ACY3 (aminoacylase 3) - Rat Genome Database

Name: ACY3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: ACY3 (aminoacylase 3) Canis lupus familiaris

Analyze

Symbol:

ACY3

Name:

aminoacylase 3

RGD ID:

12403290

Description:

ENCODES a protein that exhibits aminoacylase activity (ortholog); identical protein binding (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

aspartoacylase (aminocyclase) 3; N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACY3 (aminoacylase 3)	HGNC	NCBI
Mus musculus (house mouse):	Acy3 (aminoacylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Acy3 (aminoacylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Acy3 (aminoacylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACY3 (aminoacylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Acy3 (aminoacylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACY3 (aminoacylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACY3 (aminoacylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Acy3 (aminoacylase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	49,860,273 - 49,865,202 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	48,469,597 - 48,473,282 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	50,780,849 - 50,785,072 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	18	49,994,833 - 49,998,518 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	49,569,279 - 49,573,502 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	50,363,245 - 50,366,930 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 3 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

apical plasma membrane (ISO)

cytoplasm (ISO)

membrane (ISO)

Molecular Function

aminoacylase activity (ISO)

identical protein binding (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ACY3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	49,860,273 - 49,865,202 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	48,469,597 - 48,473,282 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	50,780,849 - 50,785,072 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	18	49,994,833 - 49,998,518 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	49,569,279 - 49,573,502 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	50,363,245 - 50,366,930 (+)	NCBI		UU_Cfam_GSD_1.0

ACY3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	67,642,555 - 67,650,730 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	67,642,555 - 67,650,730 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	67,410,026 - 67,418,201 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	67,166,602 - 67,174,706 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	67,166,602 - 67,174,706	NCBI
Celera	11	64,744,479 - 64,752,583 (-)	NCBI		Celera
Cytogenetic Map	11	q13.2	NCBI
HuRef	11	63,739,298 - 63,747,404 (-)	NCBI		HuRef
CHM1_1	11	67,293,077 - 67,301,181 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	67,637,243 - 67,645,420 (-)	NCBI		T2T-CHM13v2.0

Acy3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	4,036,570 - 4,040,007 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	4,036,570 - 4,040,007 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	3,986,570 - 3,990,007 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	3,986,570 - 3,990,007 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	3,986,661 - 3,990,007 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	3,986,661 - 3,990,007 (+)	NCBI		MGSCv36	mm8
Celera	19	3,857,714 - 3,861,060 (+)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	3.7	NCBI

Acy3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	210,709,238 - 210,715,258 (+)	NCBI		GRCr8
mRatBN7.2	1	201,279,751 - 201,285,803 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	201,279,851 - 201,283,175 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	209,632,150 - 209,635,503 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	216,725,326 - 216,728,655 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	209,416,345 - 209,419,674 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	219,233,712 - 219,237,103 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	219,233,750 - 219,237,098 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	226,104,367 - 226,107,754 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	206,569,504 - 206,572,833 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	206,722,956 - 206,726,281 (+)	NCBI
Celera	1	198,824,909 - 198,828,238 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

Acy3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	17,852,329 - 17,859,781 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	17,852,295 - 17,856,946 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACY3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	68,871,815 - 68,881,661 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	69,914,464 - 69,923,233 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	63,003,244 - 63,011,737 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	66,314,527 - 66,322,765 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	66,314,527 - 66,322,759 (-)	Ensembl	panpan1.1		panPan2

Acy3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	5,701,597 - 5,707,235 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	2,145,865 - 2,149,576 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	2,146,162 - 2,149,527 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACY3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	4,932,836 - 4,938,249 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	3,573,068 - 3,578,494 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACY3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	1	6,623,588 - 6,628,304 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	103,899,138 - 103,906,069 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acy3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	18,909,552 - 18,914,076 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	18,908,849 - 18,914,222 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ACY3
74 total Variants

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022405126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038425541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038501862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038564495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038628614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_022405126 ⟹ XP_022260834

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	18	49,860,273 - 49,865,202 (+)	NCBI
Dog10K_Boxer_Tasha	18	48,469,597 - 48,473,282 (+)	NCBI

Sequence:

show sequence

ATGGGAAGCCAGGAGCTGAGCCAGCTACTGGGGCCCAAGGCCTCAGGCAGGGTGATCAACTTTG
CCCTTGATCCACACACCACTGCAGCCAGCATGGGCACCTGTCTCATCACAGAAGCTGTCCACAA
GGTCTCTGCCATGCACCTGTGCCACTACCTTCTGGTGGCCCTGCCCCCTCAGAGGACAAACGGC
AGGACCCCTGCCCAGTCTTTCTGTACCAGCTGCCAGGGGAGAAGAGTTACACCCAAGGAAGTAA
TGGGTGGGCTGGGACCTCAGGATGACTGGTCCCCAGCCCTGGATCTGGGACCCCAGCCTCAGGG
CCCGCTGCAGGCAGACNNCATGAGGACCCTGGTTGCCGAAGTCCTGGACTTTATTGAGCTCTTC
AATCAGGTCTTGGGCACAAGCATGGCCTTTCCTGCTTTTGAGATGGAAGCAAACAGAACCGTGG
GCAGCGTGGACTTCGCACGCACCGAGTCTGGGGACCTGGCAGGCACCGCGCATCCTCAGCTGCC
GGGGTGTGCCCAAGACTCCCAGCCGCTGCTGCCCGGGATGCCCATCTCCCAGATGTTCAGTGAT
GAAGATGTGCTCTCTGAGGGGGAGTCCACTGTGTACCCCGTGTTCATCAATGAGGCCGCCTACT
ATGAGAACGGCATGGCTGTCATCCAGATTGAGAAGCTCCCACTCTGTGCCTGCCCTGCCGGTGT
TGGCCCTCACCCCCACCTCAGGGCCCTAACCCCCACCCAGATCCACCCAGCCTCAGCTCTCCCA
TCCGAACAATGTGTCCTGAGCCACAGTCCTGAGTCCAGGGGCCCCCTTTGCCACCCGCTATAAT
ACCATGTTTCTTGCTATGCCCCATACCTCCGTGCCTCAGTTTCTCTATAAAATGGAAGATGTGT
GGGGTTAATGATTCATATCCTCTGTCCTGCATGGTCCCTCTGTGACCTCAGGATCTGGGGCAGG
TCTACCCCAGGGTGGTTCCAGGGGGAGGATCCCACTTGTAGAAAAACTGTGCTGGAGACAACAG
AGCCCACCCCCACCCCCACCCCCACCAACCCACCAGGGCCAGAGAGTCAGTCTGAGAGGGCAGA
AGCATGTGCCCATGTGTATGCACACATGTGTGGGTGACCATGCGTGTGCCTGCCTGGGTGTTGT
GTGTGTGTGACCTTTAGCAAGTCACACACATGCATTCCAAGAGCTTCAGTACCTTGGGCGTCCT
TCTAGGGGGGATCTCTATGTGGCTGGGCACACAGCCCAGACGTGCATTTCCAATGTGCAATGTG
CCCATGAGGGCTCAGGGGGAGTCAGGGCTGGGGAAGGGGTGGGATAGCCCATCCAGGGGTAGGG
GAAGTCCGACCAGGGAGGCTGGAACTACTCAGCGCTCCAGGAGGAAGCAGGCACAAGGTCGGCT
GCTGGGGTCCCCTCAGTCCTGATCCAGGCACTCTGCAGGGCATCTACGCAGGCCAAACTGAACA
CAACTTGACAGCTTCCACAGCAACCTGAGCCTCACAGGGTGCCTGGGGGGCCCAGAGCTCCGTG
CATGGGCGGTATCACTCCCCAGCCCCTCTGCACCCCTGCCTGGCCCATCCATCTCCCTGCGGCC
ACAGCTGCCATGTGGCCTCCTGCTATTGAGCAGTGAGATGAGAAGGTGTGAAGGATACGAGGAC
ACCAGGGACAGGCTGGCAGGCAAGATGGATGAGGGGGCAGGGGGGCCAGCAGGCGCCTCCGGCA
GGAAGGGCAGGCCAGCCATAGAGGAGGTTGTGCAGAGGGGCGCGCCTGTGTGCATGGTGTATGT
GCAAGAGAGAGCATGTATATCCATGCACACAGGAGCTTGTGCATGCATGCACACGAGTGATTGT
GGGCATCAGGCCTAGAGCTCATCTGTGTGCATGTGGGTCGGCATGTCAGTGTGCTCAAATACTG
TGAGGGGGTGTTTCCCATCACACAGATCAGAGCTGCATGCAAGTACGCACACACACACAACACA
CACACACACACACACACACACACACACACACACAATCAGTAGCCTCCAGAACCGCGGGCCAGCC
CACTCCGGGGAGCCTCGGCTGAGGGGG

hide sequence

RefSeq Acc Id:

XM_038425541 ⟹ XP_038281469

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	18	50,780,849 - 50,785,072 (+)	NCBI

RefSeq Acc Id:

XM_038501862 ⟹ XP_038357790

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	18	49,994,833 - 49,998,518 (+)	NCBI

RefSeq Acc Id:

XM_038564495 ⟹ XP_038420423

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	18	50,363,245 - 50,366,930 (+)	NCBI

RefSeq Acc Id:

XM_038628614 ⟹ XP_038484542

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	18	49,569,279 - 49,573,502 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_022260834	(Get FASTA)	NCBI Sequence Viewer
	XP_038281469	(Get FASTA)	NCBI Sequence Viewer
	XP_038357790	(Get FASTA)	NCBI Sequence Viewer
	XP_038420423	(Get FASTA)	NCBI Sequence Viewer
	XP_038484542	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_022260834 ⟸ XM_022405126

- Peptide Label:

isoform X4

- Sequence:

show sequence

MGSQELSQLLGPKASGRVINFALDPHTTAASMGTCLITEAVHKVSAMHLCHYLLVALPPQRTNG
RTPAQSFCTSCQGRRVTPKEVMGGLGPQDDWSPALDLGPQPQGPLQADXMRTLVAEVLDFIELF
NQVLGTSMAFPAFEMEANRTVGSVDFARTESGDLAGTAHPQLPGCAQDSQPLLPGMPISQMFSD
EDVLSEGESTVYPVFINEAAYYENGMAVIQIEKLPLCACPAGVGPHPHLRALTPTQIHPASALP
SEQCVLSHSPESRGPLCHPL

hide sequence

RefSeq Acc Id:	XP_038357790 ⟸ XM_038501862
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038484542 ⟸ XM_038628614
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038281469 ⟸ XM_038425541
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038420423 ⟸ XM_038564495
- Peptide Label:	isoform X3

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	ACY3	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-09-12	ACY3	aminoacylase 3		aspartoacylase (aminocyclase) 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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