WLS (Wnt ligand secretion mediator)

Gene: WLS (Wnt ligand secretion mediator) Canis lupus familiaris

Analyze

Symbol:

WLS

Name:

Wnt ligand secretion mediator

RGD ID:

12430477

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); mu-type opioid receptor binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); cementum mineralization (ortholog); exocrine pancreas development (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN dendrite cytoplasm (ortholog); dendrite membrane (ortholog); endoplasmic reticulum membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

G protein-coupled receptor 177; GPR177; protein wntless homolog; wntless homolog; wntless Wnt ligand secretion mediator

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	77,053,242 - 77,146,549 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	77,053,237 - 77,317,761 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	79,664,500 - 79,757,209 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	77,650,853 - 77,743,886 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	77,650,543 - 77,764,760 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	77,209,157 - 77,301,736 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	77,102,941 - 77,195,585 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	77,592,036 - 77,684,885 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Zaki syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior axis specification (ISO)

cementum mineralization (ISO)

exocrine pancreas development (ISO)

hindbrain development (ISO)

intracellular protein transport (IEA)

mesoderm formation (ISO)

midbrain development (ISO)

positive regulation of canonical Wnt signaling pathway (IEA)

positive regulation of dendrite morphogenesis (ISO)

positive regulation of Wnt protein secretion (IEA)

positive regulation of Wnt signaling pathway (IEA)

Wnt protein secretion (IEA,ISO)

Wnt signaling pathway (IEA)

Cellular Component

cytoplasmic vesicle (IEA)

cytoplasmic vesicle membrane (IEA)

cytosol (IEA)

dendrite cytoplasm (ISO)

dendrite membrane (ISO)

early endosome (IEA)

endomembrane system (IEA)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (ISO)

Golgi apparatus (IEA)

Golgi membrane (IEA)

membrane (IEA)

plasma membrane (IEA)

trans-Golgi network (IEA)

Molecular Function

identical protein binding (ISO)

mu-type opioid receptor binding (ISO)

protein binding (ISO)

Wnt-protein binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling, canonical pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

WLS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	77,053,242 - 77,146,549 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	77,053,237 - 77,317,761 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	79,664,500 - 79,757,209 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	77,650,853 - 77,743,886 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	77,650,543 - 77,764,760 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	77,209,157 - 77,301,736 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	77,102,941 - 77,195,585 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	77,592,036 - 77,684,885 (+)	NCBI		UU_Cfam_GSD_1.0

WLS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	68,098,459 - 68,232,546 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	68,098,473 - 68,233,120 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	68,564,142 - 68,698,229 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	68,336,739 - 68,470,841 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	66,854,843 - 66,988,904 (-)	NCBI		Celera
Cytogenetic Map	1	p31.3	NCBI
HuRef	1	66,674,244 - 66,808,306 (-)	NCBI		HuRef
CHM1_1	1	68,679,493 - 68,813,680 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	67,975,934 - 68,110,470 (-)	NCBI		T2T-CHM13v2.0

Wls
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	159,545,287 - 159,644,302 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	159,545,309 - 159,644,300 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	159,839,650 - 159,938,666 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	159,839,672 - 159,938,664 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	159,502,659 - 159,598,042 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	159,775,030 - 159,871,126 (+)	NCBI		MGSCv36	mm8
Celera	3	166,277,256 - 166,372,735 (+)	NCBI		Celera
Cytogenetic Map	3	H4	NCBI
cM Map	3	82.65	NCBI

Wls
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	251,590,653 - 251,705,991 (+)	NCBI		GRCr8
mRatBN7.2	2	248,931,885 - 249,047,248 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	248,931,903 - 249,048,298 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	256,651,639 - 256,774,797 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	254,545,165 - 254,668,321 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	249,504,626 - 249,627,778 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	266,315,036 - 266,431,220 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	266,315,036 - 266,432,558 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	284,950,842 - 285,064,166 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	258,014,437 - 258,128,180 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	258,029,043 - 258,141,986 (+)	NCBI
Celera	2	240,667,931 - 240,781,679 (+)	NCBI		Celera
Cytogenetic Map	2	q45	NCBI

Wls
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	23,374,401 - 23,466,475 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	23,374,401 - 23,465,308 (+)	NCBI	ChiLan1.0	ChiLan1.0

