TMEM259 (transmembrane protein 259) - Rat Genome Database

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Gene: TMEM259 (transmembrane protein 259) Canis lupus familiaris
Analyze
Symbol: TMEM259
Name: transmembrane protein 259
RGD ID: 12377153
Description: INVOLVED IN positive regulation of ERAD pathway (inferred); response to endoplasmic reticulum stress (inferred); ASSOCIATED WITH cerebral creatine deficiency syndrome (ortholog); cyclic hematopoiesis (ortholog); Peutz-Jeghers syndrome (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C20H19orf6; membralin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,695,004 - 57,703,650 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,695,002 - 57,749,891 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,497,098 - 57,505,634 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,437,023 - 58,445,561 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,437,018 - 58,445,559 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,492,365 - 57,500,879 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,971,883 - 57,980,411 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,174,902 - 58,183,421 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TMEM259
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,695,004 - 57,703,650 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,695,002 - 57,749,891 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,497,098 - 57,505,634 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,437,023 - 58,445,561 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,437,018 - 58,445,559 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,492,365 - 57,500,879 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,971,883 - 57,980,411 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,174,902 - 58,183,421 (+)NCBIUU_Cfam_GSD_1.0
TMEM259
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,009,653 - 1,021,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,009,648 - 1,021,179 (-)EnsemblGRCh38hg38GRCh38
GRCh37191,009,652 - 1,021,122 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619960,650 - 972,141 (-)NCBINCBI36Build 36hg18NCBI36
Build 3419960,649 - 972,114NCBI
Celera19941,988 - 953,479 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19782,787 - 794,267 (-)NCBIHuRef
CHM1_1191,008,804 - 1,020,294 (-)NCBICHM1_1
T2T-CHM13v2.019972,322 - 983,792 (-)NCBIT2T-CHM13v2.0
Tmem259
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,812,954 - 79,820,159 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,810,782 - 79,820,164 (-)EnsemblGRCm39 Ensembl
GRCm381079,977,120 - 79,984,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,974,948 - 79,984,330 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,439,865 - 79,447,075 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,380,249 - 79,387,291 (-)NCBIMGSCv36mm8
Celera1080,991,927 - 80,999,137 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Tmem259
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,374,804 - 10,381,566 (+)NCBIGRCr8
mRatBN7.279,724,196 - 9,730,932 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,722,485 - 9,730,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,606,557 - 12,613,232 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,481,879 - 14,488,554 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,343,077 - 12,349,752 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,771,239 - 12,777,901 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,771,227 - 12,779,862 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,940,961 - 12,947,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,236,953 - 11,244,044 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,237,414 - 11,244,044 (+)NCBI
Celera77,899,960 - 7,906,553 (+)NCBICelera
Cytogenetic Map7q11NCBI
Tmem259
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,852,278 - 6,859,351 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,856,609 - 6,859,948 (+)NCBIChiLan1.0ChiLan1.0
TMEM259
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,339,668 - 5,351,257 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,578,967 - 4,590,546 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl19983,507 - 994,212 (-)Ensemblpanpan1.1panPan2
Tmem259
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,385,339 - 217,394,323 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588441,135 - 449,444 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588440,460 - 449,440 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM259
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,393,611 - 77,402,262 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,393,577 - 77,402,266 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,595,383 - 77,604,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM259
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16766,097 - 777,348 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6765,587 - 777,399 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,142,463 - 8,153,815 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem259
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,606,339 - 7,614,107 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,606,177 - 7,614,644 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TMEM259
