GCLC (glutamate-cysteine ligase catalytic subunit) - Rat Genome Database

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Gene: GCLC (glutamate-cysteine ligase catalytic subunit) Canis lupus familiaris
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Symbol: GCLC
Name: glutamate-cysteine ligase catalytic subunit
RGD ID: 12410696
Description: ENCODES a protein that exhibits glutamate-cysteine ligase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to fibroblast growth factor stimulus (ortholog); cellular response to follicle-stimulating hormone stimulus (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; glutamic acid/glutamate metabolic pathway; ASSOCIATED WITH amino acid metabolic disorder (ortholog); cataract (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN glutamate-cysteine ligase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutamate--cysteine ligase catalytic subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,999,815 - 21,047,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1221,000,792 - 21,047,779 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,898,243 - 20,947,109 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01221,495,557 - 21,544,499 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1221,496,624 - 21,545,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11220,996,643 - 21,045,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01221,104,936 - 21,153,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01221,243,198 - 21,292,135 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel diameter maintenance  (IEA)
cell redox homeostasis  (IEA)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to thyroxine stimulus  (ISO)
cysteine metabolic process  (IEA)
glutamate metabolic process  (IEA)
glutathione biosynthetic process  (IEA,ISO)
glutathione metabolic process  (IEA,ISO)
L-ascorbic acid metabolic process  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of hepatic stellate cell activation  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
regulation of mitochondrial depolarization  (IEA,ISO)
response to activity  (ISO)
response to arsenic-containing substance  (IEA,ISO)
response to auditory stimulus  (ISO)
response to cadmium ion  (ISO)
response to heat  (IEA)
response to hormone  (IEA)
response to human chorionic gonadotropin  (ISO)
response to interleukin-1  (ISO)
response to nitrosative stress  (ISO)
response to nutrient  (ISO)
response to oxidative stress  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GCLC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,999,815 - 21,047,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1221,000,792 - 21,047,779 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,898,243 - 20,947,109 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01221,495,557 - 21,544,499 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1221,496,624 - 21,545,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11220,996,643 - 21,045,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01221,104,936 - 21,153,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01221,243,198 - 21,292,135 (-)NCBIUU_Cfam_GSD_1.0
GCLC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38653,497,341 - 53,545,101 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl653,497,341 - 53,616,970 (-)EnsemblGRCh38hg38GRCh38
GRCh37653,362,139 - 53,409,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36653,470,098 - 53,517,790 (-)NCBINCBI36Build 36hg18NCBI36
Build 34653,470,097 - 53,517,790NCBI
Celera655,024,301 - 55,071,990 (-)NCBICelera
Cytogenetic Map6p12.1NCBI
HuRef653,193,712 - 53,241,391 (-)NCBIHuRef
CHM1_1653,363,932 - 53,411,726 (-)NCBICHM1_1
T2T-CHM13v2.0653,337,262 - 53,388,129 (-)NCBIT2T-CHM13v2.0
Gclc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39977,661,817 - 77,701,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl977,661,817 - 77,701,767 (+)EnsemblGRCm39 Ensembl
GRCm38977,754,535 - 77,794,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl977,754,535 - 77,794,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv37977,602,617 - 77,641,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36977,540,494 - 77,579,335 (+)NCBIMGSCv36mm8
Celera974,927,826 - 74,966,687 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.36NCBI
Gclc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,510,251 - 87,548,896 (+)NCBIGRCr8
mRatBN7.2878,629,899 - 78,668,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,117,437 - 84,155,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,394,078 - 82,432,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,216,769 - 80,255,182 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,059,051 - 85,097,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0884,627,768 - 84,666,188 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4882,724,429 - 82,762,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1882,743,482 - 82,781,899 (+)NCBI
Celera878,379,669 - 78,418,088 (+)NCBICelera
Cytogenetic Map8q31NCBI
Gclc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554112,593,541 - 2,616,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554112,593,523 - 2,617,553 (+)NCBIChiLan1.0ChiLan1.0
