ACOT4 (acyl-CoA thioesterase 4) - Rat Genome Database

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Gene: ACOT4 (acyl-CoA thioesterase 4) Canis lupus familiaris
Analyze
Symbol: ACOT4 (Ensembl: ACOT6)
Name: acyl-CoA thioesterase 4 (Ensembl:acyl-CoA thioesterase 6)
RGD ID: 12408187
Description: ENCODES a protein that exhibits fatty acyl-CoA hydrolase activity (ortholog); succinyl-CoA hydrolase activity (ortholog); INVOLVED IN butyrate metabolic process (ortholog); dicarboxylic acid catabolic process (ortholog); dicarboxylic acid metabolic process (ortholog); ASSOCIATED WITH intellectual disability (ortholog); FOUND IN peroxisome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acyl-coenzyme A thioesterase 4; LOC490771; peroxisomal succinyl-coenzyme A thioesterase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1846,889,326 - 46,894,379 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl846,852,880 - 46,911,640 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha846,573,784 - 46,580,670 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0847,118,497 - 47,125,383 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1846,786,164 - 46,791,040 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0846,804,351 - 46,811,227 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,194,704 - 47,201,587 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
peroxisome  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ACOT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1846,889,326 - 46,894,379 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl846,852,880 - 46,911,640 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha846,573,784 - 46,580,670 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0847,118,497 - 47,125,383 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1846,786,164 - 46,791,040 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0846,804,351 - 46,811,227 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,194,704 - 47,201,587 (+)NCBIUU_Cfam_GSD_1.0
ACOT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381473,591,873 - 73,595,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1473,591,873 - 73,595,766 (+)EnsemblGRCh38hg38GRCh38
GRCh371474,058,577 - 74,062,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361473,128,163 - 73,132,223 (+)NCBINCBI36Build 36hg18NCBI36
Celera1454,094,503 - 54,098,556 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1454,226,329 - 54,230,382 (+)NCBIHuRef
CHM1_11473,998,002 - 74,002,055 (+)NCBICHM1_1
T2T-CHM13v2.01467,799,383 - 67,803,276 (+)NCBIT2T-CHM13v2.0
Acot4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,084,028 - 84,091,497 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,085,153 - 84,095,375 (+)EnsemblGRCm39 Ensembl
GRCm381284,037,254 - 84,044,723 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,038,379 - 84,048,601 (+)EnsemblGRCm38mm10GRCm38
MGSCv371285,379,329 - 85,385,673 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361284,928,127 - 84,934,471 (+)NCBIMGSCv36mm8
Celera1285,484,852 - 85,491,186 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.01NCBI
Acot4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,399,032 - 109,405,138 (+)NCBIGRCr8
mRatBN7.26103,668,699 - 103,674,037 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6103,668,753 - 103,673,917 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6103,830,503 - 103,835,783 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,129,719 - 104,134,999 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06103,499,170 - 103,504,450 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06107,517,668 - 107,522,952 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6107,517,668 - 107,522,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06118,021,264 - 118,026,536 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,075,508 - 108,080,792 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6101,498,707 - 101,503,970 (+)NCBICelera
Cytogenetic Map6q31NCBI
ACOT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21574,680,646 - 74,687,296 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11473,895,275 - 73,907,168 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01454,150,843 - 54,155,119 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11473,008,597 - 73,012,673 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,008,909 - 73,012,561 (+)Ensemblpanpan1.1panPan2
Acot4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864029,152,711 - 29,157,109 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364882,912,016 - 2,914,995 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364882,912,016 - 2,914,995 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100158115
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl796,868,157 - 96,949,358 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1796,941,065 - 96,945,834 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27102,787,631 - 102,791,737 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12450,806,736 - 50,811,294 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2450,807,212 - 50,811,181 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605338,972,271 - 38,996,921 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ACOT4
63 total Variants

Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_038483746   ⟹   XP_038339674
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1846,786,164 - 46,791,040 (+)NCBI
RefSeq Acc Id: XM_038545223   ⟹   XP_038401151
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0847,194,704 - 47,199,603 (+)NCBI
RefSeq Acc Id: XM_038545224   ⟹   XP_038401152
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0847,194,704 - 47,201,587 (+)NCBI
RefSeq Acc Id: XM_038590816   ⟹   XP_038446744
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha846,573,784 - 46,580,670 (+)NCBI
RefSeq Acc Id: XM_038609319   ⟹   XP_038465247
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0846,804,351 - 46,809,248 (+)NCBI
RefSeq Acc Id: XM_038609320   ⟹   XP_038465248
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0846,804,351 - 46,811,227 (+)NCBI
RefSeq Acc Id: XM_038674146   ⟹   XP_038530074
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0847,118,497 - 47,123,397 (+)NCBI
RefSeq Acc Id: XM_038674147   ⟹   XP_038530075
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0847,118,497 - 47,125,383 (+)NCBI
RefSeq Acc Id: XM_547893   ⟹   XP_547893
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1846,889,326 - 46,894,379 (+)NCBI
Dog10K_Boxer_Tasha846,573,784 - 46,578,684 (+)NCBI
Sequence:
RefSeq Acc Id: XP_547893   ⟸   XM_547893
- Peptide Label: isoform X1
- UniProtKB: A0A8C0S1M5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038339674   ⟸   XM_038483746
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038465248   ⟸   XM_038609320
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038465247   ⟸   XM_038609319
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530075   ⟸   XM_038674147
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038530074   ⟸   XM_038674146
- Peptide Label: isoform X1
- UniProtKB: A0A8C0S1M5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038446744   ⟸   XM_038590816
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038401152   ⟸   XM_038545224
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038401151   ⟸   XM_038545223
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P4A4 (UniProtKB/TrEMBL),   A0A8C0S1M5 (UniProtKB/TrEMBL)
Protein Domains
Acyl-CoA thioester hydrolase/bile acid-CoA amino   BAAT/Acyl-CoA thioester hydrolase C-terminal

Promoters
RGD ID:13684271
Promoter ID:EPDNEW_C2339
Type:initiation region
Name:ACOT4_1
Description:acyl-CoA thioesterase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1846,889,434 - 46,889,494EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023467 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022557 UniProtKB/TrEMBL
  ENSCAFG00040009008 UniProtKB/TrEMBL
  ENSCAFG00040009054 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000063865.2 UniProtKB/TrEMBL
  ENSCAFT00000063992.2 UniProtKB/TrEMBL
  ENSCAFT00000077033.2 UniProtKB/TrEMBL
  ENSCAFT00030041432.1 UniProtKB/TrEMBL
  ENSCAFT00040016738.1 UniProtKB/TrEMBL
  ENSCAFT00040016822.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2240 UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Acyl-CoA_thioEstase_long-chain UniProtKB/TrEMBL
  BAAT_C UniProtKB/TrEMBL
  Thio_Ohase/aa_AcTrfase UniProtKB/TrEMBL
  Thio_Ohase/BAAT_N UniProtKB/TrEMBL
NCBI Gene LOC490771 ENTREZGENE
PANTHER ACYL-COENZYME A THIOESTERASE-RELATED UniProtKB/TrEMBL
  PEROXISOMAL SUCCINYL-COENZYME A THIOESTERASE UniProtKB/TrEMBL
Pfam BAAT_C UniProtKB/TrEMBL
  Bile_Hydr_Trans UniProtKB/TrEMBL
PIRSF Acyl-CoA_hydro UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A8C0P4A4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S1M5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S1T8_CANLF UniProtKB/TrEMBL
  A0A8P0PFC2_CANLF UniProtKB/TrEMBL
  A0A8P0SXN6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:49744 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 ACOT4  acyl-CoA thioesterase 4  LOC490771  acyl-coenzyme A thioesterase 4  Symbol and/or name change 5135510 APPROVED