GHRL (ghrelin and obestatin prepropeptide) - Rat Genome Database

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Gene: GHRL (ghrelin and obestatin prepropeptide) Canis lupus familiaris
Analyze
Symbol: GHRL
Name: ghrelin and obestatin prepropeptide
RGD ID: 12390112
Description: ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); ghrelin receptor binding (ortholog); growth hormone-releasing hormone activity (ortholog); INVOLVED IN actin polymerization or depolymerization (ortholog); adult feeding behavior (ortholog); decidualization (ortholog); PARTICIPATES IN ghrelin system pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); Atrioventricular Septal Defect 2 (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: appetite-regulating hormone; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin preprohormone; growth hormone secretagogue; growth hormone-releasing peptide; motilin related peptide; MTLRP; MTLRP-AP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,092,921 - 8,097,512 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,092,957 - 8,097,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,127,316 - 8,131,869 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,122,116 - 8,127,217 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,122,662 - 8,127,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1207,844,540 - 7,849,093 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,190,266 - 8,194,819 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,163,907 - 8,168,460 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin polymerization or depolymerization  (ISS)
adult feeding behavior  (ISO)
decidualization  (ISS)
dendrite development  (ISO,ISS)
excitatory postsynaptic potential  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
gastric acid secretion  (IBA)
negative regulation of apoptotic process  (ISS)
negative regulation of circadian sleep/wake cycle, REM sleep  (ISO)
negative regulation of endothelial cell proliferation  (ISS)
negative regulation of inflammatory response  (IBA,ISS)
negative regulation of insulin secretion  (ISO,ISS)
negative regulation of interleukin-1 beta production  (ISO,ISS)
negative regulation of interleukin-6 production  (ISS)
negative regulation of locomotion  (ISO)
negative regulation of tumor necrosis factor production  (ISO,ISS)
positive regulation of adipose tissue development  (ISO)
positive regulation of appetite  (ISO)
positive regulation of bone development  (ISO)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of corticotropin secretion  (ISO)
positive regulation of cortisol secretion  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISS)
positive regulation of eating behavior  (ISO)
positive regulation of feeding behavior  (ISO)
positive regulation of gastric mucosal blood circulation  (ISO)
positive regulation of gastro-intestinal system smooth muscle contraction  (ISO)
positive regulation of growth  (ISO)
positive regulation of growth hormone secretion  (IBA)
positive regulation of growth rate  (ISO)
positive regulation of insulin secretion  (ISS)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of MAPK cascade  (ISS)
positive regulation of response to food  (ISO,ISS)
positive regulation of small intestinal transit  (ISO)
positive regulation of small intestine smooth muscle contraction  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of synapse assembly  (ISO,ISS)
positive regulation of vascular endothelial cell proliferation  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
regulation of cell population proliferation  (ISS)
regulation of gastric motility  (ISO)
regulation of postsynapse organization  (ISO)
regulation of response to food  (IBA,ISO,ISS)
regulation of transmission of nerve impulse  (ISO)
response to electrical stimulus  (ISO)
response to estrogen  (ISS)
response to hormone  (ISS)
response to nutrient levels  (ISO)
signal transduction  (IEA)
synapse assembly  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:11786190   PMID:21126551   PMID:22301074   PMID:22999388   PMID:24855152   PMID:30032202  


Genomics

Comparative Map Data
GHRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,092,921 - 8,097,512 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,092,957 - 8,097,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,127,316 - 8,131,869 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,122,116 - 8,127,217 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,122,662 - 8,127,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1207,844,540 - 7,849,093 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,190,266 - 8,194,819 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,163,907 - 8,168,460 (+)NCBIUU_Cfam_GSD_1.0
GHRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38310,285,666 - 10,292,947 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl310,285,666 - 10,292,947 (-)EnsemblGRCh38hg38GRCh38
GRCh37310,327,350 - 10,334,631 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,302,434 - 10,307,409 (-)NCBINCBI36Build 36hg18NCBI36
Build 34310,302,433 - 10,307,409NCBI
Celera310,263,242 - 10,270,439 (-)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef310,262,844 - 10,269,999 (-)NCBIHuRef
CHM1_1310,277,571 - 10,284,767 (-)NCBICHM1_1
T2T-CHM13v2.0310,278,965 - 10,286,246 (-)NCBIT2T-CHM13v2.0
Ghrl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,693,080 - 113,696,872 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6113,693,080 - 113,696,841 (-)EnsemblGRCm39 Ensembl
GRCm386113,716,119 - 113,719,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,716,119 - 113,719,880 (-)EnsemblGRCm38mm10GRCm38
MGSCv376113,666,113 - 113,669,874 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366113,681,896 - 113,685,657 (-)NCBIMGSCv36mm8
Celera6115,541,628 - 115,545,391 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.84NCBI
Ghrl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84148,421,315 - 148,431,128 (-)NCBIGRCr8
mRatBN7.24146,865,712 - 146,869,621 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,865,712 - 146,869,621 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4152,250,366 - 152,254,274 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04148,031,237 - 148,035,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,659,480 - 146,663,373 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,674,157 - 145,678,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,674,157 - 145,678,066 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,969,963 - 208,976,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,622,566 - 149,628,111 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,867,406 - 149,872,952 (-)NCBI
Celera4135,420,041 - 135,423,946 (-)NCBICelera
Cytogenetic Map4q42NCBI
Ghrl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,676,576 - 1,681,812 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,676,475 - 1,682,205 (-)NCBIChiLan1.0ChiLan1.0
GHRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2210,281,654 - 10,288,926 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1310,286,078 - 10,301,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0310,221,829 - 10,229,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1310,573,537 - 10,580,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl310,573,537 - 10,580,723 (-)Ensemblpanpan1.1panPan2
Ghrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,867,085 - 15,872,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366023,038,549 - 3,042,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366023,037,862 - 3,044,863 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,445,992 - 66,452,917 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11366,442,106 - 66,453,576 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,453,082 - 73,480,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q31NCBI
GHRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12246,326,458 - 46,332,906 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2246,325,913 - 46,330,962 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041120,205,064 - 120,210,786 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ghrl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247315,257,830 - 5,262,473 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247315,257,813 - 5,262,878 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GHRL
38 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 3 5 11 12 11 3 4 3 3 19 13 5 10 8

