ALKBH5 (alkB homolog 5, RNA demethylase) - Rat Genome Database

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Gene: ALKBH5 (alkB homolog 5, RNA demethylase) Canis lupus familiaris
Analyze
Symbol: ALKBH5
Name: alkB homolog 5, RNA demethylase
RGD ID: 12389879
Description: ENCODES a protein that exhibits lysophospholipase activity (ortholog); INVOLVED IN gamma-delta T cell proliferation (ortholog); regulation of mRNA export from nucleus (ortholog); regulation of mRNA processing (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Birt-Hogg-Dube syndrome (ortholog); common variable immunodeficiency 2 (ortholog); FOUND IN paraspeckles (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alkB, alkylation repair homolog 5; RNA demethylase ALKBH5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,339,292 - 41,365,641 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,343,241 - 41,364,547 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,478,767 - 41,504,424 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,445,991 - 41,471,674 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,446,003 - 41,472,037 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1541,413,849 - 41,439,509 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,361,292 - 41,386,942 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,553,123 - 41,578,789 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
Golgi apparatus  (IEA)
nuclear speck  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)
paraspeckles  (IEA,ISO)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ALKBH5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,339,292 - 41,365,641 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,343,241 - 41,364,547 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,478,767 - 41,504,424 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,445,991 - 41,471,674 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,446,003 - 41,472,037 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1541,413,849 - 41,439,509 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,361,292 - 41,386,942 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,553,123 - 41,578,789 (-)NCBIUU_Cfam_GSD_1.0
ALKBH5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,183,828 - 18,209,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,183,078 - 18,209,954 (+)EnsemblGRCh38hg38GRCh38
GRCh371718,087,142 - 18,113,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,027,592 - 18,053,993 (+)NCBINCBI36Build 36hg18NCBI36
Celera1719,028,003 - 19,054,331 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,840,215 - 17,866,584 (+)NCBIHuRef
CHM1_11718,095,612 - 18,122,007 (+)NCBICHM1_1
T2T-CHM13v2.01718,130,641 - 18,156,760 (+)NCBIT2T-CHM13v2.0
Alkbh5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,428,509 - 60,449,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,427,207 - 60,449,338 (+)EnsemblGRCm39 Ensembl
GRCm381160,537,683 - 60,558,512 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,536,381 - 60,558,512 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,351,185 - 60,372,014 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,354,173 - 60,372,092 (+)NCBIMGSCv36mm8
Celera1165,862,595 - 65,871,990 (-)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.81NCBI
Alkbh5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,844,411 - 45,865,853 (+)NCBIGRCr8
mRatBN7.21045,344,888 - 45,366,331 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,343,395 - 45,366,331 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,045,424 - 50,066,927 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,535,808 - 49,557,314 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,039,416 - 45,060,918 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,906,314 - 46,927,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,906,115 - 46,930,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,679,920 - 46,700,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,811,205 - 46,832,649 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11046,824,567 - 46,845,705 (+)NCBI
Celera1044,601,477 - 44,622,922 (+)NCBICelera
Cytogenetic Map10q22NCBI
Alkbh5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547811,105,920 - 11,128,222 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547811,104,445 - 11,128,980 (-)NCBIChiLan1.0ChiLan1.0
ALKBH5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21953,057,922 - 53,085,590 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11757,769,067 - 57,795,721 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01732,725,632 - 32,753,021 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,003,362 - 38,030,715 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,003,362 - 38,030,715 (-)Ensemblpanpan1.1panPan2
Alkbh5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,112,447 - 61,137,218 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,729,679 - 1,757,419 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,729,707 - 1,756,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALKBH5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,507,667 - 60,529,733 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,507,662 - 60,530,239 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALKBH5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,221,643 - 17,249,038 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,222,378 - 17,249,117 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660593,656,506 - 3,683,620 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alkbh5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,257,459 - 3,280,245 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,257,460 - 3,280,870 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ALKBH5
172 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 5 16 3 6 6 12 8 10 2
Low 2 6 6 3 6 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000029091   ⟹   ENSCAFP00000027050
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl541,343,241 - 41,364,547 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845038196   ⟹   ENSCAFP00845029916
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl541,446,003 - 41,472,037 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845038258   ⟹   ENSCAFP00845029966
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl541,446,003 - 41,471,267 (-)Ensembl
RefSeq Acc Id: XM_038475905   ⟹   XP_038331833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1541,413,849 - 41,439,509 (-)NCBI
RefSeq Acc Id: XM_038537095   ⟹   XP_038393023
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0541,553,123 - 41,578,789 (-)NCBI
RefSeq Acc Id: XM_038601226   ⟹   XP_038457154
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0541,361,292 - 41,386,942 (-)NCBI
RefSeq Acc Id: XM_038665788   ⟹   XP_038521716
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0541,445,991 - 41,471,674 (-)NCBI
RefSeq Acc Id: XM_846626   ⟹   XP_851719
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1541,339,292 - 41,365,641 (-)NCBI
Dog10K_Boxer_Tasha541,478,767 - 41,504,424 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_851719   ⟸   XM_846626
- UniProtKB: A0A8C0L8U1 (UniProtKB/TrEMBL),   A0A8C0RA14 (UniProtKB/TrEMBL),   A0A8P0SMG1 (UniProtKB/TrEMBL),   A0A8I3S550 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000027050   ⟸   ENSCAFT00000029091
RefSeq Acc Id: XP_038331833   ⟸   XM_038475905
RefSeq Acc Id: XP_038457154   ⟸   XM_038601226
RefSeq Acc Id: XP_038521716   ⟸   XM_038665788
- UniProtKB: A0A8I3PNP4 (UniProtKB/TrEMBL),   A0A8I3S550 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038393023   ⟸   XM_038537095
- UniProtKB: A0A8C0L8U1 (UniProtKB/TrEMBL),   A0A8C0RA14 (UniProtKB/TrEMBL),   A0A8I3S550 (UniProtKB/TrEMBL),   A0A8P0SMG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845029916   ⟸   ENSCAFT00845038196
RefSeq Acc Id: ENSCAFP00845029966   ⟸   ENSCAFT00845038258
Protein Domains
Alpha-ketoglutarate-dependent dioxygenase AlkB-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018315 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001234 UniProtKB/TrEMBL
  ENSCAFG00040003021 UniProtKB/TrEMBL
  ENSCAFG00845021653 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029091.6 UniProtKB/TrEMBL
  ENSCAFT00000098188.1 UniProtKB/TrEMBL
  ENSCAFT00030002142.1 UniProtKB/TrEMBL
  ENSCAFT00040005728.1 UniProtKB/TrEMBL
  ENSCAFT00845038196 ENTREZGENE
  ENSCAFT00845038196.1 UniProtKB/TrEMBL
  ENSCAFT00845038258.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.590 UniProtKB/TrEMBL
InterPro AlkB-like UniProtKB/TrEMBL
  AlkB-like_sf UniProtKB/TrEMBL
  ALKBH5 UniProtKB/TrEMBL
KEGG Report cfa:609383 UniProtKB/TrEMBL
NCBI Gene ALKBH5 ENTREZGENE
PANTHER PTHR32074 UniProtKB/TrEMBL
  RNA DEMETHYLASE ALKBH5 UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_2 UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
UniProt A0A8C0L8U1 ENTREZGENE
  A0A8C0RA14 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PNP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S550 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PJY7_CANLF UniProtKB/TrEMBL
  A0A8P0SMG1 ENTREZGENE
UniProt Secondary A0A8P0SMG1 UniProtKB/TrEMBL
VGNC ID VGNC:53262 ENTREZGENE