Gnmt (glycine N-methyltransferase)

Gene: Gnmt (glycine N-methyltransferase) Ictidomys tridecemlineatus

Analyze

Symbol:

Gnmt

Name:

glycine N-methyltransferase

RGD ID:

12438678

Description:

ENCODES a protein that exhibits folic acid binding (ortholog); glycine N-methyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN glycine metabolic process (ortholog); glycogen metabolic process (ortholog); methionine metabolic process (ortholog); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH Chronic Hepatitis (ortholog); genetic disease (ortholog); glycine N-methyltransferase deficiency (ortholog); FOUND IN methyltransferase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC101964621

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	46,995,031 - 46,998,424 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	16,957,270 - 16,965,346 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	16,961,734 - 16,965,487 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chronic Hepatitis (ISO)

genetic disease (ISO)

glycine N-methyltransferase deficiency (ISO)

hepatitis (ISO)

hepatocellular carcinoma (ISO)

hyperhomocysteinemia (ISO)

hypermethioninemia (ISO)

infantile Refsum disease (ISO)

Liver Neoplasms (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

Prostatic Neoplasms (ISO)

Zellweger syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glycine metabolic process (ISO)

glycogen metabolic process (IEA,ISO)

methionine metabolic process (IEA,ISO)

methylation (IEA)

one-carbon metabolic process (IEA,ISO)

protein homotetramerization (IEA)

regulation of gluconeogenesis (IEA,ISO)

S-adenosylhomocysteine metabolic process (IEA,ISO)

S-adenosylmethionine metabolic process (IEA,ISO)

sarcosine metabolic process (IEA,ISO)

Cellular Component

cytosol (IEA)

methyltransferase complex (ISO)

Molecular Function

folic acid binding (IEA,ISO)

glycine binding (IEA)

glycine N-methyltransferase activity (IEA,ISO)

identical protein binding (IEA,ISO)

methyltransferase activity (IEA)

protein binding (ISO)

S-adenosyl-L-methionine binding (IEA)

S-adenosylmethionine-dependent methyltransferase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

dihydropyrimidine dehydrogenase deficiency pathway (ISO)

dimethylglycine dehydrogenase deficiency pathway (ISO)

folate mediated one-carbon metabolic pathway (ISO)

folate metabolic pathway (ISO)

homocysteine metabolic pathway (ISO)

methionine cycle/metabolic pathway (ISO)

nonketotic hyperglycinemia pathway (ISO)

sarcosinemia pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gnmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	46,995,031 - 46,998,424 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	16,957,270 - 16,965,346 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	16,961,734 - 16,965,487 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNMT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	42,960,754 - 42,963,880 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	42,960,754 - 42,963,880 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	42,928,492 - 42,931,618 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	43,036,478 - 43,039,596 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	43,036,477 - 43,039,595	NCBI
Celera	6	44,480,758 - 44,483,869 (+)	NCBI		Celera
Cytogenetic Map	6	p21.1	NCBI
HuRef	6	42,645,801 - 42,648,911 (+)	NCBI		HuRef
CHM1_1	6	42,930,969 - 42,934,095 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	42,789,900 - 42,793,018 (+)	NCBI		T2T-CHM13v2.0

Gnmt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	47,036,590 - 47,040,091 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	47,036,590 - 47,040,094 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	46,725,664 - 46,729,211 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	46,725,664 - 46,729,168 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	46,862,613 - 46,866,114 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	46,188,855 - 46,192,356 (-)	NCBI		MGSCv36	mm8
Celera	17	50,161,350 - 50,164,841 (-)	NCBI		Celera
Cytogenetic Map	17	C	NCBI
cM Map	17	22.9	NCBI

