PTMA (prothymosin alpha) - Rat Genome Database

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Gene: PTMA (prothymosin alpha) Canis lupus familiaris
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Symbol: PTMA
Name: prothymosin alpha
RGD ID: 12388650
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); histone chaperone activity (ortholog); INVOLVED IN chromatin organization (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); ASSOCIATED WITH adenoma (ortholog); genetic disease (ortholog); Joubert syndrome 22 (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: prothymosin, alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC609022  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,563,145 - 43,567,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,562,395 - 43,675,699 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,056,313 - 44,061,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02543,818,611 - 43,823,463 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,817,860 - 43,823,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,746,908 - 43,751,731 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02543,590,250 - 43,595,085 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,745,404 - 43,750,240 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PTMA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,563,145 - 43,567,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,562,395 - 43,675,699 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,056,313 - 44,061,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02543,818,611 - 43,823,463 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,817,860 - 43,823,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,746,908 - 43,751,731 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02543,590,250 - 43,595,085 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,745,404 - 43,750,240 (+)NCBIUU_Cfam_GSD_1.0
PTMA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,708,525 - 231,713,551 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,706,895 - 231,713,551 (+)EnsemblGRCh38hg38GRCh38
GRCh372232,573,235 - 232,578,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,281,479 - 232,286,495 (+)NCBINCBI36Build 36hg18NCBI36
Build 342232,398,740 - 232,403,754NCBI
Celera2226,349,751 - 226,354,767 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2224,415,419 - 224,421,126 (+)NCBIHuRef
CHM1_12232,579,058 - 232,584,074 (+)NCBICHM1_1
T2T-CHM13v2.02232,193,095 - 232,198,121 (+)NCBIT2T-CHM13v2.0
Ptma
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,454,442 - 86,458,434 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,454,448 - 86,458,434 (+)EnsemblGRCm39 Ensembl
GRCm38186,526,557 - 86,530,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,526,726 - 86,530,712 (+)EnsemblGRCm38mm10GRCm38
MGSCv37188,423,311 - 88,427,273 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36188,357,907 - 88,361,869 (+)NCBIMGSCv36mm8
Celera189,496,434 - 89,500,314 (+)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.96NCBI
Ptma
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,624,194 - 94,628,276 (+)NCBIGRCr8
mRatBN7.2987,176,251 - 87,180,333 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,176,230 - 87,180,333 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx995,593,165 - 95,597,249 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09100,722,287 - 100,726,371 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,104,565 - 99,108,647 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0993,545,396 - 93,549,436 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,545,396 - 93,549,436 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,273,333 - 93,277,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,291,203 - 85,295,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1985,474,621 - 85,478,661 (+)NCBI
Celera984,591,345 - 84,595,385 (+)NCBICelera
Cytogenetic Map9q35NCBI
Ptma
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554534,036,503 - 4,037,788 (-)NCBIChiLan1.0ChiLan1.0
PTMA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213134,329,362 - 134,335,272 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B134,344,327 - 134,350,223 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B118,959,382 - 118,964,364 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B237,746,118 - 237,750,806 (+)NCBIpanpan1.1PanPan1.1panPan2
Ptma
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,679,168 - 185,685,998 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365255,253,723 - 5,258,300 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTMA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15132,355,655 - 132,361,435 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115132,353,763 - 132,361,442 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTMA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,721,097 - 117,722,065 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604081,712,038 - 81,716,974 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptma
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248434,728,963 - 4,732,839 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248434,728,963 - 4,732,659 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTMA
70 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 3 5 3 6 10
Medium 2 5 17 6 3 6 6 12 8 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000045403   ⟹   ENSCAFP00000038620
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2543,563,174 - 43,675,699 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000082146   ⟹   ENSCAFP00000049712
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2543,562,395 - 43,675,699 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845042440   ⟹   ENSCAFP00845033272
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2543,817,860 - 43,823,463 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845042662   ⟹   ENSCAFP00845033453
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2543,820,187 - 43,823,463 (+)Ensembl
RefSeq Acc Id: NM_001252198   ⟹   NP_001239127
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12543,563,145 - 43,567,983 (+)NCBI
Dog10K_Boxer_Tasha2544,056,313 - 44,061,150 (+)NCBI
ROS_Cfam_1.02543,818,611 - 43,823,459 (+)NCBI
UMICH_Zoey_3.12543,746,908 - 43,751,731 (+)NCBI
UNSW_CanFamBas_1.02543,590,250 - 43,595,085 (+)NCBI
UU_Cfam_GSD_1.02543,745,404 - 43,750,240 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038434582   ⟹   XP_038290510
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02543,818,611 - 43,823,463 (+)NCBI
RefSeq Acc Id: NP_001239127   ⟸   NM_001252198
- UniProtKB: A0A8C0NMI3 (UniProtKB/TrEMBL),   A0A8I3PVA7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000038620   ⟸   ENSCAFT00000045403
RefSeq Acc Id: ENSCAFP00000049712   ⟸   ENSCAFT00000082146
RefSeq Acc Id: XP_038290510   ⟸   XM_038434582
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NMI3 (UniProtKB/TrEMBL),   A0A8I3PVA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845033272   ⟸   ENSCAFT00845042440
RefSeq Acc Id: ENSCAFP00845033453   ⟸   ENSCAFT00845042662

Promoters
RGD ID:13687820
Promoter ID:EPDNEW_C5889
Type:multiple initiation site
Name:PTMA_1
Description:prothymosin alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12543,563,163 - 43,563,223EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032596 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017983 UniProtKB/TrEMBL
  ENSCAFG00040024265 UniProtKB/TrEMBL
  ENSCAFG00845024019 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000045403.3 UniProtKB/TrEMBL
  ENSCAFT00000082146.2 UniProtKB/TrEMBL
  ENSCAFT00030033242.1 UniProtKB/TrEMBL
  ENSCAFT00030033311.1 UniProtKB/TrEMBL
  ENSCAFT00040045231.1 UniProtKB/TrEMBL
  ENSCAFT00845042440 ENTREZGENE
  ENSCAFT00845042440.1 UniProtKB/TrEMBL
  ENSCAFT00845042662.1 UniProtKB/TrEMBL
InterPro Pro/parathymosin UniProtKB/TrEMBL
NCBI Gene PTMA ENTREZGENE
PANTHER PROTHYMOSIN ALPHA UniProtKB/TrEMBL
  PROTHYMOSIN ALPHA UniProtKB/TrEMBL
  PTHR22745 UniProtKB/TrEMBL
Pfam Prothymosin UniProtKB/TrEMBL
UniProt A0A8C0NMI3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NUP7_CANLF UniProtKB/TrEMBL
  A0A8I3PVA7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PVL2_CANLF UniProtKB/TrEMBL
  A0A8P0NQA3_CANLF UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-30 PTMA  prothymosin alpha    prothymosin, alpha  Symbol and/or name change 5135510 APPROVED