PARD6A (par-6 family cell polarity regulator alpha)

Gene: PARD6A (par-6 family cell polarity regulator alpha) Canis lupus familiaris

Analyze

Symbol:

PARD6A

Name:

par-6 family cell polarity regulator alpha

RGD ID:

12405675

Description:

ENCODES a protein that exhibits GTP-dependent protein binding (inferred); small GTPase binding (inferred); INVOLVED IN negative regulation of protein phosphorylation (ortholog); regulation of cellular localization (ortholog); PARTICIPATES IN adenosine signaling pathway; insulin signaling pathway; protein kinase C (PKC) signaling pathway; ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); chromosome 16q22 deletion syndrome (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); axonal growth cone (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

par-6 partitioning defective 6 homolog alpha; partitioning defective 6 homolog alpha

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	81,787,424 - 81,789,833 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	81,787,553 - 81,790,324 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	81,777,186 - 81,779,574 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	82,222,592 - 82,224,980 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	82,222,721 - 82,225,620 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	82,048,921 - 82,051,309 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	81,730,456 - 81,732,843 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	82,373,005 - 82,375,393 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 6 (ISO)

chromosome 16q22 deletion syndrome (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

cell-cell junction maintenance (IEA)

centrosome cycle (IEA)

establishment or maintenance of cell polarity (IEA)

establishment or maintenance of epithelial cell apical/basal polarity (IEA)

negative regulation of protein phosphorylation (IEA,ISO)

positive regulation of protein localization to centrosome (IEA)

positive regulation of protein secretion (IEA)

regulation of cellular localization (IEA,ISO)

Cellular Component

anchoring junction (IEA)

apical part of cell (ISO)

apical plasma membrane (IEA)

axonal growth cone (ISO)

bicellular tight junction (IEA)

cell cortex (IEA)

centriolar satellite (IEA)

centrosome (IEA)

cytoplasm (IEA)

neuronal cell body (ISO)

nucleus (IEA)

PAR polarity complex (IEA,ISO)

plasma membrane (IEA)

protein-containing complex (ISO)

Molecular Function

GTP-dependent protein binding (IEA)

protein binding (ISO)

small GTPase binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

adenosine signaling pathway (ISO)

insulin signaling pathway (ISO)

protein kinase C (PKC) signaling pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

PARD6A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	81,787,424 - 81,789,833 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	81,787,553 - 81,790,324 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	81,777,186 - 81,779,574 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	82,222,592 - 82,224,980 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	82,222,721 - 82,225,620 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	82,048,921 - 82,051,309 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	81,730,456 - 81,732,843 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	82,373,005 - 82,375,393 (-)	NCBI		UU_Cfam_GSD_1.0

PARD6A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	67,660,960 - 67,662,774 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	67,660,946 - 67,662,774 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	67,694,863 - 67,696,677 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	66,252,352 - 66,254,182 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	66,252,362 - 66,254,177	NCBI
Celera	16	52,203,341 - 52,205,171 (+)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	53,567,763 - 53,569,593 (+)	NCBI		HuRef
CHM1_1	16	69,102,564 - 69,104,394 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	73,455,728 - 73,457,542 (+)	NCBI		T2T-CHM13v2.0

Pard6a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	106,427,780 - 106,430,126 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	106,427,780 - 106,430,128 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	105,701,148 - 105,703,494 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	105,701,148 - 105,703,496 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	108,225,054 - 108,227,394 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	108,590,812 - 108,592,595 (+)	NCBI		MGSCv36	mm8
Celera	8	109,926,072 - 109,928,412 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.04	NCBI

Pard6a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	50,499,420 - 50,502,301 (+)	NCBI		GRCr8
mRatBN7.2	19	33,589,531 - 33,591,900 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	33,589,542 - 33,591,900 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	40,405,102 - 40,407,471 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	41,058,434 - 41,060,803 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	43,356,207 - 43,358,576 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	37,668,133 - 37,670,450 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,668,133 - 37,672,729 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	48,534,837 - 48,537,154 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	35,533,395 - 35,535,711 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	35,538,275 - 35,540,592 (+)	NCBI
Celera	19	33,017,530 - 33,019,847 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Pard6a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	9,019,929 - 9,021,995 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	9,019,929 - 9,022,561 (-)	NCBI	ChiLan1.0	ChiLan1.0

