MYCN (MYCN proto-oncogene, bHLH transcription factor) - Rat Genome Database

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Gene: MYCN (MYCN proto-oncogene, bHLH transcription factor) Canis lupus familiaris
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Symbol: MYCN
Name: MYCN proto-oncogene, bHLH transcription factor
RGD ID: 12405529
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN astrocyte differentiation (ortholog); autosome genomic imprinting (ortholog); branching morphogenesis of an epithelial tube (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Agenesis of Gallbladder (ortholog); amenorrhea (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: N-MYC1; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11711,720,857 - 11,724,308 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1711,663,228 - 11,669,338 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01711,848,344 - 11,854,451 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1711,848,002 - 11,854,448 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11711,707,661 - 11,713,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01711,718,338 - 11,724,418 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01711,742,671 - 11,748,783 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleolus  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:25403511   PMID:30032202  


Genomics

Comparative Map Data
MYCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11711,720,857 - 11,724,308 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1711,663,228 - 11,669,338 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01711,848,344 - 11,854,451 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1711,848,002 - 11,854,448 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11711,707,661 - 11,713,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01711,718,338 - 11,724,418 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01711,742,671 - 11,748,783 (+)NCBIUU_Cfam_GSD_1.0
MYCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38215,940,550 - 15,947,004 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl215,940,550 - 15,947,007 (+)EnsemblGRCh38hg38GRCh38
GRCh37216,080,672 - 16,087,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36215,998,134 - 16,004,580 (+)NCBINCBI36Build 36hg18NCBI36
Build 34216,032,643 - 16,037,721NCBI
Celera215,998,381 - 16,004,827 (+)NCBICelera
Cytogenetic Map2p24.3NCBI
HuRef215,934,021 - 15,938,396 (+)NCBIHuRef
CHM1_1216,010,469 - 16,016,915 (+)NCBICHM1_1
T2T-CHM13v2.0215,972,182 - 15,978,635 (+)NCBIT2T-CHM13v2.0
Mycn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391212,986,094 - 12,991,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1212,986,094 - 12,991,915 (-)EnsemblGRCm39 Ensembl
GRCm381212,936,093 - 12,941,836 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1212,936,093 - 12,941,914 (-)EnsemblGRCm38mm10GRCm38
MGSCv371212,942,899 - 12,948,642 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361212,962,079 - 12,967,694 (-)NCBIMGSCv36mm8
Celera1213,282,496 - 13,288,240 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map126.14NCBI
Mycn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8641,446,683 - 41,452,584 (-)NCBIGRCr8
mRatBN7.2635,717,764 - 35,723,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl635,717,764 - 35,723,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx636,030,195 - 36,036,011 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0636,344,835 - 36,350,651 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0635,812,708 - 35,818,534 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0638,222,554 - 38,228,419 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl638,222,555 - 38,228,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0651,348,169 - 51,354,719 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4636,508,262 - 36,514,071 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera635,082,308 - 35,088,132 (-)NCBICelera
Cytogenetic Map6q15NCBI
Mycn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554879,219,528 - 9,224,818 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554879,219,528 - 9,224,818 (+)NCBIChiLan1.0ChiLan1.0
MYCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212110,580,807 - 110,585,956 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A110,584,779 - 110,591,313 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A15,925,130 - 15,931,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A16,058,298 - 16,064,547 (+)NCBIpanpan1.1PanPan1.1panPan2
Mycn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629256,215,359 - 56,221,421 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649314,618,060 - 14,624,315 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649314,618,176 - 14,624,201 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3121,543,109 - 121,549,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13121,543,201 - 121,549,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23129,821,890 - 129,827,921 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11491,685,376 - 91,692,091 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604520,532,406 - 20,539,075 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mycn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624865780,163 - 785,776 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MYCN
62 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00845028681   ⟹   ENSCAFP00845022573
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1711,848,002 - 11,854,448 (+)Ensembl
RefSeq Acc Id: XM_038453499   ⟹   XP_038309427
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1711,663,228 - 11,669,338 (+)NCBI
RefSeq Acc Id: XM_038498263   ⟹   XP_038354191
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11711,707,661 - 11,713,769 (+)NCBI
RefSeq Acc Id: XM_038560817   ⟹   XP_038416745
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01711,742,671 - 11,748,783 (+)NCBI
RefSeq Acc Id: XM_038624843   ⟹   XP_038480771
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01711,718,338 - 11,724,418 (+)NCBI
RefSeq Acc Id: XM_038690753   ⟹   XP_038546681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01711,848,344 - 11,854,451 (+)NCBI
RefSeq Acc Id: XP_038354191   ⟸   XM_038498263
RefSeq Acc Id: XP_038480771   ⟸   XM_038624843
RefSeq Acc Id: XP_038546681   ⟸   XM_038690753
- UniProtKB: A0A8I3NNK6 (UniProtKB/TrEMBL),   A0A8P0PJJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038309427   ⟸   XM_038453499
- UniProtKB: A0A8C0N7C9 (UniProtKB/TrEMBL),   A0A8P0PJJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038416745   ⟸   XM_038560817
- UniProtKB: A0A8P0PJJ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845022573   ⟸   ENSCAFT00845028681
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000050948 UniProtKB/TrEMBL
  ENSCAFG00030012614 UniProtKB/TrEMBL
  ENSCAFG00040011107 UniProtKB/TrEMBL
  ENSCAFG00845016124 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000100701.1 UniProtKB/TrEMBL
  ENSCAFT00030023360.1 UniProtKB/TrEMBL
  ENSCAFT00040020490.1 UniProtKB/TrEMBL
  ENSCAFT00845028681 ENTREZGENE
  ENSCAFT00845028681.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Myc_transcription_factors UniProtKB/TrEMBL
  Tscrpt_reg_Myc UniProtKB/TrEMBL
  Tscrpt_reg_Myc_N UniProtKB/TrEMBL
NCBI Gene MYCN ENTREZGENE
PANTHER MYC PROTO-ONCOGENE UniProtKB/TrEMBL
  N-MYC PROTO-ONCOGENE PROTEIN UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
  Myc_N UniProtKB/TrEMBL
PIRSF Myc_protein UniProtKB/TrEMBL
PRINTS LEUZIPPRMYC UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A8C0N7C9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S9G2_CANLF UniProtKB/TrEMBL
  A0A8I3NNK6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PJJ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-08 MYCN  MYCN proto-oncogene, bHLH transcription factor    v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog  Symbol and/or name change 5135510 APPROVED