ALOX15B (arachidonate 15-lipoxygenase type B) - Rat Genome Database

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Gene: ALOX15B (arachidonate 15-lipoxygenase type B) Canis lupus familiaris
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Symbol: ALOX15B
Name: arachidonate 15-lipoxygenase type B
RGD ID: 12416451
Description: ENCODES a protein that exhibits arachidonate 8(S)-lipoxygenase activity (ortholog); calcium ion binding (ortholog); linoleate 13S-lipoxygenase activity (ortholog); INVOLVED IN cannabinoid biosynthetic process (ortholog); endocannabinoid signaling pathway (ortholog); lipoxin A4 biosynthetic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH common variable immunodeficiency (ortholog); cone-rod dystrophy 6 (ortholog); COVID-19 (ortholog); FOUND IN adherens junction (ortholog); cytoskeleton (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: arachidonate 15-lipoxygenase B; arachidonate 15-lipoxygenase, type B; polyunsaturated fatty acid lipoxygenase ALOX15B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,878,348 - 32,888,253 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,878,338 - 32,888,316 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha533,014,628 - 33,024,494 (+)NCBI
ROS_Cfam_1.0532,981,218 - 32,991,101 (+)NCBI
ROS_Cfam_1.0 Ensembl532,981,035 - 32,991,180 (+)Ensembl
UMICH_Zoey_3.1532,948,241 - 32,958,102 (+)NCBI
UNSW_CanFamBas_1.0532,904,002 - 32,913,858 (+)NCBI
UU_Cfam_GSD_1.0533,084,046 - 33,093,901 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
ALOX15B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,878,348 - 32,888,253 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,878,338 - 32,888,316 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha533,014,628 - 33,024,494 (+)NCBI
ROS_Cfam_1.0532,981,218 - 32,991,101 (+)NCBI
ROS_Cfam_1.0 Ensembl532,981,035 - 32,991,180 (+)Ensembl
UMICH_Zoey_3.1532,948,241 - 32,958,102 (+)NCBI
UNSW_CanFamBas_1.0532,904,002 - 32,913,858 (+)NCBI
UU_Cfam_GSD_1.0533,084,046 - 33,093,901 (+)NCBI
ALOX15B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,039,059 - 8,049,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl178,039,034 - 8,049,134 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,942,377 - 7,952,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,883,083 - 7,893,177 (+)NCBINCBI36hg18NCBI36
Build 34177,883,126 - 7,893,174NCBI
Celera177,969,928 - 7,980,051 (+)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,837,153 - 7,847,282 (+)NCBIHuRef
CHM1_1177,951,127 - 7,961,240 (+)NCBICHM1_1
T2T-CHM13v2.0177,944,477 - 7,954,568 (+)NCBI
Alox8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,074,711 - 69,088,669 (-)NCBIGRCm39mm39
GRCm39 Ensembl1169,074,758 - 69,088,669 (-)Ensembl
GRCm381169,183,885 - 69,197,843 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,183,932 - 69,197,843 (-)EnsemblGRCm38mm10GRCm38
MGSCv371168,997,387 - 69,011,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,000,080 - 69,014,034 (-)NCBImm8
Celera1176,136,086 - 76,151,253 (-)NCBICelera
Cytogenetic Map11B3NCBI
Alox15b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21053,892,496 - 53,901,812 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1053,892,466 - 53,901,812 (-)Ensembl
Rnor_6.01055,773,748 - 55,783,489 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,774,006 - 55,783,489 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,517,096 - 55,526,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,951,005 - 55,960,265 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11055,964,626 - 55,973,888 (-)NCBI
Celera1053,057,844 - 53,067,039 (-)NCBICelera
Cytogenetic Map10q24NCBI
Alox15b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,895,095 - 8,906,009 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,896,740 - 8,906,032 (-)NCBIChiLan1.0ChiLan1.0
ALOX15B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11748,340,759 - 48,350,808 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,340,777 - 48,350,808 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01743,609,146 - 43,619,713 (-)NCBIMhudiblu_PPA_v0panPan3
Alox15b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,805,676 - 47,815,516 (+)NCBI
SpeTri2.0NW_0049365951,279,944 - 1,288,321 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX15B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,271,583 - 53,281,123 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,259,867 - 53,281,127 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,734,620 - 55,757,204 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX15B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,425,533 - 7,435,896 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl167,425,990 - 7,435,327 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605913,969,096 - 13,979,121 (-)NCBIVero_WHO_p1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 1
Low 5 3 1
Below cutoff 5 5 22 6 6 6 5 12 8 7 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026794   ⟹   ENSCAFP00000024897
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,878,338 - 32,888,316 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000060879   ⟹   ENSCAFP00000058672
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,878,338 - 32,888,316 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000060921   ⟹   ENSCAFP00000050439
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,878,338 - 32,888,316 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000069635   ⟹   ENSCAFP00000053193
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,878,338 - 32,888,316 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000077688   ⟹   ENSCAFP00000063831
