UNC119 (unc-119 lipid binding chaperone) - Rat Genome Database

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Gene: UNC119 (unc-119 lipid binding chaperone) Canis lupus familiaris
Analyze
Symbol: UNC119
Name: unc-119 lipid binding chaperone
RGD ID: 12422727
Description: ENCODES a protein that exhibits lipid binding (ortholog); INVOLVED IN lipoprotein transport (ortholog); mitotic cytokinesis (ortholog); negative regulation of caveolin-mediated endocytosis (ortholog); ASSOCIATED WITH cone-rod dystrophy (ortholog); Cone-Rod Dystrophy 24 (ortholog); genetic disease (ortholog); FOUND IN centrosome (ortholog); intercellular bridge (ortholog); spindle midzone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CRG4; Protein unc-119 homolog A; Retinal protein 4; RG4; unc-119 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,754,575 - 42,760,337 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,754,887 - 42,760,482 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,911,236 - 41,917,005 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,573,537 - 43,579,307 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,573,540 - 43,579,444 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,356,587 - 42,362,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,649,035 - 42,654,797 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,726,501 - 42,732,272 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centrosome  (IBA,IEA,ISS)
cytoplasm  (IEA)
cytoskeleton  (IEA)
intercellular bridge  (IBA,IEA,ISS)
spindle  (IEA)
spindle midzone  (IBA,IEA,ISS)
spindle pole  (IBA,IEA,ISS)

Molecular Function
lipid binding  (IBA,IEA,ISS)
protein binding  (ISO)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
UNC119
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,754,575 - 42,760,337 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,754,887 - 42,760,482 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,911,236 - 41,917,005 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,573,537 - 43,579,307 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,573,540 - 43,579,444 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,356,587 - 42,362,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,649,035 - 42,654,797 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,726,501 - 42,732,272 (-)NCBIUU_Cfam_GSD_1.0
UNC119
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,546,707 - 28,552,628 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,546,708 - 28,552,631 (-)EnsemblGRCh38hg38GRCh38
GRCh371726,873,725 - 26,879,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,897,852 - 23,903,770 (-)NCBINCBI36Build 36hg18NCBI36
Build 341723,897,852 - 23,903,770NCBI
Celera1723,732,750 - 23,738,671 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1723,082,548 - 23,088,469 (-)NCBIHuRef
CHM1_11726,935,427 - 26,941,348 (-)NCBICHM1_1
T2T-CHM13v2.01729,489,330 - 29,495,251 (-)NCBIT2T-CHM13v2.0
Unc119
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,234,321 - 78,239,990 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,234,308 - 78,239,990 (+)EnsemblGRCm39 Ensembl
GRCm381178,343,495 - 78,349,164 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,343,482 - 78,349,164 (+)EnsemblGRCm38mm10GRCm38
MGSCv371178,157,024 - 78,162,658 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,159,717 - 78,165,351 (+)NCBIMGSCv36mm8
Celera1187,975,604 - 87,981,238 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Unc119
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,735,927 - 63,741,404 (+)NCBIGRCr8
mRatBN7.21063,237,862 - 63,243,339 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,237,903 - 63,243,339 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,870,234 - 67,875,633 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,375,583 - 67,380,982 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01062,846,688 - 62,852,088 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,606,919 - 65,612,324 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,606,898 - 65,612,324 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,026,840 - 66,032,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,285,993 - 64,291,392 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,299,615 - 64,305,015 (-)NCBI
Celera1062,215,606 - 62,221,005 (+)NCBICelera
Cytogenetic Map10q25NCBI
Unc119
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,597,839 - 4,603,313 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,597,839 - 4,603,313 (+)NCBIChiLan1.0ChiLan1.0
UNC119
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21935,907,677 - 35,913,612 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,787,803 - 37,793,737 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,223,428 - 28,229,361 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,729,569 - 28,732,229 (+)NCBIpanpan1.1PanPan1.1panPan2
Unc119
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,894,288 - 41,900,215 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,772,283 - 4,778,137 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,772,236 - 4,778,149 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UNC119
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,801,267 - 44,807,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,801,265 - 44,807,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21246,785,656 - 46,791,681 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UNC119
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,315,900 - 22,321,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660757,804,980 - 7,810,919 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Unc119
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247861,134,162 - 1,141,474 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247861,134,508 - 1,140,831 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in UNC119
46 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 12 6 1 12 10 2
Low 3 5 10 6 6 5 6 8 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022423339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038486398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038486399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038486400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038548237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038548238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038548239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038610627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038612202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038612203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038677460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038677461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038677462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_548289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000029702   ⟹   ENSCAFP00000027605
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl942,754,887 - 42,760,482 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000084875   ⟹   ENSCAFP00000045433
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl942,755,525 - 42,760,482 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090732   ⟹   ENSCAFP00000052946
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl942,755,525 - 42,757,193 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013409   ⟹   ENSCAFP00845010402
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl943,573,540 - 43,579,444 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013434   ⟹   ENSCAFP00845010426
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl943,574,355 - 43,576,155 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013452   ⟹   ENSCAFP00845010437
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl943,574,487 - 43,579,292 (-)Ensembl
RefSeq Acc Id: XM_022423339   ⟹   XP_022279047
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1942,754,575 - 42,760,285 (-)NCBI
Dog10K_Boxer_Tasha941,911,236 - 41,916,978 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038486398   ⟹   XP_038342326
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1942,356,587 - 42,362,348 (-)NCBI
RefSeq Acc Id: XM_038486399   ⟹   XP_038342327
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1942,356,587 - 42,362,324 (-)NCBI
RefSeq Acc Id: XM_038486400   ⟹   XP_038342328
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1942,356,587 - 42,362,351 (-)NCBI
RefSeq Acc Id: XM_038548237   ⟹   XP_038404165
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0942,726,501 - 42,732,269 (-)NCBI
RefSeq Acc Id: XM_038548238   ⟹   XP_038404166
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0942,726,501 - 42,732,245 (-)NCBI
RefSeq Acc Id: XM_038548239   ⟹   XP_038404167
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0942,726,501 - 42,732,272 (-)NCBI
RefSeq Acc Id: XM_038610627   ⟹   XP_038466555
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha941,911,236 - 41,917,005 (-)NCBI
RefSeq Acc Id: XM_038612202   ⟹   XP_038468130
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0942,649,035 - 42,654,794 (-)NCBI
RefSeq Acc Id: XM_038612203   ⟹   XP_038468131
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0942,649,035 - 42,654,797 (-)NCBI
RefSeq Acc Id: XM_038677460   ⟹   XP_038533388
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0943,573,537 - 43,579,304 (-)NCBI
RefSeq Acc Id: XM_038677461   ⟹   XP_038533389
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0943,573,537 - 43,579,280 (-)NCBI
RefSeq Acc Id: XM_038677462   ⟹   XP_038533390
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0943,573,537 - 43,579,307 (-)NCBI
RefSeq Acc Id: XM_548289   ⟹   XP_548289
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1942,754,575 - 42,760,337 (-)NCBI
Dog10K_Boxer_Tasha941,911,236 - 41,917,002 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_548289   ⟸   XM_548289
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RJA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022279047   ⟸   XM_022423339
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000027605   ⟸   ENSCAFT00000029702
RefSeq Acc Id: ENSCAFP00000045433   ⟸   ENSCAFT00000084875
RefSeq Acc Id: ENSCAFP00000052946   ⟸   ENSCAFT00000090732
RefSeq Acc Id: XP_038342328   ⟸   XM_038486400
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038342326   ⟸   XM_038486398
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038342327   ⟸   XM_038486399
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038468131   ⟸   XM_038612203
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038468130   ⟸   XM_038612202
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038533390   ⟸   XM_038677462
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038533388   ⟸   XM_038677460
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RJA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038533389   ⟸   XM_038677461
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038466555   ⟸   XM_038610627
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038404167   ⟸   XM_038548239
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038404165   ⟸   XM_038548237
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RJA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038404166   ⟸   XM_038548238
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845010402   ⟸   ENSCAFT00845013409
RefSeq Acc Id: ENSCAFP00845010437   ⟸   ENSCAFT00845013452
RefSeq Acc Id: ENSCAFP00845010426   ⟸   ENSCAFT00845013434
Protein Domains
GMP phosphodiesterase delta subunit