PARD6A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	77,189,120 - 77,190,952 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	83,101,588 - 83,103,415 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	48,004,822 - 48,006,656 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	67,394,252 - 67,395,991 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	67,394,252 - 67,395,991 (+)	Ensembl	panpan1.1		panPan2

Pard6a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	41,533,814 - 41,536,924 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	18,052,181 - 18,054,620 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	18,052,768 - 18,054,620 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PARD6A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	28,280,502 - 28,283,788 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	28,280,502 - 28,282,923 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PARD6A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	59,781,890 - 59,783,990 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666047	22,535,640 - 22,537,747 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pard6a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	18,686,921 - 18,688,703 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	18,686,916 - 18,688,739 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PARD6A
12 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium			11						12	8	1
Low	4	2	11	6	6	6	5	6			8	4
Below cutoff	1	3					1				1	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005620817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022419316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038477391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038477392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038477393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038538598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038538599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038538600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038602713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038602714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038602715	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038667322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038667323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038667324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_546876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000050072 ⟹ ENSCAFP00000040187

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	5	81,787,553 - 81,790,324 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845012222 ⟹ ENSCAFP00845009554

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	5	82,222,721 - 82,225,620 (-)	Ensembl

RefSeq Acc Id:

XM_005620817 ⟹ XP_005620874

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	81,787,424 - 81,789,833 (-)	NCBI
Dog10K_Boxer_Tasha	5	81,777,186 - 81,779,069 (-)	NCBI

Sequence:

show sequence

AACGTGTGTGCAGACTCTGTTTCGGGACGGTGGGTGCCAACGTGCTTGGTTTACCCCAGTGCCT
CCGAGGAACGGCCCGCCGTGTGGGCCGTTCGTCAAGACTCCCGTGCCGCCGGGCAGGATGGGGC
CCAGGGCTGGCTGGGATGGGAAGGGAAGGATCTGGAGCTTGAGGCTGCGGCCACGAGTGGTCAA
GCGAGTTGGCTCAAAGCCACTTCAACACCGTGTGAACCGAGTTGCTCAGCAAATACTTATGGTT
CAGTTTCCTCATCTAAACGTGCAGTCTCGTAAGGCCAGTGGAAATACTAGGACACAGACAACAC
TCGGTAAACGCCACTTCCCTGTCTCCCCTCGGATTGGCGAAGCCCCACCCCCAGACTCGGAGAC
TGGCGCGCAGGAGCGTAATGACGCAAGAGCACACGAAGACGCCCCCACCCCATCTCCGTTTCCT
AGGAAACGTGGACTCCGCGTACCGCTCACTGTCGCTGCCCCCTTGACGTCATGGTCCGGACGGG
AGGGCGGGGCGAGTGCTACCGCCAGGGGCGGGGCGACGGGCCGGTCGCCCGGGCTGTGCACCTG
CGCCCAGGCGGGCCGCCTGGGGCACCGTCCCCGGCCCGCCGGCCTCACCATGGCCAGGCCGCAG
AGGACTCCGGCGCGCAGTCCCGACAACATCGTCGAGGTGAAGAGCAAATTTGATGCTGAGTTCC
GACGCTTCGCGCTGCCCCGCGCTTCGGTGAGTGGCTTCCAAGAGTTTTCGCGGTTGCTGCGTGC
AGTCCACCAGATCCCGGGCCTGGATGTGCTGCTTGGCTATACAGATGCTCACGGTGACCTACTG
CCCCTCACCAACGACGACAGCCTGCACCGGGCCCTGGCCAGCGGGCCCCCACCGCTGCGCCTGC
TAGTACAGAAGCGGGAAGCTGACTCCAGTGGCCTGGCCTTTGCCTCCAACTCTCTGCAGCGGCG
GAAGAAAGGGCTCCTACTTCGGCCAGTGGCACCCCTGCGCACCCGGCCACCCCTGCTAATCAGC
CTGCCCCAAGATTTCCGCCAGGTTTCTTCAGTCATAGATGTGGACCTACTGCCTGAGACCCACC
GACGGGTTCGGCTGCACAAGCATGGCTCGGACCGCCCCCTGGGTTTCTACATTCGAGATGGCAT
GAGTGTCCGTGTAGCTCCCCAGGGCTTGGAACGGGTTCCAGGCATCTTCATCTCCCGCCTGGTA
CGAGGGGGCCTGGCTGAGAGTACGGGGCTGCTGGCAGTCAGTGATGAGATCCTCGAGGTCAATG
GTATTGAGGTGGCTGGGAAGACCTTGGACCAAGTGACGGACATGATGGTCGCCAACAGCCACAA
TCTCATTGTCACTGTCAAGCCAGCCAATCAGCGCAATAATGTGGTGCGGGGAGCATCTGGGCGT
CTGACAGGGCCTTCCTCTGCTGGGCCTGGGCCTACTGAGGCTGAGAGTGACGATGATAGCAATG
ATCTGGTCATTGAAAACCGCCAGCCTCCCTGTTCCAATGGGCTGTCTCAAGGGCCTCCATGCTG
GGACCTGCGCCAGGGCCGTCTACTTCCTGGTGCCCGCAGTTCTCTGCCCTCCCTGGATGATCAG
GAGCAGGCCAGCTCTGGCTGGGGGAGTAGCATGCGAGGAGATGGTAGTGGCTTTAGCCTCTGAT
GGGCAAGGATGCAACCCCTTGCTACTCCAGGCTGCTGGGACATGGCAGGGACTTCCTTGGTGGG
GGTTTTTAGCTTGCTCACAGGGCCCTCTCAGTCTGGGGAACATTAAAGGTTTTCTACAAATGCA