Gnmt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	21,752,235 - 21,756,368 (+)	NCBI		GRCr8
mRatBN7.2	9	14,254,675 - 14,258,028 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	14,254,675 - 14,258,434 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	22,837,543 - 22,840,774 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	27,901,607 - 27,904,956 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	26,200,917 - 26,204,148 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	16,565,274 - 16,568,626 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	16,565,225 - 16,568,627 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	15,471,889 - 15,475,241 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	10,127,092 - 10,130,444 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	10,124,413 - 10,127,766 (+)	NCBI
Celera	9	12,003,123 - 12,006,473 (+)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

Gnmt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	8,944,047 - 8,946,642 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	8,944,288 - 8,946,642 (+)	NCBI	ChiLan1.0	ChiLan1.0

GNMT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	57,453,015 - 57,462,242 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	53,326,193 - 53,342,571 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	42,550,631 - 42,554,385 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	43,846,560 - 43,849,679 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	43,846,560 - 43,849,679 (+)	Ensembl	panpan1.1		panPan2

GNMT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	11,500,363 - 11,503,075 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	11,500,392 - 11,503,481 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	11,527,380 - 11,530,090 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	11,981,562 - 11,984,272 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	11,981,589 - 11,984,224 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	11,509,980 - 11,512,694 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	11,594,281 - 11,596,795 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	11,688,299 - 11,691,025 (+)	NCBI		UU_Cfam_GSD_1.0

GNMT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	38,038,358 - 38,041,217 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	38,038,359 - 38,041,218 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	43,486,726 - 43,489,585 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GNMT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	29,196,142 - 29,199,728 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	29,196,321 - 29,198,947 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	43,019,849 - 43,022,686 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005318674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000009463 ⟹ ENSSTOP00000008488

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936476	16,957,270 - 16,965,346 (-)	Ensembl

RefSeq Acc Id:

XM_005318674 ⟹ XP_005318731

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	46,995,031 - 46,998,424 (+)	NCBI
SpeTri2.0	NW_004936476	16,961,734 - 16,965,487 (-)	NCBI

Sequence:

show sequence

AAGTCCTTTAGAAGAGTGCTCAGTAGGCCACAAATTGGAAGGACCAGACTCCTCCACTGTAGGA
GGCTCTGGGGAAAAAAAGCTGATGCCATCATCTATGTTAAAGGCACACTCGCTTCCAGGTGAGT
GAGGATGATTCTAGGGTAGGGCCTTGCTCTGCCTTTGGACTTTCATGGACAGACCGCATTATCC
TAGACTTCAAAAATCTTCCCTGCCCTGGCTTGCTAGTCCCTTCCAGATGGACATTCCTTCCTTA
GATATGCTAATTTCTTCCCTCCCAGGGCGCTAGCCAATCCTGCCTTATGGGACTTTTCCGATTT
AGGTAGGGGTGGAGAGAGCAATCTCACTGCTCCGCCCTCTCTTGGCACAGCCCCCCGCCCCCGG
ATTAGGTGGGCAAAGGGTCAAAGAGTGGTCTCATGGTGGAGATTGCACAGAGGGCTCGAAGAGC
GAAGAGCGGGATCCAGGATTGCGATGCTGAGCCCTCCCGCGGGCAAGGACAGACCAGGCGTAGA
GCCCACCAGGGGCGTGTCCCCATGCTCACCTGCCATTGGCCAGGTGGGGCCGCCGAACACAGCC
TAACTATAAATGCGGAGGTGGTGGTTGCCGAGCCAGGCTTGCGAAGGATGGTGGACAGCGTGTA
CCGAACCCGCTCTCTAGGGGTGGCAGCCGAAGGGATACCGGACCAGTATGCAGACGGGGAGGCG
GCGCGCGTGTGGCAGCTCTACATCGGGGACACCCGCAGCCGCACCGCCGAGTACAAGGCGTGGC
TGCTCGGGCTGCTACGCCAGCATGGCTGCCAGCGGGTGCTCGACGTGGCTTGCGGCACGGGGGT
GGACTCCATCATGCTCGTGGAAGAGGGTTTCAGTGTGACGAGTGTGGACGCCAGTGACAAGATG
CTGAAGTATGCACTTAAGGAGCGCTGGAACCGACGGCAGGAGCCTGCATTTGACAAGTGGGTCA
TTGAAGAAGCCAACTGGATGACTCTGGATAAAGATGTGCCCAGACCAGCAGGAGGTGGCTTCGA
TGCAGTCATCTGTCTTGGAAACAGTTTTGCCCATTTGCCAGACTGCAAAGGTGACCAGAGTGAG
CATCGGCAGGCACTGAAGAACATTGCAAGCATGGTGCGGTCAGGGGGCCTGCTAGTCATTGATC
ATCGCAACTATGACCACATCCTGAGCACAGGTTGTGCACCCCCAGGGAAGAACATCTACTACAA
GAGTGACTCGACCAAGGACATCACAACATCAGTGCTAACAGTGAATAACAAAGCCCACATGGTG
ACCCTGGACTACACAGTGCAGGTGACGGACGCTGGCCCGGATGGTTCTCCTAGCTTCAGTAAAT
TCCGGCTCTCCTACTACCCACACTGTCTGGCGTCCTTCACGGAGTTGCTCCAAGCAGCCTTTGG
GGGCAAGTGCCAACACAGCATACTGGGTGACTTCAAGCCTTACAAGCTGGGCCAGACCTACATT
CCCTGCTACTTCATCCACGTGCTCAAGAAGACAGAATGAAGGTGGTCTTGCCTCCCATGATCCC
CTGCCTAGGTACTCCAGCTCTGGGAAGGTAGGGATCCATGGCCCCATACCAAGCCCAACCCTAG
TACAGAGACACTGCAGTTGAGGTTCATGGATGTGGGTTCAGGCAAAAAAAAAAAAGAATAAACA
ATACAATTTGTGCCTTTTAATTCCCTAAGCCTTGTGTTTATGTCTAAAGGAACAGGCCCCCAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005318731	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008488.2
GenBank Protein	KAG3289483	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005318731 ⟸ XM_005318674

- UniProtKB:

I3MDL6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVEIAQRARRAKSGIQDCDAEPSRGQGQTRRRAHQGRVPMLTCHWPGGAAEHSLTINAEVVVAE
PGLRRMVDSVYRTRSLGVAAEGIPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQ
RVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRQEPAFDKWVIEEANWMTLDK
DVPRPAGGGFDAVICLGNSFAHLPDCKGDQSEHRQALKNIASMVRSGGLLVIDHRNYDHILSTG
CAPPGKNIYYKSDSTKDITTSVLTVNNKAHMVTLDYTVQVTDAGPDGSPSFSKFRLSYYPHCLA
SFTELLQAAFGGKCQHSILGDFKPYKLGQTYIPCYFIHVLKKTE

hide sequence

RefSeq Acc Id:

ENSSTOP00000008488 ⟸ ENSSTOT00000009463

Protein Domains

Methyltransferase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009464	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009463.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
	Glycine N-methyltransferase, chain A, domain 1	UniProtKB/TrEMBL
InterPro	Gly/Sar_N_MeTrfase	UniProtKB/TrEMBL
	Methyltransf_25	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
NCBI Gene	Gnmt	ENTREZGENE
PANTHER	GLYCINE N-METHYLTRANSFERASE	UniProtKB/TrEMBL
	PTHR16458	UniProtKB/TrEMBL
Pfam	Methyltransf_25	UniProtKB/TrEMBL
PIRSF	Gly_N-mtase	UniProtKB/TrEMBL
PROSITE	SAM_GNMT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	I3MDL6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-26	Gnmt	glycine N-methyltransferase	LOC101964621	glycine N-methyltransferase	Symbol and/or name change	5135510	APPROVED
2017-07-13	LOC101964621	glycine N-methyltransferase	Gnmt		Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB