S100A12 (S100 calcium binding protein A12) - Rat Genome Database

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Gene: S100A12 (S100 calcium binding protein A12) Canis lupus familiaris
Analyze
Symbol: S100A12 (Ensembl: S100A8)
Name: S100 calcium binding protein A12
RGD ID: 12393773
Description: ENCODES a protein that exhibits zinc ion binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (inferred); defense response to fungus (inferred); killing of cells of another organism (inferred); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); immunodeficiency 42 (ortholog); FOUND IN collagen-containing extracellular matrix (inferred); cytoplasm (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein S100-A12
RGD Orthologs
Human
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,554,078 - 43,555,470 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,554,146 - 43,555,475 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha743,046,910 - 43,048,352 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,503,704 - 43,505,146 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,503,822 - 43,505,151 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,206,024 - 43,207,465 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,259,932 - 43,261,373 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,543,469 - 43,544,911 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:24518653   PMID:26370713   PMID:30032202  


Genomics

Comparative Map Data
S100A12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,554,078 - 43,555,470 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,554,146 - 43,555,475 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha743,046,910 - 43,048,352 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,503,704 - 43,505,146 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,503,822 - 43,505,151 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,206,024 - 43,207,465 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,259,932 - 43,261,373 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,543,469 - 43,544,911 (+)NCBIUU_Cfam_GSD_1.0
S100A12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381153,373,711 - 153,375,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1153,373,711 - 153,375,621 (-)EnsemblGRCh38hg38GRCh38
GRCh371153,346,187 - 153,348,097 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,612,808 - 151,614,699 (-)NCBINCBI36Build 36hg18NCBI36
Build 341150,159,256 - 150,161,148NCBI
Celera1126,417,439 - 126,419,330 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1124,709,595 - 124,711,486 (-)NCBIHuRef
CHM1_11154,741,897 - 154,743,788 (-)NCBICHM1_1
T2T-CHM13v2.01152,510,935 - 152,512,845 (-)NCBIT2T-CHM13v2.0
S100A12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2196,462,114 - 96,464,031 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,197,768 - 96,199,685 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01128,725,102 - 128,727,021 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,354,132 - 132,356,085 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,354,132 - 132,356,085 (-)Ensemblpanpan1.1panPan2
S100A12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl496,225,691 - 96,227,127 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1496,225,691 - 96,227,030 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24105,075,389 - 105,076,728 (-)NCBISscrofa10.2Sscrofa10.2susScr3
S100A12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12010,377,418 - 10,379,638 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660389,847,458 - 9,848,394 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in S100A12
17 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1
Medium 9 6 6 6 5 2 6 5
Low 5 5 13 6 8 1 4 1
Below cutoff 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000046588   ⟹   ENSCAFP00000042882
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl743,554,146 - 43,555,475 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003941   ⟹   ENSCAFP00845003142
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl743,503,822 - 43,505,151 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003947   ⟹   ENSCAFP00845003148
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl743,504,350 - 43,505,151 (+)Ensembl
RefSeq Acc Id: XM_003434905   ⟹   XP_003434953
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1743,554,078 - 43,555,470 (+)NCBI
Dog10K_Boxer_Tasha743,046,910 - 43,048,352 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038482632   ⟹   XP_038338560
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1743,206,024 - 43,207,465 (+)NCBI
RefSeq Acc Id: XM_038541784   ⟹   XP_038397712
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0743,543,469 - 43,544,911 (+)NCBI
RefSeq Acc Id: XM_038605910   ⟹   XP_038461838
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0743,259,932 - 43,261,373 (+)NCBI
RefSeq Acc Id: XM_038670619   ⟹   XP_038526547
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0743,503,704 - 43,505,146 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003434953   ⟸   XM_003434905
- UniProtKB: A0A8C0RX73 (UniProtKB/TrEMBL),   A0A8C0KBF8 (UniProtKB/TrEMBL),   A0A8I3MKN5 (UniProtKB/TrEMBL),   A0A8I3N1I2 (UniProtKB/TrEMBL),   A0A8P0PSB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000042882   ⟸   ENSCAFT00000046588
RefSeq Acc Id: XP_038338560   ⟸   XM_038482632
RefSeq Acc Id: XP_038461838   ⟸   XM_038605910
RefSeq Acc Id: XP_038526547   ⟸   XM_038670619
- UniProtKB: A0A8C0RX73 (UniProtKB/TrEMBL),   A0A8C0KBF8 (UniProtKB/TrEMBL),   A0A8I3MKN5 (UniProtKB/TrEMBL),   A0A8I3N1I2 (UniProtKB/TrEMBL),   A0A8P0PSB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038397712   ⟸   XM_038541784
- UniProtKB: A0A8C0KBF8 (UniProtKB/TrEMBL),   A0A8C0RX73 (UniProtKB/TrEMBL),   A0A8I3MKN5 (UniProtKB/TrEMBL),   A0A8I3N1I2 (UniProtKB/TrEMBL),   A0A8P0PSB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003142   ⟸   ENSCAFT00845003941
RefSeq Acc Id: ENSCAFP00845003148   ⟸   ENSCAFT00845003947
Protein Domains
EF-hand

Promoters
RGD ID:13684048
Promoter ID:EPDNEW_C2117
Type:single initiation site
Name:S100A12_1
Description:S100 calcium binding protein A12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1743,554,138 - 43,554,198EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023324 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019886 UniProtKB/TrEMBL
  ENSCAFG00040003523 UniProtKB/TrEMBL
  ENSCAFG00845002254 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046588.3 UniProtKB/TrEMBL
  ENSCAFT00000096513.1 UniProtKB/TrEMBL
  ENSCAFT00030036546.1 UniProtKB/TrEMBL
  ENSCAFT00030036579.1 UniProtKB/TrEMBL
  ENSCAFT00040006691.1 UniProtKB/TrEMBL
  ENSCAFT00040006707.1 UniProtKB/TrEMBL
  ENSCAFT00040006728.1 UniProtKB/TrEMBL
  ENSCAFT00845003941 ENTREZGENE
  ENSCAFT00845003941.1 UniProtKB/TrEMBL
  ENSCAFT00845003947.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  S-100_dom UniProtKB/TrEMBL
  S100/CaBP7/8-like_CS UniProtKB/TrEMBL
  S100_Ca-bd_sub UniProtKB/TrEMBL
KEGG Report cfa:100683919 UniProtKB/TrEMBL
NCBI Gene S100A12 ENTREZGENE
PANTHER PROTEIN S100-A12 UniProtKB/TrEMBL
  PROTEIN S100-A8 UniProtKB/TrEMBL
  S100 CALCIUM-BINDING PROTEIN UniProtKB/TrEMBL
Pfam EF-hand_1 UniProtKB/TrEMBL
  EF-hand_5 UniProtKB/TrEMBL
  S_100 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  S100_CABP UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
  S_100 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8C0KBF8 ENTREZGENE
  A0A8C0PY77_CANLF UniProtKB/TrEMBL
  A0A8C0QDV9_CANLF UniProtKB/TrEMBL
  A0A8C0RX73 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MKN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N1I2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PSB8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45824 ENTREZGENE