DPYS (dihydropyrimidinase) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: DPYS (dihydropyrimidinase) Canis lupus familiaris
Analyze
Symbol: DPYS
Name: dihydropyrimidinase
RGD ID: 12403345
Description: ENCODES a protein that exhibits amino acid binding (ortholog); dihydropyrimidinase activity (ortholog); identical protein binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); CMP catabolic process (ortholog); dCMP catabolic process (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH dihydropyrimidinase deficiency (ortholog); Experimental Liver Cirrhosis (ortholog); purine-pyrimidine metabolic disorder (ortholog); FOUND IN cytosol (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl135,583,801 - 5,659,463 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1135,583,795 - 5,659,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
DPYS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl135,583,801 - 5,659,463 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1135,583,795 - 5,659,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
DPYS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8104,330,324 - 104,467,055 (-)EnsemblGRCh38hg38GRCh38
GRCh388104,379,429 - 104,467,074 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378105,391,659 - 105,479,283 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh378105,391,652 - 105,479,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368105,460,829 - 105,548,453 (-)NCBINCBI36hg18NCBI36
Build 348105,460,828 - 105,548,453NCBI
Celera8101,578,319 - 101,665,933 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef8100,592,683 - 100,680,266 (-)NCBIHuRef
CHM1_18105,432,468 - 105,520,073 (-)NCBICHM1_1
Dpys
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391539,631,881 - 39,720,866 (-)NCBIGRCm39mm39
GRCm381539,768,485 - 39,857,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1539,768,487 - 39,857,470 (-)EnsemblGRCm38mm10GRCm38
MGSCv371539,600,031 - 39,689,016 (-)NCBIGRCm37mm9NCBIm37
MGSCv361539,598,559 - 39,687,541 (-)NCBImm8
Celera1540,252,611 - 40,341,397 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Dpys
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2770,822,648 - 70,929,255 (-)NCBI
Rnor_6.0 Ensembl778,769,807 - 78,847,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0778,769,918 - 78,847,941 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0778,796,405 - 78,873,615 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4775,368,238 - 75,446,160 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1775,449,118 - 75,466,890 (-)NCBI
Celera767,904,867 - 67,982,691 (-)NCBICelera
Cytogenetic Map7q31NCBI
Dpys
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541728,185,407 - 28,244,307 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541728,183,771 - 28,244,309 (-)NCBIChiLan1.0ChiLan1.0
DPYS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18103,160,922 - 103,248,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8103,160,922 - 103,248,303 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08101,008,090 - 101,096,234 (-)NCBIMhudiblu_PPA_v0panPan3
Dpys
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647039,564,431 - 39,637,394 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl432,789,460 - 32,879,489 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1432,791,152 - 32,879,489 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2435,528,834 - 35,616,166 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1899,216,623 - 99,303,969 (-)NCBI
ChlSab1.1 Ensembl899,216,354 - 99,303,282 (-)Ensembl
Dpys
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476320,618,515 - 20,680,790 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 13 6 6 3 8
Low 5 4 2 3 6 5
Below cutoff 5 4 4 2 4 2 5 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001047   ⟹   ENSCAFP00000000959
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl135,583,801 - 5,659,463 (-)Ensembl
RefSeq Acc Id: XM_003639441   ⟹   XP_003639489
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1135,583,795 - 5,659,355 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_003639489   ⟸   XM_003639441
- Sequence:
RefSeq Acc Id: ENSCAFP00000000959   ⟸   ENSCAFT00000001047
Protein Domains
Amidohydro-rel

Promoters
RGD ID:13685569
Promoter ID:EPDNEW_C3638
Type:single initiation site
Name:DPYS_1
Description:dihydropyrimidinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1135,659,286 - 5,659,346EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000676 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000000959 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001047 UniProtKB/TrEMBL
Gene3D-CATH 2.30.40.10 UniProtKB/TrEMBL
InterPro Amidohydro-rel UniProtKB/TrEMBL
  Hydantoinase/dihydroPyrase UniProtKB/TrEMBL
  Metal-dep_hydrolase_composite UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
NCBI Gene DPYS ENTREZGENE
Pfam Amidohydro_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51338 UniProtKB/TrEMBL
  SSF51556 UniProtKB/TrEMBL
TIGRFAMs D-hydantoinase UniProtKB/TrEMBL
UniProt E2RSE5_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40082 ENTREZGENE