ASCL1 (achaete-scute family bHLH transcription factor 1) - Rat Genome Database
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Gene: ASCL1 (achaete-scute family bHLH transcription factor 1) Canis lupus familiaris
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Symbol: ASCL1
Name: achaete-scute family bHLH transcription factor 1
RGD ID: 12409252
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN adrenal chromaffin cell differentiation (ortholog); carotid body glomus cell differentiation (ortholog); cell differentiation (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); congenital central hypoventilation syndrome (ortholog); Hyperplasia (ortholog); FOUND IN neuronal cell body (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: achaete-scute complex homolog 1; achaete-scute homolog 1; ASH1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1541,694,269 - 41,695,391 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11541,694,021 - 41,696,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal chromaffin cell differentiation  (IEA,ISO)
carotid body glomus cell differentiation  (IEA,ISO)
cell differentiation  (ISO)
cell maturation  (IEA,ISO)
cellular response to magnetism  (ISO)
central nervous system neuron development  (IEA,ISO)
cerebral cortex development  (IEA,ISO)
cerebral cortex GABAergic interneuron differentiation  (IEA)
commitment of neuronal cell to specific neuron type in forebrain  (IEA,ISO)
forebrain neuron differentiation  (ISO)
generation of neurons  (ISO)
glial cell differentiation  (ISO)
heart development  (ISO)
lung neuroendocrine cell differentiation  (IEA,ISO)
musculoskeletal movement, spinal reflex action  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transcription, DNA-templated  (ISO)
nervous system development  (ISO)
neuroblast fate determination  (IEA,ISO)
neuroblast proliferation  (IEA,ISO)
neurogenesis  (ISO)
neuron development  (ISO)
neuron differentiation  (IBA,ISO)
neuron fate commitment  (ISO)
neuron fate specification  (IEA,ISO)
neuron migration  (IEA,ISO)
noradrenergic neuron development  (IEA,ISO)
noradrenergic neuron fate commitment  (IEA)
Notch signaling pathway  (IEA,ISO)
olfactory pit development  (IEA,ISO)
oligodendrocyte cell fate commitment  (ISO)
oligodendrocyte development  (IEA,ISO)
oligodendrocyte differentiation  (ISO)
pattern specification process  (ISO)
positive regulation of cell cycle  (IEA,ISO)
positive regulation of neural precursor cell proliferation  (IEA,ISO)
positive regulation of neurogenesis  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of Notch signaling pathway  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of cell population proliferation  (ISO)
regulation of epithelial cell differentiation  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of mitotic cell cycle  (IEA,ISO)
regulation of neurogenesis  (IBA,ISO)
regulation of Notch signaling pathway  (ISO)
regulation of timing of subpallium neuron differentiation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to epidermal growth factor  (ISO)
response to folic acid  (ISO)
response to lithium ion  (ISO)
response to retinoic acid  (IEA,ISO)
sensory organ development  (IBA)
spinal cord association neuron differentiation  (IEA,ISO)
spinal cord oligodendrocyte cell differentiation  (ISO)
spinal cord oligodendrocyte cell fate specification  (IEA,ISO)
stomach neuroendocrine cell differentiation  (IEA,ISO)
subpallium neuron fate commitment  (IEA,ISO)
sympathetic ganglion development  (IEA,ISO)
ventral spinal cord interneuron fate commitment  (IEA,ISO)
vestibular nucleus development  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:25403511  


Genomics

Comparative Map Data
ASCL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1541,694,269 - 41,695,391 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11541,694,021 - 41,696,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ASCL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12102,957,674 - 102,960,513 (+)EnsemblGRCh38hg38GRCh38
GRCh3812102,957,674 - 102,960,513 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712103,351,452 - 103,354,291 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3712103,351,452 - 103,354,294 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612101,875,594 - 101,878,421 (+)NCBINCBI36hg18NCBI36
Build 3412101,853,930 - 101,856,754NCBI
Celera12103,015,725 - 103,018,566 (+)NCBI
Cytogenetic Map12q23.2NCBI
HuRef12100,410,703 - 100,413,544 (+)NCBIHuRef
CHM1_112103,318,246 - 103,321,086 (+)NCBICHM1_1
Ascl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391087,326,681 - 87,329,522 (-)NCBIGRCm39mm39
GRCm381087,490,819 - 87,493,660 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1087,490,819 - 87,493,660 (-)EnsemblGRCm38mm10GRCm38
MGSCv371086,953,786 - 86,956,405 (-)NCBIGRCm37mm9NCBIm37
MGSCv361086,920,621 - 86,922,980 (-)NCBImm8
Celera1089,464,389 - 89,467,010 (-)NCBICelera
Cytogenetic Map10C1NCBI
Ascl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2721,904,153 - 21,906,003 (-)NCBI
Rnor_6.0 Ensembl728,038,662 - 28,040,510 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0728,038,662 - 28,040,504 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0728,152,425 - 28,154,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,145,578 - 24,168,494 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1724,165,848 - 24,167,679 (-)NCBI
Celera719,079,344 - 19,081,186 (-)NCBICelera
Cytogenetic Map7q13NCBI
Ascl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540537,941,243 - 37,943,641 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540537,941,243 - 37,943,641 (+)NCBIChiLan1.0ChiLan1.0
ASCL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112103,931,707 - 103,934,554 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12103,932,302 - 103,932,999 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012100,536,895 - 100,539,737 (+)NCBIMhudiblu_PPA_v0panPan3
Ascl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649211,315,929 - 11,317,166 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASCL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1581,357,431 - 81,360,335 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ASCL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11198,182,213 - 98,185,057 (+)NCBI
ChlSab1.1 Ensembl1198,182,787 - 98,183,506 (+)Ensembl
Ascl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247505,487,046 - 5,489,399 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8 2 2 8 3
Low 9 2 2 4 8 2
Below cutoff 5 3 4 1 6 1 6 3 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011723   ⟹   ENSCAFP00000010864
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1541,694,269 - 41,695,391 (+)Ensembl
RefSeq Acc Id: XM_005629297   ⟹   XP_005629354
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11541,694,023 - 41,696,933 (+)NCBI
Sequence:
RefSeq Acc Id: XM_539745   ⟹   XP_539745
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11541,694,021 - 41,696,933 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_539745   ⟸   XM_539745
- UniProtKB: E2R359 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005629354   ⟸   XM_005629297
- UniProtKB: E2R359 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010864   ⟸   ENSCAFT00000011723
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007324 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000010864 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011723 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro Achaete-scute-rel UniProtKB/TrEMBL
  bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene ASCL1 ENTREZGENE
PANTHER PTHR13935 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt E2R359 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38173 ENTREZGENE