hide sequence

RefSeq Acc Id:

XM_022419316 ⟹ XP_022275024

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	81,787,424 - 81,789,833 (-)	NCBI
Dog10K_Boxer_Tasha	5	81,777,186 - 81,779,032 (-)	NCBI

Sequence:

show sequence

AACGTGTGTGCAGACTCTGTTTCGGGACGGTGGGTGCCAACGTGCTTGGTTTACCCCAGTGCCT
CCGAGGAACGGCCCGCCGTGTGGGCCGTTCGTCAAGACTCCCGTGCCGCCGGGCAGGATGGGGC
CCAGGGCTGGCTGGGATGGGAAGGGAAGGATCTGGAGCTTGAGGCTGCGGCCACGAGTGGTCAA
GCGAGTTGGCTCAAAGCCACTTCAACACCGTGTGAACCGAGTTGCTCAGCAAATACTTATGGTT
CAGTTTCCTCATCTAAACGTGCAGTCTCGTAAGGCCAGTGGAAATACTAGGACACAGACAACAC
TCGGTAAACGCCACTTCCCTGTCTCCCCTCGGATTGGCGAAGCCCCACCCCCAGACTCGGAGAC
TGGCGCGCAGGAGCGTAATGACGCAAGAGCACACGAAGACGCCCCCACCCCATCTCCGTTTCCT
AGGAAACGTGGACTCCGCGTACCGCTCACTGTCGCTGCCCCCTTGACGTCATGGTCCGGACGGG
AGGGCGGGGCGAGTGCTACCGCCAGGGGCGGGGCGACGGGCCGGTCGCCCGGGCTGTGCACCTG
CGCCCAGGCGGGCCGCCTGGGGCACCGTCCCCGGCCCGCCGGCCTCACCATGGCCAGGCCGCAG
AGGACTCCGGCGCGCAGTCCCGACAACATCGTCGAGTTTGATGCTGAGTTCCGACGCTTCGCGC
TGCCCCGCGCTTCGGTGAGTGGCTTCCAAGAGTTTTCGCGGTTGCTGCGTGCAGTCCACCAGAT
CCCGGGCCTGGATGTGCTGCTTGGCTATACAGATGCTCACGGTGACCTACTGCCCCTCACCAAC
GACGACAGCCTGCACCGGGCCCTGGCCAGCGGGCCCCCACCGCTGCGCCTGCTAGTACAGAAGC
GGGCAGAAGCTGACTCCAGTGGCCTGGCCTTTGCCTCCAACTCTCTGCAGCGGCGGAAGAAAGG
GCTCCTACTTCGGCCAGTGGCACCCCTGCGCACCCGGCCACCCCTGCTAATCAGCCTGCCCCAA
GATTTCCGCCAGGTTTCTTCAGTCATAGATGTGGACCTACTGCCTGAGACCCACCGACGGGTTC
GGCTGCACAAGCATGGCTCGGACCGCCCCCTGGGTTTCTACATTCGAGATGGCATGAGTGTCCG
TGTAGCTCCCCAGGGCTTGGAACGGGTTCCAGGCATCTTCATCTCCCGCCTGGTACGAGGGGGC
CTGGCTGAGAGTACGGGGCTGCTGGCAGTCAGTGATGAGATCCTCGAGGTCAATGGTATTGAGG
TGGCTGGGAAGACCTTGGACCAAGTGACGGACATGATGGTCGCCAACAGCCACAATCTCATTGT
CACTGTCAAGCCAGCCAATCAGCGCAATAATGTGGTGCGGGGAGCATCTGGGCGTCTGACAGGG
CCTTCCTCTGCTGGGCCTGGGCCTACTGAGGCTGAGAGTGACGATGATAGCAATGATCTGGTCA
TTGAAAACCGCCAGCCTCCCTGTTCCAATGGGCTGTCTCAAGGGCCTCCATGCTGGGACCTGCG
CCAGGGCCGTCTACTTCCTGGTGCCCGCAGTTCTCTGCCCTCCCTGGATGATCAGGAGCAGGCC
AGCTCTGGCTGGGGGAGTAGCATGCGAGGAGATGGTAGTGGCTTTAGCCTCTGATGGGCAAGGA
TGCAACCCCTTGCTACTCCAGGCTGCTGGGACATGGCAGGGACTTCCTTGGTGGGGGTTTTTAG
CTTGCTCACAGGGCCCTCTCAGTCTGGGGAACATTAAAGGTTTTCTACAAATGCA