GCLC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2567,968,397 - 68,019,315 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1663,844,833 - 63,895,670 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0653,052,145 - 53,102,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1654,687,315 - 54,738,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl654,687,315 - 54,734,994 (-)Ensemblpanpan1.1panPan2
Gclc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494656,541,439 - 56,588,950 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364767,371,149 - 7,418,958 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364767,371,270 - 7,418,756 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCLC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl727,209,565 - 27,253,530 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1727,209,565 - 27,253,535 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2731,702,759 - 31,747,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GCLC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11719,012,994 - 19,060,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1719,013,026 - 19,060,659 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604453,368,286 - 53,415,900 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gclc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624850749,050 - 793,959 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624850749,046 - 793,654 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GCLC
576 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 22 6 3 6 6 12 10 6
Low 1 5 3 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000003595   ⟹   ENSCAFP00000003329
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1221,000,792 - 21,047,779 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000080041   ⟹   ENSCAFP00000054344
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1221,000,792 - 21,047,779 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018193   ⟹   ENSCAFP00845014183
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1221,496,624 - 21,545,459 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018228   ⟹   ENSCAFP00845014218
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1221,496,624 - 21,545,459 (-)Ensembl
RefSeq Acc Id: XM_038492059   ⟹   XP_038347987
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11220,996,643 - 21,045,520 (-)NCBI
RefSeq Acc Id: XM_038554326   ⟹   XP_038410254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01221,243,198 - 21,292,135 (-)NCBI
RefSeq Acc Id: XM_038618188   ⟹   XP_038474116
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01221,104,936 - 21,153,860 (-)NCBI
RefSeq Acc Id: XM_038683776   ⟹   XP_038539704
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01221,495,557 - 21,544,499 (-)NCBI
RefSeq Acc Id: XM_847752   ⟹   XP_852845
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11220,999,815 - 21,047,779 (-)NCBI
Dog10K_Boxer_Tasha1220,898,243 - 20,947,109 (-)NCBI
Sequence:
RefSeq Acc Id: XP_852845   ⟸   XM_847752
- UniProtKB: A0A8P0N5C9 (UniProtKB/TrEMBL),   A0A8C0QHV3 (UniProtKB/TrEMBL),   A0A8I3NES9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000054344   ⟸   ENSCAFT00000080041
RefSeq Acc Id: ENSCAFP00000003329   ⟸   ENSCAFT00000003595
RefSeq Acc Id: XP_038347987   ⟸   XM_038492059
RefSeq Acc Id: XP_038474116   ⟸   XM_038618188
RefSeq Acc Id: XP_038539704   ⟸   XM_038683776
- UniProtKB: A0A8P0N5C9 (UniProtKB/TrEMBL),   A0A8C0QHV3 (UniProtKB/TrEMBL),   A0A8I3NES9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038410254   ⟸   XM_038554326
- UniProtKB: A0A8C0QHV3 (UniProtKB/TrEMBL),   A0A8I3NES9 (UniProtKB/TrEMBL),   A0A8P0N5C9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845014218   ⟸   ENSCAFT00845018228
RefSeq Acc Id: ENSCAFP00845014183   ⟸   ENSCAFT00845018193

Promoters
RGD ID:13685465
Promoter ID:EPDNEW_C3534
Type:multiple initiation site
Name:GCLC_1
Description:glutamate-cysteine ligase catalytic subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11221,048,270 - 21,048,330EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002288 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016802 UniProtKB/TrEMBL
  ENSCAFG00040006771 UniProtKB/TrEMBL
  ENSCAFG00845010300 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003595.5 UniProtKB/TrEMBL
  ENSCAFT00030031569.1 UniProtKB/TrEMBL
  ENSCAFT00040012860.1 UniProtKB/TrEMBL
  ENSCAFT00845018193 ENTREZGENE
  ENSCAFT00845018193.1 UniProtKB/TrEMBL
  ENSCAFT00845018228.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.960 UniProtKB/TrEMBL
  3.30.590.50 UniProtKB/TrEMBL
InterPro GCS UniProtKB/TrEMBL
  Gln_synth/guanido_kin_cat_dom UniProtKB/TrEMBL
KEGG Report cfa:609822 UniProtKB/TrEMBL
NCBI Gene GCLC ENTREZGENE
PANTHER GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT UniProtKB/TrEMBL
  PTHR11164 UniProtKB/TrEMBL
Pfam GCS UniProtKB/TrEMBL
Superfamily-SCOP SSF55931 UniProtKB/TrEMBL
UniProt A0A8C0QHV3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NAE6_CANLF UniProtKB/TrEMBL
  A0A8I3NES9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N5C9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41147 ENTREZGENE