LOC100855558 (hemoglobin subunit alpha-like)

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Gene: LOC100855558 (hemoglobin subunit alpha-like) Canis lupus familiaris

Analyze

Symbol:

LOC100855558

Name:

hemoglobin subunit alpha-like

RGD ID:

12383407

Description:

ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); haptoglobin binding (ortholog); heme binding (ortholog); INVOLVED IN erythrocyte development (ortholog); hydrogen peroxide catabolic process (ortholog); in utero embryonic development (ortholog); ASSOCIATED WITH alpha thalassemia (ortholog); Alpha-Thalassemia 2 (ortholog); Alpha-Thalassemia-2, Nondeletional (ortholog); FOUND IN extracellular space (ortholog); haptoglobin-hemoglobin complex (ortholog); hemoglobin complex (ortholog)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hemoglobin subunit alpha1

RGD Orthologs

Human

Mouse

Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	40,328,053 - 40,329,002 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	41,591,692 - 41,593,018 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	40,671,209 - 40,672,537 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	40,359,320 - 40,360,638 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	40,320,283 - 40,321,596 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	40,798,910 - 40,800,239 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alpha thalassemia (ISO)

Alpha-Thalassemia 2 (ISO)

Alpha-Thalassemia-2, Nondeletional (ISO)

anemia (ISO)

beta thalassemia (ISO)

Chloracne (ISO)

Escherichia Coli Infections (ISO)

familial erythrocytosis 7 (ISO)

genetic disease (ISO)

Heinz body anemia (ISO)

hemoglobin H disease (ISO)

hemoglobinopathy (ISO)

Hydrops Fetalis (ISO)

polycythemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

erythrocyte development (ISO)

hydrogen peroxide catabolic process (ISO)

in utero embryonic development (ISO)

nitric oxide transport (ISO)

oxygen transport (IEA)

response to bacterium (ISO)

response to hydrogen peroxide (ISO)

Cellular Component

extracellular space (ISO)

haptoglobin-hemoglobin complex (ISO)

hemoglobin complex (IEA,ISO)

Molecular Function

G protein-coupled receptor binding (ISO)

haptoglobin binding (ISO)

heme binding (IEA,ISO)

iron ion binding (IEA)

metal ion binding (IEA)

organic acid binding (ISO)

oxygen binding (IEA,ISO)

oxygen carrier activity (IEA)

peroxidase activity (ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

References

Additional References at PubMed

PMID:21543841	PMID:31362306

Genomics

Comparative Map Data

LOC100855558
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	40,328,053 - 40,329,002 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	41,591,692 - 41,593,018 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	40,671,209 - 40,672,537 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	40,359,320 - 40,360,638 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	40,320,283 - 40,321,596 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	40,798,910 - 40,800,239 (-)	NCBI		UU_Cfam_GSD_1.0

HBA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	172,876 - 173,710 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	172,876 - 173,710 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	222,875 - 223,709 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	162,875 - 163,708 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	162,874 - 163,705	NCBI
Celera	16	426,165 - 427,036 (+)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	140,887 - 141,750 (+)	NCBI		HuRef
CHM1_1	16	222,852 - 223,715 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	166,917 - 167,751 (+)	NCBI		T2T-CHM13v2.0

Hba-a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	32,246,492 - 32,247,310 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	32,246,489 - 32,247,298 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	32,296,492 - 32,297,310 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	32,296,489 - 32,297,298 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	32,196,492 - 32,197,310 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
Celera	11	34,701,680 - 34,701,823 (+)	NCBI		Celera
Cytogenetic Map	11	A4	NCBI
cM Map	11	18.87	NCBI

Hba-a3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	15,311,637 - 15,312,481 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	15,311,634 - 15,312,481 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_WKY_Bbb_1.0	10	15,039,603 - 15,040,447 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	15,577,249 - 15,577,977 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	15,577,249 - 15,577,977 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	15,472,343 - 15,473,071 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	15,558,815 - 15,559,543 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	15,559,862 - 15,560,591 (-)	NCBI
Celera	10	14,979,302 - 14,980,030 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

Variants

Variants in LOC100855558
34 total Variants

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001270885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DN415010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MK720824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MK720826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_001270885 ⟹ NP_001257814

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	6	40,328,053 - 40,329,002 (-)	NCBI
Dog10K_Boxer_Tasha	6	41,591,692 - 41,593,018 (-)	NCBI
ROS_Cfam_1.0	6	40,671,209 - 40,672,537 (-)	NCBI
UMICH_Zoey_3.1	6	40,359,320 - 40,360,638 (-)	NCBI
UNSW_CanFamBas_1.0	6	40,320,283 - 40,321,596 (-)	NCBI
UU_Cfam_GSD_1.0	6	40,798,910 - 40,800,239 (-)	NCBI

Sequence:

show sequence

CCTCAGACTCAGAAGGAACCCACCATGGTGCTGTCTCCCGCCGATAAGACCAACATCAAGTCCA
CTTGGGATAAGATTGGTGGCCACGCTGGCGACTACGGCGGAGAGGCGCTGGACAGGACCTTCCA
GTCCTTCCCCACCACCAAGACCTACTTCCCGCACTTCGACCTGAGCCCCGGCTCCGCCCAGGTC
AAGGCCCACGGCAAGAAGGTGGCTGATGCGCTGACCACCGCCGTGGCCCACCTGGACGACCTGC
CCGGTGCCCTGTCCGCCCTCAGCGACCTGCACGCCTACAAGCTGCGCGTGGACCCCGTCAACTT
CAAGCTCCTGAGCCACTGCCTGCTGGTGACCCTGGCCTGCCACCACCCCACCGAATTCACCCCT
GCCGTCCACGCCTCCCTGGACAAGTTCTTCGCCGCCGTGAGCACCGTGCTGACCTCCAAGTACC
GTTAAGCTGCAGCCATGGCGGCGGGAGCCCCTGCCCTGGGCCCCTGGGTGGCCTCCTGCAACCG
TGCCCTACACTTCCTGATGTTTGAATAAAGTCTGAGTGGGCTGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001257814	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	QDY81623	(Get FASTA)	NCBI Sequence Viewer
	QDY81625	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001257814 ⟸ NM_001270885
- UniProtKB:	J9NXL3 (UniProtKB/TrEMBL), A0A8C0K8B3 (UniProtKB/TrEMBL), A0A8C0MX81 (UniProtKB/TrEMBL), A0A8P0NPV8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVLSPADKTNIKSTWDKIGGHAGDYGGEALDRTFQSFPTTKTYFPHFDLSPGSAQVKAHGKKVA DALTTAVAHLDDLPGALSALSDLHAYKLRVDPVNFKLLSHCLLVTLACHHPTEFTPAVHASLDK FFAAVSTVLTSKYR hide sequence

Protein Domains

Globin family profile

Promoters

RGD ID:

13683769

Promoter ID:

EPDNEW_C1838

Type:

single initiation site

Name:

ENSCAFT00000050211_1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	6	40,329,016 - 40,329,076	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000032615	UniProtKB/TrEMBL
	ENSCAFG00030008793	UniProtKB/TrEMBL
	ENSCAFG00845000903	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSCAFP00000038026.3	UniProtKB/TrEMBL
	ENSCAFP00000054823.1	UniProtKB/TrEMBL
	ENSCAFP00000066242.2	UniProtKB/TrEMBL
	ENSCAFP00000070247.1	UniProtKB/TrEMBL
	ENSCAFP00030014187.1	UniProtKB/TrEMBL
	ENSCAFP00030014232.1	UniProtKB/TrEMBL
	ENSCAFP00030014274.1	UniProtKB/TrEMBL
	ENSCAFP00030014397.1	UniProtKB/TrEMBL
	ENSCAFP00030014424.1	UniProtKB/TrEMBL
	ENSCAFP00030014468.1	UniProtKB/TrEMBL
	ENSCAFP00845001206.1	UniProtKB/TrEMBL
	ENSCAFP00845001219.1	UniProtKB/TrEMBL
	ENSCAFP00845001229.1	UniProtKB/TrEMBL
	ENSCAFP00845001261	ENTREZGENE
	ENSCAFP00845001261.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000050211.3	UniProtKB/TrEMBL
	ENSCAFT00000079668.2	UniProtKB/TrEMBL
	ENSCAFT00000093253.2	UniProtKB/TrEMBL
	ENSCAFT00000099930.1	UniProtKB/TrEMBL
	ENSCAFT00030016251.1	UniProtKB/TrEMBL
	ENSCAFT00030016301.1	UniProtKB/TrEMBL
	ENSCAFT00030016344.1	UniProtKB/TrEMBL
	ENSCAFT00030016482.1	UniProtKB/TrEMBL
	ENSCAFT00030016512.1	UniProtKB/TrEMBL
	ENSCAFT00030016560.1	UniProtKB/TrEMBL
	ENSCAFT00845001533.1	UniProtKB/TrEMBL
	ENSCAFT00845001547.1	UniProtKB/TrEMBL
	ENSCAFT00845001557.1	UniProtKB/TrEMBL
	ENSCAFT00845001592	ENTREZGENE
	ENSCAFT00845001592.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.490.10	UniProtKB/TrEMBL
InterPro	Globin	UniProtKB/TrEMBL
	Globin-like_sf	UniProtKB/TrEMBL
	Globin/Proto	UniProtKB/TrEMBL
	Haemoglobin_a-typ	UniProtKB/TrEMBL
	Haemoglobin_pi	UniProtKB/TrEMBL
KEGG Report	cfa:100855558	UniProtKB/TrEMBL
NCBI Gene	LOC100855558	ENTREZGENE
PANTHER	HEMOGLOBIN FAMILY MEMBER	UniProtKB/TrEMBL
	HEMOGLOBIN SUBUNIT ALPHA	UniProtKB/TrEMBL
	HEMOGLOBIN SUBUNIT THETA-1	UniProtKB/TrEMBL
	HEMOGLOBIN SUBUNIT ZETA	UniProtKB/TrEMBL
Pfam	Globin	UniProtKB/TrEMBL
PRINTS	ALPHAHAEM	UniProtKB/TrEMBL
	PIHAEM	UniProtKB/TrEMBL
PROSITE	GLOBIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46458	UniProtKB/TrEMBL
UniProt	A0A5B8JID5_CANLF	UniProtKB/TrEMBL
	A0A8C0K8B3	ENTREZGENE
	A0A8C0MRB6_CANLF	UniProtKB/TrEMBL
	A0A8C0MSV2_CANLF	UniProtKB/TrEMBL
	A0A8C0MTD2_CANLF	UniProtKB/TrEMBL
	A0A8C0MX81	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0N1E7_CANLF	UniProtKB/TrEMBL
	A0A8I3MCD6_CANLF	UniProtKB/TrEMBL
	A0A8I3MCE8_CANLF	UniProtKB/TrEMBL
	A0A8I3RPI6_CANLF	UniProtKB/TrEMBL
	A0A8P0NPV8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0THK3_CANLF	UniProtKB/TrEMBL
	A0A8P0TN59_CANLF	UniProtKB/TrEMBL
	J9NXL3	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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