hide sequence

RefSeq Acc Id:

XM_038477391 ⟹ XP_038333319

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	82,048,921 - 82,051,309 (-)	NCBI

RefSeq Acc Id:

XM_038477392 ⟹ XP_038333320

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	82,048,921 - 82,050,804 (-)	NCBI

RefSeq Acc Id:

XM_038477393 ⟹ XP_038333321

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	82,048,921 - 82,050,767 (-)	NCBI

RefSeq Acc Id:

XM_038538598 ⟹ XP_038394526

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	82,373,005 - 82,375,393 (-)	NCBI

RefSeq Acc Id:

XM_038538599 ⟹ XP_038394527

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	82,373,005 - 82,374,888 (-)	NCBI

RefSeq Acc Id:

XM_038538600 ⟹ XP_038394528

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	82,373,005 - 82,374,851 (-)	NCBI

RefSeq Acc Id:

XM_038602713 ⟹ XP_038458641

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	81,730,456 - 81,732,843 (-)	NCBI

RefSeq Acc Id:

XM_038602714 ⟹ XP_038458642

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	81,730,456 - 81,732,339 (-)	NCBI

RefSeq Acc Id:

XM_038602715 ⟹ XP_038458643

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	81,730,456 - 81,732,302 (-)	NCBI

RefSeq Acc Id:

XM_038667322 ⟹ XP_038523250

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	82,222,592 - 82,224,980 (-)	NCBI

RefSeq Acc Id:

XM_038667323 ⟹ XP_038523251

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	82,222,592 - 82,224,475 (-)	NCBI

RefSeq Acc Id:

XM_038667324 ⟹ XP_038523252

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	82,222,592 - 82,224,438 (-)	NCBI

RefSeq Acc Id:

XM_546876 ⟹ XP_546876

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	81,787,424 - 81,789,833 (-)	NCBI
Dog10K_Boxer_Tasha	5	81,777,186 - 81,779,574 (-)	NCBI

Sequence:

show sequence

AACGTGTGTGCAGACTCTGTTTCGGGACGGTGGGTGCCAACGTGCTTGGTTTACCCCAGTGCCT
CCGAGGAACGGCCCGCCGTGTGGGCCGTTCGTCAAGACTCCCGTGCCGCCGGGCAGGATGGGGC
CCAGGGCTGGCTGGGATGGGAAGGGAAGGATCTGGAGCTTGAGGCTGCGGCCACGAGTGGTCAA
GCGAGTTGGCTCAAAGCCACTTCAACACCGTGTGAACCGAGTTGCTCAGCAAATACTTATGGTT
CAGTTTCCTCATCTAAACGTGCAGTCTCGTAAGGCCAGTGGAAATACTAGGACACAGACAACAC
TCGGTAAACGCCACTTCCCTGTCTCCCCTCGGATTGGCGAAGCCCCACCCCCAGACTCGGAGAC
TGGCGCGCAGGAGCGTAATGACGCAAGAGCACACGAAGACGCCCCCACCCCATCTCCGTTTCCT
AGGAAACGTGGACTCCGCGTACCGCTCACTGTCGCTGCCCCCTTGACGTCATGGTCCGGACGGG
AGGGCGGGGCGAGTGCTACCGCCAGGGGCGGGGCGACGGGCCGGTCGCCCGGGCTGTGCACCTG
CGCCCAGGCGGGCCGCCTGGGGCACCGTCCCCGGCCCGCCGGCCTCACCATGGCCAGGCCGCAG
AGGACTCCGGCGCGCAGTCCCGACAACATCGTCGAGGTGAAGAGCAAATTTGATGCTGAGTTCC
GACGCTTCGCGCTGCCCCGCGCTTCGGTGAGTGGCTTCCAAGAGTTTTCGCGGTTGCTGCGTGC
AGTCCACCAGATCCCGGGCCTGGATGTGCTGCTTGGCTATACAGATGCTCACGGTGACCTACTG
CCCCTCACCAACGACGACAGCCTGCACCGGGCCCTGGCCAGCGGGCCCCCACCGCTGCGCCTGC
TAGTACAGAAGCGGGCAGAAGCTGACTCCAGTGGCCTGGCCTTTGCCTCCAACTCTCTGCAGCG
GCGGAAGAAAGGGCTCCTACTTCGGCCAGTGGCACCCCTGCGCACCCGGCCACCCCTGCTAATC
AGCCTGCCCCAAGATTTCCGCCAGGTTTCTTCAGTCATAGATGTGGACCTACTGCCTGAGACCC
ACCGACGGGTTCGGCTGCACAAGCATGGCTCGGACCGCCCCCTGGGTTTCTACATTCGAGATGG
CATGAGTGTCCGTGTAGCTCCCCAGGGCTTGGAACGGGTTCCAGGCATCTTCATCTCCCGCCTG
GTACGAGGGGGCCTGGCTGAGAGTACGGGGCTGCTGGCAGTCAGTGATGAGATCCTCGAGGTCA
ATGGTATTGAGGTGGCTGGGAAGACCTTGGACCAAGTGACGGACATGATGGTCGCCAACAGCCA
CAATCTCATTGTCACTGTCAAGCCAGCCAATCAGCGCAATAATGTGGTGCGGGGAGCATCTGGG
CGTCTGACAGGGCCTTCCTCTGCTGGGCCTGGGCCTACTGAGGCTGAGAGTGACGATGATAGCA
ATGATCTGGTCATTGAAAACCGCCAGCCTCCCTGTTCCAATGGGCTGTCTCAAGGGCCTCCATG
CTGGGACCTGCGCCAGGGCCGTCTACTTCCTGGTGCCCGCAGTTCTCTGCCCTCCCTGGATGAT
CAGGAGCAGGCCAGCTCTGGCTGGGGGAGTAGCATGCGAGGAGATGGTAGTGGCTTTAGCCTCT
GATGGGCAAGGATGCAACCCCTTGCTACTCCAGGCTGCTGGGACATGGCAGGGACTTCCTTGGT
GGGGGTTTTTAGCTTGCTCACAGGGCCCTCTCAGTCTGGGGAACATTAAAGGTTTTCTACAAAT
GCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005620874	(Get FASTA)	NCBI Sequence Viewer
	XP_022275024	(Get FASTA)	NCBI Sequence Viewer
	XP_038333319	(Get FASTA)	NCBI Sequence Viewer
	XP_038333320	(Get FASTA)	NCBI Sequence Viewer
	XP_038333321	(Get FASTA)	NCBI Sequence Viewer
	XP_038394526	(Get FASTA)	NCBI Sequence Viewer
	XP_038394527	(Get FASTA)	NCBI Sequence Viewer
	XP_038394528	(Get FASTA)	NCBI Sequence Viewer
	XP_038458641	(Get FASTA)	NCBI Sequence Viewer
	XP_038458642	(Get FASTA)	NCBI Sequence Viewer
	XP_038458643	(Get FASTA)	NCBI Sequence Viewer
	XP_038523250	(Get FASTA)	NCBI Sequence Viewer
	XP_038523251	(Get FASTA)	NCBI Sequence Viewer
	XP_038523252	(Get FASTA)	NCBI Sequence Viewer
	XP_546876	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000040187.2
	ENSCAFP00030030343.1
	ENSCAFP00040024841.1
	ENSCAFP00845009554
	ENSCAFP00845009554.1

