PEX14 (peroxisomal biogenesis factor 14) - Rat Genome Database

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Gene: PEX14 (peroxisomal biogenesis factor 14) Canis lupus familiaris
Analyze
Symbol: PEX14 (Ensembl: CENPS)
Name: peroxisomal biogenesis factor 14 (Ensembl:centromere protein S)
RGD ID: 12386265
Description: ENCODES a protein that exhibits double-stranded DNA binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN peroxisome organization (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); chromosome 1p36 deletion syndrome (ortholog); genetic disease (ortholog); FOUND IN chromatin (ortholog); FANCM-MHF complex (ortholog); inner kinetochore (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: APITD1; apoptosis-inducing, TAF9-like domain 1; CENPS; centromere protein S
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1285,379,378 - 85,389,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,981,475 - 81,990,564 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0286,111,196 - 86,124,207 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl286,114,196 - 86,124,084 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,862,365 - 82,871,454 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,864,867 - 83,873,956 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,927,777 - 84,936,866 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PEX14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1285,379,378 - 85,389,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,981,475 - 81,990,564 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0286,111,196 - 86,124,207 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl286,114,196 - 86,124,084 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,862,365 - 82,871,454 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,864,867 - 83,873,956 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,927,777 - 84,936,866 (-)NCBIUU_Cfam_GSD_1.0
CENPS-CORT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38110,430,433 - 10,452,153 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl110,430,102 - 10,452,153 (+)EnsemblGRCh38hg38GRCh38
GRCh37110,490,490 - 10,512,210 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p36.22NCBI
HuRef19,643,798 - 9,665,676 (+)NCBIHuRef
CHM1_1110,477,737 - 10,499,802 (+)NCBICHM1_1
T2T-CHM13v2.019,974,048 - 9,995,769 (+)NCBIT2T-CHM13v2.0

Variants

.
Variants in PEX14
81 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 5 12 8 10 6
Low 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845005941   ⟹   ENSCAFP00845004726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl286,114,196 - 86,124,084 (-)Ensembl
RefSeq Acc Id: NM_001204929   ⟹   NP_001191858
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1285,379,980 - 85,389,069 (-)NCBI
Dog10K_Boxer_Tasha281,981,475 - 81,990,564 (-)NCBI
ROS_Cfam_1.0286,114,995 - 86,124,084 (-)NCBI
UMICH_Zoey_3.1282,862,365 - 82,871,454 (-)NCBI
UNSW_CanFamBas_1.0283,864,867 - 83,873,956 (-)NCBI
UU_Cfam_GSD_1.0284,927,777 - 84,936,866 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038657842   ⟹   XP_038513770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0286,111,196 - 86,124,203 (-)NCBI
RefSeq Acc Id: XM_038657844   ⟹   XP_038513772
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0286,114,544 - 86,124,202 (-)NCBI
RefSeq Acc Id: XM_038657845   ⟹   XP_038513773
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0286,111,196 - 86,124,205 (-)NCBI
RefSeq Acc Id: XM_038657846   ⟹   XP_038513774
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0286,111,196 - 86,124,207 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001191858   ⟸   NM_001204929
- UniProtKB: A0A8C0NTG5 (UniProtKB/TrEMBL),   A0A8C0LD30 (UniProtKB/TrEMBL),   A0A8P0NI70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038513774   ⟸   XM_038657846
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038513773   ⟸   XM_038657845
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038513770   ⟸   XM_038657842
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038513772   ⟸   XM_038657844
- Peptide Label: isoform X2
- UniProtKB: A0A8I3MJZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845004726   ⟸   ENSCAFT00845005941
Protein Domains
Peroxisome membrane anchor protein Pex14p N-


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000054131 UniProtKB/TrEMBL
  ENSCAFG00030019941 UniProtKB/TrEMBL
  ENSCAFG00040008073 UniProtKB/TrEMBL
  ENSCAFG00845003340 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026576.5 UniProtKB/TrEMBL
  ENSCAFT00030036719.1 UniProtKB/TrEMBL
  ENSCAFT00040015159.1 UniProtKB/TrEMBL
  ENSCAFT00040015262.1 UniProtKB/TrEMBL
  ENSCAFT00845005941 ENTREZGENE
  ENSCAFT00845005941.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
  Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain UniProtKB/TrEMBL
InterPro CENP-S/Mhf1 UniProtKB/TrEMBL
  Histone-fold UniProtKB/TrEMBL
  PEX14 UniProtKB/TrEMBL
  Pex14_N UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report cfa:487450 UniProtKB/TrEMBL
NCBI Gene APITD1 ENTREZGENE
PANTHER CENTROMERE PROTEIN S UniProtKB/TrEMBL
  CORTISTATIN UniProtKB/TrEMBL
  PEROXISOMAL MEMBRANE PROTEIN PEX14 UniProtKB/TrEMBL
  PEROXISOMAL MEMBRANE PROTEIN PEX14 UniProtKB/TrEMBL
Pfam CENP-S UniProtKB/TrEMBL
  Pex14_N UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/TrEMBL
UniProt A0A8C0LD30 ENTREZGENE
  A0A8C0NTG5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S0N4_CANLF UniProtKB/TrEMBL
  A0A8I3MJZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NI70 ENTREZGENE
UniProt Secondary A0A8P0NI70 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-04 PEX14  peroxisomal biogenesis factor 14  CENPS  centromere protein S  Symbol and/or name change 19259463 PROVISIONAL
2017-09-12 CENPS  centromere protein S  APITD1  apoptosis-inducing, TAF9-like domain 1  Symbol and/or name change 5135510 APPROVED