TMPRSS6 (transmembrane serine protease 6)

Gene: TMPRSS6 (transmembrane serine protease 6) Canis lupus familiaris

Analyze

Symbol:

TMPRSS6

Name:

transmembrane serine protease 6

RGD ID:

12396771

Description:

ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN BMP signaling pathway (ortholog); multicellular organismal-level iron ion homeostasis (ortholog); negative regulation of BMP signaling pathway (ortholog); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN extracellular space (inferred); membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transmembrane protease serine 6; transmembrane protease, serine 6

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	27,393,650 - 27,435,893 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	27,397,123 - 27,435,908 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	27,353,491 - 27,390,639 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	28,190,798 - 28,228,167 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	28,190,967 - 28,228,124 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	27,912,441 - 27,949,753 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	28,221,179 - 28,258,351 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	28,399,083 - 28,436,250 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenylosuccinase lyase deficiency (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

genetic disease (ISO)

iron deficiency anemia (ISO)

microcytic anemia (ISO)

myoclonic dystonia 26 (ISO)

neurodegeneration with brain iron accumulation 2A (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

BMP signaling pathway (IEA,ISO)

intracellular iron ion homeostasis (IEA)

membrane protein proteolysis (IEA)

multicellular organismal-level iron ion homeostasis (IEA,ISO)

negative regulation of BMP signaling pathway (IEA,ISO)

negative regulation of DNA-templated transcription (IEA)

negative regulation of transcription by RNA polymerase II (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

proteolysis (IEA)

self proteolysis (IEA)

Cellular Component

extracellular space (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

hydrolase activity (IEA)

peptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

TMPRSS6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	27,393,650 - 27,435,893 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	27,397,123 - 27,435,908 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	27,353,491 - 27,390,639 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	28,190,798 - 28,228,167 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	28,190,967 - 28,228,124 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	27,912,441 - 27,949,753 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	28,221,179 - 28,258,351 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	28,399,083 - 28,436,250 (+)	NCBI		UU_Cfam_GSD_1.0

TMPRSS6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	37,065,436 - 37,110,536 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	37,065,436 - 37,109,713 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	37,461,476 - 37,505,753 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	35,791,425 - 35,829,639 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	35,785,978 - 35,824,193	NCBI
Celera	22	21,262,809 - 21,300,772 (-)	NCBI		Celera
Cytogenetic Map	22	q12.3	NCBI
HuRef	22	20,426,706 - 20,464,791 (-)	NCBI		HuRef
CHM1_1	22	37,420,983 - 37,458,920 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	37,525,034 - 37,570,488 (-)	NCBI		T2T-CHM13v2.0

Tmprss6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	78,323,867 - 78,352,848 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	78,323,867 - 78,352,834 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	78,439,667 - 78,468,648 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	78,439,667 - 78,468,634 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	78,270,097 - 78,299,064 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	78,266,931 - 78,295,735 (-)	NCBI		MGSCv36	mm8
Celera	15	79,902,371 - 79,931,350 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	37.49	NCBI

Tmprss6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	111,871,504 - 111,902,127 (-)	NCBI		GRCr8
mRatBN7.2	7	109,991,008 - 110,021,626 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	109,985,931 - 110,021,624 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	111,741,252 - 111,771,803 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	113,964,790 - 113,995,347 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	113,932,869 - 113,963,426 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	119,659,323 - 119,689,953 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	119,659,324 - 119,689,938 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	119,649,831 - 119,680,259 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	116,391,730 - 116,419,671 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	116,425,992 - 116,456,922 (-)	NCBI
Celera	7	106,329,190 - 106,359,893 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Tmprss6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	23,580,530 - 23,612,276 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	23,579,946 - 23,615,277 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMPRSS6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	46,921,683 - 46,967,316 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	49,610,237 - 49,655,886 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	17,979,094 - 18,032,590 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	35,815,051 - 35,867,818 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	35,815,051 - 35,859,940 (-)	Ensembl	panpan1.1		panPan2

Tmprss6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	10,804,553 - 10,838,236 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	3,819,309 - 3,848,075 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	3,819,347 - 3,848,372 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMPRSS6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	10,663,635 - 10,705,471 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	10,663,491 - 10,704,583 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	8,263,703 - 8,304,970 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMPRSS6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	19,771,303 - 19,811,751 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	19,771,952 - 19,806,420 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	106,017,797 - 106,057,808 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmprss6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	10,693,634 - 10,727,269 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	10,693,895 - 10,727,269 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TMPRSS6
624 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium			6	6		6
Low	2		12		1				6	1	9	1
Below cutoff	3	5	4		5		6	3	6	7	1	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_014117371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038488701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038550664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038614596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038679956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_845457	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000002359 ⟹ ENSCAFP00000002181

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	27,397,123 - 27,435,908 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000036302 ⟹ ENSCAFP00000031662

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	27,398,573 - 27,435,908 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000063548 ⟹ ENSCAFP00000065448

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	27,398,573 - 27,435,908 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000069726 ⟹ ENSCAFP00000049861

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	27,398,573 - 27,435,908 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845013420 ⟹ ENSCAFP00845010413

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	28,190,967 - 28,228,124 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845013477 ⟹ ENSCAFP00845010455

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	28,190,967 - 28,228,124 (+)	Ensembl

RefSeq Acc Id:

XM_038488701 ⟹ XP_038344629

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	10	27,912,441 - 27,949,753 (+)	NCBI

RefSeq Acc Id:

XM_038550664 ⟹ XP_038406592

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	10	28,399,083 - 28,436,250 (+)	NCBI

RefSeq Acc Id:

XM_038614596 ⟹ XP_038470524

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	10	28,221,179 - 28,258,351 (+)	NCBI

RefSeq Acc Id:

XM_038679956 ⟹ XP_038535884

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	28,190,798 - 28,228,167 (+)	NCBI

RefSeq Acc Id:

XM_845457 ⟹ XP_850550

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	27,398,787 - 27,435,893 (+)	NCBI
Dog10K_Boxer_Tasha	10	27,353,491 - 27,390,639 (+)	NCBI

Sequence:

show sequence

TTACCTGTGCTCAGTCACAGTGCCGACCTGAACCCGGCAGAAGGCCCATGGAGCCTGGGGCCAC
AGGCCACAGGGGACAAGGGCCAGACACCCTGGCCATGGCTCTGGGCCATTGATCCAGCCCAGGC
TGGCTGGGTGGGGGTGGGGAGACCTTGGCCCGGACAAACAGAGGCTCTGTGGCCTGCGTGCAGG
CCCGGCACCCACCTGCCACTCCCAAAGGATGCCCATGGCCGAGGCCCCCCAAGCGGCCGGCGGA
CAGGGCGACGGAGGTGACGGTGAGGAAGCAGAGCCGGAGGGGATGTTCAAGGCCACCGAAATTT
CCAAGAGAAAAGTTCGGGACTACCTCCGCCTGGTGCCCCTGTGGCTGGCCCTGGTCGTGCTAGC
TTCGGTGGGGGTCCTGCTCTGGTATTTCCTAGGGTACAAGGCGGAGGTCACCGTCAGCCAGGTG
TACTCAGGCAGCGTGCGCGTGCTCAACCGCCACTTCTCCCAGGACCTCGCCCGCCGGGAGTCCA
GTGCCTTCCGCAGCGAAACTGCCAAAGCCCAGAAGATGCTCAAGGAGCTCATCGCCAGCACCCG
CCTGGGTACTTACTACAACTCCAGCTCGGTCTACTCCTTCGGAGAGGGGCCTCTCACCTGCTTC
TTCTGGTTCATCCTCCAAATCCCCGAGCACCGCCGGCCGATGCTGAGTCCTGAGGTGGTGCGGG
CACTGCTGGTGGAGGAGCTGCTGTCCACGGCCAACAGCTCGGCCCCCGCCCCCTACAGGGCCGA
GTACGAGGTGGACCCCGAGGGCCTGGTGATCCTGGAAGCCAGCGTGAAAGACATAGTTGCCCTG
AATGCCACGCTGGGCTGCTACCGCTACAGCTACGTGGGCCAGGGCCAGGTCCTCCGGCTGAAGG
GGCCCGATCACCTGGCCTCCAGCTGCCTGTGGCACCTACAGGGCCCCAAGGATCTCATGCTCAA
ACTCCGGCTCGAGTGGACGCTGGCCGAGTGCCGGGACCGACTGGCCATGTACGACGTGGCTGGA
CCCCTGGAGAGGAGGCTCATCACCTCGGTGTACGGCTGCAGTCGCCAGGAGCCCGTGGTGGAGG
TCCTGGCATCCGGGGCCGTCATGGCTGTGGTCTGGAAGAAGGGTCTGCACAGCTACTACGACCC
CTTTGTTCTTTCCGTGCAGCCCGTGGCCTTCCAGGCTTGTGAGGTGAACCTGACCCTGGAGGGC
CGTCTGGAACCACAGGGCGTCCTCAGCACGCCTTACTTCCCCAGCTACTACTCGCCCAGCACCC
ACTGCTCCTGGCACCTCACGGTGCCCTCTCTGGACTATGGCTTGGCCCTCTGGTTTGACGCCTA
TGCTCTGCGGAGGCAGAAGTATGACCTGCCATGCACCCAGGGACAGTGGACAATCCAGAACCGG
AGGCTGTGTGGCCTGCGCACCCTGCAGCCCTATGCCGAGAGGATCCCCGTGGTGGCCACTGCCG
GCATCACCGTCAACTTCACATCCCAGATCCCCCTCACCGGGCCCGGTGTGCAGGTGCACTACGG
CTTATACAACCAGTCGGATCCCTGCCCTGGAGAGTTCCTCTGCTCTGTGAATGGACTATGTGTG
CCTGCCTGCGATGGGGTCAAGGACTGTCCCAACGGCCTGGATGAGAGAAACTGTGTTTGCAGAG
CCACATTCCAGTGCCAAGAAGACAGCACCTGCATCTCACTGTCCAGAGTCTGTGACCGGCAGCC
TGACTGTCTCAATGGGAGTGACGAAGAGCACTGCCAGGAAGGGGTGCCTTGTGGGACATTCACC
TTCCAGTGTGAGGACCGCAGCTGCGTGAAGAAGCCCAACCCGCAGTGTGATGGGCTGCCTGACT
GCCGGGACGGCTCGGACGAGCAGCACTGTGACTGTGGCCTCCAGGGCCCTTCTGGCCGCATAGT
GGGCGGGGCCGTGTCTTCAGAGGGCGAGTGGCCCTGGCAGGCCAGCCTCCAGATTCGAGGCCGA
CACATCTGCGGGGGGGCGCTCATCGCTGACCGCTGGGTGATAACAGCTGCCCACTGCTTCCAGG
ACGACAGCATGGCCTCCCCAGCGCTGTGGACCGTATTCCTGGGCAAAGTGTGGCAAAGCTCGCG
TTGGCCGGGCGAGGTGTCCTTCAAGGTGAGCCGCCTGCTCCTGCACCCTTACCACGAGGAGGAC
AGCCACGACTACGATGTGGCCCTGCTGCAGCTCGACCACCCCGTGGTGCGCTCGGCCGCCGTGC
GCCCCGTTTGCCTGCCTGCGCGCTCCCACTTCTTCGAGCCCGGCCTACACTGCTGGATCACGGG
CTGGGGCGCCCTGCGTGAGGGTGGCCCCACCAGCAATGGTCTGCAGAAGGTGGATGTGCAGCTG
ATCCCGCAGGACCTGTGCAGCGAGGCCTATCGCTACCAGGTGACACCCCGCATGCTGTGTGCCG
GCTACCGGAAGGGCAAGAAGGATGCCTGCCAGGGCGACTCGGGAGGCCCGTTAGTGTGCAAGGA
ACCCAGTGGCCGCTGGTTCCTGGCAGGGCTGGTCAGCTGGGGCCTGGGCTGCGGCCGGCCCAAC
TACTTTGGTGTCTACACCCGCATCACAGGTGTGATTGGCTGGATCCAACAGGTGCTGACCTGAG
GAGCTCCCCTCCCTGCAGAGCTGGGGCCCACCTGCTGGACTCAGAGAGTCCAGAGCACCCACTA
GTCAGGGGAGCAAGTAATTGTGGGGGCAGCAGGGCCCCGCGGAGGTCAACTCCCCCTGCACCGC
AGGGCCTGGATGGTCAGCCAGCCCGCTGGAGGGGTTCACATCTAGCCCTTTTGCCTCCTGATTC
TCTCTCCTCCTTCCCCTTCCTCTGCTGCCCACTGGGAATGGTTCAGCAGTGATAACGGGGCTTC
CAGGTCCCAACAGGGGTGTCTGAGCTCCAACCCCCCCCGCCAATGCAGAGAGCAGATCCAGCCT
GTGAACTTGAGGGGTGGGGATAGAAGGCGCCCACAGGGAGGGGCCCCCAGAGCCCTAGAGACAG
CCAAGTGGGCCAGCTGCCACCATAAGCCAAAGGGTGGGGGAGCCCCAGGTCTAGGGTCCTCACC
CTACCACCTGTCCCCTGGGCCTCCACTGCCCACTCTCACCTGGAAGTGAGCTCCACCACCCTGT
GGAATAAAGTTGTTTGATCTGAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_038344629	(Get FASTA)	NCBI Sequence Viewer
	XP_038406592	(Get FASTA)	NCBI Sequence Viewer
	XP_038470524	(Get FASTA)	NCBI Sequence Viewer
	XP_038535884	(Get FASTA)	NCBI Sequence Viewer
	XP_850550	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000002181.5
	ENSCAFP00000031662.3
	ENSCAFP00030014810.1
	ENSCAFP00040016948.1
	ENSCAFP00845010413
	ENSCAFP00845010413.1
	ENSCAFP00845010455.1

RefSeq Acc Id:

XP_850550 ⟸ XM_845457

- UniProtKB:

A0A8C0MPB1 (UniProtKB/TrEMBL), A0A8I3RU13 (UniProtKB/TrEMBL), A0A8C0JUF4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPMAEAPQAAGGQGDGGDGEEAEPEGMFKATEISKRKVRDYLRLVPLWLALVVLASVGVLLWYF
LGYKAEVTVSQVYSGSVRVLNRHFSQDLARRESSAFRSETAKAQKMLKELIASTRLGTYYNSSS
VYSFGEGPLTCFFWFILQIPEHRRPMLSPEVVRALLVEELLSTANSSAPAPYRAEYEVDPEGLV
ILEASVKDIVALNATLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAE
CRDRLAMYDVAGPLERRLITSVYGCSRQEPVVEVLASGAVMAVVWKKGLHSYYDPFVLSVQPVA
FQACEVNLTLEGRLEPQGVLSTPYFPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQKYDL
PCTQGQWTIQNRRLCGLRTLQPYAERIPVVATAGITVNFTSQIPLTGPGVQVHYGLYNQSDPCP
GEFLCSVNGLCVPACDGVKDCPNGLDERNCVCRATFQCQEDSTCISLSRVCDRQPDCLNGSDEE
HCQEGVPCGTFTFQCEDRSCVKKPNPQCDGLPDCRDGSDEQHCDCGLQGPSGRIVGGAVSSEGE
WPWQASLQIRGRHICGGALIADRWVITAAHCFQDDSMASPALWTVFLGKVWQSSRWPGEVSFKV
SRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGP
TSNGLQKVDVQLIPQDLCSEAYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKEPSGRWFLAG
LVSWGLGCGRPNYFGVYTRITGVIGWIQQVLT

hide sequence

RefSeq Acc Id:

ENSCAFP00000049861 ⟸ ENSCAFT00000069726

RefSeq Acc Id:

ENSCAFP00000065448 ⟸ ENSCAFT00000063548

RefSeq Acc Id:

ENSCAFP00000002181 ⟸ ENSCAFT00000002359

RefSeq Acc Id:

ENSCAFP00000031662 ⟸ ENSCAFT00000036302

RefSeq Acc Id:

XP_038344629 ⟸ XM_038488701

RefSeq Acc Id:

XP_038470524 ⟸ XM_038614596

RefSeq Acc Id:	XP_038535884 ⟸ XM_038679956
- UniProtKB:	A0A8C0MPB1 (UniProtKB/TrEMBL), A0A8I3RU13 (UniProtKB/TrEMBL), A0A8C0JUF4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038406592 ⟸ XM_038550664
- UniProtKB:	A0A8C0JUF4 (UniProtKB/TrEMBL), A0A8C0MPB1 (UniProtKB/TrEMBL), A0A8I3RU13 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845010413 ⟸ ENSCAFT00845013420

RefSeq Acc Id:

ENSCAFP00845010455 ⟸ ENSCAFT00845013477

Protein Domains

CUB Peptidase S1 SEA

Promoters

RGD ID:

13684986

Promoter ID:

EPDNEW_C3054

Type:

multiple initiation site

Name:

TMPRSS6_2

Description:

transmembrane serine protease 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_C3055

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	27,398,799 - 27,398,859	EPDNEW

RGD ID:

13684988

Promoter ID:

EPDNEW_C3055

Type:

multiple initiation site

Name:

TMPRSS6_1

Description:

transmembrane serine protease 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_C3054

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	27,398,950 - 27,399,010	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000001512	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030009077	UniProtKB/TrEMBL
	ENSCAFG00040010444	UniProtKB/TrEMBL
	ENSCAFG00845007611	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000002359.5	UniProtKB/TrEMBL
	ENSCAFT00000036302.5	UniProtKB/TrEMBL
	ENSCAFT00030016944.1	UniProtKB/TrEMBL
	ENSCAFT00040019526.1	UniProtKB/TrEMBL
	ENSCAFT00845013420	ENTREZGENE
	ENSCAFT00845013420.1	UniProtKB/TrEMBL
	ENSCAFT00845013477.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	2.60.120.290	UniProtKB/TrEMBL
	3.30.70.960	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
InterPro	CUB_dom	UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	SEA_dom	UniProtKB/TrEMBL
	SEA_dom_sf	UniProtKB/TrEMBL
	Sperma_CUB_dom_sf	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
KEGG Report	cfa:608593	UniProtKB/TrEMBL
NCBI Gene	TMPRSS6	ENTREZGENE
PANTHER	ACROSIN-RELATED	UniProtKB/TrEMBL
	LOW QUALITY PROTEIN: TRANSMEMBRANE PROTEASE SERINE 6	UniProtKB/TrEMBL
Pfam	Ldl_recept_a	UniProtKB/TrEMBL
	SEA	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	CUB	UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/TrEMBL
	SEA	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	LDLa	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49854	UniProtKB/TrEMBL
	SSF50494	UniProtKB/TrEMBL
	SSF57424	UniProtKB/TrEMBL
	SSF82671	UniProtKB/TrEMBL
UniProt	A0A8C0JUF4	ENTREZGENE
	A0A8C0MPB1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3N4E4_CANLF	UniProtKB/TrEMBL
	A0A8I3RU13	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SPH2_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:47636	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-07-24	TMPRSS6	transmembrane serine protease 6		transmembrane protease, serine 6	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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