RefSeq Acc Id:	XP_005620874 ⟸ XM_005620817
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0YZ65 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGPRAGWDGKGRIWSLRLRPRVVKRVGSKPLQHRVNRVAQQILMVQFPHLNVQSRKASGNTRTQ TTLGKRHFPVSPRIGEAPPPDSETGAQERNDARAHEDAPTPSPFPRKRGLRVPLTVAAPLTSWS GREGGASATARGGATGRSPGLCTCAQAGRLGHRPRPAGLTMARPQRTPARSPDNIVEVKSKFDA EFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPL RLLVQKREADSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPE THRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILE VNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPSSAGPGPTEAESDDD SNDLVIENRQPPCSNGLSQGPPCWDLRQGRLLPGARSSLPSLDDQEQASSGWGSSMRGDGSGFS L hide sequence

RefSeq Acc Id:	XP_546876 ⟸ XM_546876
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3RTL4 (UniProtKB/TrEMBL), A0A8P0SU80 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGPRAGWDGKGRIWSLRLRPRVVKRVGSKPLQHRVNRVAQQILMVQFPHLNVQSRKASGNTRTQ TTLGKRHFPVSPRIGEAPPPDSETGAQERNDARAHEDAPTPSPFPRKRGLRVPLTVAAPLTSWS GREGGASATARGGATGRSPGLCTCAQAGRLGHRPRPAGLTMARPQRTPARSPDNIVEVKSKFDA EFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPL RLLVQKRAEADSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLP ETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEIL EVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPSSAGPGPTEAESDD DSNDLVIENRQPPCSNGLSQGPPCWDLRQGRLLPGARSSLPSLDDQEQASSGWGSSMRGDGSGF SL hide sequence

RefSeq Acc Id:	XP_022275024 ⟸ XM_022419316
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0YZ65 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGPRAGWDGKGRIWSLRLRPRVVKRVGSKPLQHRVNRVAQQILMVQFPHLNVQSRKASGNTRTQ TTLGKRHFPVSPRIGEAPPPDSETGAQERNDARAHEDAPTPSPFPRKRGLRVPLTVAAPLTSWS GREGGASATARGGATGRSPGLCTCAQAGRLGHRPRPAGLTMARPQRTPARSPDNIVEFDAEFRR FALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLV QKRAEADSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHR RVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNG IEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPSSAGPGPTEAESDDDSND LVIENRQPPCSNGLSQGPPCWDLRQGRLLPGARSSLPSLDDQEQASSGWGSSMRGDGSGFSL hide sequence

RefSeq Acc Id:

ENSCAFP00000040187 ⟸ ENSCAFT00000050072

RefSeq Acc Id:	XP_038333319 ⟸ XM_038477391
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038333320 ⟸ XM_038477392
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038333321 ⟸ XM_038477393
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038458641 ⟸ XM_038602713
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038458642 ⟸ XM_038602714
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038458643 ⟸ XM_038602715
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038523250 ⟸ XM_038667322
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3RTL4 (UniProtKB/TrEMBL), A0A8P0SU80 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038523251 ⟸ XM_038667323
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0YZ65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038523252 ⟸ XM_038667324
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0YZ65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038394526 ⟸ XM_038538598
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3RTL4 (UniProtKB/TrEMBL), A0A8P0SU80 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038394527 ⟸ XM_038538599
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0YZ65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038394528 ⟸ XM_038538600
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0YZ65 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845009554 ⟸ ENSCAFT00845012222

Protein Domains

PB1 PDZ

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000031576	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030018917	UniProtKB/TrEMBL
	ENSCAFG00040015499	UniProtKB/TrEMBL
	ENSCAFG00845006886	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000050072.3	UniProtKB/TrEMBL
	ENSCAFT00030034799.1	UniProtKB/TrEMBL
	ENSCAFT00040028598.1	UniProtKB/TrEMBL
	ENSCAFT00845012222	ENTREZGENE
	ENSCAFT00845012222.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.42.10	UniProtKB/TrEMBL
InterPro	PB1_dom	UniProtKB/TrEMBL
	PB1_Par6	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
NCBI Gene	PARD6A	ENTREZGENE
PANTHER	PAR-6-RELATED	UniProtKB/TrEMBL
	PTHR14102:SF9	UniProtKB/TrEMBL
Pfam	PB1	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
PROSITE	PB1	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
SMART	PB1	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
Superfamily-SCOP	CAD & PB1 domains	UniProtKB/TrEMBL
	SSF50156	UniProtKB/TrEMBL
UniProt	A0A8C0YZ65	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3RTL4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SU80	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:44265	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)