MIR1-2 (microRNA mir-1-2) - Rat Genome Database

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Gene: MIR1-2 (microRNA mir-1-2) Canis lupus familiaris
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Symbol: MIR1-2
Name: microRNA mir-1-2 (Ensembl:microRNA 1-2)
RGD ID: 12394374
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-1-2; microRNA 1-2
RGD Orthologs
Human
Mouse
Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,214,380 - 66,214,438 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,214,366 - 66,214,450 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha765,668,956 - 65,669,014 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0766,279,106 - 66,279,164 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1765,945,036 - 65,945,094 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0765,967,964 - 65,968,022 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,268,331 - 66,268,389 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac conduction system development  (ISO)
cell migration involved in coronary vasculogenesis  (ISO)
heart morphogenesis  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of membrane repolarization during cardiac muscle cell action potential  (ISO)
negative regulation of myoblast proliferation  (ISO)
negative regulation of thyroid gland epithelial cell proliferation  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane  (ISO)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO)
positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of mesoderm formation  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
post-transcriptional regulation of gene expression  (ISO)
regulation of calcineurin-NFAT signaling cascade  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
regulation of translation  (ISO)
reversible differentiation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:18392026   PMID:22163007  


Genomics

Comparative Map Data
MIR1-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,214,380 - 66,214,438 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,214,366 - 66,214,450 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha765,668,956 - 65,669,014 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0766,279,106 - 66,279,164 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1765,945,036 - 65,945,094 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0765,967,964 - 65,968,022 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,268,331 - 66,268,389 (+)NCBIUU_Cfam_GSD_1.0
MIR1-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381821,829,004 - 21,829,088 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1821,829,004 - 21,829,088 (-)EnsemblGRCh38hg38GRCh38
GRCh371819,408,965 - 19,409,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361817,662,962 - 17,663,046 (-)NCBINCBI36Build 36hg18NCBI36
Celera1816,215,028 - 16,215,112 (-)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1816,256,352 - 16,256,436 (-)NCBIHuRef
CHM1_11819,336,070 - 19,336,154 (-)NCBICHM1_1
T2T-CHM13v2.01822,014,052 - 22,014,136 (-)NCBIT2T-CHM13v2.0
Mir1a-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,785,481 - 10,785,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,785,481 - 10,785,552 (-)EnsemblGRCm39 Ensembl
GRCm381810,785,481 - 10,785,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,785,481 - 10,785,552 (-)EnsemblGRCm38mm10GRCm38
MGSCv371810,785,479 - 10,785,550 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1810,815,465 - 10,815,536 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map185.4NCBI
Mir1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8182,160,327 - 2,160,413 (-)NCBIGRCr8
mRatBN7.2181,887,537 - 1,887,623 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx182,117,172 - 2,117,258 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,904,873 - 2,904,959 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0182,119,054 - 2,119,140 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,054,933 - 2,055,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0182,087,912 - 2,087,998 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera181,767,328 - 1,767,414 (-)NCBICelera
Cytogenetic Map18p13NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

musculoskeletal system
High
Medium
Low 1
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000032631
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl766,214,366 - 66,214,450 (+)Ensembl
RefSeq Acc Id: NR_049344
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1766,214,380 - 66,214,438 (+)NCBI
Dog10K_Boxer_Tasha765,668,956 - 65,669,014 (+)NCBI
ROS_Cfam_1.0766,279,106 - 66,279,164 (+)NCBI
UMICH_Zoey_3.1765,945,036 - 65,945,094 (+)NCBI
UNSW_CanFamBas_1.0765,967,964 - 65,968,022 (+)NCBI
UU_Cfam_GSD_1.0766,268,331 - 66,268,389 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020524 Ensembl
  ENSCAFG00845015840 ENTREZGENE
Ensembl Transcript ENSCAFT00845028192 ENTREZGENE
miRBase MI0008118 ENTREZGENE
NCBI Gene MIR1-2 ENTREZGENE
RNAcentral URS0000348947 RNACentral
  URS00007E4335 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR1-2  microRNA mir-1-2    microRNA 1-2  Symbol and/or name change 5135510 APPROVED