NR1H2 (nuclear receptor subfamily 1 group H member 2) - Rat Genome Database

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Gene: NR1H2 (nuclear receptor subfamily 1 group H member 2) Canis lupus familiaris
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Symbol: NR1H2
Name: nuclear receptor subfamily 1 group H member 2
RGD ID: 12400482
Description: ENCODES a protein that exhibits apolipoprotein A-I receptor binding (ortholog); ATPase binding (ortholog); DNA binding (ortholog); INVOLVED IN cellular lipid metabolic process (ortholog); cholesterol homeostasis (ortholog); lipid homeostasis (ortholog); ASSOCIATED WITH cholestasis (ortholog); Experimental Arthritis (ortholog); Experimental Autoimmune Encephalomyelitis (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); RNA polymerase II transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: oxysterols receptor LXR-beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,332,691 - 106,339,168 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,332,798 - 106,339,135 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,905,786 - 105,912,261 (-)NCBI
ROS_Cfam_1.01106,843,783 - 106,850,258 (-)NCBI
UMICH_Zoey_3.11106,515,887 - 106,522,355 (-)NCBI
UNSW_CanFamBas_1.01106,157,420 - 106,163,895 (-)NCBI
UU_Cfam_GSD_1.01106,998,070 - 107,004,546 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular lipid metabolic process  (ISO)
cholesterol homeostasis  (ISO)
lipid homeostasis  (ISO)
negative regulation of cholesterol storage  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of lipid transport  (ISO)
negative regulation of pinocytosis  (ISO)
negative regulation of proteolysis  (ISO)
negative regulation of response to endoplasmic reticulum stress  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
phosphatidylcholine acyl-chain remodeling  (ISO)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cholesterol transport  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of high-density lipoprotein particle assembly  (ISO)
positive regulation of lipid storage  (ISO)
positive regulation of lipoprotein lipase activity  (ISO)
positive regulation of pancreatic juice secretion  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of secretion of lysosomal enzymes  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to nutrient levels  (ISO)
retinoic acid receptor signaling pathway  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
NR1H2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,332,691 - 106,339,168 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,332,798 - 106,339,135 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,905,786 - 105,912,261 (-)NCBI
ROS_Cfam_1.01106,843,783 - 106,850,258 (-)NCBI
UMICH_Zoey_3.11106,515,887 - 106,522,355 (-)NCBI
UNSW_CanFamBas_1.01106,157,420 - 106,163,895 (-)NCBI
UU_Cfam_GSD_1.01106,998,070 - 107,004,546 (-)NCBI
NR1H2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1950,329,653 - 50,383,388 (+)EnsemblGRCh38hg38GRCh38
GRCh381950,376,457 - 50,383,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371950,879,714 - 50,886,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,571,497 - 55,578,079 (+)NCBINCBI36hg18NCBI36
Build 341955,571,514 - 55,578,048NCBI
Celera1947,929,924 - 47,936,510 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1947,217,814 - 47,224,423 (+)NCBIHuRef
CHM1_11950,881,453 - 50,888,062 (+)NCBICHM1_1
Nr1h2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,199,040 - 44,204,928 (-)NCBIGRCm39mm39
GRCm39 Ensembl744,199,040 - 44,203,375 (-)Ensembl
GRCm38744,549,616 - 44,553,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,549,616 - 44,553,951 (-)EnsemblGRCm38mm10GRCm38
MGSCv37751,805,002 - 51,809,293 (-)NCBIGRCm37mm9NCBIm37
MGSCv36744,417,674 - 44,421,965 (-)NCBImm8
Celera739,999,761 - 40,004,052 (-)NCBICelera
Cytogenetic Map7B3NCBI
Nr1h2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2195,041,967 - 95,047,377 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl195,041,967 - 95,047,377 (-)Ensembl
Rnor_6.01100,554,577 - 100,559,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,554,544 - 100,559,942 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,619,964 - 101,625,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,027,197 - 95,032,516 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1195,105,321 - 95,110,627 (-)NCBI
Celera189,304,444 - 89,309,763 (-)NCBICelera
Cytogenetic Map1q22NCBI
Nr1h2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955559730,670 - 737,505 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955559731,630 - 736,973 (-)NCBIChiLan1.0ChiLan1.0
NR1H2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11956,243,124 - 56,250,024 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,243,124 - 56,250,024 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01947,340,077 - 47,346,737 (+)NCBIMhudiblu_PPA_v0panPan3
Nr1h2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,347,505 - 22,353,794 (+)NCBI
SpeTri2.0NW_004936889223,137 - 229,968 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR1H2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,237,953 - 55,245,456 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,238,536 - 55,245,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,087,383 - 51,094,318 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR1H2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,438,428 - 43,445,190 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl643,437,950 - 43,446,063 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607323,425,677 - 23,432,503 (+)NCBIVero_WHO_p1.0
Nr1h2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248324,136,052 - 4,141,648 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005616270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022423354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_846223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000005346   ⟹   ENSCAFP00000004950
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1106,332,798 - 106,339,110 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000079748   ⟹   ENSCAFP00000049201
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1106,332,798 - 106,339,135 (-)Ensembl
RefSeq Acc Id: XM_005616270   ⟹   XP_005616327
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11106,332,691 - 106,339,168 (-)NCBI
Dog10K_Boxer_Tasha1105,905,786 - 105,912,260 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022423354   ⟹   XP_022279062
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11106,332,691 - 106,339,168 (-)NCBI
Dog10K_Boxer_Tasha1105,905,786 - 105,912,261 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038467403   ⟹   XP_038323331
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11106,515,887 - 106,522,354 (-)NCBI
RefSeq Acc Id: XM_038467404   ⟹   XP_038323332
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11106,515,887 - 106,522,332 (-)NCBI
RefSeq Acc Id: XM_038467405   ⟹   XP_038323333
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11106,515,887 - 106,522,355 (-)NCBI
RefSeq Acc Id: XM_038528101   ⟹   XP_038384029
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01106,998,070 - 107,004,545 (-)NCBI
RefSeq Acc Id: XM_038528102   ⟹   XP_038384030
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01106,998,070 - 107,004,523 (-)NCBI
RefSeq Acc Id: XM_038528103   ⟹   XP_038384031
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01106,998,070 - 107,004,546 (-)NCBI
RefSeq Acc Id: XM_038592398   ⟹   XP_038448326
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01106,157,420 - 106,163,894 (-)NCBI
RefSeq Acc Id: XM_038592399   ⟹   XP_038448327
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01106,157,420 - 106,163,872 (-)NCBI
RefSeq Acc Id: XM_038592400   ⟹   XP_038448328
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01106,157,420 - 106,163,895 (-)NCBI
RefSeq Acc Id: XM_038656190   ⟹   XP_038512118
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01106,843,783 - 106,850,257 (-)NCBI
RefSeq Acc Id: XM_038656191   ⟹   XP_038512119
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01106,843,783 - 106,850,235 (-)NCBI
RefSeq Acc Id: XM_038656192   ⟹   XP_038512120
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01106,843,783 - 106,850,258 (-)NCBI
RefSeq Acc Id: XM_846223   ⟹   XP_851316
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11106,332,691 - 106,339,167 (-)NCBI
Dog10K_Boxer_Tasha1105,905,786 - 105,912,238 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_851316   ⟸   XM_846223
- Sequence:
RefSeq Acc Id: XP_005616327   ⟸   XM_005616270
- Sequence:
RefSeq Acc Id: XP_022279062   ⟸   XM_022423354
- Sequence:
RefSeq Acc Id: ENSCAFP00000004950   ⟸   ENSCAFT00000005346
RefSeq Acc Id: ENSCAFP00000049201   ⟸   ENSCAFT00000079748
RefSeq Acc Id: XP_038323333   ⟸   XM_038467405
RefSeq Acc Id: XP_038323331   ⟸   XM_038467403
RefSeq Acc Id: XP_038323332   ⟸   XM_038467404
RefSeq Acc Id: XP_038448328   ⟸   XM_038592400
RefSeq Acc Id: XP_038448326   ⟸   XM_038592398
RefSeq Acc Id: XP_038448327   ⟸   XM_038592399
RefSeq Acc Id: XP_038512120   ⟸   XM_038656192
RefSeq Acc Id: XP_038512118   ⟸   XM_038656190
RefSeq Acc Id: XP_038512119   ⟸   XM_038656191
RefSeq Acc Id: XP_038384031   ⟸   XM_038528103
RefSeq Acc Id: XP_038384029   ⟸   XM_038528101
RefSeq Acc Id: XP_038384030   ⟸   XM_038528102


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003338 Ensembl
NCBI Gene NR1H2 ENTREZGENE
VGNC ID VGNC:43942 ENTREZGENE