SPRY3 (sprouty RTK signaling antagonist 3) - Rat Genome Database

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Gene: SPRY3 (sprouty RTK signaling antagonist 3) Canis lupus familiaris
Analyze
Symbol: SPRY3
Name: sprouty RTK signaling antagonist 3
RGD ID: 12415891
Description: INVOLVED IN negative regulation of ERK1 and ERK2 cascade (ortholog); negative regulation of MAPK cascade (ortholog); negative regulation of neuron projection arborization (ortholog); ASSOCIATED WITH autistic disorder (ortholog); high grade glioma (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: protein sprouty homolog 3; sprouty homolog 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X123,436,201 - 123,624,816 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX123,620,920 - 123,621,786 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX108,425,110 - 108,612,073 (+)NCBI
ROS_Cfam_1.0X126,568,537 - 126,761,891 (+)NCBI
UMICH_Zoey_3.1X122,307,070 - 122,494,024 (+)NCBI
UNSW_CanFamBas_1.0X124,829,781 - 125,016,753 (+)NCBI
UU_Cfam_GSD_1.0X124,560,893 - 124,747,839 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

Genomics

Comparative Map Data
SPRY3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X123,436,201 - 123,624,816 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX123,620,920 - 123,621,786 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX108,425,110 - 108,612,073 (+)NCBI
ROS_Cfam_1.0X126,568,537 - 126,761,891 (+)NCBI
UMICH_Zoey_3.1X122,307,070 - 122,494,024 (+)NCBI
UNSW_CanFamBas_1.0X124,829,781 - 125,016,753 (+)NCBI
UU_Cfam_GSD_1.0X124,560,893 - 124,747,839 (+)NCBI
SPRY3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX155,612,572 - 155,782,459 (+)EnsemblGRCh38hg38GRCh38
GRCh38Y56,923,423 - 56,968,979 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38X155,612,586 - 155,782,459 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X154,842,247 - 155,012,121 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37Y59,100,403 - 59,115,127 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X154,650,645 - 154,665,311 (+)NCBINCBI36hg18NCBI36
Build 36Y57,509,845 - 57,524,511 (+)NCBINCBI36hg18NCBI36
Build 34Y57,438,581 - 57,453,248NCBI
CeleraX155,151,125 - 155,165,835 (+)NCBI
Cytogenetic MapXq28 and Yq12NCBI
HuRefX143,477,606 - 143,492,323 (+)NCBIHuRef
CHM1_1X154,909,069 - 154,923,770 (+)NCBICHM1_1
Spry3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic MapX NCBI
Spry3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21216,663,188 - 16,673,124 (+)NCBI
Rnor_6.0 Ensembl1218,931,477 - 18,940,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01218,930,087 - 18,940,622 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01220,923,714 - 20,933,886 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,343,080 - 17,344,990 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1218,607,973 - 18,609,883 (+)NCBICelera
Cytogenetic Map12q11NCBI
Spry3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594151,117 - 158,627 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955594151,117 - 158,627 (-)NCBIChiLan1.0ChiLan1.0
SPRY3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X155,125,484 - 155,134,534 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX155,131,596 - 155,132,462 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X145,080,299 - 145,239,922 (+)NCBIMhudiblu_PPA_v0panPan3
Spry3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X120,329,720 - 120,451,847 (+)NCBI
SpeTri2.0NW_004936958225,179 - 232,843 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRY3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,754,671 - 125,763,639 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,744,643 - 125,764,342 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,637,587 - 142,728,609 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPRY3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X129,727,879 - 129,840,393 (+)NCBI
ChlSab1.1 EnsemblX129,838,996 - 129,839,862 (+)Ensembl
Vero_WHO_p1.0NW_02366606567,816,067 - 67,935,491 (+)NCBI
Spry3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624980209,271 - 311,332 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 17 4 1 4 2 12 4 6
