CHRNB1 (cholinergic receptor nicotinic beta 1 subunit)

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Gene: CHRNB1 (cholinergic receptor nicotinic beta 1 subunit) Canis lupus familiaris

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Symbol:

CHRNB1

Name:

cholinergic receptor nicotinic beta 1 subunit

RGD ID:

12396673

Description:

ENCODES a protein that exhibits acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); ligand-gated monoatomic ion channel activity (ortholog); INVOLVED IN monoatomic cation transport (ortholog); regulation of membrane potential (ortholog); skeletal muscle contraction (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH common variable immunodeficiency (ortholog); congenital myasthenic syndrome (ortholog); congenital myasthenic syndrome 2A (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); neuromuscular junction (ortholog); postsynaptic specialization membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

acetylcholine receptor subunit beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	32,375,152 - 32,383,517 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	32,375,215 - 32,382,929 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	32,513,277 - 32,521,649 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	32,480,862 - 32,489,239 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	32,480,903 - 32,489,017 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	32,446,084 - 32,454,448 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	32,404,809 - 32,413,162 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	32,582,085 - 32,590,461 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

common variable immunodeficiency (ISO)

congenital myasthenic syndrome (ISO)

congenital myasthenic syndrome 2A (ISO)

congenital myasthenic syndrome 2C (ISO)

congenital myasthenic syndrome 4C (ISO)

Congenital Myasthenic Syndrome, with Facial Dysmorphism, associated with Acetylcholine Receptor Deficiency (ISO)

dyskeratosis congenita (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Li-Fraumeni syndrome (ISO)

very long chain acyl-CoA dehydrogenase deficiency (ISO)

Weissenbacher-Zweymuller syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

behavioral response to nicotine (IEA)

excitatory postsynaptic potential (IEA)

monoatomic cation transport (IEA,ISO)

monoatomic ion transmembrane transport (IEA)

muscle cell development (IEA)

muscle contraction (IEA)

nervous system process (IEA)

neuromuscular synaptic transmission (IEA)

postsynaptic membrane organization (IEA)

regulation of membrane potential (IEA,ISO)

regulation of postsynaptic membrane potential (IEA)

signal transduction (IEA)

skeletal muscle contraction (ISO)

synaptic transmission, cholinergic (IEA)

Cellular Component

acetylcholine-gated channel complex (IEA,ISO)

neuromuscular junction (IEA,ISO)

plasma membrane (IEA)

postsynaptic membrane (IEA)

postsynaptic specialization membrane (IEA,ISO)

synapse (IEA)

Molecular Function

acetylcholine binding (IEA)

acetylcholine receptor activity (IEA,ISO)

acetylcholine-gated monoatomic cation-selective channel activity (IEA,ISO)

channel activity (IEA)

ligand-gated monoatomic ion channel activity (ISO)

protein binding (ISO)

transmembrane signaling receptor activity (IEA)

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CHRNB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	32,375,152 - 32,383,517 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	32,375,215 - 32,382,929 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	32,513,277 - 32,521,649 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	32,480,862 - 32,489,239 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	32,480,903 - 32,489,017 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	32,446,084 - 32,454,448 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	32,404,809 - 32,413,162 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	32,582,085 - 32,590,461 (+)	NCBI		UU_Cfam_GSD_1.0

CHRNB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	7,445,061 - 7,457,710 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	7,445,061 - 7,457,710 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	7,348,380 - 7,361,029 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	7,289,130 - 7,301,656 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	7,289,129 - 7,301,656	NCBI
Celera	17	7,374,294 - 7,386,883 (+)	NCBI		Celera
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	7,242,351 - 7,254,625 (+)	NCBI		HuRef
CHM1_1	17	7,357,504 - 7,370,035 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	7,349,120 - 7,361,750 (+)	NCBI		T2T-CHM13v2.0

