LANCL2 (LanC like glutathione S-transferase 2) - Rat Genome Database

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Gene: LANCL2 (LanC like glutathione S-transferase 2) Canis lupus familiaris
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Symbol: LANCL2
Name: LanC like glutathione S-transferase 2
RGD ID: 12423281
Description: ENCODES a protein that exhibits phosphatidylinositol-3-phosphate binding (inferred); phosphatidylinositol-4-phosphate binding (inferred); phosphatidylinositol-5-phosphate binding (inferred); INVOLVED IN carbohydrate metabolic process (inferred); negative regulation of DNA-templated transcription (inferred); peptide modification (inferred); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN cortical actin cytoskeleton (inferred); cytosol (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LanC like 2; lanC-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1186,131,536 - 6,237,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl186,197,989 - 6,234,856 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha186,035,458 - 6,082,375 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0186,232,306 - 6,279,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl186,231,806 - 6,280,793 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1186,222,155 - 6,269,095 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0186,196,304 - 6,243,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0186,302,518 - 6,349,674 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LANCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1186,131,536 - 6,237,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl186,197,989 - 6,234,856 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha186,035,458 - 6,082,375 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0186,232,306 - 6,279,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl186,231,806 - 6,280,793 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1186,222,155 - 6,269,095 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0186,196,304 - 6,243,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0186,302,518 - 6,349,674 (+)NCBIUU_Cfam_GSD_1.0
LANCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38755,365,337 - 55,433,737 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl755,365,337 - 55,433,737 (+)EnsemblGRCh38hg38GRCh38
GRCh37755,433,030 - 55,501,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36755,400,635 - 55,468,929 (+)NCBINCBI36Build 36hg18NCBI36
Build 34755,207,349 - 55,275,644NCBI
Celera755,536,348 - 55,604,629 (+)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef755,268,359 - 55,336,642 (+)NCBIHuRef
CHM1_1755,435,807 - 55,504,119 (+)NCBICHM1_1
T2T-CHM13v2.0755,525,667 - 55,594,061 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2755,437,426 - 55,505,717 (+)NCBI
Lancl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39657,679,440 - 57,716,434 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl657,679,525 - 57,716,424 (+)EnsemblGRCm39 Ensembl
GRCm38657,702,455 - 57,739,449 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl657,702,540 - 57,739,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv37657,652,449 - 57,689,443 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36657,632,214 - 57,668,060 (+)NCBIMGSCv36mm8
Celera658,446,120 - 58,483,175 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.82NCBI
Lancl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8488,771,974 - 88,813,920 (-)NCBIGRCr8
mRatBN7.2487,441,821 - 87,483,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl487,441,823 - 87,482,800 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx492,665,021 - 92,704,609 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0488,440,426 - 88,480,014 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0486,803,501 - 86,843,013 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0488,524,212 - 88,565,113 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl488,525,695 - 88,565,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04153,346,850 - 153,387,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4487,197,364 - 87,236,803 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1487,439,372 - 87,480,274 (-)NCBI
Celera482,209,185 - 82,248,518 (-)NCBICelera
Cytogenetic Map4q24NCBI
Lancl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955456204,434 - 229,371 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955456204,434 - 250,143 (-)NCBIChiLan1.0ChiLan1.0
LANCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2660,198,037 - 60,264,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17108,522,754 - 108,589,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0755,958,850 - 56,025,166 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1756,268,426 - 56,335,549 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl756,268,426 - 56,335,549 (+)Ensemblpanpan1.1panPan2
Lancl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118109,623,089 - 109,672,284 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936678219,991 - 265,627 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936678217,272 - 268,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LANCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1848,550,944 - 48,593,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11848,550,752 - 48,593,055 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LANCL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,435,435 - 3,503,802 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,434,909 - 3,501,335 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606219,087,225 - 19,155,311 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lancl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624740485,874 - 514,638 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624740487,173 - 514,484 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LANCL2
1248 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 14 4 1 6 12 8 10 6
Low 2 5 8 6 2 6 5
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000005584   ⟹   ENSCAFP00000005173
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl186,197,989 - 6,234,856 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845020460   ⟹   ENSCAFP00845016040
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl186,231,806 - 6,280,793 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845020494   ⟹   ENSCAFP00845016067
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl186,232,287 - 6,280,793 (+)Ensembl
RefSeq Acc Id: XM_038423677   ⟹   XP_038279605
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0186,232,306 - 6,279,253 (+)NCBI
RefSeq Acc Id: XM_038454065   ⟹   XP_038309993
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha186,035,458 - 6,082,375 (+)NCBI
RefSeq Acc Id: XM_038500044   ⟹   XP_038355972
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1186,222,155 - 6,269,095 (+)NCBI
RefSeq Acc Id: XM_038562626   ⟹   XP_038418554
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0186,302,518 - 6,349,674 (+)NCBI
RefSeq Acc Id: XM_038626706   ⟹   XP_038482634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0186,196,304 - 6,243,241 (+)NCBI
RefSeq Acc Id: ENSCAFP00000005173   ⟸   ENSCAFT00000005584
RefSeq Acc Id: XP_038355972   ⟸   XM_038500044
RefSeq Acc Id: XP_038482634   ⟸   XM_038626706
RefSeq Acc Id: XP_038279605   ⟸   XM_038423677
- UniProtKB: A0A8C0R6P4 (UniProtKB/TrEMBL),   A0A8I3NL82 (UniProtKB/TrEMBL),   A0A8I3NDV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038309993   ⟸   XM_038454065
- UniProtKB: A0A8C0R6P4 (UniProtKB/TrEMBL),   A0A8I3NL82 (UniProtKB/TrEMBL),   A0A8I3NDV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418554   ⟸   XM_038562626
- UniProtKB: A0A8C0R6P4 (UniProtKB/TrEMBL),   A0A8I3NDV5 (UniProtKB/TrEMBL),   A0A8I3NL82 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845016067   ⟸   ENSCAFT00845020494
RefSeq Acc Id: ENSCAFP00845016040   ⟸   ENSCAFT00845020460


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003470 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845011534 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005584.5 UniProtKB/TrEMBL
  ENSCAFT00000097132.1 UniProtKB/TrEMBL
  ENSCAFT00845020460.1 UniProtKB/TrEMBL
  ENSCAFT00845020494 ENTREZGENE
  ENSCAFT00845020494.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
InterPro 6hp_glycosidase-like_sf UniProtKB/TrEMBL
  LANC-like UniProtKB/TrEMBL
  LanC-like_prot_euk UniProtKB/TrEMBL
NCBI Gene LANCL2 ENTREZGENE
PANTHER LANC-LIKE PROTEIN UniProtKB/TrEMBL
  LANC-LIKE PROTEIN 2 UniProtKB/TrEMBL
Pfam LANC_like UniProtKB/TrEMBL
PRINTS LANCEUKARYTE UniProtKB/TrEMBL
  LANCSUPER UniProtKB/TrEMBL
SMART LANC_like UniProtKB/TrEMBL
Superfamily-SCOP LanC-like UniProtKB/TrEMBL
UniProt A0A8C0R6P4 ENTREZGENE
  A0A8I3NDV5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NL82 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PL07_CANLF UniProtKB/TrEMBL
  A0A8P0S960_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:49916 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-20 LANCL2  LanC like glutathione S-transferase 2  LANCL2  LanC like 2  Symbol and/or name change 19259463 PROVISIONAL