WLS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	158,639,149 - 158,773,214 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	157,798,726 - 157,958,728 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	67,336,009 - 67,470,265 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	69,291,878 - 69,425,652 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	69,318,742 - 69,425,652 (-)	Ensembl	panpan1.1		panPan2

Wls
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	80,849,811 - 80,951,545 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936591	3,537,981 - 3,639,774 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936591	3,537,981 - 3,639,774 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WLS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	144,399,926 - 144,555,880 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	144,242,639 - 144,529,659 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	133,711,371 - 133,819,072 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WLS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	64,879,594 - 64,987,460 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	64,879,864 - 64,977,038 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	52,598,873 - 52,734,627 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wls
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	27,481,427 - 27,570,439 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	27,481,480 - 27,570,439 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in WLS
2739 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5	5	22	6	6	6	6		12		10	6
Low								6		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038480344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038541696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038605832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038670427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_848742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000032538 ⟹ ENSCAFP00000030302

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	77,053,237 - 77,146,127 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000060386 ⟹ ENSCAFP00000050113

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	77,060,874 - 77,146,127 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000064131 ⟹ ENSCAFP00000059026

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	77,053,342 - 77,168,621 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000070731 ⟹ ENSCAFP00000061697

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	77,068,358 - 77,146,127 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000078234 ⟹ ENSCAFP00000066460

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	77,053,237 - 77,317,761 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000093793 ⟹ ENSCAFP00000050135

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	77,053,342 - 77,146,127 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845024521 ⟹ ENSCAFP00845019284

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	6	77,650,543 - 77,734,640 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845024720 ⟹ ENSCAFP00845019456

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	6	77,650,847 - 77,743,885 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845024835 ⟹ ENSCAFP00845019535

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	6	77,650,952 - 77,764,760 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845024859 ⟹ ENSCAFP00845019556

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	6	77,650,952 - 77,743,885 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845024866 ⟹ ENSCAFP00845019561

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	6	77,666,389 - 77,743,781 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845024878 ⟹ ENSCAFP00845019571

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	6	77,667,563 - 77,743,885 (+)	Ensembl

RefSeq Acc Id:

XM_038480344 ⟹ XP_038336272

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	6	77,209,157 - 77,301,736 (+)	NCBI

RefSeq Acc Id:

XM_038541696 ⟹ XP_038397624

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	6	77,592,036 - 77,684,885 (+)	NCBI

RefSeq Acc Id:

XM_038605832 ⟹ XP_038461760

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	6	77,102,941 - 77,195,585 (+)	NCBI

RefSeq Acc Id:

XM_038670427 ⟹ XP_038526355

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	6	77,650,853 - 77,743,886 (+)	NCBI

RefSeq Acc Id:

XM_848742 ⟹ XP_853835

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	6	77,053,242 - 77,146,549 (+)	NCBI
Dog10K_Boxer_Tasha	6	79,664,500 - 79,757,209 (+)	NCBI

Sequence:

show sequence

CCAGTCTCGCGCCGGCCCCGGGAGCGCCCCGCGCCGCGCAGCCCGGAGTCGGGGCCCCGAGGGC
GCGGCGGGGCGAGCGCGCGCGGCGAGGGGCGCAGCCATGGCCGGGGCCATCATCGAGAACATGA
GCACCAGGAAGCTGTGCGTCGTCGGGGGCGCCCTGCTGGCGCTGCAGGTCGCCGCCTTCCTGGT
GGGAGGCCTGGTCGCTCCAGGACCCACGACGGCAGTGTCCTACATGTCCGTGAAATGTGTGGAC
GTCCGTAAAAACCATCACAAGGCAAAATGGTTAATGCCTTGGGGACCCAACCAGTGCGACAAGA
TCCGGGACATCGAGGAAGCGATTCCAAGAGAAATCGAAGCCAACGACATTGTATTTTCTGTCCA
CATTCCCCTGCCCTCCATGGAGATGAGTCCTTGGTTCCAGTTCATGCTGTTTATTCTGCAGCTG
GACATCGCGTTCAAGCTGAACAACCAAATCAGAGAAAACGCGGAAGTTTCCATGGATGTCTCCC
TGGCTTACCGTGACGATATGTTTGCTGAGTGGACTGAGATGGCCCATGAGAGAGTGCCCCGGAA
GCTCAAATGTACCTTCACATCCCCCAAGACCCCAGAGTATGAGGGCCGTTACTACGAATGCGAT
GTCCTTCCTTTCATGGAAATTGGGTCTGTAGCTCACAAGTACTACCTTCTGAACATCCGGCTGC
CTGTGAACGAGAAGAAGAAAATCAACGTTGGGATCGGGGAGATAAAGGATATTCAGTTGGTGGG
GATCCACCAGAATGGAGGCTTCACCAAGGTGTGGTTCGCCATGAAGACCTTCCTCACGCCCAGC
ATCTTCATCATCATGGTGTGGTACTGGAGGAGGATCACTATGATGTCCCGACCCCCCGTGCTTC
TGGAGAAAGTCATCTTTGCTCTTGGGATTTCCATGACTTTTATCAACATCCCCGTGGAATGGTT
TTCCATCGGATTCGACTGGACCTGGATGCTGCTGTTCGGCGACATCCGACAGGGCATCTTTTAC
GCGATGCTCCTGTCCTTCTGGATCATCTTCTGTGGAGAGCATATGATGGATCAGCATGAGCGGA
ATCACATAGCCGGGTACTGGAAGCAGGTGGGACCCATTGCCGTCGGCTCTTTCTGCCTCTTCAT
ATTTGACATGTGTGAGAGGGGGGTACAGCTCACGAACCCCTTCTACAGCATCTGGACGACAGAT
GTTGGAACGGAGCTGGCCATGGCCTTCATCATCGTGGCCGGCATCTGCCTGTGCCTCTACTTCC
TGTTTCTGTGCTTCATGGTGTTCCAGGTGTTCCGCAACATCAGCGGGAAGCAGTCCAGCCTGCC
TGCCATGAGCAAAGTCCGGCGGCTGCACTACGAGGGGCTGATTTTCAGGTTCAAGTTCCTCATG
CTGATCACCTTGGCCTGTGCTGCTATGACCGTCATCTTCTTCATCGTTAGTCAGGTGACCGAAG
GCCACTGGAAGTGGGGCGGCGTCACGGTCCAGGTGAACAGTGCCTTCTTCACAGGCATCTATGG
GATGTGGAACCTGTACGTCTTTGCTTTGATGTTCCTGTACGCACCGTCCCATAAGAACTACGGG
GAGGACCAGTCCAATGGTGACCTGGGCGTCCACAGCGGGGAGGAAGTGCAGCTCACCACCACCA
TCACCCACGTGGACGGCCCCACCGAGATCTACAAGCTGACCCGCAAGGAGGCCCAGGAGTAGGA
GCGCCAGCCAGTGGGGAGCGTGCCAGCGTGGGGCCGACGGCGCGCGGGGCTCCAGCCGTGGCTT
CGTGGGCCGGTGGCCTAGACGTGTGTCCGCTGGCTTTCCGACTGCGGCTCCCGGAGGACGGTTC
CTGCGGCCACTAGGGCGTGCGTGTGGGAACAGCCTCCGATGGGACACGCTCTCTGCTCGTCGTG
AACTAGGGACGTAGGAGCATCCGTAGCAGGTGCTTAGGAAGCCTCTTGCGCGGGGTGCTCTCCT
GGGGGATGGTTCGGGCCGGAGGGGTCTCTGTGGAGTGGGATATTGACTCTTTTTCCTGTTTTAG
ATTCTAGGATAGATTTTAACACCTTTGCAGGCCAGGGTAGGCTGGTGGCTTAGTCTTCTCAAAC
CTAGTCTGTGACCACTTGGGGTTTTTTTTTTTTTTTTTGTCTCATTTTTTTTTCTATTTATATC
ACCAGGTAGCCTATTGAGTTAATATTTAAGTTGTCAATAGATACGTGTCCCTGTTTTTTATGGC
ATAATATGAAATAACTGCGTTTCATGAGAAGGTCTGTTACACCAGGGGCATCTCGGCTTTGAAA
CCAAATCTGTGTTTCCAGTACTAACCAGTCTGTCGGATGTGGGTTTTGAAAAACTGTTTGCTAA
ACTACCCAAGTAGGATTCATTGTATTAAATGGCCTTTGGGTCTGAAAAGCTTTTTTACCTCTTG
CTTAAAATGTGTTTTCTTTGGATAAGATGCTTCCCACAGCCTCCCAACGTGTAGATCCCACCAT
TTGAATAAACCTGTCTGTATATGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038336272	(Get FASTA)	NCBI Sequence Viewer
	XP_038397624	(Get FASTA)	NCBI Sequence Viewer
	XP_038461760	(Get FASTA)	NCBI Sequence Viewer
	XP_038526355	(Get FASTA)	NCBI Sequence Viewer
	XP_853835	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000030302.3
	ENSCAFP00000050113.2
	ENSCAFP00000050135.1
	ENSCAFP00000059026.2
	ENSCAFP00000061697.2
	ENSCAFP00000066460.2
	ENSCAFP00030022342.1
	ENSCAFP00030022383.1
	ENSCAFP00030022543.1
	ENSCAFP00030022649.1
	ENSCAFP00030022731.1
	ENSCAFP00030022818.1
	ENSCAFP00030022919.1
	ENSCAFP00030023015.1
	ENSCAFP00040003514.1
	ENSCAFP00040003536.1
	ENSCAFP00040003564.1
	ENSCAFP00040003601.1
	ENSCAFP00040003608.1
	ENSCAFP00845019284.1
	ENSCAFP00845019456
	ENSCAFP00845019456.1
	ENSCAFP00845019535.1
	ENSCAFP00845019556.1
	ENSCAFP00845019561.1
	ENSCAFP00845019571.1

RefSeq Acc Id:

XP_853835 ⟸ XM_848742

- UniProtKB:

A0A8C0KZ79 (UniProtKB/TrEMBL), A0A8C0NA19 (UniProtKB/TrEMBL), A0A8I3P126 (UniProtKB/TrEMBL), A0A8C0NFN0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGAIIENMSTRKLCVVGGALLALQVAAFLVGGLVAPGPTTAVSYMSVKCVDVRKNHHKAKWLM
PWGPNQCDKIRDIEEAIPREIEANDIVFSVHIPLPSMEMSPWFQFMLFILQLDIAFKLNNQIRE
NAEVSMDVSLAYRDDMFAEWTEMAHERVPRKLKCTFTSPKTPEYEGRYYECDVLPFMEIGSVAH
KYYLLNIRLPVNEKKKINVGIGEIKDIQLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRI
TMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCG
EHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDVGTELAMAFIIV
AGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVI
FFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHS
GEEVQLTTTITHVDGPTEIYKLTRKEAQE

hide sequence

RefSeq Acc Id:

ENSCAFP00000066460 ⟸ ENSCAFT00000078234

RefSeq Acc Id:

ENSCAFP00000059026 ⟸ ENSCAFT00000064131

RefSeq Acc Id:

ENSCAFP00000050113 ⟸ ENSCAFT00000060386

RefSeq Acc Id:

ENSCAFP00000061697 ⟸ ENSCAFT00000070731

RefSeq Acc Id:

ENSCAFP00000050135 ⟸ ENSCAFT00000093793

RefSeq Acc Id:

ENSCAFP00000030302 ⟸ ENSCAFT00000032538

RefSeq Acc Id:

XP_038336272 ⟸ XM_038480344

RefSeq Acc Id:

XP_038461760 ⟸ XM_038605832

RefSeq Acc Id:	XP_038526355 ⟸ XM_038670427
- UniProtKB:	A0A8C0KZ79 (UniProtKB/TrEMBL), A0A8C0NA19 (UniProtKB/TrEMBL), A0A8I3P126 (UniProtKB/TrEMBL), A0A8C0NFN0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038397624 ⟸ XM_038541696
- UniProtKB:	A0A8C0KZ79 (UniProtKB/TrEMBL), A0A8C0NA19 (UniProtKB/TrEMBL), A0A8C0NFN0 (UniProtKB/TrEMBL), A0A8I3P126 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845019535 ⟸ ENSCAFT00845024835

RefSeq Acc Id:

ENSCAFP00845019456 ⟸ ENSCAFT00845024720

RefSeq Acc Id:

ENSCAFP00845019561 ⟸ ENSCAFT00845024866

RefSeq Acc Id:

ENSCAFP00845019284 ⟸ ENSCAFT00845024521

RefSeq Acc Id:

ENSCAFP00845019571 ⟸ ENSCAFT00845024878

RefSeq Acc Id:

ENSCAFP00845019556 ⟸ ENSCAFT00845024859

Protein Domains

Wntless-like transmembrane

Promoters

RGD ID:

13683855

Promoter ID:

EPDNEW_C1920

Type:

initiation region

Name:

WLS_1

Description:

wntless Wnt ligand secretion mediator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	6	77,053,244 - 77,053,304	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000020432	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030013670	UniProtKB/TrEMBL
	ENSCAFG00040002160	UniProtKB/TrEMBL
	ENSCAFG00845013715	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000032538.5	UniProtKB/TrEMBL
	ENSCAFT00000060386.2	UniProtKB/TrEMBL
	ENSCAFT00000064131.2	UniProtKB/TrEMBL
	ENSCAFT00000070731.2	UniProtKB/TrEMBL
	ENSCAFT00000078234.2	UniProtKB/TrEMBL
	ENSCAFT00000093793.2	UniProtKB/TrEMBL
	ENSCAFT00030025589.1	UniProtKB/TrEMBL
	ENSCAFT00030025634.1	UniProtKB/TrEMBL
	ENSCAFT00030025804.1	UniProtKB/TrEMBL
	ENSCAFT00030025930.1	UniProtKB/TrEMBL
	ENSCAFT00030026030.1	UniProtKB/TrEMBL
	ENSCAFT00030026126.1	UniProtKB/TrEMBL
	ENSCAFT00030026246.1	UniProtKB/TrEMBL
	ENSCAFT00030026360.1	UniProtKB/TrEMBL
	ENSCAFT00040004101.1	UniProtKB/TrEMBL
	ENSCAFT00040004126.1	UniProtKB/TrEMBL
	ENSCAFT00040004160.1	UniProtKB/TrEMBL
	ENSCAFT00040004198.1	UniProtKB/TrEMBL
	ENSCAFT00040004206.1	UniProtKB/TrEMBL
	ENSCAFT00845024521.1	UniProtKB/TrEMBL
	ENSCAFT00845024720	ENTREZGENE
	ENSCAFT00845024720.1	UniProtKB/TrEMBL
	ENSCAFT00845024835.1	UniProtKB/TrEMBL
	ENSCAFT00845024859.1	UniProtKB/TrEMBL
	ENSCAFT00845024866.1	UniProtKB/TrEMBL
	ENSCAFT00845024878.1	UniProtKB/TrEMBL
InterPro	WLS-like_TM	UniProtKB/TrEMBL
	Wntless	UniProtKB/TrEMBL
KEGG Report	cfa:611491	UniProtKB/TrEMBL
NCBI Gene	WLS	ENTREZGENE
PANTHER	PROTEIN WNTLESS HOMOLOG	UniProtKB/TrEMBL
	PTHR13449	UniProtKB/TrEMBL
Pfam	MIG-14_Wnt-bd	UniProtKB/TrEMBL
UniProt	A0A8C0KZ79	ENTREZGENE
	A0A8C0N7U4_CANLF	UniProtKB/TrEMBL
	A0A8C0NA19	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0NBB1_CANLF	UniProtKB/TrEMBL
	A0A8C0NBU0_CANLF	UniProtKB/TrEMBL
	A0A8C0NFN0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0NG17_CANLF	UniProtKB/TrEMBL
	A0A8C0NHW9_CANLF	UniProtKB/TrEMBL
	A0A8C0PSW1_CANLF	UniProtKB/TrEMBL
	A0A8C0PT56_CANLF	UniProtKB/TrEMBL
	A0A8C0PX27_CANLF	UniProtKB/TrEMBL
	A0A8C0RVX0_CANLF	UniProtKB/TrEMBL
	A0A8I3NH31_CANLF	UniProtKB/TrEMBL
	A0A8I3NNR0_CANLF	UniProtKB/TrEMBL
	A0A8I3NRJ4_CANLF	UniProtKB/TrEMBL
	A0A8I3NSK5_CANLF	UniProtKB/TrEMBL
	A0A8I3NU33_CANLF	UniProtKB/TrEMBL
	A0A8I3P126	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NZZ1_CANLF	UniProtKB/TrEMBL
	A0A8P0TDG7_CANLF	UniProtKB/TrEMBL
	A0A8P0THR4_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:48417	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-22	WLS	Wnt ligand secretion mediator		wntless Wnt ligand secretion mediator	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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