ASCL1 (achaete-scute family bHLH transcription factor 1)

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Gene: ASCL1 (achaete-scute family bHLH transcription factor 1) Canis lupus familiaris

Analyze

Symbol:

ASCL1

Name:

achaete-scute family bHLH transcription factor 1

RGD ID:

12409252

Description:

ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN adrenal chromaffin cell differentiation (ortholog); carotid body glomus cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); congenital central hypoventilation syndrome (ortholog); Hyperplasia (ortholog); FOUND IN neuronal cell body (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

achaete-scute complex homolog 1; achaete-scute homolog 1; ASH1

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	15	41,694,269 - 41,695,391 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	15	41,694,021 - 41,696,933 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

congenital central hypoventilation syndrome (ISO)

Hyperplasia (ISO)

intellectual disability (ISO)

lung small cell carcinoma (ISO)

nervous system disease (ISO)

status epilepticus (ISO)

Stroke (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adrenal chromaffin cell differentiation (IEA,ISO)

carotid body glomus cell differentiation (IEA,ISO)

cell differentiation (ISO)

cell maturation (IEA,ISO)

cellular response to magnetism (ISO)

central nervous system neuron development (IEA,ISO)

cerebral cortex development (IEA,ISO)

cerebral cortex GABAergic interneuron differentiation (IEA)

commitment of neuronal cell to specific neuron type in forebrain (IEA,ISO)

forebrain neuron differentiation (ISO)

generation of neurons (ISO)

glial cell differentiation (ISO)

heart development (ISO)

lung neuroendocrine cell differentiation (IEA,ISO)

musculoskeletal movement, spinal reflex action (IEA,ISO)

negative regulation of apoptotic process (IEA)

negative regulation of neuron differentiation (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA)

negative regulation of transcription, DNA-templated (ISO)

nervous system development (ISO)

neuroblast fate determination (IEA,ISO)

neuroblast proliferation (IEA,ISO)

neurogenesis (ISO)

neuron development (ISO)

neuron differentiation (IBA,ISO)

neuron fate commitment (ISO)

neuron fate specification (IEA,ISO)

neuron migration (IEA,ISO)

noradrenergic neuron development (IEA,ISO)

noradrenergic neuron fate commitment (IEA)

Notch signaling pathway (IEA,ISO)

olfactory pit development (IEA,ISO)

oligodendrocyte cell fate commitment (ISO)

oligodendrocyte development (IEA,ISO)

oligodendrocyte differentiation (ISO)

pattern specification process (ISO)

positive regulation of cell cycle (IEA,ISO)

positive regulation of neural precursor cell proliferation (IEA,ISO)

positive regulation of neurogenesis (IEA,ISO)

positive regulation of neuron apoptotic process (IEA,ISO)

positive regulation of neuron differentiation (ISO)

positive regulation of Notch signaling pathway (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IBA,ISO)

regulation of cell population proliferation (ISO)

regulation of epithelial cell differentiation (IEA,ISO)

regulation of gene expression (ISO)

regulation of mitotic cell cycle (IEA,ISO)

regulation of neurogenesis (IBA,ISO)

regulation of Notch signaling pathway (ISO)

regulation of timing of subpallium neuron differentiation (IEA,ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

response to epidermal growth factor (ISO)

response to folic acid (ISO)

response to lithium ion (ISO)

response to retinoic acid (IEA,ISO)

sensory organ development (IBA)

spinal cord association neuron differentiation (IEA,ISO)

spinal cord oligodendrocyte cell differentiation (ISO)

spinal cord oligodendrocyte cell fate specification (IEA,ISO)

stomach neuroendocrine cell differentiation (IEA,ISO)

subpallium neuron fate commitment (IEA,ISO)

sympathetic ganglion development (IEA,ISO)

ventral spinal cord interneuron fate commitment (IEA,ISO)

vestibular nucleus development (IEA,ISO)

Cellular Component

neuronal cell body (IEA,ISO)

nucleus (ISO)

RNA polymerase II transcription regulator complex (IBA)

Molecular Function

bHLH transcription factor binding (IEA)

chromatin binding (IEA,ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

double-stranded DNA binding (ISO)

E-box binding (IEA)

identical protein binding (ISO)

protein binding (ISO)

protein dimerization activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

Additional References at PubMed

PMID:25403511

Genomics

Comparative Map Data

ASCL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	15	41,694,269 - 41,695,391 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	15	41,694,021 - 41,696,933 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

ASCL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	12	102,957,674 - 102,960,513 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	12	102,957,674 - 102,960,513 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	12	103,351,452 - 103,354,291 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	12	103,351,452 - 103,354,294 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	101,875,594 - 101,878,421 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	12	101,853,930 - 101,856,754	NCBI
Celera	12	103,015,725 - 103,018,566 (+)	NCBI
Cytogenetic Map	12	q23.2	NCBI
HuRef	12	100,410,703 - 100,413,544 (+)	NCBI		HuRef
CHM1_1	12	103,318,246 - 103,321,086 (+)	NCBI		CHM1_1

Ascl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	87,326,681 - 87,329,522 (-)	NCBI	GRCm39		mm39
GRCm38	10	87,490,819 - 87,493,660 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	87,490,819 - 87,493,660 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	86,953,786 - 86,956,405 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	86,920,621 - 86,922,980 (-)	NCBI			mm8
Celera	10	89,464,389 - 89,467,010 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI

Ascl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	21,904,153 - 21,906,003 (-)	NCBI
Rnor_6.0 Ensembl	7	28,038,662 - 28,040,510 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	28,038,662 - 28,040,504 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	28,152,425 - 28,154,275 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	24,145,578 - 24,168,494 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	24,165,848 - 24,167,679 (-)	NCBI
Celera	7	19,079,344 - 19,081,186 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

Ascl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	37,941,243 - 37,943,641 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	37,941,243 - 37,943,641 (+)	NCBI	ChiLan1.0	ChiLan1.0

ASCL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	103,931,707 - 103,934,554 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	103,932,302 - 103,932,999 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	100,536,895 - 100,539,737 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

Ascl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936492	11,315,929 - 11,317,166 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ASCL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	81,357,431 - 81,360,335 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ASCL1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	98,182,213 - 98,185,057 (+)	NCBI
ChlSab1.1 Ensembl	11	98,182,787 - 98,183,506 (+)	Ensembl

Ascl1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624750	5,487,046 - 5,489,399 (-)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium			8	2		2			8		3
Low			9	2		2			4	8	2
Below cutoff	5	3	4	1	6	1	6	3			5	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005629297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038496466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038496467	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038558863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038558864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038622785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038622786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038688456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038688457	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_539745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCAFT00000011723 ⟹ ENSCAFP00000010864

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	15	41,694,269 - 41,695,391 (+)	Ensembl

RefSeq Acc Id:

XM_005629297 ⟹ XP_005629354

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	15	41,694,023 - 41,696,933 (+)	NCBI

Sequence:

show sequence

GAGGCGGGGCCAGGGCTGCGCTTGGGGCTGGGTGTCCCATTGAAAAGGCGGCCGCACTCCAGCC
GCCCAGCACTCTCTCACTTCTGGCCAGGGAACGTGGAAGGCGCACCGACAGGGGAGCGGCCAGG
GAGGGCGAGTTAAAGAAGGAAAAGAGAAAGGAAGGGAGTTAACAAAATAATAAAAACAGCCCGA
GCCACGGCTGGAGAGACCGAAAGCCGGCGCAAGAGAGCGCAGCCCTAGGGGGCGAGGAGCGGGA
GACTCAGCAGGGCGTGCTCGCCACTGACTTTTGCTGCTGCTGCTGCTGCTGCTGCTGCTTCTTC
CTTTTTTTTTTTTAAACAAGAAGGCGCTAGCGGCAGCCTCACACGCGAGCGCCACGCGAGGCTC
CTGAAGCCAACCCGCGAAGGGAGGAGGGGAGGGAGGAGGAGGAGTGGAGGGAGGAGGAAAAGCG
TTTGCACCTTCTTCTGCTCCCACCCTAAGAAGTCTCCGGGGATTTTGTGTTTTTCTAACTTCCC
TCCGGCCTCACTGTTCAGCTCTCCCCTTCTTCCCCTCTCGGTTCGCGCACCCGAGTCCTGCCCG
CGTGCCCCCGCGCGCCCGCACCTCGCGGCCTCGCTTCTCCCCTTGCGCGACTCCTCGGCGGCCG
CTGCGCATGGAGAGCCCTGCCAAGATGGAGAGCGGCGGCGCCGGCCCGCAGCCGCAGCCGCAGC
CGCAGCCCCAGCCGCAGCCGCAGCCCCAGCCGCAGCCCTTCCTGCCGCCCGCAGCCTGCTTCTT
CGCCACGGCGGCGGCGGCGGCGGCGCAGAGCGCGCAGCAGCAGCCGCAGCCGCAGCCGCAGCCG
CAGCCGCAGCAGGCGCCGCAGCTGAGCCCGGCGGCGGACGGCCAGCCCTCAGGGGGCGGTCACA
AGTCAGCGTCCAAGCAAGTGAAGCGACAGCGCTCGTCCTCGCCCGAACTGATGCGCTGCAAACG
GCGCCTCAACTTCAGCGGCTTCGGCTACAGCCTGCCGCAGCAGCAGCCGGCCGCCGTGGCGCGC
CGCAACGAGCGCGAGCGCAACCGCGTCAAGCTTGTCAACCTGGGCTTCGCCACCCTGCGGGAGC
ACGTCCCCAACGGCGCGGCCAACAAGAAGATGAGCAAGGTGGAGACGCTGCGCTCGGCGGTCGA
GTACATACGCGCGCTGCAGCAGCTGCTGGACGAACACGACGCGGTGAGCGCCGCCTTCCAGGCG
GGCGTCCTGTCGCCCACCATCTCCCCCAACTACTCCAACGACTTGAACTCCATGGCCGGCTCGC
CGGTCTCCTCCTACTCGTCCGACGAGGGCTCCTACGACCCCCTGAGCCCCGAGGAGCAGGAGCT
GCTCGACTTCACCAACTGGTTCTGAGGGGCTCGGCCTGGCCAGGCCCTGGTGCCAACGGACTTT
GGAAGCAGTTACAGGGGGACCGCACAACCTGCATCTTTCATGCTTTCTTGTCAGTGATGTCAGA
AGGGAGAAAAAAAGAAAAAGAAGAAAAGAAGGAAAAACAATAAAATAACATCAGGCAACCGACC
CCAAGACCAACTAAGCATTGCCTGCCTGAGAAGCAAGGCTCTGGCAAAACAGGGATGCGCTCAG
AACTGTATCTTTGCACTCCAATTGTCGCCGGAGCTCTGAAGGGTGACTAGGACCTGAGTCAACG
CGCAGAATGCAGCTTGTGTGCAAAGGCACTGGGCTCCCGGCAGAAGGGAGCAGCAGAGCCCTAT
AGAAACTCCCACCCACCAGTAACAGGCAGAACCACCGAAAGCACTCGCTAGGATGCCTTCACCT
CCCTGCCCTCTGTGAAAGCGCAGTTCTTAGCCCTATAGAAATGGGTTGGTGTCTCTCTTCGAAG
CATCCCCCATCCTATCCCTATAAGCTGTGGACATCTGTCTGCAGTGAAATTATGCTCTACTCAG
TCCTTTGAAACTCCGATCCTCGGCGGGGGCGGGGGGAGGGGGGCTCCCTACATCCCCATTTCCT
CACATCATCTTTTCTACCATTTTCATCATAGAATGCTTCCAATCTTTTGTGAATTTTTTTATTA
TAAGAAAAATCTATTTGTATCTATCCTAACCAGTTTGGGGATATATTAAGATATTTTTGTACAT
AAGAGAGAAAGAGAAAAAATTTATAGAGTTTTGTACAAATGGTTTAAAATGTGTATATCTTGAT
ACTTTAACATGTAATGCTATTACCTCTGCATATTTTAGATGTGTAGTTCACGTTACAACTGCCA
TTTCTCCTATGTGGTTTTGTAAAGAACTCTCCTCATAGGTGAGATCAAAAGGCCACCAGATGTA
CTTCAGCACCAATGTGTCTTACTTTATAGAAACTTTGTTAATGTATTAATGATGTTATTAAATA
CTGTTCAAGAAGAACAAAGTTTATGCAGCTACTGTCCAAACGTCAAGTGTGGCAGCCAGTTGGT
TTTGATAGGTTGCCTTTTGGGAAATTTCTATCACTGCCTTTTTTTTCTTACTGTTTTATTACAA
ACTTACAAGAAACGTGTATAACCCTGTTTTATACAAACTAGTTTCGTAATAAAACTTTTTTCTT
TTTTATAAATGAAAATTA

hide sequence

RefSeq Acc Id:

