TSPO (translocator protein) - Rat Genome Database

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Gene: TSPO (translocator protein) Canis lupus familiaris
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Symbol: TSPO
Name: translocator protein
RGD ID: 12423057
Description: ENCODES a protein that exhibits androgen binding (ortholog); benzodiazepine receptor activity (ortholog); INVOLVED IN adrenal gland development (ortholog); behavioral response to pain (ortholog); cellular hypotonic response (ortholog); PARTICIPATES IN heme biosynthetic pathway; ASSOCIATED WITH cholesterol ester storage disease (ortholog); COVID-19 (ortholog); Developmental Delay with Variable Intellectual Impairment and Behavioral Abnormalities (ortholog); FOUND IN mitochondrial outer membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,388,498 - 22,399,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1022,274,405 - 22,399,297 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,325,190 - 22,336,049 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01023,132,949 - 23,143,978 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1023,132,954 - 23,135,891 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11022,852,287 - 22,863,109 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,171,467 - 23,182,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,347,120 - 23,357,948 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
behavioral response to pain  (ISO)
cellular hypotonic response  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to zinc ion  (ISO)
chloride transport  (ISO)
cholesterol homeostasis  (ISO)
contact inhibition  (ISO)
establishment of protein localization to mitochondrion  (IEA)
glial cell migration  (ISO)
lipid transport  (IEA)
maintenance of protein location in mitochondrion  (IEA)
monoatomic ion transport  (ISO)
negative regulation of ATP metabolic process  (IEA)
negative regulation of corticosterone secretion  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of mitophagy  (IEA)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of protein ubiquitination  (IEA)
negative regulation of tumor necrosis factor production  (ISO)
obsolete negative regulation of mitochondrion organization  (IEA)
peripheral nervous system axon regeneration  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of programmed necrotic cell death  (ISO)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
regulation of steroid biosynthetic process  (ISO)
response to acetylcholine  (ISO)
response to axon injury  (ISO)
response to manganese ion  (ISO)
response to pain  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
response to vitamin B1  (ISO)
response to xenobiotic stimulus  (ISO)
steroid biosynthetic process  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TSPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,388,498 - 22,399,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1022,274,405 - 22,399,297 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,325,190 - 22,336,049 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01023,132,949 - 23,143,978 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1023,132,954 - 23,135,891 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11022,852,287 - 22,863,109 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,171,467 - 23,182,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,347,120 - 23,357,948 (-)NCBIUU_Cfam_GSD_1.0
TSPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382243,151,559 - 43,163,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2243,151,547 - 43,163,242 (+)EnsemblGRCh38hg38GRCh38
GRCh372243,547,565 - 43,559,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,877,479 - 41,889,192 (+)NCBINCBI36Build 36hg18NCBI36
Build 342241,872,050 - 41,883,745NCBI
Celera2227,457,910 - 27,469,623 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2226,505,727 - 26,517,455 (+)NCBIHuRef
CHM1_12243,507,104 - 43,518,509 (+)NCBICHM1_1
T2T-CHM13v2.02243,632,715 - 43,644,077 (+)NCBIT2T-CHM13v2.0
Tspo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,447,774 - 83,458,404 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1583,447,793 - 83,458,404 (+)EnsemblGRCm39 Ensembl
GRCm381583,563,573 - 83,574,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,563,592 - 83,574,203 (+)EnsemblGRCm38mm10GRCm38
MGSCv371583,394,003 - 83,404,633 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361583,391,377 - 83,401,962 (+)NCBIMGSCv36mm8
Celera1585,689,315 - 85,701,021 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
Tspo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,600,214 - 116,610,461 (+)NCBIGRCr8
mRatBN7.27114,720,188 - 114,730,450 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,720,188 - 114,730,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7116,467,236 - 116,477,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,693,096 - 118,703,201 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,662,565 - 118,672,671 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,460,358 - 124,470,610 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,460,358 - 124,470,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07124,449,361 - 124,459,090 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,597,084 - 121,599,342 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17121,631,313 - 121,633,572 (+)NCBI
