LOC487375 (elongation factor 1-alpha 1-like) - Rat Genome Database

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Gene: LOC487375 (elongation factor 1-alpha 1-like) Canis lupus familiaris
Analyze
Symbol: LOC487375
Name: elongation factor 1-alpha 1-like
RGD ID: 12429077
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN positive regulation of apoptotic process (ortholog); response to electrical stimulus (ortholog); response to inorganic substance (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); autistic disorder (ortholog); autosomal dominant intellectual developmental disorder 38 (ortholog); FOUND IN cytoplasm (ortholog); eukaryotic translation elongation factor 1 complex (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,787,450 - 75,797,662 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,357,766 - 72,367,782 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,347,000 - 76,357,024 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1273,169,322 - 73,179,344 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,176,170 - 74,186,373 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,181,724 - 75,191,917 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC487375
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,787,450 - 75,797,662 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,357,766 - 72,367,782 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,347,000 - 76,357,024 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1273,169,322 - 73,179,344 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,176,170 - 74,186,373 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,181,724 - 75,191,917 (-)NCBIUU_Cfam_GSD_1.0
EEF1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,488,014 - 63,499,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,488,013 - 63,499,239 (-)EnsemblGRCh38hg38GRCh38
GRCh372062,119,367 - 62,130,436 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,589,810 - 61,600,949 (-)NCBINCBI36Build 36hg18NCBI36
Build 342061,589,809 - 61,600,949NCBI
Celera2058,799,722 - 58,810,854 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,848,703 - 58,860,885 (-)NCBIHuRef
CHM1_12062,020,420 - 62,031,789 (-)NCBICHM1_1
T2T-CHM13v2.02065,299,508 - 65,311,765 (-)NCBIT2T-CHM13v2.0
Eef1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,783,551 - 180,798,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,789,446 - 180,798,807 (-)EnsemblGRCm39 Ensembl
GRCm382181,141,758 - 181,157,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,147,653 - 181,157,014 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,882,397 - 180,891,720 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,077,100 - 181,086,422 (-)NCBIMGSCv36mm8
Celera2185,234,189 - 185,243,512 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.6NCBI
Eef1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,643,455 - 188,652,633 (-)NCBIGRCr8
mRatBN7.23168,265,893 - 168,275,071 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,195,357 - 168,275,071 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,646,092 - 172,655,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,605,190 - 181,614,396 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,266,847 - 178,276,025 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,657,104 - 176,666,282 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,657,107 - 176,666,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,367,136 - 180,376,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,295,327 - 170,304,505 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,201,363 - 170,210,541 (-)NCBI
Celera3164,310,775 - 164,319,957 (+)NCBICelera
Cytogenetic Map3q43NCBI
Eef1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528717,338 - 729,692 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955528717,338 - 726,383 (+)NCBIChiLan1.0ChiLan1.0
EEF1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,290,289 - 69,302,459 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,282,295 - 69,294,390 (-)NCBINHGRI_mPanPan1
PanPan1.12061,412,059 - 61,421,820 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,412,122 - 61,421,735 (-)Ensemblpanpan1.1panPan2
Eef1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,345,359 - 195,353,489 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,798,671 - 10,807,132 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,799,002 - 10,807,132 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EEF1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,517,503 - 62,526,190 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,517,811 - 62,526,379 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EEF1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12712,020 - 724,843 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2713,522 - 724,859 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605048,273,352 - 48,285,738 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eef1a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,154,993 - 29,163,799 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,154,762 - 29,163,794 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LOC487375
159 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 1
Low
Below cutoff 4 4 18 3 6 3 6 5 12 8 10 6

Sequence


RefSeq Acc Id: XM_022413410   ⟹   XP_022269118
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1275,787,450 - 75,797,662 (-)NCBI
Dog10K_Boxer_Tasha272,357,766 - 72,367,782 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038470765   ⟹   XP_038326693
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1273,169,322 - 73,179,344 (-)NCBI
RefSeq Acc Id: XM_038531629   ⟹   XP_038387557
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0275,181,724 - 75,191,917 (-)NCBI
RefSeq Acc Id: XM_038595861   ⟹   XP_038451789
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0274,176,170 - 74,186,373 (-)NCBI
RefSeq Acc Id: XM_038659935   ⟹   XP_038515863
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0276,347,000 - 76,357,024 (-)NCBI
RefSeq Acc Id: XP_022269118   ⟸   XM_022413410
- UniProtKB: A0A8C0L709 (UniProtKB/TrEMBL),   A0A8C0PQW1 (UniProtKB/TrEMBL),   A0A8I3NWI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038326693   ⟸   XM_038470765
RefSeq Acc Id: XP_038451789   ⟸   XM_038595861
RefSeq Acc Id: XP_038515863   ⟸   XM_038659935
- UniProtKB: A0A8C0L709 (UniProtKB/TrEMBL),   A0A8C0PQW1 (UniProtKB/TrEMBL),   A0A8I3NWI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387557   ⟸   XM_038531629
- UniProtKB: A0A8C0M5G6 (UniProtKB/TrEMBL)
Protein Domains
tr-type G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013249 UniProtKB/TrEMBL
  ENSCAFG00030001452 UniProtKB/TrEMBL
  ENSCAFG00040001700 UniProtKB/TrEMBL
  ENSCAFG00845015043 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021042.5 UniProtKB/TrEMBL
  ENSCAFT00030002606.1 UniProtKB/TrEMBL
  ENSCAFT00040003231.1 UniProtKB/TrEMBL
  ENSCAFT00845026909 ENTREZGENE
  ENSCAFT00845026909.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Translation factors UniProtKB/TrEMBL
InterPro EFTu-like_2 UniProtKB/TrEMBL
  G_TR_CS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  T_Tr_GTP-bd_dom UniProtKB/TrEMBL
  Transl_B-barrel_sf UniProtKB/TrEMBL
  Transl_elong_EF1A/Init_IF2_C UniProtKB/TrEMBL
  Transl_elong_EF1A_euk/arc UniProtKB/TrEMBL
  Transl_elong_EFTu/EF1A_C UniProtKB/TrEMBL
NCBI Gene LOC487375 ENTREZGENE
PANTHER ELONGATION FACTOR 1-ALPHA UniProtKB/TrEMBL
  TRANSLATION FACTOR UniProtKB/TrEMBL
Pfam GTP_EFTU UniProtKB/TrEMBL
  GTP_EFTU_D2 UniProtKB/TrEMBL
  GTP_EFTU_D3 UniProtKB/TrEMBL
PRINTS ELONGATNFCT UniProtKB/TrEMBL
PROSITE G_TR_1 UniProtKB/TrEMBL
  G_TR_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF50447 UniProtKB/TrEMBL
  SSF50465 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0L709 ENTREZGENE
  A0A8C0M5G6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PQW1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NWI9 ENTREZGENE, UniProtKB/TrEMBL