XM_539745 ⟹ XP_539745

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	15	41,694,021 - 41,696,933 (+)	NCBI

Sequence:

show sequence

GCGAGGCGGGGCCAGGGCTGCGCTTGGGGCTGGGTGTCCCATTGAAAAGGCGGCCGCACTCCAG
CCGCCCAGCACTCTCTCACTTCTGGCCAGGGAACGTGGAAGGCGCACCGACAGGGGAGCGGCCA
GGGAGGGCGAGTTAAAGAAGGAAAAGAGAAAGGAAGGGAGTTAACAAAATAATAAAAACAGCCC
GAGCCACGGCTGGAGAGACCGAAAGCCGGCGCAAGAGAGCGCAGCCCTAGGGGGCGAGGAGCGG
GAGACTCAGCAGGGCGTGCTCGCCACTGACTTTTGCTGCTGCTGCTGCTGCTGCTGCTGCTTCT
TCCTTTTTTTTTTTTAAACAAGAAGGCGCTAGCGGCAGCCTCACACGCGAGCGCCACGCGAGGC
TCCTGAAGCCAACCCGCGAAGGGAGGAGGGGAGGGAGGAGGAGGAGTGGAGGGAGGAGGAAAAG
CGTTTGCACCTTCTTCTGCTCCCACCCTAAGAAGTCTCCGGGGATTTTGTGTTTTTCTAACTTC
CCTCCGGCCTCACTGTTCAGCTCTCCCCTTCTTCCCCTCTCGGTTCGCGCACCCGAGTCCTGCC
CGCGTGCCCCCGCGCGCCCGCACCTCGCGGCCTCGCTTCTCCCCTTGCGCGACTCCTCGGCGGC
CGCTGCGCATGGAGAGCCCTGCCAAGATGGAGAGCGGCGGCGCCGGCCCGCAGCCGCAGCCGCA
GCCGCAGCCCCAGCCGCAGCCGCAGCCCCAGCCGCAGCCCTTCCTGCCGCCCGCAGCCTGCTTC
TTCGCCACGGCGGCGGCGGCGGCGGCGCAGAGCGCGCAGCAGCAGCCGCAGCCGCAGCCGCAGC
CGCAGCCGCAGCAGGCGCCGCAGCTGAGCCCGGCGGCGGACGGCCAGCCCTCAGGGGGCGGTCA
CAAGTCAGCGTCCAAGCAAGTGAAGCGACAGCGCTCGTCCTCGCCCGAACTGATGCGCTGCAAA
CGGCGCCTCAACTTCAGCGGCTTCGGCTACAGCCTGCCGCAGCAGCAGCCGGCCGCCGTGGCGC
GCCGCAACGAGCGCGAGCGCAACCGCGTCAAGCTTGTCAACCTGGGCTTCGCCACCCTGCGGGA
GCACGTCCCCAACGGCGCGGCCAACAAGAAGATGAGCAAGGTGGAGACGCTGCGCTCGGCGGTC
GAGTACATACGCGCGCTGCAGCAGCTGCTGGACGAACACGACGCGGTGAGCGCCGCCTTCCAGG
CGGGCGTCCTGTCGCCCACCATCTCCCCCAACTACTCCAACGACTTGAACTCCATGGCCGGCTC
GCCGGTCTCCTCCTACTCGTCCGACGAGGGCTCCTACGACCCCCTGAGCCCCGAGGAGCAGGAG
CTGCTCGACTTCACCAACTGGTTCTGAGGGGCTCGGCCTGGCCAGGCCCTGGTGCCAACGGACT
TTGGAAGCAGGGGGACCGCACAACCTGCATCTTTCATGCTTTCTTGTCAGTGATGTCAGAAGGG
AGAAAAAAAGAAAAAGAAGAAAAGAAGGAAAAACAATAAAATAACATCAGGCAACCGACCCCAA
GACCAACTAAGCATTGCCTGCCTGAGAAGCAAGGCTCTGGCAAAACAGGGATGCGCTCAGAACT
GTATCTTTGCACTCCAATTGTCGCCGGAGCTCTGAAGGGTGACTAGGACCTGAGTCAACGCGCA
GAATGCAGCTTGTGTGCAAAGGCACTGGGCTCCCGGCAGAAGGGAGCAGCAGAGCCCTATAGAA
ACTCCCACCCACCAGTAACAGGCAGAACCACCGAAAGCACTCGCTAGGATGCCTTCACCTCCCT
GCCCTCTGTGAAAGCGCAGTTCTTAGCCCTATAGAAATGGGTTGGTGTCTCTCTTCGAAGCATC
CCCCATCCTATCCCTATAAGCTGTGGACATCTGTCTGCAGTGAAATTATGCTCTACTCAGTCCT
TTGAAACTCCGATCCTCGGCGGGGGCGGGGGGAGGGGGGCTCCCTACATCCCCATTTCCTCACA
TCATCTTTTCTACCATTTTCATCATAGAATGCTTCCAATCTTTTGTGAATTTTTTTATTATAAG
AAAAATCTATTTGTATCTATCCTAACCAGTTTGGGGATATATTAAGATATTTTTGTACATAAGA
GAGAAAGAGAAAAAATTTATAGAGTTTTGTACAAATGGTTTAAAATGTGTATATCTTGATACTT
TAACATGTAATGCTATTACCTCTGCATATTTTAGATGTGTAGTTCACGTTACAACTGCCATTTC
