MAT2A (methionine adenosyltransferase 2A) - Rat Genome Database

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Gene: MAT2A (methionine adenosyltransferase 2A) Canis lupus familiaris
Analyze
Symbol: MAT2A
Name: methionine adenosyltransferase 2A
RGD ID: 12433472
Description: ENCODES a protein that exhibits amino acid binding (ortholog); ATP binding (ortholog); methionine adenosyltransferase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); circadian rhythm (ortholog); response to cAMP (ortholog); PARTICIPATES IN choline metabolic pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; ASSOCIATED WITH combined deficiency of vitamin K-dependent clotting factors 1 (ortholog); thoracic aortic aneurysm (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: S-adenosylmethionine synthase; S-adenosylmethionine synthase isoform type-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,525,635 - 39,532,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,525,626 - 39,532,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,197,011 - 39,203,887 (-)NCBI
ROS_Cfam_1.01740,272,327 - 40,279,204 (-)NCBI
UMICH_Zoey_3.11739,401,948 - 39,408,822 (-)NCBI
UNSW_CanFamBas_1.01739,473,851 - 39,480,724 (-)NCBI
UU_Cfam_GSD_1.01739,873,693 - 39,880,568 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
MAT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,525,635 - 39,532,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,525,626 - 39,532,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,197,011 - 39,203,887 (-)NCBI
ROS_Cfam_1.01740,272,327 - 40,279,204 (-)NCBI
UMICH_Zoey_3.11739,401,948 - 39,408,822 (-)NCBI
UNSW_CanFamBas_1.01739,473,851 - 39,480,724 (-)NCBI
UU_Cfam_GSD_1.01739,873,693 - 39,880,568 (-)NCBI
MAT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl285,539,168 - 85,545,281 (+)EnsemblGRCh38hg38GRCh38
GRCh38285,539,168 - 85,545,281 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37285,766,291 - 85,772,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,619,799 - 85,625,914 (+)NCBINCBI36hg18NCBI36
Build 34285,677,945 - 85,684,059NCBI
Celera285,594,476 - 85,600,591 (+)NCBI
Cytogenetic Map2p11.2NCBI
HuRef285,662,610 - 85,669,745 (+)NCBIHuRef
CHM1_1285,695,908 - 85,702,210 (+)NCBICHM1_1
Mat2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,409,779 - 72,416,539 (-)NCBIGRCm39mm39
GRCm39 Ensembl672,409,782 - 72,416,541 (-)Ensembl
GRCm38672,432,796 - 72,439,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,432,799 - 72,439,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,382,793 - 72,389,552 (-)NCBIGRCm37mm9NCBIm37
MGSCv36672,362,308 - 72,369,067 (-)NCBImm8
Celera674,527,849 - 74,534,608 (-)NCBICelera
Cytogenetic Map6C1NCBI
Mat2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24104,489,877 - 104,495,447 (-)NCBI
Rnor_6.0 Ensembl4100,296,075 - 100,303,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04100,297,478 - 100,303,047 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04165,067,990 - 165,073,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,739,943 - 105,745,472 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14105,984,423 - 105,989,953 (-)NCBI
Celera493,642,240 - 93,647,807 (-)NCBICelera
Cytogenetic Map4q31NCBI
Mat2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,953,623 - 1,961,164 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554241,953,623 - 1,961,164 (-)NCBIChiLan1.0ChiLan1.0
MAT2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A87,140,504 - 87,148,322 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,141,857 - 87,148,322 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A85,589,301 - 85,595,437 (+)NCBIMhudiblu_PPA_v0panPan3
Mat2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,141,369 - 79,147,930 (+)NCBI
SpeTri2.0NW_0049367121,710,513 - 1,717,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAT2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,211,157 - 59,225,261 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1359,220,203 - 59,225,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,132,444 - 62,137,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAT2A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,609,533 - 21,615,822 (-)NCBI
ChlSab1.1 Ensembl1421,611,040 - 21,615,615 (-)Ensembl
Vero_WHO_p1.0NW_02366604590,847,836 - 90,855,647 (+)NCBI
Mat2a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474917,596,381 - 17,603,804 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 20 4 6 4 6 6 12 8 10 6
Low 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012419   ⟹   ENSCAFP00000011509
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1739,525,626 - 39,532,512 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000082108   ⟹   ENSCAFP00000058714
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1739,525,635 - 39,532,512 (-)Ensembl
RefSeq Acc Id: NM_001287067   ⟹   NP_001273996
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11739,525,635 - 39,532,512 (-)NCBI
Dog10K_Boxer_Tasha1739,197,011 - 39,203,887 (-)NCBI
ROS_Cfam_1.01740,272,327 - 40,279,204 (-)NCBI
UMICH_Zoey_3.11739,401,948 - 39,408,822 (-)NCBI
UNSW_CanFamBas_1.01739,473,851 - 39,480,724 (-)NCBI
UU_Cfam_GSD_1.01739,873,693 - 39,880,568 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001273996 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001273996   ⟸   NM_001287067
- UniProtKB: E2R431 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000058714   ⟸   ENSCAFT00000082108
RefSeq Acc Id: ENSCAFP00000011509   ⟸   ENSCAFT00000012419
Promoters
RGD ID:13686286
Promoter ID:EPDNEW_C4354
Type:single initiation site
Name:MAT2A_1
Description:methionine adenosyltransferase 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11739,532,530 - 39,532,590EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007755 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000011509 UniProtKB/TrEMBL
  ENSCAFP00000058714 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012419 UniProtKB/TrEMBL
  ENSCAFT00000082108 ENTREZGENE, UniProtKB/TrEMBL
InterPro ADOMET_SYNTHASE_CS UniProtKB/TrEMBL
  S-AdoMet_synt_C UniProtKB/TrEMBL
  S-AdoMet_synt_central UniProtKB/TrEMBL
  S-AdoMet_synt_N UniProtKB/TrEMBL
  S-AdoMet_synthetase UniProtKB/TrEMBL
  S-AdoMet_synthetase_sfam UniProtKB/TrEMBL
KEGG Report cfa:475770 UniProtKB/TrEMBL
NCBI Gene MAT2A ENTREZGENE
PANTHER PTHR11964 UniProtKB/TrEMBL
Pfam S-AdoMet_synt_C UniProtKB/TrEMBL
  S-AdoMet_synt_M UniProtKB/TrEMBL
  S-AdoMet_synt_N UniProtKB/TrEMBL
PIRSF MAT UniProtKB/TrEMBL
PROSITE ADOMET_SYNTHASE_1 UniProtKB/TrEMBL
  ADOMET_SYNTHASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55973 UniProtKB/TrEMBL
TIGRFAMs metK UniProtKB/TrEMBL
UniProt A0A5F4CWJ3_CANLF UniProtKB/TrEMBL
  E2R431 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:49922 ENTREZGENE