PLG (plasminogen) - Rat Genome Database

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Gene: PLG (plasminogen) Canis lupus familiaris
Analyze
Symbol: PLG
Name: plasminogen
RGD ID: 12402167
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); enzyme binding (ortholog); INVOLVED IN labyrinthine layer blood vessel development (ortholog); mononuclear cell migration (ortholog); muscle cell cellular homeostasis (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH plasminogen deficiency type I; acute kidney failure (ortholog); atypical hemolytic-uremic syndrome (ortholog); FOUND IN cell surface (ortholog); extrinsic component of plasma membrane (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,497,229 - 49,535,260 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,497,229 - 49,535,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,340,229 - 50,378,262 (-)NCBI
ROS_Cfam_1.0149,682,496 - 49,720,525 (-)NCBI
UMICH_Zoey_3.1149,564,853 - 49,602,878 (-)NCBI
UNSW_CanFamBas_1.0149,436,580 - 49,474,619 (-)NCBI
UU_Cfam_GSD_1.0150,051,672 - 50,089,725 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:16185080   PMID:18981180   PMID:22174817   PMID:24520380   PMID:26360520  


Genomics

Comparative Map Data
PLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,497,229 - 49,535,260 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,497,229 - 49,535,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,340,229 - 50,378,262 (-)NCBI
ROS_Cfam_1.0149,682,496 - 49,720,525 (-)NCBI
UMICH_Zoey_3.1149,564,853 - 49,602,878 (-)NCBI
UNSW_CanFamBas_1.0149,436,580 - 49,474,619 (-)NCBI
UU_Cfam_GSD_1.0150,051,672 - 50,089,725 (-)NCBI
PLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6160,702,238 - 160,754,097 (+)EnsemblGRCh38hg38GRCh38
GRCh386160,702,193 - 160,754,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376161,123,225 - 161,175,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,043,273 - 161,094,328 (+)NCBINCBI36hg18NCBI36
Build 346161,093,693 - 161,144,749NCBI
Celera6161,842,077 - 161,894,063 (+)NCBI
Cytogenetic Map6q26NCBI
HuRef6158,568,041 - 158,620,052 (+)NCBIHuRef
CHM1_16161,385,876 - 161,437,750 (+)NCBICHM1_1
Plg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,597,496 - 12,638,271 (+)NCBIGRCm39mm39
GRCm39 Ensembl1712,597,495 - 12,638,272 (+)Ensembl
GRCm381712,378,609 - 12,419,384 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,378,608 - 12,419,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371712,571,475 - 12,612,250 (+)NCBIGRCm37mm9NCBIm37
MGSCv361712,221,966 - 12,262,743 (+)NCBImm8
Celera1712,409,327 - 12,450,146 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.5NCBI
Plg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2148,325,186 - 48,367,643 (-)NCBI
Rnor_6.0 Ensembl148,521,772 - 48,563,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0148,521,828 - 48,563,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0151,192,273 - 51,233,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,782,464 - 42,825,149 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1142,785,408 - 42,828,097 (-)NCBI
Celera144,117,228 - 44,159,691 (-)NCBICelera
Cytogenetic Map1q11NCBI
Plg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,317,552 - 20,366,475 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,317,814 - 20,366,724 (+)NCBIChiLan1.0ChiLan1.0
LOC100982214
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16163,674,142 - 163,722,630 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,673,464 - 163,736,777 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06158,662,192 - 158,713,413 (+)NCBIMhudiblu_PPA_v0panPan3
Plg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,523,021 - 144,556,568 (-)NCBI
SpeTri2.0NW_00493648911,775,243 - 11,808,482 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,061,191 - 7,110,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,062,399 - 7,109,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,740,127 - 8,787,546 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11388,266,054 - 88,321,596 (+)NCBI
ChlSab1.1 Ensembl1388,268,198 - 88,322,644 (+)Ensembl
Vero_WHO_p1.0NW_02366604060,598,947 - 60,654,431 (+)NCBI
Plg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248552,362,793 - 2,401,519 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 2 2 2
Medium 4 4 4
Low
Below cutoff 3 3 8 5 4 3 5 4 6 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001286960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY069985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY514750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP853099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP853100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP853101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP853102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP853103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP853104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP853105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP853106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP853107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP853108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000001179   ⟹   ENSCAFP00000001078
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl149,497,229 - 49,535,260 (-)Ensembl
RefSeq Acc Id: NM_001286960   ⟹   NP_001273889
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1149,497,229 - 49,535,260 (-)NCBI
Dog10K_Boxer_Tasha150,340,229 - 50,378,262 (-)NCBI
ROS_Cfam_1.0149,682,496 - 49,720,525 (-)NCBI
UMICH_Zoey_3.1149,564,853 - 49,602,878 (-)NCBI
UNSW_CanFamBas_1.0149,436,580 - 49,474,619 (-)NCBI
UU_Cfam_GSD_1.0150,051,672 - 50,089,725 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001273889   ⟸   NM_001286960
- Peptide Label: precursor
- UniProtKB: F1Q421 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001078   ⟸   ENSCAFT00000001179
Protein Domains
Apple   Kringle   Peptidase S1

Promoters
RGD ID:13682023
Promoter ID:EPDNEW_C92
Type:initiation region
Name:PLG_1
Description:Canis lupus familiaris plasminogen , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1149,535,229 - 49,535,289EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000758 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000001078 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001179 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pan_app UniProtKB/TrEMBL
  Pept_S1A_plasmin UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403602 UniProtKB/TrEMBL
NCBI Gene PLG ENTREZGENE
Pfam Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN_1 UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Plasmin UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAN_AP UniProtKB/TrEMBL
  SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H4NYY1_CANLF UniProtKB/TrEMBL
  A0A0H4NYY6_CANLF UniProtKB/TrEMBL
  F1Q421 ENTREZGENE, UniProtKB/TrEMBL
  P80009 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6JDI3_CANLF UniProtKB/TrEMBL