Chrnb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	69,674,862 - 69,686,742 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	69,674,862 - 69,686,769 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	69,784,036 - 69,795,966 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	69,784,036 - 69,795,943 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	69,597,538 - 69,609,439 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	69,600,232 - 69,612,138 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	70,368,144 - 70,380,050 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B3	NCBI
cM Map	11	42.87	NCBI

Chrnb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	54,999,943 - 55,015,137 (-)	NCBI		GRCr8
mRatBN7.2	10	54,501,096 - 54,516,418 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	54,501,093 - 54,516,345 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	59,166,354 - 59,178,879 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	58,654,919 - 58,667,445 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	54,162,545 - 54,175,096 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	56,390,671 - 56,403,255 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	56,390,671 - 56,403,188 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	56,135,720 - 56,148,237 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	56,604,907 - 56,617,423 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	56,618,529 - 56,631,046 (-)	NCBI
Celera	10	53,658,103 - 53,670,628 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

Chrnb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	9,471,962 - 9,482,370 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	9,471,962 - 9,482,370 (-)	NCBI	ChiLan1.0	ChiLan1.0

CHRNB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	15,041,812 - 15,053,022 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	17,007,603 - 17,018,838 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	7,479,056 - 7,490,314 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	7,465,229 - 7,476,099 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	7,465,229 - 7,476,099 (+)	Ensembl	panpan1.1		panPan2

Chrnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	47,253,704 - 47,261,819 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936595	727,980 - 735,783 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936595	727,907 - 735,783 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRNB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	52,749,473 - 52,758,488 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	52,749,422 - 52,774,642 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	54,977,614 - 55,002,976 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHRNB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	6,821,842 - 6,832,758 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	6,822,065 - 6,833,768 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	14,575,541 - 14,586,609 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chrnb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	10,056,478 - 10,065,735 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	10,056,458 - 10,065,768 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CHRNB1
72 total Variants

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022418516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038475510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038475511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038536684	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038536685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038600876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038600877	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038665406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038665407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_546591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000025890 ⟹ ENSCAFP00000024042

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	5	32,375,215 - 32,382,929 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845039621 ⟹ ENSCAFP00845031037

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	5	32,480,903 - 32,489,017 (+)	Ensembl

RefSeq Acc Id:

XM_022418516 ⟹ XP_022274224

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	32,375,152 - 32,383,517 (+)	NCBI
Dog10K_Boxer_Tasha	5	32,513,277 - 32,521,649 (+)	NCBI

Sequence:

show sequence

GGCGCCTCGTCACTTCCCCCCCCCCCCCCGCGTTGGTGAATCGAGCGAACTCACTGAGCAACCA
ACCGGCCGAGCTATGACCGCAGGGGCGCTGCTGCTGCTGCTGGGGGCGTTGGGGGTGCCACTCG
CCCCGGGCGCCCGCGGCACGGAGGTGGAGGGCCGGCTCCGCGAGAAGCTTTTCTTGGGCTACGA
CAGCTCGGTGCGGCCGGCGCGGGAGGTGGGGGATAGCGTGGGGAACGAGAAGGATGAGGAGATG
AGCACAAAGGTGTACTTAGACCTGGAGTGGACTGACTACAGGCTGAGCTGGGACCCTGCAGAGT
ACGAGGGTATCGATTCACTCCGCATAACGGCTGGATCCGTGTGGCTTCCAGACGTGGTGCTCCT
GAACAACAACGACGGCAATTTCGACGTTGCTCTGGACTTGAACGTCGTGGTGTCCTCAGACGGC
TCCGTGCGCTGGCAGCCTCCAGGCCTCTACCGTAGCAGCTGCAGCATCCAGGTCACCTACTTCC
CCTTCGACTGGCAGAACTGCACCATGGTGTTCAGCTCCTACAGCTATGACAGCTCAGAGGTCAG
CCTGCACACGGGCTTGGGTCCTGACAGGCAGGAGCTGCAGGAAGTGCACATTCATGAAGGGACC
TTCATTGAGAATGGCCAGTGGGAAATTATCCACAAGCCTTCCCGGCTAGTGCAGCCTCCGGTGG
ATCCTAGGCGGGGCGGGGAAGGACAGCGGCAAGAAGTCACCTTCTACCTCATCATCCGCAGGAA
GCCTCTCTTCTACCTGGTCAACGTCATTGCCCCTTGCATCCTCATCACCCTCCTGGCCATCTTC
GTCTTCTACCTGCCACCAGATGCAGGAGAAAAGATGGGGCTCTCCATCTTTGCCCTGCTCACCC
TCACTGTGTTCCTGTTGCTGCTGGCAGACAAAGTTCCTGAGACCTCCCTGTCTGTCCCCATCAT
TATCAAGTACCTCATGTTTACCATGATCCTCGTCACTTTCTCCGTCATCCTGAGCGTTGTGGTC
CTCAACCTGCACCATCGCTCACCCCACACCCACCAAATGCCCACTTGGGTCCGCCAGATCTTCA
TCCACAAACTCCCTCTATACCTGGGTCTGAAGAGGCCCAAACCTGAGAGAGACCTGATGCCGGA
GCCACCTCCCGTAGCCCTCAGGGATTCTCCAGGAAGTGGCTGGGGTCGGGGAACAGATGAATAT
TTCATCCGGAAGCCACTGAACGATTTTCTCTTCCCCAAACCCAACAGATTCCAGCCTGAATTGT
CTGCCCCGGACCTGCGGCGACTTGTCGATGGTCCAAACCCGGCTGTGGGCCTGCCTCCCGAGCT
ACGGGAGGTCGTTTCCTCGATTAGCTACATCGCTCGGCAGCTGCAGGAACAGGAGGACCACCAC
GCGCTGAAAGAAGACTGGCAATTTGTGGCCATGGTAGTGGATCGCCTTTTCCTGTGGACCTTCA
TCATCTTCACTAGCGTTGGGACCCTCGTCATCTTCCTGGACGCCTCCTATCACTTGCCCCCTGC
GGACCCTTTTCCTTGAGGACAGAGGGCCAAGAGCCAGGACCTCGCAGCTCCACTTGGAATCCAG
TCCTCTCACACCATTGCCTTGGTGGGGAGAGCGCCCAAGTGGGACGGGGCGGGCGGAAGCCGTG
GCCCCTCCAGAAATGCACTGTTTTCTGGTTTCTTGTAGAAGTTTCTTTGGAGAGTAACACTAGG
TTGCCGGTAGAATGGAACAAAGATCAAGAAGTAGACTGTACGCCCTACCTATGAGGGCAGGAAC
TGTGTTTTGTTCACTGTAATATCCCCAGCGCCTAGCACGGGTCCTGACCCATAGGATAGCAGGT
GCTTAACATTTGTTGAGTGATTAGGGAATTTTTTCTTTTCTTTCTTTCTGGGAAGGAAATGCAC
CAATGAATAGTGCCTGTGTTTGCATGTTGGGACTAGTGGTCATTCTCTTTGTTTTTACCTTCTT
GTAACATATTGTTTTCGGATAAGTGTTATCCATAGGATTTTTTTGAAAAGTTATTTCTAAAAGG
ATGCATTTGTAATGAGAGCTCACTTTAAAAAAAAAAAAGCAAAAAACAACCTTCAAATTCCAGC
TTTGGTGCTCAAACTTTGTATAAGGTAC

hide sequence

RefSeq Acc Id:

XM_038475510 ⟹ XP_038331438

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	32,446,084 - 32,454,448 (+)	NCBI

RefSeq Acc Id:

XM_038475511 ⟹ XP_038331439

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	32,446,084 - 32,454,448 (+)	NCBI

RefSeq Acc Id:

XM_038536684 ⟹ XP_038392612

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	32,582,085 - 32,590,461 (+)	NCBI

RefSeq Acc Id:

XM_038536685 ⟹ XP_038392613

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	32,582,085 - 32,590,461 (+)	NCBI

RefSeq Acc Id:

XM_038600876 ⟹ XP_038456804

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	32,404,809 - 32,413,162 (+)	NCBI

RefSeq Acc Id:

XM_038600877 ⟹ XP_038456805

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	32,404,809 - 32,413,162 (+)	NCBI

RefSeq Acc Id:

XM_038665406 ⟹ XP_038521334

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	32,480,862 - 32,489,239 (+)	NCBI

RefSeq Acc Id:

XM_038665407 ⟹ XP_038521335

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	32,480,862 - 32,489,239 (+)	NCBI

RefSeq Acc Id:

XM_546591 ⟹ XP_546591

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	32,375,152 - 32,383,517 (+)	NCBI
Dog10K_Boxer_Tasha	5	32,513,277 - 32,521,649 (+)	NCBI

Sequence:

show sequence

GGCGCCTCGTCACTTCCCCCCCCCCCCCCGCGTTGGTGAATCGAGCGAACTCACTGAGCAACCA
ACCGGCCGAGCTATGACCGCAGGGGCGCTGCTGCTGCTGCTGGGGGCGTTGGGGGTGCCACTCG
CCCCGGGCGCCCGCGGCACGGAGGTGGAGGGCCGGCTCCGCGAGAAGCTTTTCTTGGGCTACGA
CAGCTCGGTGCGGCCGGCGCGGGAGGTGGGGGATAGCGTGGGGGTCAGTGTCGGCCTCAGCCTG
GCGCAACTCATCAGCCTGAACGAGAAGGATGAGGAGATGAGCACAAAGGTGTACTTAGACCTGG
AGTGGACTGACTACAGGCTGAGCTGGGACCCTGCAGAGTACGAGGGTATCGATTCACTCCGCAT
AACGGCTGGATCCGTGTGGCTTCCAGACGTGGTGCTCCTGAACAACAACGACGGCAATTTCGAC
GTTGCTCTGGACTTGAACGTCGTGGTGTCCTCAGACGGCTCCGTGCGCTGGCAGCCTCCAGGCC
TCTACCGTAGCAGCTGCAGCATCCAGGTCACCTACTTCCCCTTCGACTGGCAGAACTGCACCAT
GGTGTTCAGCTCCTACAGCTATGACAGCTCAGAGGTCAGCCTGCACACGGGCTTGGGTCCTGAC
AGGCAGGAGCTGCAGGAAGTGCACATTCATGAAGGGACCTTCATTGAGAATGGCCAGTGGGAAA
TTATCCACAAGCCTTCCCGGCTAGTGCAGCCTCCGGTGGATCCTAGGCGGGGCGGGGAAGGACA
GCGGCAAGAAGTCACCTTCTACCTCATCATCCGCAGGAAGCCTCTCTTCTACCTGGTCAACGTC
ATTGCCCCTTGCATCCTCATCACCCTCCTGGCCATCTTCGTCTTCTACCTGCCACCAGATGCAG
GAGAAAAGATGGGGCTCTCCATCTTTGCCCTGCTCACCCTCACTGTGTTCCTGTTGCTGCTGGC
AGACAAAGTTCCTGAGACCTCCCTGTCTGTCCCCATCATTATCAAGTACCTCATGTTTACCATG
ATCCTCGTCACTTTCTCCGTCATCCTGAGCGTTGTGGTCCTCAACCTGCACCATCGCTCACCCC
ACACCCACCAAATGCCCACTTGGGTCCGCCAGATCTTCATCCACAAACTCCCTCTATACCTGGG
TCTGAAGAGGCCCAAACCTGAGAGAGACCTGATGCCGGAGCCACCTCCCGTAGCCCTCAGGGAT
TCTCCAGGAAGTGGCTGGGGTCGGGGAACAGATGAATATTTCATCCGGAAGCCACTGAACGATT
TTCTCTTCCCCAAACCCAACAGATTCCAGCCTGAATTGTCTGCCCCGGACCTGCGGCGACTTGT
CGATGGTCCAAACCCGGCTGTGGGCCTGCCTCCCGAGCTACGGGAGGTCGTTTCCTCGATTAGC
TACATCGCTCGGCAGCTGCAGGAACAGGAGGACCACCACGCGCTGAAAGAAGACTGGCAATTTG
TGGCCATGGTAGTGGATCGCCTTTTCCTGTGGACCTTCATCATCTTCACTAGCGTTGGGACCCT
CGTCATCTTCCTGGACGCCTCCTATCACTTGCCCCCTGCGGACCCTTTTCCTTGAGGACAGAGG
GCCAAGAGCCAGGACCTCGCAGCTCCACTTGGAATCCAGTCCTCTCACACCATTGCCTTGGTGG
GGAGAGCGCCCAAGTGGGACGGGGCGGGCGGAAGCCGTGGCCCCTCCAGAAATGCACTGTTTTC
TGGTTTCTTGTAGAAGTTTCTTTGGAGAGTAACACTAGGTTGCCGGTAGAATGGAACAAAGATC
AAGAAGTAGACTGTACGCCCTACCTATGAGGGCAGGAACTGTGTTTTGTTCACTGTAATATCCC
CAGCGCCTAGCACGGGTCCTGACCCATAGGATAGCAGGTGCTTAACATTTGTTGAGTGATTAGG
GAATTTTTTCTTTTCTTTCTTTCTGGGAAGGAAATGCACCAATGAATAGTGCCTGTGTTTGCAT
GTTGGGACTAGTGGTCATTCTCTTTGTTTTTACCTTCTTGTAACATATTGTTTTCGGATAAGTG
TTATCCATAGGATTTTTTTGAAAAGTTATTTCTAAAAGGATGCATTTGTAATGAGAGCTCACTT
TAAAAAAAAAAAAGCAAAAAACAACCTTCAAATTCCAGCTTTGGTGCTCAAACTTTGTATAAGG
TAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_022274224	(Get FASTA)	NCBI Sequence Viewer
	XP_038331438	(Get FASTA)	NCBI Sequence Viewer
	XP_038331439	(Get FASTA)	NCBI Sequence Viewer
	XP_038392612	(Get FASTA)	NCBI Sequence Viewer
	XP_038392613	(Get FASTA)	NCBI Sequence Viewer
	XP_038456804	(Get FASTA)	NCBI Sequence Viewer
	XP_038456805	(Get FASTA)	NCBI Sequence Viewer
	XP_038521334	(Get FASTA)	NCBI Sequence Viewer
	XP_038521335	(Get FASTA)	NCBI Sequence Viewer
	XP_546591	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000024042.5
	ENSCAFP00030023871.1
	ENSCAFP00040008142.1
	ENSCAFP00845031037
	ENSCAFP00845031037.1

RefSeq Acc Id:	XP_546591 ⟸ XM_546591
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0NEP4 (UniProtKB/TrEMBL), A0A8C0QXB9 (UniProtKB/TrEMBL), A0A8I3PJZ8 (UniProtKB/TrEMBL), A0A8C0QFR5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTAGALLLLLGALGVPLAPGARGTEVEGRLREKLFLGYDSSVRPAREVGDSVGVSVGLSLAQLI SLNEKDEEMSTKVYLDLEWTDYRLSWDPAEYEGIDSLRITAGSVWLPDVVLLNNNDGNFDVALD LNVVVSSDGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLHTGLGPDRQEL QEVHIHEGTFIENGQWEIIHKPSRLVQPPVDPRRGGEGQRQEVTFYLIIRRKPLFYLVNVIAPC ILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMILVT FSVILSVVVLNLHHRSPHTHQMPTWVRQIFIHKLPLYLGLKRPKPERDLMPEPPPVALRDSPGS GWGRGTDEYFIRKPLNDFLFPKPNRFQPELSAPDLRRLVDGPNPAVGLPPELREVVSSISYIAR QLQEQEDHHALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDASYHLPPADPFP hide sequence

RefSeq Acc Id:	XP_022274224 ⟸ XM_022418516
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0K5H6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTAGALLLLLGALGVPLAPGARGTEVEGRLREKLFLGYDSSVRPAREVGDSVGNEKDEEMSTKV YLDLEWTDYRLSWDPAEYEGIDSLRITAGSVWLPDVVLLNNNDGNFDVALDLNVVVSSDGSVRW QPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLHTGLGPDRQELQEVHIHEGTFIEN GQWEIIHKPSRLVQPPVDPRRGGEGQRQEVTFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYL PPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMILVTFSVILSVVVLNLH HRSPHTHQMPTWVRQIFIHKLPLYLGLKRPKPERDLMPEPPPVALRDSPGSGWGRGTDEYFIRK PLNDFLFPKPNRFQPELSAPDLRRLVDGPNPAVGLPPELREVVSSISYIARQLQEQEDHHALKE DWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDASYHLPPADPFP hide sequence

Ensembl Acc Id:

ENSCAFP00000024042 ⟸ ENSCAFT00000025890

RefSeq Acc Id:	XP_038331438 ⟸ XM_038475510
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038331439 ⟸ XM_038475511
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038456804 ⟸ XM_038600876
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038456805 ⟸ XM_038600877
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038521334 ⟸ XM_038665406
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0NEP4 (UniProtKB/TrEMBL), A0A8C0QXB9 (UniProtKB/TrEMBL), A0A8I3PJZ8 (UniProtKB/TrEMBL), A0A8C0QFR5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038521335 ⟸ XM_038665407
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0K5H6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038392612 ⟸ XM_038536684
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0NEP4 (UniProtKB/TrEMBL), A0A8C0QFR5 (UniProtKB/TrEMBL), A0A8C0QXB9 (UniProtKB/TrEMBL), A0A8I3PJZ8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038392613 ⟸ XM_038536685
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0K5H6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845031037 ⟸ ENSCAFT00845039621

Protein Domains

Neurotransmitter-gated ion-channel ligand-binding Neurotransmitter-gated ion-channel transmembrane

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000016315	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030014805	UniProtKB/TrEMBL
	ENSCAFG00040005011	UniProtKB/TrEMBL
	ENSCAFG00845022447	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000025890.5	UniProtKB/TrEMBL
	ENSCAFT00030027357.1	UniProtKB/TrEMBL
	ENSCAFT00040009398.1	UniProtKB/TrEMBL
	ENSCAFT00845039621	ENTREZGENE
	ENSCAFT00845039621.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.390	UniProtKB/TrEMBL
	2.70.170.10	UniProtKB/TrEMBL
InterPro	Neur_chan_lig-bd	UniProtKB/TrEMBL
	Neur_chan_lig-bd_sf	UniProtKB/TrEMBL
	Neur_channel	UniProtKB/TrEMBL
	Neuro-gated_channel_TM_sf	UniProtKB/TrEMBL
	Neuro_actylchol_rec	UniProtKB/TrEMBL
	Neurotrans-gated_channel_TM	UniProtKB/TrEMBL
	Neurotransmitter_ion_chnl_CS	UniProtKB/TrEMBL
	Nicotinic_acetylcholine_rcpt	UniProtKB/TrEMBL
NCBI Gene	CHRNB1	ENTREZGENE
PANTHER	ACETYLCHOLINE RECEPTOR SUBUNIT BETA	UniProtKB/TrEMBL
	PTHR18945	UniProtKB/TrEMBL
Pfam	Neur_chan_LBD	UniProtKB/TrEMBL
	Neur_chan_memb	UniProtKB/TrEMBL
PRINTS	NICOTINICR	UniProtKB/TrEMBL
	NRIONCHANNEL	UniProtKB/TrEMBL
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63712	UniProtKB/TrEMBL
	SSF90112	UniProtKB/TrEMBL
UniProt	A0A8C0K5H6	ENTREZGENE
	A0A8C0NEP4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0QFR5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0QXB9	ENTREZGENE
	A0A8I3PJZ8	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:39242	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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