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,878,338 - 32,888,316 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000081556   ⟹   ENSCAFP00000065495
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl532,878,338 - 32,888,316 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048173   ⟹   ENSCAFP00845037788
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl532,981,035 - 32,991,180 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048267   ⟹   ENSCAFP00845037862
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl532,981,035 - 32,991,180 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048361   ⟹   ENSCAFP00845037942
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl532,981,035 - 32,991,180 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048413   ⟹   ENSCAFP00845037981
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl532,981,035 - 32,991,180 (+)Ensembl
RefSeq Acc Id: XM_038477636   ⟹   XP_038333564
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1532,948,241 - 32,958,102 (+)NCBI
RefSeq Acc Id: XM_038477637   ⟹   XP_038333565
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1532,948,241 - 32,958,102 (+)NCBI
RefSeq Acc Id: XM_038504551   ⟹   XP_038360479
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha533,014,628 - 33,024,494 (+)NCBI
RefSeq Acc Id: XM_038535522   ⟹   XP_038391450
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0533,084,046 - 33,093,901 (+)NCBI
RefSeq Acc Id: XM_038535523   ⟹   XP_038391451
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0533,084,046 - 33,093,901 (+)NCBI
RefSeq Acc Id: XM_038599744   ⟹   XP_038455672
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0532,904,002 - 32,913,858 (+)NCBI
RefSeq Acc Id: XM_038599745   ⟹   XP_038455673
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0532,904,002 - 32,913,858 (+)NCBI
RefSeq Acc Id: XM_038664273   ⟹   XP_038520201
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0532,981,218 - 32,991,101 (+)NCBI
RefSeq Acc Id: XM_038664274   ⟹   XP_038520202
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0532,981,218 - 32,991,101 (+)NCBI
RefSeq Acc Id: XM_546603   ⟹   XP_546603
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1532,878,348 - 32,888,253 (+)NCBI
Dog10K_Boxer_Tasha533,014,628 - 33,024,494 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_546603   ⟸   XM_546603
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000058672   ⟸   ENSCAFT00000060879
RefSeq Acc Id: ENSCAFP00000053193   ⟸   ENSCAFT00000069635
RefSeq Acc Id: ENSCAFP00000050439   ⟸   ENSCAFT00000060921
RefSeq Acc Id: ENSCAFP00000063831   ⟸   ENSCAFT00000077688
RefSeq Acc Id: ENSCAFP00000024897   ⟸   ENSCAFT00000026794
RefSeq Acc Id: ENSCAFP00000065495   ⟸   ENSCAFT00000081556
RefSeq Acc Id: XP_038333565   ⟸   XM_038477637
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038333564   ⟸   XM_038477636
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038455673   ⟸   XM_038599745
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038455672   ⟸   XM_038599744
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038520202   ⟸   XM_038664274
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038520201   ⟸   XM_038664273
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038360479   ⟸   XM_038504551
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038391451   ⟸   XM_038535523
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038391450   ⟸   XM_038535522
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845037788   ⟸   ENSCAFT00845048173
RefSeq Acc Id: ENSCAFP00845037862   ⟸   ENSCAFT00845048267
RefSeq Acc Id: ENSCAFP00845037981   ⟸   ENSCAFT00845048413
RefSeq Acc Id: ENSCAFP00845037942   ⟸   ENSCAFT00845048361

Promoters
RGD ID:13683238
Promoter ID:EPDNEW_C1307
Type:single initiation site
Name:ALOX15B_1
Description:arachidonate 15-lipoxygenase, type B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1532,878,409 - 32,878,469EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 32884182 32884183 G T snv Siberian Husky (KKH2684)
5 32884822 32884823 C T snv Miniature Bullterrier (BT007)
5 32887500 32887501 C A snv Tibetan Mastiff (TM2), Chinese indigenous dogs (YJ3)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016928 Ensembl
  ENSCAFG00845027303 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845037788.1 UniProtKB/TrEMBL
  ENSCAFP00845037862 ENTREZGENE
  ENSCAFP00845037862.1 UniProtKB/TrEMBL
  ENSCAFP00845037942.1 UniProtKB/TrEMBL
  ENSCAFP00845037981.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845048173.1 UniProtKB/TrEMBL
  ENSCAFT00845048267 ENTREZGENE
  ENSCAFT00845048267.1 UniProtKB/TrEMBL
  ENSCAFT00845048361.1 UniProtKB/TrEMBL
  ENSCAFT00845048413.1 UniProtKB/TrEMBL
InterPro LipOase UniProtKB/TrEMBL
  LipOase_C UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/TrEMBL
  LipOase_CS UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/TrEMBL
  LipOase_mml UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/TrEMBL
NCBI Gene ALOX15B ENTREZGENE
PANTHER PTHR11771 UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PRINTS LIPOXYGENASE UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/TrEMBL
  SSF49723 UniProtKB/TrEMBL
UniProt A0A8I3PS89_CANLF UniProtKB/TrEMBL
  A0A8I3PU89_CANLF UniProtKB/TrEMBL
  A0A8I3Q0Z3_CANLF UniProtKB/TrEMBL
  A0A8I3Q2D9_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:37812 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 ALOX15B  arachidonate 15-lipoxygenase type B    arachidonate 15-lipoxygenase, type B  Symbol and/or name change 5135510 APPROVED