Sequence


Ensembl Acc Id: ENSCAFT00000008248   ⟹   ENSCAFP00000007641
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl208,092,957 - 8,097,510 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845013921   ⟹   ENSCAFP00845010788
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl208,122,662 - 8,127,215 (+)Ensembl
RefSeq Acc Id: NM_001003052   ⟹   NP_001003052
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1208,092,957 - 8,097,510 (+)NCBI
Dog10K_Boxer_Tasha208,127,316 - 8,131,869 (+)NCBI
ROS_Cfam_1.0208,122,662 - 8,127,215 (+)NCBI
UMICH_Zoey_3.1207,844,540 - 7,849,093 (+)NCBI
UNSW_CanFamBas_1.0208,190,266 - 8,194,819 (+)NCBI
UU_Cfam_GSD_1.0208,163,907 - 8,168,460 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038426353   ⟹   XP_038282281
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0208,122,185 - 8,127,217 (+)NCBI
RefSeq Acc Id: XM_038426354   ⟹   XP_038282282
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0208,122,116 - 8,127,217 (+)NCBI
RefSeq Acc Id: NP_001003052   ⟸   NM_001003052
- Peptide Label: preproprotein
- UniProtKB: Q9BEF7 (UniProtKB/Swiss-Prot),   Q9BEF8 (UniProtKB/Swiss-Prot),   A0A8C0QXL3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000007641   ⟸   ENSCAFT00000008248
RefSeq Acc Id: XP_038282282   ⟸   XM_038426354
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038282281   ⟸   XM_038426353
- Peptide Label: isoform X1
- UniProtKB: Q9BEF8 (UniProtKB/Swiss-Prot),   Q9BEF7 (UniProtKB/Swiss-Prot),   A0A8C0QXL3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845010788   ⟸   ENSCAFT00845013921

Promoters
RGD ID:13686781
Promoter ID:EPDNEW_C4849
Type:multiple initiation site
Name:GHRL_1
Description:ghrelin and obestatin prepropeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1208,092,947 - 8,093,007EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005129 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030005337 UniProtKB/Swiss-Prot
  ENSCAFG00040023482 UniProtKB/Swiss-Prot
  ENSCAFG00805005670 UniProtKB/Swiss-Prot
  ENSCAFG00845007901 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000008248.5 UniProtKB/Swiss-Prot
  ENSCAFT00030009815.1 UniProtKB/Swiss-Prot
  ENSCAFT00040043692.1 UniProtKB/Swiss-Prot
  ENSCAFT00805010377 UniProtKB/Swiss-Prot
  ENSCAFT00845013921 ENTREZGENE
  ENSCAFT00845013921.1 UniProtKB/Swiss-Prot
InterPro Motilin_assoc UniProtKB/Swiss-Prot
  Motilin_ghrelin UniProtKB/Swiss-Prot
  Preproghrelin UniProtKB/Swiss-Prot
KEGG Report cfa:403587 UniProtKB/Swiss-Prot
NCBI Gene GHRL ENTREZGENE
PANTHER APPETITE-REGULATING HORMONE UniProtKB/Swiss-Prot
  PTHR14122 UniProtKB/Swiss-Prot
Pfam Motilin_assoc UniProtKB/Swiss-Prot
  Motilin_ghrelin UniProtKB/Swiss-Prot
PRINTS GHRELIN UniProtKB/Swiss-Prot
UniProt A0A8C0QXL3 ENTREZGENE
  GHRL_CANLF UniProtKB/Swiss-Prot
  Q9BEF7 ENTREZGENE
  Q9BEF8 ENTREZGENE
UniProt Secondary Q9BEF7 UniProtKB/Swiss-Prot
VGNC ID VGNC:41209 ENTREZGENE