FBXO43 (F-box protein 43) - Rat Genome Database

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Gene: FBXO43 (F-box protein 43) Canis lupus familiaris
Analyze
Symbol: FBXO43
Name: F-box protein 43
RGD ID: 12402396
Description: ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN meiotic nuclear division (ortholog); negative regulation of meiotic nuclear division (ortholog); negative regulation of protein catabolic process (ortholog); ASSOCIATED WITH Cohen syndrome (ortholog); genetic disease (ortholog); Oocyte/Zygote/Embryo Maturation Arrest 12 (ortholog); FOUND IN female germ cell nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-box only protein 43
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1132,037,270 - 2,057,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl132,038,408 - 2,052,741 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,035,158 - 2,054,848 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0132,189,300 - 2,210,531 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl132,191,213 - 2,203,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1132,033,543 - 2,054,732 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0132,145,577 - 2,166,765 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0132,148,055 - 2,167,777 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FBXO43
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1132,037,270 - 2,057,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl132,038,408 - 2,052,741 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,035,158 - 2,054,848 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0132,189,300 - 2,210,531 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl132,191,213 - 2,203,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1132,033,543 - 2,054,732 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0132,145,577 - 2,166,765 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0132,148,055 - 2,167,777 (-)NCBIUU_Cfam_GSD_1.0
FBXO43
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388100,133,351 - 100,150,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8100,133,351 - 100,145,817 (-)EnsemblGRCh38hg38GRCh38
GRCh378101,145,579 - 101,158,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368101,214,835 - 101,227,252 (-)NCBINCBI36Build 36hg18NCBI36
Celera897,330,985 - 97,343,496 (-)NCBICelera
Cytogenetic Map8q22.2NCBI
HuRef896,348,421 - 96,360,932 (-)NCBIHuRef
CHM1_18101,185,882 - 101,198,393 (-)NCBICHM1_1
T2T-CHM13v2.08101,258,131 - 101,275,344 (-)NCBIT2T-CHM13v2.0
Fbxo43
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391536,150,206 - 36,170,086 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1536,150,206 - 36,165,030 (-)EnsemblGRCm39 Ensembl
GRCm381536,150,060 - 36,169,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1536,150,060 - 36,164,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv371536,079,815 - 36,094,639 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361536,094,649 - 36,109,473 (-)NCBIMGSCv36mm8
Celera1536,777,573 - 36,792,407 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1514.46NCBI
Fbxo43
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8769,218,298 - 69,231,873 (-)NCBIGRCr8
mRatBN7.2767,333,161 - 67,346,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl767,333,162 - 67,346,751 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx769,221,626 - 69,235,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0771,424,242 - 71,437,811 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0771,292,102 - 71,305,672 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0774,925,091 - 74,938,796 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl774,925,092 - 74,938,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0775,081,329 - 75,094,991 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4771,670,329 - 71,683,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1771,691,059 - 71,704,631 (-)NCBI
Celera764,414,991 - 64,428,564 (-)NCBICelera
Cytogenetic Map7q22NCBI
Fbxo43
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541715,390,969 - 15,406,751 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541715,394,481 - 15,406,751 (-)NCBIChiLan1.0ChiLan1.0
FBXO43
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27117,474,806 - 117,498,887 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1893,013,613 - 93,037,589 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0896,774,246 - 96,786,933 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1898,948,145 - 98,960,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl898,948,145 - 98,960,382 (-)Ensemblpanpan1.1panPan2
Fbxo43
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530335,662,044 - 35,674,874 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647043,088,714 - 43,100,973 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647043,091,516 - 43,100,973 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl436,856,937 - 36,871,618 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1436,856,662 - 36,872,753 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2439,772,435 - 39,787,507 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO43
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1894,983,189 - 94,996,480 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl894,983,640 - 94,994,672 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603945,685,902 - 45,699,132 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in FBXO43