Celera7111,031,561 - 111,041,788 (+)NCBICelera
RH 3.4 Map7906.4RGD
Cytogenetic Map7q34NCBI
Tspo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541328,308,658 - 28,315,075 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541328,309,105 - 28,315,075 (+)NCBIChiLan1.0ChiLan1.0
TSPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22352,974,420 - 52,985,872 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12255,667,318 - 55,678,778 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02224,034,918 - 24,046,370 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12242,233,186 - 42,244,930 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2242,233,619 - 42,244,930 (+)Ensemblpanpan1.1panPan2
Tspo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049455,984,991 - 5,987,864 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936718992,301 - 995,995 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936718992,301 - 995,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,723,190 - 5,735,131 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.155,723,190 - 5,735,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,145,792 - 3,157,669 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,678,602 - 25,690,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1925,686,981 - 25,690,768 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604599,748,097 - 99,760,895 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tspo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247525,814,784 - 5,820,141 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247525,814,784 - 5,820,250 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TSPO
200 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 7 8 10 6
Low 6 5
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000001416   ⟹   ENSCAFP00000001302
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1022,388,501 - 22,391,432 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000063239   ⟹   ENSCAFP00000052954
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1022,274,405 - 22,399,297 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845025440   ⟹   ENSCAFP00845020028
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1023,132,954 - 23,135,891 (-)Ensembl
RefSeq Acc Id: XM_005625774   ⟹   XP_005625831
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11022,388,498 - 22,399,329 (-)NCBI
Dog10K_Boxer_Tasha1022,325,190 - 22,336,049 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038488382   ⟹   XP_038344310
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11022,852,287 - 22,863,109 (-)NCBI
RefSeq Acc Id: XM_038550296   ⟹   XP_038406224
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01023,347,120 - 23,357,948 (-)NCBI
RefSeq Acc Id: XM_038614275   ⟹   XP_038470203
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01023,171,467 - 23,182,483 (-)NCBI
RefSeq Acc Id: XM_038679615   ⟹   XP_038535543
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01023,132,949 - 23,143,978 (-)NCBI
RefSeq Acc Id: XP_005625831   ⟸   XM_005625774
- UniProtKB: A0A8C0KCS8 (UniProtKB/TrEMBL),   A0A8C0M9V3 (UniProtKB/TrEMBL),   A0A8I3NSR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001302   ⟸   ENSCAFT00000001416
RefSeq Acc Id: ENSCAFP00000052954   ⟸   ENSCAFT00000063239
RefSeq Acc Id: XP_038344310   ⟸   XM_038488382
RefSeq Acc Id: XP_038470203   ⟸   XM_038614275
RefSeq Acc Id: XP_038535543   ⟸   XM_038679615
- UniProtKB: A0A8C0KCS8 (UniProtKB/TrEMBL),   A0A8C0M9V3 (UniProtKB/TrEMBL),   A0A8I3NSR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406224   ⟸   XM_038550296
- UniProtKB: A0A8C0KCS8 (UniProtKB/TrEMBL),   A0A8C0M9V3 (UniProtKB/TrEMBL),   A0A8I3NSR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845020028   ⟸   ENSCAFT00845025440

Promoters
RGD ID:13684935
Promoter ID:EPDNEW_C3003
Type:multiple initiation site
Name:TSPO_1
Description:translocator protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11022,399,285 - 22,399,345EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000913 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004276 UniProtKB/TrEMBL
  ENSCAFG00040013355 UniProtKB/TrEMBL
  ENSCAFG00845014235 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001416.5 UniProtKB/TrEMBL
  ENSCAFT00030007878.1 UniProtKB/TrEMBL
  ENSCAFT00040024676.1 UniProtKB/TrEMBL
  ENSCAFT00845025440 ENTREZGENE
  ENSCAFT00845025440.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.100 UniProtKB/TrEMBL
InterPro TspO/MBR-related_sf UniProtKB/TrEMBL
  TspO_MBR UniProtKB/TrEMBL
KEGG Report cfa:474475 UniProtKB/TrEMBL
NCBI Gene TSPO ENTREZGENE
PANTHER PTHR10057 UniProtKB/TrEMBL
  PTHR10057:SF5 UniProtKB/TrEMBL
Pfam TspO_MBR UniProtKB/TrEMBL
PIRSF PBR UniProtKB/TrEMBL
UniProt A0A8C0KCS8 ENTREZGENE
  A0A8C0M9V3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NSR5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54552 ENTREZGENE