NDUFA12 (NADH:ubiquinone oxidoreductase subunit A12) - Rat Genome Database

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Gene: NDUFA12 (NADH:ubiquinone oxidoreductase subunit A12) Canis lupus familiaris
Analyze
Symbol: NDUFA12
Name: NADH:ubiquinone oxidoreductase subunit A12
RGD ID: 12395127
Description: INVOLVED IN mitochondrial ATP synthesis coupled electron transport (inferred); mitochondrial respiratory chain complex I assembly (inferred); response to oxidative stress (inferred); ASSOCIATED WITH genetic disease (ortholog); Leigh disease (ortholog); nuclear type mitochondrial complex I deficiency 23 (ortholog); FOUND IN mitochondrial respiratory chain complex I (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11534,971,944 - 34,996,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1534,954,364 - 34,996,409 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1535,358,281 - 35,383,326 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01535,635,803 - 35,660,916 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1535,635,806 - 35,660,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11534,909,186 - 34,934,255 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,004,611 - 35,029,415 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01535,267,564 - 35,292,067 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NDUFA12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11534,971,944 - 34,996,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1534,954,364 - 34,996,409 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1535,358,281 - 35,383,326 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01535,635,803 - 35,660,916 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1535,635,806 - 35,660,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11534,909,186 - 34,934,255 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,004,611 - 35,029,415 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01535,267,564 - 35,292,067 (-)NCBIUU_Cfam_GSD_1.0
NDUFA12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381294,971,333 - 95,003,697 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1294,895,297 - 95,003,748 (-)EnsemblGRCh38hg38GRCh38
GRCh371295,365,109 - 95,397,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361293,889,240 - 93,921,642 (-)NCBINCBI36Build 36hg18NCBI36
Celera1295,036,378 - 95,068,792 (-)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1292,432,352 - 92,464,771 (-)NCBIHuRef
CHM1_11295,329,770 - 95,362,041 (-)NCBICHM1_1
T2T-CHM13v2.01294,952,013 - 94,984,403 (-)NCBIT2T-CHM13v2.0
Ndufa12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391094,034,897 - 94,057,302 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1094,034,582 - 94,057,305 (+)EnsemblGRCm39 Ensembl
GRCm381094,199,035 - 94,221,440 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1094,198,720 - 94,221,443 (+)EnsemblGRCm38mm10GRCm38
MGSCv371093,661,754 - 93,683,693 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361093,628,808 - 93,650,747 (+)NCBIMGSCv36mm8
Celera1096,174,550 - 96,195,781 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.83NCBI
Ndufa12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8730,658,316 - 30,685,302 (+)NCBIGRCr8
mRatBN7.2728,771,330 - 28,798,316 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,771,330 - 28,798,315 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx730,769,386 - 30,796,332 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,931,634 - 32,958,580 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0732,702,401 - 32,729,402 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0735,125,516 - 35,163,182 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl735,125,424 - 35,167,406 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0735,193,809 - 35,229,887 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4731,349,357 - 31,376,151 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1731,366,696 - 31,396,332 (+)NCBI
Celera725,862,251 - 25,888,618 (+)NCBICelera
Cytogenetic Map7q13NCBI
Ndufa12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540531,606,924 - 31,621,590 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540531,607,182 - 31,621,538 (-)NCBIChiLan1.0ChiLan1.0
NDUFA12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210103,039,002 - 103,076,665 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112103,035,393 - 103,073,056 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01292,557,630 - 92,594,947 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11295,953,485 - 95,989,618 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1295,953,491 - 95,989,618 (-)Ensemblpanpan1.1panPan2
Ndufa12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,979,023 - 25,073,028 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493650711,254,729 - 11,256,395 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFA12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1588,292,760 - 88,317,111 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2592,639,666 - 92,664,026 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFA12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11190,371,129 - 90,413,695 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1190,369,526 - 90,413,841 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037154,755,371 - 154,797,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufa12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475012,026,148 - 12,053,377 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NDUFA12
249 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000010062   ⟹   ENSCAFP00000009334
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1534,971,942 - 34,996,393 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000067436   ⟹   ENSCAFP00000046667
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1534,972,022 - 34,996,409 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000074535   ⟹   ENSCAFP00000062382
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1534,954,364 - 34,996,409 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000077684   ⟹   ENSCAFP00000049153
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1534,972,200 - 34,996,409 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845039965   ⟹   ENSCAFP00845031295
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1535,635,806 - 35,660,851 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845040030   ⟹   ENSCAFP00845031346
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1535,635,886 - 35,660,867 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845040068   ⟹   ENSCAFP00845031376
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1535,636,064 - 35,660,867 (-)Ensembl
RefSeq Acc Id: XM_038496282   ⟹   XP_038352210
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11534,909,186 - 34,934,255 (-)NCBI
RefSeq Acc Id: XM_038558667   ⟹   XP_038414595
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01535,267,564 - 35,292,067 (-)NCBI
RefSeq Acc Id: XM_038622578   ⟹   XP_038478506
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01535,004,611 - 35,029,415 (-)NCBI
RefSeq Acc Id: XM_038688254   ⟹   XP_038544182
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01535,635,803 - 35,660,916 (-)NCBI
RefSeq Acc Id: XM_532652   ⟹   XP_532652
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11534,971,944 - 34,996,458 (-)NCBI
Dog10K_Boxer_Tasha1535,358,281 - 35,383,326 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_532652   ⟸   XM_532652
- UniProtKB: F1PWZ9 (UniProtKB/TrEMBL),   A0A8C0LGU3 (UniProtKB/TrEMBL),   A0A8C0NJ48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000062382   ⟸   ENSCAFT00000074535
RefSeq Acc Id: ENSCAFP00000049153   ⟸   ENSCAFT00000077684
RefSeq Acc Id: ENSCAFP00000009334   ⟸   ENSCAFT00000010062
RefSeq Acc Id: ENSCAFP00000046667   ⟸   ENSCAFT00000067436
RefSeq Acc Id: XP_038352210   ⟸   XM_038496282
RefSeq Acc Id: XP_038478506   ⟸   XM_038622578
RefSeq Acc Id: XP_038544182   ⟸   XM_038688254
- UniProtKB: A0A8C0LGU3 (UniProtKB/TrEMBL),   A0A8C0NJ48 (UniProtKB/TrEMBL),   F1PWZ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414595   ⟸   XM_038558667
- UniProtKB: A0A8C0LGU3 (UniProtKB/TrEMBL),   A0A8C0NJ48 (UniProtKB/TrEMBL),   F1PWZ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845031376   ⟸   ENSCAFT00845040068
RefSeq Acc Id: ENSCAFP00845031295   ⟸   ENSCAFT00845039965
RefSeq Acc Id: ENSCAFP00845031346   ⟸   ENSCAFT00845040030

Promoters
RGD ID:13685957
Promoter ID:EPDNEW_C4025
Type:initiation region
Name:NDUFA12_1
Description:NADH:ubiquinone oxidoreductase subunit A12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11534,996,400 - 34,996,460EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006232 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014393 UniProtKB/TrEMBL
  ENSCAFG00040004650 UniProtKB/TrEMBL
  ENSCAFG00845022634 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010062.5 UniProtKB/TrEMBL
  ENSCAFT00030026590.1 UniProtKB/TrEMBL
  ENSCAFT00030026610.1 UniProtKB/TrEMBL
  ENSCAFT00030026670.1 UniProtKB/TrEMBL
  ENSCAFT00040008774.1 UniProtKB/TrEMBL
  ENSCAFT00040008802.1 UniProtKB/TrEMBL
  ENSCAFT00040008820.1 UniProtKB/TrEMBL
  ENSCAFT00845039965 ENTREZGENE
  ENSCAFT00845039965.1 UniProtKB/TrEMBL
  ENSCAFT00845040030.1 UniProtKB/TrEMBL
  ENSCAFT00845040068.1 UniProtKB/TrEMBL
InterPro NDUFA12 UniProtKB/TrEMBL
KEGG Report cfa:475428 UniProtKB/TrEMBL
NCBI Gene NDUFA12 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12 UniProtKB/TrEMBL
  PTHR12910 UniProtKB/TrEMBL
Pfam NDUFA12 UniProtKB/TrEMBL
UniProt A0A8C0LGU3 ENTREZGENE
  A0A8C0NGG1_CANLF UniProtKB/TrEMBL
  A0A8C0NJ48 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q7U7_CANLF UniProtKB/TrEMBL
  A0A8I3PKR0_CANLF UniProtKB/TrEMBL
  A0A8I3S387_CANLF UniProtKB/TrEMBL
  F1PWZ9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43685 ENTREZGENE