180 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low
Below cutoff 5 5 22 6 6 6 6 6 12 10 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005627826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005627827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038492924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038492925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038492926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038492927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038555193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038619088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_539103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000000837   ⟹   ENSCAFP00000000767
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl132,038,408 - 2,052,741 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845049452   ⟹   ENSCAFP00845038800
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl132,191,213 - 2,203,034 (-)Ensembl
RefSeq Acc Id: XM_005627827   ⟹   XP_005627884
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1132,037,996 - 2,057,465 (-)NCBI
Dog10K_Boxer_Tasha132,035,158 - 2,054,848 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038492924   ⟹   XP_038348852
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1132,035,044 - 2,050,198 (-)NCBI
RefSeq Acc Id: XM_038492925   ⟹   XP_038348853
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1132,035,042 - 2,054,732 (-)NCBI
RefSeq Acc Id: XM_038492926   ⟹   XP_038348854
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1132,035,531 - 2,050,199 (-)NCBI
RefSeq Acc Id: XM_038492927   ⟹   XP_038348855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1132,033,543 - 2,050,198 (-)NCBI
RefSeq Acc Id: XM_038555193   ⟹   XP_038411121
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0132,148,055 - 2,167,777 (-)NCBI
RefSeq Acc Id: XM_038619085   ⟹   XP_038475013
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0132,147,078 - 2,162,232 (-)NCBI
RefSeq Acc Id: XM_038619086   ⟹   XP_038475014
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0132,147,076 - 2,166,765 (-)NCBI
RefSeq Acc Id: XM_038619087   ⟹   XP_038475015
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0132,147,565 - 2,162,233 (-)NCBI
RefSeq Acc Id: XM_038619088   ⟹   XP_038475016
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0132,145,577 - 2,162,232 (-)NCBI
RefSeq Acc Id: XM_038684705   ⟹   XP_038540633
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0132,190,801 - 2,205,991 (-)NCBI
RefSeq Acc Id: XM_038684706   ⟹   XP_038540634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0132,190,799 - 2,210,531 (-)NCBI
RefSeq Acc Id: XM_038684707   ⟹   XP_038540635
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0132,191,288 - 2,205,992 (-)NCBI
RefSeq Acc Id: XM_038684708   ⟹   XP_038540636
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0132,189,300 - 2,205,991 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005627884   ⟸   XM_005627827
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JGD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000767   ⟸   ENSCAFT00000000837
RefSeq Acc Id: XP_038348855   ⟸   XM_038492927
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038348853   ⟸   XM_038492925
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038348852   ⟸   XM_038492924
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038348854   ⟸   XM_038492926
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038475016   ⟸   XM_038619088
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038475014   ⟸   XM_038619086
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038475013   ⟸   XM_038619085
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038475015   ⟸   XM_038619087
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038540636   ⟸   XM_038684708
- Peptide Label: isoform X4
- UniProtKB: A0A8I3PYV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038540634   ⟸   XM_038684706
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JGD8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038540633   ⟸   XM_038684705
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JGD8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038540635   ⟸   XM_038684707
- Peptide Label: isoform X3
- UniProtKB: A0A8I3PYV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411121   ⟸   XM_038555193
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JGD8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845038800   ⟸   ENSCAFT00845049452
Protein Domains
ZBR-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000544 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845028017 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000837.5 UniProtKB/TrEMBL
  ENSCAFT00845049452 ENTREZGENE
  ENSCAFT00845049452.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  2.20.25.20 UniProtKB/TrEMBL
InterPro F-box_dom UniProtKB/TrEMBL
  FBX5_43 UniProtKB/TrEMBL
  IBR_dom UniProtKB/TrEMBL
  ZF_ZBR UniProtKB/TrEMBL
NCBI Gene FBXO43 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 43 UniProtKB/TrEMBL
  F-BOX ONLY PROTEIN 5 AND 43 UniProtKB/TrEMBL
Pfam F-box UniProtKB/TrEMBL
PROSITE ZF_ZBR UniProtKB/TrEMBL
SMART IBR UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8C0JGD8 ENTREZGENE
  A0A8I3PYV7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N3R8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40783 ENTREZGENE