TCCTATGTGGTTTTGTAAAGAACTCTCCTCATAGGTGAGATCAAAAGGCCACCAGATGTACTTC
AGCACCAATGTGTCTTACTTTATAGAAACTTTGTTAATGTATTAATGATGTTATTAAATACTGT
TCAAGAAGAACAAAGTTTATGCAGCTACTGTCCAAACGTCAAGTGTGGCAGCCAGTTGGTTTTG
ATAGGTTGCCTTTTGGGAAATTTCTATCACTGCCTTTTTTTTCTTACTGTTTTATTACAAACTT
ACAAGAAACGTGTATAACCCTGTTTTATACAAACTAGTTTCGTAATAAAACTTTTTTCTTTTTT
ATAAATGAAAATTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005629354	(Get FASTA)	NCBI Sequence Viewer
	XP_038352394	(Get FASTA)	NCBI Sequence Viewer
	XP_038352395	(Get FASTA)	NCBI Sequence Viewer
	XP_038414791	(Get FASTA)	NCBI Sequence Viewer
	XP_038414792	(Get FASTA)	NCBI Sequence Viewer
	XP_038478713	(Get FASTA)	NCBI Sequence Viewer
	XP_038478714	(Get FASTA)	NCBI Sequence Viewer
	XP_038544384	(Get FASTA)	NCBI Sequence Viewer
	XP_038544385	(Get FASTA)	NCBI Sequence Viewer
	XP_539745	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_539745 ⟸ XM_539745

- UniProtKB:

E2R359 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESPAKMESGGAGPQPQPQPQPQPQPQPQPQPFLPPAACFFATAAAAAAQSAQQQPQPQPQPQP
QQAPQLSPAADGQPSGGGHKSASKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRN
ERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGV
LSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF

hide sequence

RefSeq Acc Id:

XP_005629354 ⟸ XM_005629297

- UniProtKB:

E2R359 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESPAKMESGGAGPQPQPQPQPQPQPQPQPQPFLPPAACFFATAAAAAAQSAQQQPQPQPQPQP
QQAPQLSPAADGQPSGGGHKSASKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRN
ERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGV
LSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF

hide sequence

RefSeq Acc Id:

ENSCAFP00000010864 ⟸ ENSCAFT00000011723

Protein Domains

bHLH

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000007324	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSCAFP00000010864	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000011723	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
InterPro	Achaete-scute-rel	UniProtKB/TrEMBL
	bHLH_dom	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	ASCL1	ENTREZGENE
PANTHER	PTHR13935	UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/TrEMBL
PROSITE	BHLH	UniProtKB/TrEMBL
SMART	HLH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/TrEMBL
UniProt	E2R359	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:38173	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM