348,555,117 - 48,598,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,530,121 - 48,569,231 (-)NCBINCBI36Build 36hg18NCBI36
Build 34348,530,122 - 48,569,231NCBI
Celera348,510,977 - 48,550,079 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,613,565 - 48,652,666 (-)NCBIHuRef
CHM1_1348,507,387 - 48,546,534 (-)NCBICHM1_1
T2T-CHM13v2.0348,546,648 - 48,592,093 (-)NCBIT2T-CHM13v2.0
Pfkfb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,817,336 - 108,861,302 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,820,846 - 108,861,296 (+)EnsemblGRCm39 Ensembl
GRCm389108,988,272 - 109,032,236 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,991,778 - 109,032,228 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,893,947 - 108,934,739 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,848,901 - 108,889,603 (+)NCBIMGSCv36mm8
Celera9108,549,891 - 108,591,002 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
Pfkfb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,522,371 - 118,565,478 (+)NCBIGRCr8
mRatBN7.28109,643,558 - 109,687,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,643,937 - 109,685,634 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,262,543 - 115,300,538 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,461,728 - 113,499,717 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,304,523 - 111,342,518 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,733,347 - 117,776,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,737,117 - 117,775,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,085,098 - 117,128,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,012,543 - 114,050,534 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,031,997 - 114,069,989 (+)NCBI
Celera8108,939,193 - 108,977,086 (+)NCBICelera
Cytogenetic Map8q32NCBI
Pfkfb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955532606,643 - 644,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955532606,597 - 644,238 (-)NCBIChiLan1.0ChiLan1.0
PFKFB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,491,191 - 48,533,286 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,497,153 - 48,538,038 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,439,542 - 48,479,501 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,521,541 - 49,560,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,521,550 - 49,560,711 (-)Ensemblpanpan1.1panPan2
PFKFB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,556,548 - 40,587,036 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,556,790 - 40,585,652 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,470,623 - 40,504,538 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02041,038,756 - 41,072,657 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,038,813 - 41,072,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,276,197 - 40,310,107 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,680,959 - 40,715,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,961,893 - 40,995,823 (+)NCBIUU_Cfam_GSD_1.0
PFKFB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,212,552 - 31,259,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,212,553 - 31,259,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,457,005 - 34,504,235 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PFKFB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,920,252 - 9,962,243 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,919,764 - 9,957,543 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041157,123,631 - 157,165,404 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkfb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247302,519,678 - 2,563,059 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247302,519,661 - 2,566,664 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000010189   ⟹   ENSSTOP00000009142
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936529303,843 - 342,935 (-)Ensembl
RefSeq Acc Id: XM_005326873   ⟹   XP_005326930
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560263,543,590 - 63,582,192 (-)NCBI
SpeTri2.0NW_004936529304,090 - 342,734 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013359421   ⟹   XP_013214875
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560263,543,590 - 63,582,192 (-)NCBI
SpeTri2.0NW_004936529304,090 - 342,671 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013359424   ⟹   XP_013214878
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560263,543,590 - 63,582,192 (-)NCBI
SpeTri2.0NW_004936529304,090 - 342,671 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021727424   ⟹   XP_021583099
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560263,543,590 - 63,585,774 (-)NCBI
SpeTri2.0NW_004936529304,090 - 346,281 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040269661   ⟹   XP_040125595
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560263,543,590 - 63,582,385 (-)NCBI
RefSeq Acc Id: XM_040269662   ⟹   XP_040125596
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560263,543,590 - 63,582,192 (-)NCBI
RefSeq Acc Id: XM_040269663   ⟹   XP_040125597
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560263,543,590 - 63,582,152 (-)NCBI
RefSeq Acc Id: XP_005326930   ⟸   XM_005326873
- Peptide Label: isoform X1
- UniProtKB: I3MF04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013214875   ⟸   XM_013359421
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013214878   ⟸   XM_013359424
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_021583099   ⟸   XM_021727424
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_040125595   ⟸   XM_040269661
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040125596   ⟸   XM_040269662
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040125597   ⟸   XM_040269663
- Peptide Label: isoform X6
RefSeq Acc Id: ENSSTOP00000009142   ⟸   ENSSTOT00000010189
Protein Domains
6-phosphofructo-2-kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000010184 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000010189.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1240 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro 6Pfruct_kin UniProtKB/TrEMBL
  6Phosfructo_kin UniProtKB/TrEMBL
  His_Pase_superF_clade-1 UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PG/BPGM_mutase_AS UniProtKB/TrEMBL
NCBI Gene Pfkfb4 ENTREZGENE
PANTHER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 4 UniProtKB/TrEMBL
  PTHR10606 UniProtKB/TrEMBL
Pfam 6PF2K UniProtKB/TrEMBL
  His_Phos_1 UniProtKB/TrEMBL
PIRSF 6PFK_2-Ptase UniProtKB/TrEMBL
PRINTS 6PFRUCTKNASE UniProtKB/TrEMBL
PROSITE PG_MUTASE UniProtKB/TrEMBL
SMART PGAM UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF53254 UniProtKB/TrEMBL
UniProt I3MF04 ENTREZGENE, UniProtKB/TrEMBL