MIR374A (microRNA mir-374a) - Rat Genome Database

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Gene: MIR374A (microRNA mir-374a) Canis lupus familiaris
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Symbol: MIR374A (Ensembl: cfa-mir-374a)
Name: microRNA mir-374a (Ensembl:cfa-mir-374a)
RGD ID: 12391252
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-374a; microRNA 374a
RGD Orthologs
Human
Pig
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X57,590,394 - 57,590,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX57,590,394 - 57,590,445 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX48,770,976 - 48,771,027 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X58,804,747 - 58,804,798 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X56,550,922 - 56,550,973 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X58,129,055 - 58,129,106 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X57,736,344 - 57,736,395 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:18392026  


Genomics

Comparative Map Data
MIR374A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X57,590,394 - 57,590,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX57,590,394 - 57,590,445 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX48,770,976 - 48,771,027 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X58,804,747 - 58,804,798 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X56,550,922 - 56,550,973 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X58,129,055 - 58,129,106 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X57,736,344 - 57,736,395 (-)NCBIUU_Cfam_GSD_1.0
MIR374A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X74,287,286 - 74,287,357 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX74,287,286 - 74,287,357 (-)EnsemblGRCh38hg38GRCh38
GRCh37X73,507,121 - 73,507,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X73,423,845 - 73,423,916 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX73,790,587 - 73,790,658 (-)NCBICelera
Cytogenetic MapXq13.2NCBI
HuRefX67,142,715 - 67,142,786 (-)NCBIHuRef
CHM1_1X73,400,117 - 73,400,188 (-)NCBICHM1_1
T2T-CHM13v2.0X72,720,792 - 72,720,863 (-)NCBIT2T-CHM13v2.0
MIR374A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX59,602,875 - 59,602,954 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X59,602,875 - 59,602,954 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X67,530,361 - 67,530,440 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system nervous system respiratory system
High
Medium
Low 1
Below cutoff 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000039921
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX57,590,394 - 57,590,445 (-)Ensembl
RefSeq Acc Id: NR_049405
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X57,590,394 - 57,590,445 (-)NCBI
Dog10K_Boxer_TashaX48,770,976 - 48,771,027 (-)NCBI
ROS_Cfam_1.0X58,804,747 - 58,804,798 (-)NCBI
UMICH_Zoey_3.1X56,550,922 - 56,550,973 (-)NCBI
UNSW_CanFamBas_1.0X58,129,055 - 58,129,106 (-)NCBI
UU_Cfam_GSD_1.0X57,736,344 - 57,736,395 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000025638 Ensembl
  ENSCAFG00845029949 ENTREZGENE
Ensembl Transcript ENSCAFT00845053043 ENTREZGENE
miRBase MI0008179 ENTREZGENE
NCBI Gene MIR374A ENTREZGENE
RNAcentral URS00002D08A9 RNACentral
  URS00007E35F5 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR374A  microRNA mir-374a    microRNA 374a  Symbol and/or name change 5135510 APPROVED