MIEN1 (migration and invasion enhancer 1) - Rat Genome Database

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Gene: MIEN1 (migration and invasion enhancer 1) Canis lupus familiaris
Analyze
Symbol: MIEN1
Name: migration and invasion enhancer 1
RGD ID: 12408498
Description: INVOLVED IN negative regulation of apoptotic process (inferred); positive regulation of cell migration (inferred); positive regulation of filopodium assembly (inferred); ASSOCIATED WITH genetic disease (ortholog); hypertrophic cardiomyopathy 25 (ortholog); FOUND IN cytoplasmic side of plasma membrane (inferred); cytosol (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,758,493 - 22,759,935 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,758,538 - 22,759,886 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,230,962 - 22,232,404 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,552,029 - 23,553,471 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,552,074 - 23,553,422 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,324,830 - 22,326,273 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,585,827 - 22,587,269 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,710,944 - 22,712,386 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MIEN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,758,493 - 22,759,935 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,758,538 - 22,759,886 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,230,962 - 22,232,404 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,552,029 - 23,553,471 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,552,074 - 23,553,422 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,324,830 - 22,326,273 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,585,827 - 22,587,269 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,710,944 - 22,712,386 (+)NCBIUU_Cfam_GSD_1.0
MIEN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,728,510 - 39,730,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,728,496 - 39,730,532 (-)EnsemblGRCh38hg38GRCh38
GRCh371737,884,763 - 37,886,785 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,138,935 - 35,140,314 (-)NCBINCBI36Build 36hg18NCBI36
Build 341735,138,936 - 35,140,314NCBI
Celera1734,545,142 - 34,546,521 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,679,153 - 33,680,533 (-)NCBIHuRef
CHM1_11738,121,161 - 38,122,540 (-)NCBICHM1_1
T2T-CHM13v2.01740,592,070 - 40,594,092 (-)NCBIT2T-CHM13v2.0
Mien1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,328,534 - 98,349,056 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,328,534 - 98,329,817 (-)EnsemblGRCm39 Ensembl
GRCm381198,437,708 - 98,458,230 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,437,708 - 98,438,991 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,299,022 - 98,300,302 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,253,815 - 98,255,060 (-)NCBIMGSCv36mm8
Celera11108,091,912 - 108,093,192 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
Mien1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,931,485 - 83,932,778 (-)NCBIGRCr8
mRatBN7.21083,435,198 - 83,436,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,434,710 - 83,436,488 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,379,613 - 88,380,906 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,877,698 - 87,878,991 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,270,350 - 83,271,643 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,391,848 - 86,393,141 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,391,848 - 86,393,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,187,783 - 86,189,076 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,243,039 - 87,244,331 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,257,383 - 87,258,699 (-)NCBI
Celera1082,182,638 - 82,183,897 (-)NCBICelera
Cytogenetic Map10q31NCBI
Mien1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,456,484 - 14,462,082 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,456,484 - 14,462,082 (-)NCBIChiLan1.0ChiLan1.0
MIEN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,224,970 - 25,226,391 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,119,785 - 27,121,206 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,558,422 - 17,559,849 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,775,355 - 17,777,558 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,775,355 - 17,776,941 (+)Ensemblpanpan1.1panPan2
Mien1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,163,236 - 22,164,662 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,908,449 - 14,912,369 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,910,477 - 14,911,899 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIEN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,587,919 - 22,590,251 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,588,194 - 22,589,912 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,045,691 - 23,047,404 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIEN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,433,591 - 66,434,989 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,433,628 - 66,435,243 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,335,845 - 37,344,475 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mien1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,371,384 - 3,372,812 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,371,383 - 3,372,819 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MIEN1
13 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000025915   ⟹   ENSCAFP00000024062
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl922,758,538 - 22,759,886 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845020476   ⟹   ENSCAFP00845016054
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,552,074 - 23,553,422 (+)Ensembl
RefSeq Acc Id: XM_005624552   ⟹   XP_005624609
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1922,758,493 - 22,759,935 (+)NCBI
Dog10K_Boxer_Tasha922,230,962 - 22,232,404 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038485654   ⟹   XP_038341582
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1922,324,830 - 22,326,273 (+)NCBI
RefSeq Acc Id: XM_038547422   ⟹   XP_038403350
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0922,710,944 - 22,712,386 (+)NCBI
RefSeq Acc Id: XM_038611404   ⟹   XP_038467332
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0922,585,827 - 22,587,269 (+)NCBI
RefSeq Acc Id: XM_038676600   ⟹   XP_038532528
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0923,552,029 - 23,553,471 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005624609   ⟸   XM_005624552
- UniProtKB: A0A8C0PVB7 (UniProtKB/TrEMBL),   A0A8C0L3Z5 (UniProtKB/TrEMBL),   A0A8I3N9L8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000024062   ⟸   ENSCAFT00000025915
RefSeq Acc Id: XP_038341582   ⟸   XM_038485654
RefSeq Acc Id: XP_038467332   ⟸   XM_038611404
RefSeq Acc Id: XP_038532528   ⟸   XM_038676600
- UniProtKB: A0A8C0PVB7 (UniProtKB/TrEMBL),   A0A8C0L3Z5 (UniProtKB/TrEMBL),   A0A8I3N9L8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403350   ⟸   XM_038547422
- UniProtKB: A0A8C0L3Z5 (UniProtKB/TrEMBL),   A0A8C0PVB7 (UniProtKB/TrEMBL),   A0A8I3N9L8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845016054   ⟸   ENSCAFT00845020476

Promoters
RGD ID:13684550
Promoter ID:EPDNEW_C2618
Type:multiple initiation site
Name:MIEN1_1
Description:migration and invasion enhancer 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1922,758,528 - 22,758,588EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016339 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011666 UniProtKB/TrEMBL
  ENSCAFG00040001723 UniProtKB/TrEMBL
  ENSCAFG00845011547 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025915.5 UniProtKB/TrEMBL
  ENSCAFT00030021556.1 UniProtKB/TrEMBL
  ENSCAFT00040003254.1 UniProtKB/TrEMBL
  ENSCAFT00845020476 ENTREZGENE
  ENSCAFT00845020476.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Selenoprotein_Rdx-typ UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report cfa:480532 UniProtKB/TrEMBL
NCBI Gene MIEN1 ENTREZGENE
PANTHER MIGRATION AND INVASION ENHANCER 1 UniProtKB/TrEMBL
  SELENOPROTEIN W UniProtKB/TrEMBL
Pfam Rdx UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A8C0L3Z5 ENTREZGENE
  A0A8C0PVB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N9L8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43228 ENTREZGENE