LRP12 (LDL receptor related protein 12) - Rat Genome Database

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Gene: LRP12 (LDL receptor related protein 12) Canis lupus familiaris
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Symbol: LRP12
Name: LDL receptor related protein 12
RGD ID: 12430030
Description: INVOLVED IN neuron migration (ortholog); neuron projection development (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 28 (ortholog); Cohen syndrome (ortholog); genetic disease (ortholog); FOUND IN clathrin-coated pit (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: low density lipoprotein-related protein 12; low-density lipoprotein receptor-related protein 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1135,670,932 - 5,754,076 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl135,674,649 - 5,744,740 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha135,680,437 - 5,753,788 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0135,919,440 - 5,992,861 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl135,921,147 - 5,993,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1135,688,225 - 5,761,580 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0135,807,918 - 5,881,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0135,829,034 - 5,902,423 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LRP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1135,670,932 - 5,754,076 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl135,674,649 - 5,744,740 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha135,680,437 - 5,753,788 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0135,919,440 - 5,992,861 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl135,921,147 - 5,993,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1135,688,225 - 5,761,580 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0135,807,918 - 5,881,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0135,829,034 - 5,902,423 (-)NCBIUU_Cfam_GSD_1.0
LRP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388104,489,236 - 104,589,258 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8104,489,231 - 104,589,258 (-)EnsemblGRCh38hg38GRCh38
GRCh378105,501,464 - 105,601,486 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368105,570,640 - 105,670,344 (-)NCBINCBI36Build 36hg18NCBI36
Build 348105,570,642 - 105,670,344NCBI
Celera8101,688,117 - 101,787,906 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef8100,702,436 - 100,802,059 (-)NCBIHuRef
CHM1_18105,542,268 - 105,642,040 (-)NCBICHM1_1
T2T-CHM13v2.08105,616,734 - 105,716,700 (-)NCBIT2T-CHM13v2.0
Lrp12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391539,733,985 - 39,807,417 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1539,733,985 - 39,807,390 (-)EnsemblGRCm39 Ensembl
GRCm381539,870,589 - 39,944,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1539,870,589 - 39,943,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv371539,702,149 - 39,775,303 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361539,700,677 - 39,773,831 (-)NCBIMGSCv36mm8
Celera1540,354,353 - 40,427,473 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.59NCBI
Lrp12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8772,825,979 - 72,897,308 (-)NCBIGRCr8
mRatBN7.2770,941,068 - 71,012,409 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl770,941,068 - 71,012,441 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx772,823,990 - 72,895,135 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0775,026,464 - 75,097,609 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0774,894,559 - 74,965,704 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0778,859,784 - 78,930,850 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl778,859,784 - 78,930,832 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0778,885,444 - 78,956,543 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4775,458,003 - 75,529,424 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1775,478,737 - 75,550,147 (-)NCBI
Celera767,994,544 - 68,065,573 (-)NCBICelera
Cytogenetic Map7q31NCBI
Lrp12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541728,252,145 - 28,291,663 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541728,248,620 - 28,299,845 (-)NCBIChiLan1.0ChiLan1.0
LRP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27121,841,834 - 121,941,451 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1897,352,211 - 97,464,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08101,118,465 - 101,218,272 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18103,270,456 - 103,369,548 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8103,271,889 - 103,369,552 (-)Ensemblpanpan1.1panPan2
Lrp12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530332,033,262 - 32,116,039 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647039,459,002 - 39,544,577 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647039,459,395 - 39,542,125 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl432,701,835 - 32,783,390 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1432,701,830 - 32,783,391 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2435,438,644 - 35,517,013 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRP12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1899,325,852 - 99,423,413 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl899,324,111 - 99,422,767 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603941,150,664 - 41,247,925 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476320,689,239 - 20,764,310 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476320,689,236 - 20,764,290 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LRP12
557 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 11 10 1
Low 5 5 11 6 6 6 6 6 2 8 9 6
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000001048   ⟹   ENSCAFP00000000960
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl135,674,649 - 5,744,740 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000043403   ⟹   ENSCAFP00000042981
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl135,674,649 - 5,744,740 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845017862   ⟹   ENSCAFP00845013912
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl135,921,147 - 5,993,378 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845017917   ⟹   ENSCAFP00845013956
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl135,921,147 - 5,992,801 (-)Ensembl
RefSeq Acc Id: XM_014118520   ⟹   XP_013973995
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1135,670,932 - 5,754,076 (-)NCBI
Dog10K_Boxer_Tasha135,680,437 - 5,753,788 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038426667   ⟹   XP_038282595
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha135,680,437 - 5,753,788 (-)NCBI
RefSeq Acc Id: XM_038493056   ⟹   XP_038348984
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1135,688,225 - 5,761,580 (-)NCBI
RefSeq Acc Id: XM_038493057   ⟹   XP_038348985
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1135,688,225 - 5,761,580 (-)NCBI
RefSeq Acc Id: XM_038555314   ⟹   XP_038411242
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0135,829,034 - 5,902,423 (-)NCBI
RefSeq Acc Id: XM_038555315   ⟹   XP_038411243
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0135,829,034 - 5,902,423 (-)NCBI
RefSeq Acc Id: XM_038619213   ⟹   XP_038475141
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0135,807,918 - 5,881,279 (-)NCBI
RefSeq Acc Id: XM_038619214   ⟹   XP_038475142
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0135,807,918 - 5,881,279 (-)NCBI
RefSeq Acc Id: XM_038684829   ⟹   XP_038540757
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0135,919,440 - 5,992,861 (-)NCBI
RefSeq Acc Id: XM_038684830   ⟹   XP_038540758
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0135,919,440 - 5,992,861 (-)NCBI
RefSeq Acc Id: XP_013973995   ⟸   XM_014118520
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QCD2 (UniProtKB/TrEMBL),   A0A8C0JRY2 (UniProtKB/TrEMBL),   A0A8I3NDU1 (UniProtKB/TrEMBL),   A0A8C0PFX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000960   ⟸   ENSCAFT00000001048
RefSeq Acc Id: ENSCAFP00000042981   ⟸   ENSCAFT00000043403
RefSeq Acc Id: XP_038348985   ⟸   XM_038493057
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038348984   ⟸   XM_038493056
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038475142   ⟸   XM_038619214
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038475141   ⟸   XM_038619213
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038540758   ⟸   XM_038684830
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RZQ3 (UniProtKB/TrEMBL),   A0A8I3NCM1 (UniProtKB/TrEMBL),   A0A8C0PFX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038540757   ⟸   XM_038684829
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QCD2 (UniProtKB/TrEMBL),   A0A8C0JRY2 (UniProtKB/TrEMBL),   A0A8I3NDU1 (UniProtKB/TrEMBL),   A0A8C0PFX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038282595   ⟸   XM_038426667
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RZQ3 (UniProtKB/TrEMBL),   A0A8I3NCM1 (UniProtKB/TrEMBL),   A0A8C0PFX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411243   ⟸   XM_038555315
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PFX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411242   ⟸   XM_038555314
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PFX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845013956   ⟸   ENSCAFT00845017917
RefSeq Acc Id: ENSCAFP00845013912   ⟸   ENSCAFT00845017862
Protein Domains
CUB

Promoters
RGD ID:13685571
Promoter ID:EPDNEW_C3639
Type:multiple initiation site
Name:LRP12_1
Description:LDL receptor related protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1135,744,773 - 5,744,833EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000677 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023499 UniProtKB/TrEMBL
  ENSCAFG00040007245 UniProtKB/TrEMBL
  ENSCAFG00845010152 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001048.5 UniProtKB/TrEMBL
  ENSCAFT00000043403.4 UniProtKB/TrEMBL
  ENSCAFT00030043164.1 UniProtKB/TrEMBL
  ENSCAFT00030043184.1 UniProtKB/TrEMBL
  ENSCAFT00030043217.1 UniProtKB/TrEMBL
  ENSCAFT00040013467.1 UniProtKB/TrEMBL
  ENSCAFT00040013482.1 UniProtKB/TrEMBL
  ENSCAFT00040013493.1 UniProtKB/TrEMBL
  ENSCAFT00845017862 ENTREZGENE
  ENSCAFT00845017862.1 UniProtKB/TrEMBL
  ENSCAFT00845017917 ENTREZGENE
  ENSCAFT00845017917.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
NCBI Gene LRP12 ENTREZGENE
PANTHER COILED-COIL DOMAIN-CONTAINING PROTEIN 66 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART CUB UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
Superfamily-SCOP SSF49854 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
UniProt A0A8C0JRY2 ENTREZGENE
  A0A8C0PFX2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QCD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RZQ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NCM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NDU1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:59046 ENTREZGENE