HSPA2 (heat shock protein family A (Hsp70) member 2) - Rat Genome Database

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Gene: HSPA2 (heat shock protein family A (Hsp70) member 2) Canis lupus familiaris
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Symbol: HSPA2
Name: heat shock protein family A (Hsp70) member 2
RGD ID: 12383719
Description: ENCODES a protein that exhibits protein-folding chaperone binding (ortholog); tau protein binding (ortholog); INVOLVED IN male meiosis I (ortholog); male meiotic nuclear division (ortholog); positive regulation of G2/M transition of mitotic cell cycle (ortholog); ASSOCIATED WITH Colonic Neoplasms (ortholog); genetic disease (ortholog); Myocardial Ischemia (ortholog); FOUND IN CatSper complex (inferred); cell surface (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: heat shock-related 70 kDa protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,967,104 - 38,969,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,967,400 - 38,969,313 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,658,560 - 38,661,200 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0839,188,332 - 39,191,053 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,188,237 - 39,191,347 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,810,203 - 38,812,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0838,881,460 - 38,884,183 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,241,859 - 39,244,579 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HSPA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,967,104 - 38,969,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,967,400 - 38,969,313 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,658,560 - 38,661,200 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0839,188,332 - 39,191,053 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,188,237 - 39,191,347 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,810,203 - 38,812,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0838,881,460 - 38,884,183 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,241,859 - 39,244,579 (+)NCBIUU_Cfam_GSD_1.0
HSPA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,535,905 - 64,543,237 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,535,905 - 64,546,173 (+)EnsemblGRCh38hg38GRCh38
GRCh371465,002,623 - 65,009,955 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,076,939 - 64,079,708 (+)NCBINCBI36Build 36hg18NCBI36
Build 341464,072,375 - 64,079,705NCBI
Celera1445,064,915 - 45,067,684 (+)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1445,179,854 - 45,182,623 (+)NCBIHuRef
CHM1_11464,946,881 - 64,949,650 (+)NCBICHM1_1
T2T-CHM13v2.01458,743,704 - 58,751,035 (+)NCBIT2T-CHM13v2.0
Hspa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,450,688 - 76,453,712 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,450,950 - 76,453,712 (+)EnsemblGRCm39 Ensembl
GRCm381276,403,812 - 76,406,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,404,176 - 76,406,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv371277,505,163 - 77,507,925 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,323,016 - 77,325,778 (+)NCBIMGSCv36mm8
Celera1277,495,202 - 77,497,964 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.73NCBI
Hspa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,864,172 - 100,866,946 (+)NCBIGRCr8
mRatBN7.2695,128,504 - 95,131,281 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,128,350 - 95,131,287 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,522,154 - 95,524,659 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,820,668 - 95,823,173 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,249,481 - 95,251,986 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,433,575 - 99,436,288 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,433,550 - 99,436,289 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,843,592 - 108,846,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,000,541 - 99,003,041 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,003,760 - 99,006,497 (+)NCBI
Celera693,553,144 - 93,555,644 (+)NCBICelera
Cytogenetic Map6q24NCBI
Hspa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,344,366 - 5,347,707 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554665,344,366 - 5,347,707 (-)NCBIChiLan1.0ChiLan1.0
HSPA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21565,654,654 - 65,657,531 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11464,871,169 - 64,874,046 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,124,326 - 45,127,105 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11463,373,462 - 63,376,240 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1463,373,840 - 63,375,762 (+)Ensemblpanpan1.1panPan2
Hspa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864065,945,617 - 65,948,642 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364958,243,369 - 8,246,082 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1788,607,140 - 88,609,947 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2794,987,337 - 94,990,126 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,747,485 - 41,750,266 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,747,864 - 41,749,783 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605329,924,231 - 29,927,019 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473436,476,372 - 36,478,548 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HSPA2
58 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 16 3 6 6 7 8 6 3
Low 6 6 3 6 5 4 3
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000025433   ⟹   ENSCAFP00000023616
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl838,967,400 - 38,969,313 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003845   ⟹   ENSCAFP00845003063
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl839,188,237 - 39,191,347 (+)Ensembl
RefSeq Acc Id: XM_038483461   ⟹   XP_038339389
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1838,810,203 - 38,812,923 (+)NCBI
RefSeq Acc Id: XM_038544921   ⟹   XP_038400849
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0839,241,859 - 39,244,579 (+)NCBI
RefSeq Acc Id: XM_038609037   ⟹   XP_038464965
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0838,881,460 - 38,884,183 (+)NCBI
RefSeq Acc Id: XM_038673842   ⟹   XP_038529770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0839,188,332 - 39,191,053 (+)NCBI
RefSeq Acc Id: XM_537479   ⟹   XP_537479
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1838,967,104 - 38,969,806 (+)NCBI
Dog10K_Boxer_Tasha838,658,560 - 38,661,200 (+)NCBI
Sequence:
RefSeq Acc Id: XP_537479   ⟸   XM_537479
- UniProtKB: A0A8C0K2Y6 (UniProtKB/TrEMBL),   A0A8C0QLN2 (UniProtKB/TrEMBL),   A0A8I3N1B1 (UniProtKB/TrEMBL),   A0A8C0P9Q2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023616   ⟸   ENSCAFT00000025433
RefSeq Acc Id: XP_038339389   ⟸   XM_038483461
RefSeq Acc Id: XP_038464965   ⟸   XM_038609037
RefSeq Acc Id: XP_038529770   ⟸   XM_038673842
- UniProtKB: A0A8C0K2Y6 (UniProtKB/TrEMBL),   A0A8C0QLN2 (UniProtKB/TrEMBL),   A0A8I3N1B1 (UniProtKB/TrEMBL),   A0A8C0P9Q2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400849   ⟸   XM_038544921
- UniProtKB: A0A8C0K2Y6 (UniProtKB/TrEMBL),   A0A8C0P9Q2 (UniProtKB/TrEMBL),   A0A8C0QLN2 (UniProtKB/TrEMBL),   A0A8I3N1B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003063   ⟸   ENSCAFT00845003845


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016031 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019865 UniProtKB/TrEMBL
  ENSCAFG00040007990 UniProtKB/TrEMBL
  ENSCAFG00845002192 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025433.3 UniProtKB/TrEMBL
  ENSCAFT00030036494.1 UniProtKB/TrEMBL
  ENSCAFT00040014898.1 UniProtKB/TrEMBL
  ENSCAFT00845003845 ENTREZGENE
  ENSCAFT00845003845.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/TrEMBL
KEGG Report cfa:480355 UniProtKB/TrEMBL
NCBI Gene HSPA2 ENTREZGENE
PANTHER HEAT SHOCK-RELATED 70 KDA PROTEIN 2 UniProtKB/TrEMBL
  PTHR19375 UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/TrEMBL
PRINTS HEATSHOCK70 UniProtKB/TrEMBL
PROSITE HSP70_1 UniProtKB/TrEMBL
  HSP70_2 UniProtKB/TrEMBL
  HSP70_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/TrEMBL
  SSF100934 UniProtKB/TrEMBL
  SSF53067 UniProtKB/TrEMBL
UniProt A0A8C0K2Y6 ENTREZGENE
  A0A8C0P9Q2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QLN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N1B1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:50533 ENTREZGENE