Below cutoff 5 5 2 5 2 4 6 8 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005642052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038451330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038451331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038451332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038464297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038524798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038524799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038524800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038588762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038588763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038588764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038653286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000047505   ⟹   ENSCAFP00000049149
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX123,620,920 - 123,621,786 (+)Ensembl
RefSeq Acc Id: XM_005642052   ⟹   XP_005642109
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X123,436,201 - 123,624,816 (+)NCBI
Dog10K_Boxer_TashaX108,425,110 - 108,612,073 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022416392   ⟹   XP_022272100
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X123,615,072 - 123,624,816 (+)NCBI
Dog10K_Boxer_TashaX108,425,110 - 108,612,073 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038451330   ⟹   XP_038307258
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X126,568,537 - 126,761,891 (+)NCBI
RefSeq Acc Id: XM_038451331   ⟹   XP_038307259
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X126,568,537 - 126,761,891 (+)NCBI
RefSeq Acc Id: XM_038451332   ⟹   XP_038307260
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X126,568,537 - 126,761,891 (+)NCBI
RefSeq Acc Id: XM_038464297   ⟹   XP_038320225
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_TashaX108,425,110 - 108,612,073 (+)NCBI
RefSeq Acc Id: XM_038524798   ⟹   XP_038380726
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X122,307,070 - 122,494,024 (+)NCBI
RefSeq Acc Id: XM_038524799   ⟹   XP_038380727
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X122,307,070 - 122,494,024 (+)NCBI
RefSeq Acc Id: XM_038524800   ⟹   XP_038380728
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X122,307,070 - 122,494,024 (+)NCBI
RefSeq Acc Id: XM_038588762   ⟹   XP_038444690
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X124,560,893 - 124,747,839 (+)NCBI
RefSeq Acc Id: XM_038588763   ⟹   XP_038444691
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X124,560,893 - 124,747,839 (+)NCBI
RefSeq Acc Id: XM_038588764   ⟹   XP_038444692
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X124,560,893 - 124,747,839 (+)NCBI
RefSeq Acc Id: XM_038653283   ⟹   XP_038509211
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X125,007,015 - 125,016,753 (+)NCBI
RefSeq Acc Id: XM_038653284   ⟹   XP_038509212
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X124,829,781 - 125,016,753 (+)NCBI
RefSeq Acc Id: XM_038653285   ⟹   XP_038509213
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X124,829,781 - 125,016,753 (+)NCBI
RefSeq Acc Id: XM_038653286   ⟹   XP_038509214
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X124,829,781 - 125,016,753 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005642109   ⟸   XM_005642052
- Sequence:
RefSeq Acc Id: XP_022272100   ⟸   XM_022416392
- Sequence:
RefSeq Acc Id: ENSCAFP00000049149   ⟸   ENSCAFT00000047505
RefSeq Acc Id: XP_038380726   ⟸   XM_038524798
RefSeq Acc Id: XP_038380727   ⟸   XM_038524799
RefSeq Acc Id: XP_038380728   ⟸   XM_038524800
RefSeq Acc Id: XP_038509212   ⟸   XM_038653284
RefSeq Acc Id: XP_038509213   ⟸   XM_038653285
RefSeq Acc Id: XP_038509214   ⟸   XM_038653286
RefSeq Acc Id: XP_038509211   ⟸   XM_038653283
RefSeq Acc Id: XP_038307258   ⟸   XM_038451330
RefSeq Acc Id: XP_038307259   ⟸   XM_038451331
RefSeq Acc Id: XP_038307260   ⟸   XM_038451332
RefSeq Acc Id: XP_038320225   ⟸   XM_038464297
RefSeq Acc Id: XP_038444690   ⟸   XM_038588762
RefSeq Acc Id: XP_038444691   ⟸   XM_038588763
RefSeq Acc Id: XP_038444692   ⟸   XM_038588764


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030651 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000049149 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000047505 UniProtKB/TrEMBL
InterPro Sprouty UniProtKB/TrEMBL
  SPRY3 UniProtKB/TrEMBL
KEGG Report cfa:492271 UniProtKB/TrEMBL
NCBI Gene SPRY3 ENTREZGENE
PANTHER PTHR12365:SF9 UniProtKB/TrEMBL
Pfam Sprouty UniProtKB/TrEMBL
PROSITE SPR UniProtKB/TrEMBL
UniProt A0A5F4C6M5_CANLF UniProtKB/TrEMBL