LOC610164 (carbonyl reductase [NADPH] 1) - Rat Genome Database

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Gene: LOC610164 (carbonyl reductase [NADPH] 1) Canis lupus familiaris
Analyze
Symbol: LOC610164
Name: carbonyl reductase [NADPH] 1
RGD ID: 12427647
Description: ENCODES a protein that exhibits oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); glucocorticoid metabolic process (ortholog); positive regulation of reactive oxygen species metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: carbonyl reductase 1; CBR1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13131,316,573 - 31,321,413 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3130,416,847 - 30,421,683 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03130,613,805 - 30,618,648 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13130,485,378 - 30,490,206 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03130,499,405 - 30,504,233 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03130,990,002 - 30,995,329 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:25918240   PMID:30032202  


Genomics

Comparative Map Data
LOC610164
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13131,316,573 - 31,321,413 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3130,416,847 - 30,421,683 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03130,613,805 - 30,618,648 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13130,485,378 - 30,490,206 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03130,499,405 - 30,504,233 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03130,990,002 - 30,995,329 (+)NCBIUU_Cfam_GSD_1.0
CBR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382136,070,024 - 36,073,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2136,069,941 - 36,073,166 (+)EnsemblGRCh38hg38GRCh38
GRCh372137,442,322 - 37,445,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362136,364,155 - 36,367,332 (+)NCBINCBI36Build 36hg18NCBI36
Build 342136,364,154 - 36,367,332NCBI
Celera2122,641,173 - 22,644,350 (+)NCBICelera
Cytogenetic Map21q22.12NCBI
HuRef2122,920,731 - 22,923,910 (+)NCBIHuRef
CHM1_12137,004,079 - 37,007,256 (+)NCBICHM1_1
T2T-CHM13v2.02134,453,083 - 34,456,223 (+)NCBIT2T-CHM13v2.0
Cbr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391693,404,752 - 93,407,226 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1693,402,741 - 93,407,393 (+)EnsemblGRCm39 Ensembl
GRCm381693,607,837 - 93,610,349 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1693,605,853 - 93,610,505 (+)EnsemblGRCm38mm10GRCm38
MGSCv371693,608,082 - 93,610,594 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361693,496,379 - 93,498,862 (+)NCBIMGSCv36mm8
Celera1694,690,584 - 94,693,095 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1654.53NCBI
Cbr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81146,346,405 - 46,348,815 (+)NCBIGRCr8
mRatBN7.21132,860,571 - 32,862,981 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,857,991 - 32,895,275 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1132,908,950 - 32,911,393 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,554,857 - 41,557,234 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01134,226,398 - 34,228,775 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01133,387,189 - 33,389,552 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01133,813,041 - 33,815,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01137,436,992 - 37,439,368 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41133,787,957 - 33,790,320 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11133,844,199 - 33,846,562 (+)NCBI
Celera1132,503,106 - 32,505,469 (+)NCBICelera
RH 3.4 Map11 RGD
Cytogenetic Map11q11NCBI
Cbr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540735,351,601 - 35,354,510 (-)NCBIChiLan1.0ChiLan1.0
CBR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22232,191,135 - 32,194,450 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12127,051,164 - 27,054,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02122,440,726 - 22,443,950 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12135,800,177 - 35,803,458 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2135,800,177 - 35,803,458 (+)Ensemblpanpan1.1panPan2
Cbr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497130,876,539 - 30,898,111 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365006,458,721 - 6,591,928 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365006,569,708 - 6,591,266 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13199,617,199 - 199,622,407 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113199,617,406 - 199,622,407 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103218526
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1280,096,743 - 80,099,982 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660547,919,444 - 7,922,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in LOC610164
89 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6
Low 5 1 1
Below cutoff 5 16 6 5 6 12 8 9 6

Sequence


RefSeq Acc Id: XM_038443454   ⟹   XP_038299382
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03130,613,805 - 30,618,648 (+)NCBI
RefSeq Acc Id: XM_038517869   ⟹   XP_038373797
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13130,485,378 - 30,490,206 (+)NCBI
RefSeq Acc Id: XM_038581442   ⟹   XP_038437370
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03130,990,002 - 30,995,329 (+)NCBI
RefSeq Acc Id: XM_038645818   ⟹   XP_038501746
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03130,499,405 - 30,504,233 (+)NCBI
RefSeq Acc Id: XM_847582   ⟹   XP_852675
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13131,316,573 - 31,321,413 (+)NCBI
Dog10K_Boxer_Tasha3130,416,847 - 30,421,683 (+)NCBI
Sequence:
RefSeq Acc Id: XP_852675   ⟸   XM_847582
- UniProtKB: A0A8C0LL00 (UniProtKB/TrEMBL),   A0A8C0T7M5 (UniProtKB/TrEMBL),   A0A8P0SVG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038373797   ⟸   XM_038517869
RefSeq Acc Id: XP_038501746   ⟸   XM_038645818
RefSeq Acc Id: XP_038299382   ⟸   XM_038443454
- UniProtKB: A0A8C0T7M5 (UniProtKB/TrEMBL),   A0A8P0SVG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038437370   ⟸   XM_038581442
- UniProtKB: A0A8C0LL00 (UniProtKB/TrEMBL),   A0A8C0T7M5 (UniProtKB/TrEMBL),   A0A8P0SVG9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014444 UniProtKB/TrEMBL
  ENSCAFG00040019821 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000048689.3 UniProtKB/TrEMBL
  ENSCAFT00000068084.2 UniProtKB/TrEMBL
  ENSCAFT00040036617.1 UniProtKB/TrEMBL
  ENSCAFT00040036634.1 UniProtKB/TrEMBL
  ENSCAFT00040036755.1 UniProtKB/TrEMBL
  ENSCAFT00040036908.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro CBR1-like UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/TrEMBL
  SDR_fam UniProtKB/TrEMBL
NCBI Gene LOC610164 ENTREZGENE
PANTHER CARBONYL REDUCTASE 1-RELATED UniProtKB/TrEMBL
  CARBONYL REDUCTASE [NADPH] 1 UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
PRINTS GDHRDH UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/TrEMBL
Superfamily-SCOP NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL
UniProt A0A8C0LL00 ENTREZGENE
  A0A8C0T7M5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T8C1_CANLF UniProtKB/TrEMBL
  A0A8P0SVG9 ENTREZGENE
UniProt Secondary A0A8P0SVG9 UniProtKB/TrEMBL
  A0A8P0SXS6 UniProtKB/TrEMBL