Promoters
RGD ID:13684676
Promoter ID:EPDNEW_C2743
Type:multiple initiation site
Name:UNC119_1
Description:unc-119 lipid binding chaperone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1942,760,330 - 42,760,390EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018713 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013207 UniProtKB/TrEMBL
  ENSCAFG00040020448 UniProtKB/TrEMBL
  ENSCAFG00845007604 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029702.5 UniProtKB/TrEMBL
  ENSCAFT00000090732.2 UniProtKB/TrEMBL
  ENSCAFT00030024518.1 UniProtKB/TrEMBL
  ENSCAFT00030024576.1 UniProtKB/TrEMBL
  ENSCAFT00030024609.1 UniProtKB/TrEMBL
  ENSCAFT00040037899.1 UniProtKB/TrEMBL
  ENSCAFT00040037973.1 UniProtKB/TrEMBL
  ENSCAFT00845013409.1 UniProtKB/TrEMBL
  ENSCAFT00845013434.1 UniProtKB/TrEMBL
  ENSCAFT00845013452.1 UniProtKB/TrEMBL
Gene3D-CATH 2.70.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDED_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDED_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene UNC119 ENTREZGENE
PANTHER PTHR12951:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RETINAL PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GMP_PDE_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0NCA2_CANLF UniProtKB/TrEMBL
  A0A8C0RJA3_CANLF UniProtKB/TrEMBL
  A0A8C0RJA4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N670_CANLF UniProtKB/TrEMBL
  A0A8I3N689_CANLF UniProtKB/TrEMBL
  A0A8I3RU17_CANLF UniProtKB/TrEMBL
  A0A8P0NJS8_CANLF UniProtKB/TrEMBL
  A0A8P0T5C7_CANLF UniProtKB/TrEMBL
  O19177 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:48133 ENTREZGENE