138 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005633158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005633159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022407312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038429355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038429357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038455627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038455629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038504882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038568040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038568041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038632149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038632150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000031233   ⟹   ENSCAFP00000029064
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2057,695,002 - 57,749,891 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000047485   ⟹   ENSCAFP00000041131
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2057,695,002 - 57,744,080 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000074602   ⟹   ENSCAFP00000053174
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2057,695,002 - 57,709,022 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000090577   ⟹   ENSCAFP00000065627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2057,695,002 - 57,717,679 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845025537   ⟹   ENSCAFP00845020104
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2058,437,018 - 58,445,559 (+)Ensembl
RefSeq Acc Id: XM_038429355   ⟹   XP_038285283
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02058,437,023 - 58,445,561 (+)NCBI
RefSeq Acc Id: XM_038429357   ⟹   XP_038285285
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02058,437,023 - 58,445,561 (+)NCBI
RefSeq Acc Id: XM_038455627   ⟹   XP_038311555
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2057,497,098 - 57,505,634 (+)NCBI
RefSeq Acc Id: XM_038455629   ⟹   XP_038311557
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2057,497,098 - 57,505,634 (+)NCBI
RefSeq Acc Id: XM_038504882   ⟹   XP_038360810
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12057,492,365 - 57,500,879 (+)NCBI
RefSeq Acc Id: XM_038568040   ⟹   XP_038423968
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02058,174,902 - 58,183,421 (+)NCBI
RefSeq Acc Id: XM_038568041   ⟹   XP_038423969
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02058,174,902 - 58,183,421 (+)NCBI
RefSeq Acc Id: XM_038632149   ⟹   XP_038488077
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02057,971,883 - 57,980,411 (+)NCBI
RefSeq Acc Id: XM_038632150   ⟹   XP_038488078
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02057,971,883 - 57,980,411 (+)NCBI
Ensembl Acc Id: ENSCAFP00000053174   ⟸   ENSCAFT00000074602
Ensembl Acc Id: ENSCAFP00000029064   ⟸   ENSCAFT00000031233
Ensembl Acc Id: ENSCAFP00000041131   ⟸   ENSCAFT00000047485
Ensembl Acc Id: ENSCAFP00000065627   ⟸   ENSCAFT00000090577
RefSeq Acc Id: XP_038360810   ⟸   XM_038504882
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038488077   ⟸   XM_038632149
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038488078   ⟸   XM_038632150
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038285283   ⟸   XM_038429355
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KTT2 (UniProtKB/TrEMBL),   A0A8C0NVZ2 (UniProtKB/TrEMBL),   A0A8I3NJ44 (UniProtKB/TrEMBL),   A0A8P0SNF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038285285   ⟸   XM_038429357
- Peptide Label: isoform X2
- UniProtKB: A0A8P0SNF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038311555   ⟸   XM_038455627
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KTT2 (UniProtKB/TrEMBL),   A0A8C0NVZ2 (UniProtKB/TrEMBL),   A0A8I3NJ44 (UniProtKB/TrEMBL),   A0A8P0SNF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038311557   ⟸   XM_038455629
- Peptide Label: isoform X2
- UniProtKB: A0A8P0SNF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038423968   ⟸   XM_038568040
- Peptide Label: isoform X1
- UniProtKB: A0A8P0SNF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038423969   ⟸   XM_038568041
- Peptide Label: isoform X2
- UniProtKB: A0A8P0SNF0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845020104   ⟸   ENSCAFT00845025537

Promoters
RGD ID:13687132
Promoter ID:EPDNEW_C5202
Type:multiple initiation site
Name:TMEM259_1
Description:transmembrane protein 259
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12057,694,986 - 57,695,046EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019648 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018980 UniProtKB/TrEMBL
  ENSCAFG00845014279 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031233.5 UniProtKB/TrEMBL
  ENSCAFT00000047485.3 UniProtKB/TrEMBL
  ENSCAFT00030034886.1 UniProtKB/TrEMBL
  ENSCAFT00845025537 ENTREZGENE
  ENSCAFT00845025537.1 UniProtKB/TrEMBL
InterPro Membralin UniProtKB/TrEMBL
NCBI Gene TMEM259 ENTREZGENE
PANTHER MEMBRALIN/KINETOCHORE PROTEIN NUF2 UniProtKB/TrEMBL
  PTHR21650:SF4 UniProtKB/TrEMBL
Pfam Membralin UniProtKB/TrEMBL
UniProt A0A8C0KTT2 ENTREZGENE
  A0A8C0NVZ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NJ44 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SNF0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:47561 ENTREZGENE