SDHAF2 (succinate dehydrogenase complex assembly factor 2) - Rat Genome Database

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Gene: SDHAF2 (succinate dehydrogenase complex assembly factor 2) Canis lupus familiaris
Analyze
Symbol: SDHAF2
Name: succinate dehydrogenase complex assembly factor 2
RGD ID: 12398976
Description: INVOLVED IN canonical Wnt signaling pathway (ortholog); epithelial to mesenchymal transition (ortholog); negative regulation of canonical Wnt signaling pathway (ortholog); ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Hereditary Paraganglioma-Pheochromocytoma Syndromes (ortholog); intellectual disability (ortholog); FOUND IN cytosol (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: succinate dehydrogenase assembly factor 2, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,970,987 - 54,986,676 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,971,658 - 54,987,394 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1853,545,381 - 53,559,709 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01856,018,425 - 56,034,151 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1856,018,431 - 56,034,842 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11855,078,338 - 55,092,676 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01854,698,954 - 54,714,665 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01855,580,364 - 55,594,705 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:32486318  


Genomics

Comparative Map Data
SDHAF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,970,987 - 54,986,676 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,971,658 - 54,987,394 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1853,545,381 - 53,559,709 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01856,018,425 - 56,034,151 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1856,018,431 - 56,034,842 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11855,078,338 - 55,092,676 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01854,698,954 - 54,714,665 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01855,580,364 - 55,594,705 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SDHAF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,430,124 - 61,446,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,430,042 - 61,446,839 (+)Ensemblhg38GRCh38
GRCh371161,197,596 - 61,214,205 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,954,173 - 60,970,805 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1158,533,118 - 58,549,759 (+)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1157,525,486 - 57,542,128 (+)NCBIHuRef
CHM1_11161,080,599 - 61,097,240 (+)NCBICHM1_1
T2T-CHM13v2.01161,419,022 - 61,435,631 (+)NCBIT2T-CHM13v2.0
Sdhaf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,477,876 - 10,502,573 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,477,898 - 10,503,506 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381910,500,512 - 10,525,209 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,500,534 - 10,526,142 (-)Ensemblmm10GRCm38
MGSCv371910,575,002 - 10,599,699 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361910,568,685 - 10,592,254 (-)NCBIMGSCv36mm8
Celera1911,196,361 - 11,220,981 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.6NCBI
Sdhaf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,564,002 - 216,592,877 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1216,567,861 - 216,593,540 (-)EnsemblGRCr8
mRatBN7.21207,139,070 - 207,167,830 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,139,112 - 207,168,616 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1215,521,171 - 215,546,172 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,576,801 - 222,601,616 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,271,804 - 215,296,619 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,543,671 - 226,572,414 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,547,531 - 226,572,349 (-)Ensemblrn6Rnor6.0
Rnor_5.01233,489,879 - 233,518,610 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41212,983,948 - 213,008,757 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1204,636,393 - 204,661,202 (-)NCBICelera
RGSC_v3.11213,142,378 - 213,167,187 (-)NCBI
Cytogenetic Map1q43NCBI
Sdhaf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555116,125,966 - 6,139,098 (-)Ensembl
ChiLan1.0NW_0049555116,125,966 - 6,139,098 (-)NCBIChiLan1.0ChiLan1.0
SDHAF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2962,597,981 - 62,641,505 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,641,624 - 63,658,366 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,729,314 - 56,746,075 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11160,093,656 - 60,110,288 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1160,093,656 - 60,110,288 (+)EnsemblpanPan2panpan1.1
Sdhaf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,493,919 - 11,514,572 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365811,607,698 - 1,628,414 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365811,607,741 - 1,628,347 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHAF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl210,072,920 - 10,088,117 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1210,074,965 - 10,088,185 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.229,622,544 - 9,635,304 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SDHAF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,401,164 - 12,417,389 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,398,920 - 12,417,383 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038109,778,143 - 109,794,799 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdhaf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624926792,173 - 801,954 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624926792,172 - 802,838 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in SDHAF2
205 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000046459   ⟹   ENSCAFP00000039271
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1854,971,658 - 54,987,394 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000063257   ⟹   ENSCAFP00000060196
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1854,971,891 - 54,986,609 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845022101   ⟹   ENSCAFP00845017378
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1856,018,431 - 56,034,842 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845022124   ⟹   ENSCAFP00845017396
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1856,019,328 - 56,034,057 (-)Ensembl
RefSeq Acc Id: XM_038425421   ⟹   XP_038281349
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01856,018,425 - 56,034,151 (-)NCBI
RefSeq Acc Id: XM_038425423   ⟹   XP_038281351
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01856,018,425 - 56,033,952 (-)NCBI
RefSeq Acc Id: XM_038454516   ⟹   XP_038310444
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1853,545,381 - 53,559,510 (-)NCBI
RefSeq Acc Id: XM_038501658   ⟹   XP_038357586
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11855,078,338 - 55,092,676 (-)NCBI
RefSeq Acc Id: XM_038501659   ⟹   XP_038357587
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11855,078,338 - 55,092,477 (-)NCBI
RefSeq Acc Id: XM_038564381   ⟹   XP_038420309
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01855,580,364 - 55,594,705 (-)NCBI
RefSeq Acc Id: XM_038564382   ⟹   XP_038420310
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01855,580,364 - 55,594,506 (-)NCBI
RefSeq Acc Id: XM_038628506   ⟹   XP_038484434
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01854,698,954 - 54,714,665 (-)NCBI
RefSeq Acc Id: XM_038628507   ⟹   XP_038484435
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01854,698,954 - 54,714,466 (-)NCBI
RefSeq Acc Id: XM_533273   ⟹   XP_533273
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11854,970,987 - 54,986,676 (-)NCBI
Dog10K_Boxer_Tasha1853,545,381 - 53,559,709 (-)NCBI
Sequence:
RefSeq Acc Id: XP_533273   ⟸   XM_533273
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PAQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000060196   ⟸   ENSCAFT00000063257
Ensembl Acc Id: ENSCAFP00000039271   ⟸   ENSCAFT00000046459
RefSeq Acc Id: XP_038357586   ⟸   XM_038501658
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038357587   ⟸   XM_038501659
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038484434   ⟸   XM_038628506
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038484435   ⟸   XM_038628507
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038281349   ⟸   XM_038425421
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PAQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038281351   ⟸   XM_038425423
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038310444   ⟸   XM_038454516
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038420309   ⟸   XM_038564381
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PAQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038420310   ⟸   XM_038564382
- Peptide Label: isoform X2
Ensembl Acc Id: ENSCAFP00845017396   ⟸   ENSCAFT00845022124
Ensembl Acc Id: ENSCAFP00845017378   ⟸   ENSCAFT00845022101

Promoters
RGD ID:13686667
Promoter ID:EPDNEW_C4735
Type:multiple initiation site
Name:SDHAF2_1
Description:succinate dehydrogenase complex assembly factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11854,986,604 - 54,986,664EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030303 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022636 UniProtKB/TrEMBL
  ENSCAFG00040005838 UniProtKB/TrEMBL
  ENSCAFG00845012426 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046459.3 UniProtKB/TrEMBL
  ENSCAFT00000063257.2 UniProtKB/TrEMBL
  ENSCAFT00030041613.1 UniProtKB/TrEMBL
  ENSCAFT00030041634.1 UniProtKB/TrEMBL
  ENSCAFT00040010942.1 UniProtKB/TrEMBL
  ENSCAFT00040010980.1 UniProtKB/TrEMBL
  ENSCAFT00845022101.1 UniProtKB/TrEMBL
  ENSCAFT00845022124.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.250 UniProtKB/TrEMBL
InterPro SDH UniProtKB/TrEMBL
  SDH_sf UniProtKB/TrEMBL
  SDHAF2 UniProtKB/TrEMBL
NCBI Gene SDHAF2 ENTREZGENE
PANTHER PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL UniProtKB/TrEMBL
  SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Sdh5 UniProtKB/TrEMBL
Superfamily-SCOP SSF109910 UniProtKB/TrEMBL
UniProt A0A8C0PAQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q6P5_CANLF UniProtKB/TrEMBL
  A0A8C0Q7V6_CANLF UniProtKB/TrEMBL
  A0A8I3NBG8_CANLF UniProtKB/TrEMBL
  A0A8I3NPB6_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0NQR2 UniProtKB/TrEMBL
VGNC ID VGNC:56094 ENTREZGENE