MFRP (membrane frizzled-related protein) - Rat Genome Database

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Gene: MFRP (membrane frizzled-related protein) Canis lupus familiaris
Analyze
Symbol: MFRP
Name: membrane frizzled-related protein
RGD ID: 12408119
Description: INVOLVED IN eye photoreceptor cell development (ortholog); retina development in camera-type eye (ortholog); visual perception (ortholog); ASSOCIATED WITH CD3epsilon deficiency (ortholog); Chromosome 11, Partial Trisomy 11q (ortholog); Dwarfism (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC489366
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,555,619 - 14,561,577 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,556,065 - 14,561,623 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha514,609,393 - 14,614,363 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0514,499,276 - 14,504,240 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl514,499,485 - 14,504,210 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1514,637,560 - 14,642,522 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0514,541,551 - 14,546,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0514,581,669 - 14,586,636 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
MFRP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,555,619 - 14,561,577 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,556,065 - 14,561,623 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha514,609,393 - 14,614,363 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0514,499,276 - 14,504,240 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl514,499,485 - 14,504,210 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1514,637,560 - 14,642,522 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0514,541,551 - 14,546,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0514,581,669 - 14,586,636 (+)NCBIUU_Cfam_GSD_1.0
MFRP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811119,338,942 - 119,346,705 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11119,338,942 - 119,346,705 (-)EnsemblGRCh38hg38GRCh38
GRCh3711119,209,652 - 119,217,415 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,716,836 - 118,722,580 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411118,716,835 - 118,722,580NCBI
Celera11116,370,323 - 116,378,054 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11115,150,343 - 115,158,082 (-)NCBIHuRef
CHM1_111119,096,203 - 119,103,942 (-)NCBICHM1_1
T2T-CHM13v2.011119,359,579 - 119,367,342 (-)NCBIT2T-CHM13v2.0
Mfrp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,013,067 - 44,020,484 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,013,026 - 44,020,484 (+)EnsemblGRCm39 Ensembl
GRCm38944,101,770 - 44,109,187 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,101,729 - 44,109,187 (+)EnsemblGRCm38mm10GRCm38
MGSCv37943,909,853 - 43,917,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36943,909,925 - 43,917,270 (+)NCBIMGSCv36mm8
Celera941,359,597 - 41,367,008 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map924.6NCBI
Mfrp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,342,483 - 53,347,696 (+)NCBIGRCr8
mRatBN7.2844,445,636 - 44,450,859 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,445,697 - 44,450,859 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx849,943,933 - 49,949,098 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,222,643 - 48,227,808 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,090,263 - 46,095,426 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,437,720 - 48,443,421 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,437,918 - 48,443,421 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,053,980 - 47,059,250 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,084,056 - 47,089,218 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1847,092,971 - 47,097,611 (+)NCBI
Celera844,032,894 - 44,038,056 (+)NCBICelera
Cytogenetic Map8q22NCBI
Mfrp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,421,935 - 20,426,760 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541220,421,935 - 20,426,760 (-)NCBIChiLan1.0ChiLan1.0
MFRP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29120,046,694 - 120,054,325 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111121,152,657 - 121,157,778 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011114,179,998 - 114,187,716 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111118,107,317 - 118,115,050 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11118,107,317 - 118,115,050 (-)Ensemblpanpan1.1panPan2
Mfrp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947101,350,829 - 101,355,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365424,272,264 - 4,277,252 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365424,272,250 - 4,277,231 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFRP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,550,315 - 46,556,077 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1946,550,383 - 46,556,305 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,584,361 - 51,590,860 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MFRP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,720,520 - 110,728,529 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,720,530 - 110,725,483 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604315,305,601 - 15,314,524 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfrp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478414,710,042 - 14,714,715 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478414,709,834 - 14,714,927 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MFRP
68 total Variants

Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022418205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022418206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038474774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038474775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038535919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038535920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038600114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038600115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038664652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038664653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000085839   ⟹   ENSCAFP00000043406
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl514,556,065 - 14,561,623 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087655   ⟹   ENSCAFP00000049250
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl514,556,065 - 14,561,623 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845026147   ⟹   ENSCAFP00845020610
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl514,499,485 - 14,504,210 (+)Ensembl
RefSeq Acc Id: XM_038474774   ⟹   XP_038330702
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1514,637,560 - 14,642,522 (+)NCBI
RefSeq Acc Id: XM_038474775   ⟹   XP_038330703
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1514,637,560 - 14,642,492 (+)NCBI
RefSeq Acc Id: XM_038508277   ⟹   XP_038364205
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha514,609,393 - 14,614,363 (+)NCBI
RefSeq Acc Id: XM_038508286   ⟹   XP_038364214
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha514,609,393 - 14,614,333 (+)NCBI
RefSeq Acc Id: XM_038535919   ⟹   XP_038391847
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0514,581,669 - 14,586,636 (+)NCBI
RefSeq Acc Id: XM_038535920   ⟹   XP_038391848
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0514,581,669 - 14,586,606 (+)NCBI
RefSeq Acc Id: XM_038600114   ⟹   XP_038456042
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0514,541,551 - 14,546,518 (+)NCBI
RefSeq Acc Id: XM_038600115   ⟹   XP_038456043
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0514,541,551 - 14,546,488 (+)NCBI
RefSeq Acc Id: XM_038664652   ⟹   XP_038520580
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0514,499,276 - 14,504,240 (+)NCBI
RefSeq Acc Id: XM_038664653   ⟹   XP_038520581
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0514,499,276 - 14,504,210 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000049250   ⟸   ENSCAFT00000087655
RefSeq Acc Id: ENSCAFP00000043406   ⟸   ENSCAFT00000085839
RefSeq Acc Id: XP_038330702   ⟸   XM_038474774
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038330703   ⟸   XM_038474775
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038456042   ⟸   XM_038600114
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038456043   ⟸   XM_038600115
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038520580   ⟸   XM_038664652
- Peptide Label: isoform X1
- UniProtKB: A0A8C0T6A3 (UniProtKB/TrEMBL),   A0A8I3NXK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038520581   ⟸   XM_038664653
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038364205   ⟸   XM_038508277
- Peptide Label: isoform X1
- UniProtKB: A0A8C0T6A3 (UniProtKB/TrEMBL),   A0A8I3NXK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038364214   ⟸   XM_038508286
- Peptide Label: isoform X2
- UniProtKB: A0A8C0T8Q7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038391847   ⟸   XM_038535919
- Peptide Label: isoform X1
- UniProtKB: A0A8C0T6A3 (UniProtKB/TrEMBL),   A0A8I3NXK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038391848   ⟸   XM_038535920
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845020610   ⟸   ENSCAFT00845026147
Protein Domains
CUB   FZ


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000047904 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002872 UniProtKB/TrEMBL
  ENSCAFG00040019129 UniProtKB/TrEMBL
  ENSCAFG00845014601 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000087655.2 UniProtKB/TrEMBL
  ENSCAFT00030005408.1 UniProtKB/TrEMBL
  ENSCAFT00030005444.1 UniProtKB/TrEMBL
  ENSCAFT00040035630.1 UniProtKB/TrEMBL
  ENSCAFT00040035716.1 UniProtKB/TrEMBL
  ENSCAFT00845026147 ENTREZGENE
  ENSCAFT00845026147.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
NCBI Gene MFRP ENTREZGENE
PANTHER MEMBRANE FRIZZLED-RELATED PROTEIN UniProtKB/TrEMBL
  OVOCHYMASE-RELATED UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART CUB UniProtKB/TrEMBL
  FRI UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
Superfamily-SCOP SSF49854 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
  SSF63501 UniProtKB/TrEMBL
UniProt A0A8C0M6L3_CANLF UniProtKB/TrEMBL
  A0A8C0T6A3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T8Q7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NXK3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-09 MFRP  membrane frizzled-related protein  LOC489366  membrane frizzled-related protein  Symbol and/or name change 5135510 APPROVED
2021-01-12 LOC489366  membrane frizzled-related protein  MFRP  membrane frizzled-related protein  Symbol and/or name change 5135510 APPROVED