TTK (TTK protein kinase) - Rat Genome Database

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Gene: TTK (TTK protein kinase) Canis lupus familiaris
Analyze
Symbol: TTK
Name: TTK protein kinase
RGD ID: 12392841
Description: ENCODES a protein that exhibits identical protein binding (ortholog); kinetochore binding (ortholog); INVOLVED IN female meiosis chromosome segregation (ortholog); meiotic spindle assembly checkpoint signaling (ortholog); peptidyl-serine phosphorylation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); hepatocellular carcinoma (ortholog); Pancreatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); kinetochore (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dual specificity protein kinase TTK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11240,915,733 - 40,959,423 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1240,915,439 - 40,957,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1240,787,409 - 40,829,802 (+)NCBI
ROS_Cfam_1.01241,678,975 - 41,721,444 (+)NCBI
UMICH_Zoey_3.11240,992,362 - 41,034,814 (+)NCBI
UNSW_CanFamBas_1.01240,969,244 - 41,011,626 (+)NCBI
UU_Cfam_GSD_1.01241,120,015 - 41,162,453 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Genomics

Comparative Map Data
TTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11240,915,733 - 40,959,423 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1240,915,439 - 40,957,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1240,787,409 - 40,829,802 (+)NCBI
ROS_Cfam_1.01241,678,975 - 41,721,444 (+)NCBI
UMICH_Zoey_3.11240,992,362 - 41,034,814 (+)NCBI
UNSW_CanFamBas_1.01240,969,244 - 41,011,626 (+)NCBI
UU_Cfam_GSD_1.01241,120,015 - 41,162,453 (+)NCBI
TTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl680,003,887 - 80,042,527 (+)EnsemblGRCh38hg38GRCh38
GRCh38680,004,147 - 80,042,651 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37680,714,366 - 80,752,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36680,771,078 - 80,808,958 (+)NCBINCBI36hg18NCBI36
Build 34680,771,077 - 80,808,956NCBI
Celera681,132,293 - 81,170,226 (+)NCBI
Cytogenetic Map6q14.1NCBI
HuRef677,937,044 - 77,974,979 (+)NCBIHuRef
CHM1_1680,811,776 - 80,849,705 (+)NCBICHM1_1
Ttk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39983,716,704 - 83,754,443 (+)NCBIGRCm39mm39
GRCm39 Ensembl983,716,742 - 83,754,442 (+)Ensembl
GRCm38983,834,651 - 83,872,390 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl983,834,689 - 83,872,389 (+)EnsemblGRCm38mm10GRCm38
MGSCv37983,728,296 - 83,765,997 (+)NCBIGRCm37mm9NCBIm37
MGSCv36983,631,459 - 83,669,102 (+)NCBImm8
Celera980,934,680 - 80,972,688 (+)NCBICelera
Cytogenetic Map9E2NCBI
Ttk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2884,754,329 - 84,792,653 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl884,754,315 - 84,792,651 (+)Ensembl
Rnor_6.0891,368,065 - 91,405,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl891,368,111 - 91,405,993 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0890,886,724 - 90,924,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4888,906,665 - 88,944,613 (+)NCBIRGSC3.4rn4RGSC3.4
Celera884,402,963 - 84,441,218 (+)NCBICelera
Cytogenetic Map8q31NCBI
Ttk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555027,824,194 - 7,866,879 (+)NCBIChiLan1.0ChiLan1.0
TTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1681,158,143 - 81,196,478 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl681,158,143 - 81,196,478 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0677,887,382 - 77,925,737 (+)NCBIMhudiblu_PPA_v0panPan3
Ttk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494676,256,203 - 76,303,738 (+)NCBI
SpeTri2.0NW_00493651010,176,968 - 10,213,483 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,076,583 - 86,125,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,076,576 - 86,125,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2196,781,685 - 96,828,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1134,738,849 - 4,779,563 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl134,738,959 - 4,780,627 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040180,959,238 - 181,026,938 (+)NCBIVero_WHO_p1.0
Ttk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248196,631,697 - 6,682,181 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 5 6 6 6 9 4 1
Below cutoff 5 16 6 6 6 3 6 5

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005627564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022426284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038492306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038492307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038492308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038492309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038492310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038554599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038554600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038554601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038554602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038554603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038618456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038618457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038618458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038618459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038618460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_539016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000004549   ⟹   ENSCAFP00000004205
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1240,915,439 - 40,957,060 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000042939   ⟹   ENSCAFP00000037133
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1240,915,439 - 40,957,279 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000072163   ⟹   ENSCAFP00000052131
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1240,917,026 - 40,919,756 (+)Ensembl
RefSeq Acc Id: XM_005627564   ⟹   XP_005627621
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11240,915,733 - 40,957,364 (+)NCBI
Dog10K_Boxer_Tasha1240,787,411 - 40,829,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022426281   ⟹   XP_022281989
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11240,915,733 - 40,957,364 (+)NCBI
Dog10K_Boxer_Tasha1240,787,410 - 40,829,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022426282   ⟹   XP_022281990
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11240,915,964 - 40,957,364 (+)NCBI
Dog10K_Boxer_Tasha1240,787,743 - 40,829,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022426283   ⟹   XP_022281991
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11240,915,733 - 40,957,364 (+)NCBI
Dog10K_Boxer_Tasha1240,787,409 - 40,829,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038492306   ⟹   XP_038348234
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11240,992,363 - 41,034,814 (+)NCBI
RefSeq Acc Id: XM_038492307   ⟹   XP_038348235
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11240,992,696 - 41,034,814 (+)NCBI
RefSeq Acc Id: XM_038492308   ⟹   XP_038348236
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11240,992,362 - 41,034,814 (+)NCBI
RefSeq Acc Id: XM_038492309   ⟹   XP_038348237
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11240,992,364 - 41,034,814 (+)NCBI
RefSeq Acc Id: XM_038492310   ⟹   XP_038348238
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11240,992,364 - 41,034,814 (+)NCBI
RefSeq Acc Id: XM_038554599   ⟹   XP_038410527
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01241,120,016 - 41,162,453 (+)NCBI
RefSeq Acc Id: XM_038554600   ⟹   XP_038410528
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01241,120,351 - 41,162,453 (+)NCBI
RefSeq Acc Id: XM_038554601   ⟹   XP_038410529
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01241,120,015 - 41,162,453 (+)NCBI
RefSeq Acc Id: XM_038554602   ⟹   XP_038410530
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01241,120,017 - 41,161,683 (+)NCBI
RefSeq Acc Id: XM_038554603   ⟹   XP_038410531
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01241,120,017 - 41,162,453 (+)NCBI
RefSeq Acc Id: XM_038618456   ⟹   XP_038474384
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01240,969,245 - 41,011,626 (+)NCBI
RefSeq Acc Id: XM_038618457   ⟹   XP_038474385
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01240,969,577 - 41,011,626 (+)NCBI
RefSeq Acc Id: XM_038618458   ⟹   XP_038474386
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01240,969,244 - 41,011,626 (+)NCBI
RefSeq Acc Id: XM_038618459   ⟹   XP_038474387
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01240,969,246 - 41,011,626 (+)NCBI
RefSeq Acc Id: XM_038618460   ⟹   XP_038474388
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01240,969,246 - 41,011,626 (+)NCBI
RefSeq Acc Id: XM_038684020   ⟹   XP_038539948
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01241,678,976 - 41,721,444 (+)NCBI
RefSeq Acc Id: XM_038684021   ⟹   XP_038539949
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01241,679,308 - 41,721,444 (+)NCBI
RefSeq Acc Id: XM_038684022   ⟹   XP_038539950
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01241,678,975 - 41,721,444 (+)NCBI
RefSeq Acc Id: XM_038684023   ⟹   XP_038539951
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01241,678,977 - 41,721,444 (+)NCBI
RefSeq Acc Id: XM_038684024   ⟹   XP_038539952
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01241,678,977 - 41,721,444 (+)NCBI
RefSeq Acc Id: XM_539016   ⟹   XP_539016
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11240,915,733 - 40,957,364 (+)NCBI
Dog10K_Boxer_Tasha1240,787,411 - 40,829,017 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_539016   ⟸   XM_539016
- Peptide Label: isoform X3
- UniProtKB: J9NVE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005627621   ⟸   XM_005627564
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_022281989   ⟸   XM_022426281
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022281991   ⟸   XM_022426283
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_022281990   ⟸   XM_022426282
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000004205   ⟸   ENSCAFT00000004549
RefSeq Acc Id: ENSCAFP00000037133   ⟸   ENSCAFT00000042939
RefSeq Acc Id: ENSCAFP00000052131   ⟸   ENSCAFT00000072163
RefSeq Acc Id: XP_038348236   ⟸   XM_038492308
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038348234   ⟸   XM_038492306
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038348237   ⟸   XM_038492309
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038348238   ⟸   XM_038492310
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038348235   ⟸   XM_038492307
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038474386   ⟸   XM_038618458
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038474384   ⟸   XM_038618456
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038474387   ⟸   XM_038618459
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038474388   ⟸   XM_038618460
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038474385   ⟸   XM_038618457
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038539950   ⟸   XM_038684022
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038539948   ⟸   XM_038684020
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038539951   ⟸   XM_038684023
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038539952   ⟸   XM_038684024
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038539949   ⟸   XM_038684021
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038410529   ⟸   XM_038554601
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038410527   ⟸   XM_038554599
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038410531   ⟸   XM_038554603
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038410530   ⟸   XM_038554602
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038410528   ⟸   XM_038554600
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002842 Ensembl
NCBI Gene TTK ENTREZGENE
UniProt J9NVE1 ENTREZGENE
VGNC ID VGNC:47971 ENTREZGENE