BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2) - Rat Genome Database

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Gene: BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2) Canis lupus familiaris
Analyze
Symbol: BPNT2 (Ensembl: IMPAD1)
Name: 3'(2'), 5'-bisphosphate nucleotidase 2
RGD ID: 12382329
Description: ENCODES a protein that exhibits 3',5'-nucleotide bisphosphate phosphatase activity (inferred); 3'-nucleotidase activity (inferred); metal ion binding (inferred); INVOLVED IN chondrocyte development (ortholog); chondroitin sulfate metabolic process (ortholog); embryonic digit morphogenesis (ortholog); ASSOCIATED WITH chondrodysplasia with joint dislocations gPAPP type (ortholog); genetic disease (ortholog); osteochondrodysplasia (ortholog); FOUND IN cytosol (inferred); endomembrane system (inferred); Golgi apparatus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; IMPAD1; inositol monophosphatase 3; inositol monophosphatase domain containing 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1298,176,977 - 8,215,561 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl298,182,508 - 8,215,868 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha298,489,359 - 8,527,888 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0298,248,236 - 8,286,775 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl298,248,495 - 8,286,727 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1298,265,711 - 8,304,249 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0298,391,268 - 8,430,020 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0298,670,438 - 8,708,972 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BPNT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1298,176,977 - 8,215,561 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl298,182,508 - 8,215,868 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha298,489,359 - 8,527,888 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0298,248,236 - 8,286,775 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl298,248,495 - 8,286,727 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1298,265,711 - 8,304,249 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0298,391,268 - 8,430,020 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0298,670,438 - 8,708,972 (-)NCBIUU_Cfam_GSD_1.0
BPNT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38856,957,931 - 56,993,867 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl856,957,931 - 56,993,867 (-)EnsemblGRCh38hg38GRCh38
GRCh37857,870,490 - 57,906,426 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36858,033,042 - 58,068,981 (-)NCBINCBI36Build 36hg18NCBI36
Celera853,861,222 - 53,897,192 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef853,338,861 - 53,374,799 (-)NCBIHuRef
CHM1_1857,922,244 - 57,958,186 (-)NCBICHM1_1
T2T-CHM13v2.0857,335,005 - 57,370,940 (-)NCBIT2T-CHM13v2.0
Bpnt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3944,762,484 - 4,793,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl44,762,484 - 4,793,355 (-)EnsemblGRCm39 Ensembl
GRCm3844,762,484 - 4,793,306 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl44,762,484 - 4,793,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv3744,691,489 - 4,720,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3644,691,489 - 4,720,453 (-)NCBIMGSCv36mm8
Celera44,712,407 - 4,741,376 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.56NCBI
Bpnt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8522,573,241 - 22,600,126 (-)NCBIGRCr8
mRatBN7.2517,775,684 - 17,802,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl517,772,608 - 17,802,570 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx520,008,545 - 20,035,424 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0521,607,051 - 21,633,933 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0521,357,304 - 21,388,134 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01790,191,119 - 90,218,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl517,633,766 - 17,663,589 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1790,188,043 - 90,218,013 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0522,419,595 - 22,446,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4518,086,121 - 18,109,691 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera517,116,716 - 17,144,147 (-)NCBICelera
Cytogenetic Map5q12NCBI
Bpnt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545415,899,820 - 15,918,222 (-)NCBIChiLan1.0ChiLan1.0
BPNT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2772,600,102 - 72,635,725 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1848,323,401 - 48,359,034 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0853,385,837 - 53,417,019 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1850,753,792 - 50,785,055 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl850,753,792 - 50,785,055 (-)Ensemblpanpan1.1panPan2
Bpnt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530371,263,529 - 71,285,901 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364963,500,303 - 3,521,673 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364963,498,534 - 3,521,939 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BPNT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,191,257 - 75,215,906 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,191,256 - 75,210,988 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,110,550 - 82,130,272 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BPNT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1852,962,686 - 52,999,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl852,968,532 - 52,998,996 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603988,779,510 - 88,815,872 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bpnt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248862,983,121 - 3,005,596 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248862,983,077 - 3,005,596 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BPNT2
491 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 14 6 12 8 10 5
Low 5 8 6 6 6 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011337   ⟹   ENSCAFP00000010505
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl298,182,508 - 8,215,868 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845048402   ⟹   ENSCAFP00845037973
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl298,248,495 - 8,286,727 (-)Ensembl
RefSeq Acc Id: XM_038441206   ⟹   XP_038297134
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0298,248,236 - 8,286,775 (-)NCBI
RefSeq Acc Id: XM_038515782   ⟹   XP_038371710
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1298,265,711 - 8,304,249 (-)NCBI
RefSeq Acc Id: XM_038579350   ⟹   XP_038435278
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0298,670,438 - 8,708,972 (-)NCBI
RefSeq Acc Id: XM_038643591   ⟹   XP_038499519
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0298,391,268 - 8,430,020 (-)NCBI
RefSeq Acc Id: XM_535082   ⟹   XP_535082
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1298,176,977 - 8,215,561 (-)NCBI
Dog10K_Boxer_Tasha298,489,359 - 8,527,888 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_535082   ⟸   XM_535082
- UniProtKB: A0A8C0KS54 (UniProtKB/TrEMBL),   A0A8C0NQZ6 (UniProtKB/TrEMBL),   A0A8I3PTD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010505   ⟸   ENSCAFT00000011337
RefSeq Acc Id: XP_038371710   ⟸   XM_038515782
RefSeq Acc Id: XP_038499519   ⟸   XM_038643591
RefSeq Acc Id: XP_038297134   ⟸   XM_038441206
- UniProtKB: A0A8C0KS54 (UniProtKB/TrEMBL),   A0A8C0NQZ6 (UniProtKB/TrEMBL),   A0A8I3PTD3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038435278   ⟸   XM_038579350
- UniProtKB: A0A8C0KS54 (UniProtKB/TrEMBL),   A0A8C0NQZ6 (UniProtKB/TrEMBL),   A0A8I3PTD3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845037973   ⟸   ENSCAFT00845048402

Promoters
RGD ID:13688400
Promoter ID:EPDNEW_C6468
Type:initiation region
Name:IMPAD1_1
Description:inositol monophosphatase domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1298,215,729 - 8,215,789EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007074 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018442 UniProtKB/TrEMBL
  ENSCAFG00040025434 UniProtKB/TrEMBL
  ENSCAFG00845027460 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011337.4 UniProtKB/TrEMBL
  ENSCAFT00030033979.1 UniProtKB/TrEMBL
  ENSCAFT00040047451.1 UniProtKB/TrEMBL
  ENSCAFT00845048402 ENTREZGENE
  ENSCAFT00845048402.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.190.80 UniProtKB/TrEMBL
  Fructose-1,6-Bisphosphatase, subunit A, domain 1 UniProtKB/TrEMBL
InterPro Inositol_monophosphatase-like UniProtKB/TrEMBL
  Inositol_monophosphatase_CS UniProtKB/TrEMBL
KEGG Report cfa:477890 UniProtKB/TrEMBL
NCBI Gene IMPAD1 ENTREZGENE
PANTHER 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 UniProtKB/TrEMBL
  GOLGI-RESIDENT ADENOSINE 3',5'-BISPHOSPHATE 3'-PHOSPHATASE UniProtKB/TrEMBL
Pfam Inositol_P UniProtKB/TrEMBL
PROSITE IMP_2 UniProtKB/TrEMBL
Superfamily-SCOP Carbohydrate phosphatase UniProtKB/TrEMBL
UniProt A0A8C0KS54 ENTREZGENE
  A0A8C0NQZ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PTD3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42009 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-14 BPNT2  3'(2'), 5'-bisphosphate nucleotidase 2  IMPAD1  inositol monophosphatase domain containing 1  Symbol and/or name change 5135510 APPROVED