PTAFR (platelet activating factor receptor) - Rat Genome Database

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Gene: PTAFR (platelet activating factor receptor) Canis lupus familiaris
Analyze
Symbol: PTAFR
Name: platelet activating factor receptor
RGD ID: 12375745
Description: ENCODES a protein that exhibits mitogen-activated protein kinase binding (ortholog); platelet activating factor receptor activity (ortholog); INVOLVED IN cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine (ortholog); cellular response to cAMP (ortholog); cellular response to fatty acid (ortholog); ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: PAFr; platelet-activating factor receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,225,386 - 72,256,353 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,225,386 - 72,256,352 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,803,234 - 68,834,141 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,785,522 - 72,816,261 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,785,522 - 72,816,261 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,612,919 - 69,643,905 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,622,939 - 70,654,206 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,619,611 - 71,650,615 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine  (ISO)
cellular response to cAMP  (ISO)
cellular response to fatty acid  (ISO)
cellular response to gravity  (ISO)
chemotaxis  (IEA)
G protein-coupled purinergic nucleotide receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway  (IEA,ISO)
inflammatory response  (IEA,ISO)
inositol trisphosphate biosynthetic process  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA)
negative regulation of blood pressure  (ISO)
parturition  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA)
positive regulation of cellular extravasation  (ISO)
positive regulation of gastro-intestinal system smooth muscle contraction  (ISO)
positive regulation of inositol phosphate biosynthetic process  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of leukocyte cell-cell adhesion  (ISO)
positive regulation of leukocyte tethering or rolling  (ISO)
positive regulation of maternal process involved in parturition  (ISO)
positive regulation of neutrophil degranulation  (ISO)
positive regulation of phospholipase C activity  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of transcytosis  (ISO)
positive regulation of translation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of voltage-gated chloride channel activity  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine  (ISO)
response to dexamethasone  (ISO)
response to lipopolysaccharide  (IEA,ISO)
response to organophosphorus  (ISO)
response to symbiotic bacterium  (ISO)
transcytosis  (ISO)

Cellular Component
membrane  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTAFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,225,386 - 72,256,353 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,225,386 - 72,256,352 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,803,234 - 68,834,141 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,785,522 - 72,816,261 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,785,522 - 72,816,261 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,612,919 - 69,643,905 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,622,939 - 70,654,206 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,619,611 - 71,650,615 (+)NCBIUU_Cfam_GSD_1.0
PTAFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,147,166 - 28,193,856 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,147,166 - 28,193,936 (-)EnsemblGRCh38hg38GRCh38
GRCh37128,473,677 - 28,520,367 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,348,425 - 28,375,778 (-)NCBINCBI36Build 36hg18NCBI36
Build 34128,160,005 - 28,187,333NCBI
Celera126,869,321 - 26,916,090 (-)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef126,730,992 - 26,777,615 (-)NCBIHuRef
CHM1_1128,589,192 - 28,635,951 (-)NCBICHM1_1
T2T-CHM13v2.0127,988,997 - 28,035,686 (-)NCBIT2T-CHM13v2.0
Ptafr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,291,378 - 132,309,994 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,291,378 - 132,309,994 (+)EnsemblGRCm39 Ensembl
GRCm384132,564,067 - 132,582,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,564,067 - 132,582,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,119,982 - 132,136,781 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,836,143 - 131,852,942 (+)NCBIMGSCv36mm8
Celera4130,724,940 - 130,741,731 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.56NCBI
Ptafr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,049,322 - 150,079,060 (+)NCBIGRCr8
mRatBN7.25144,765,770 - 144,795,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,765,976 - 144,795,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,473,683 - 147,495,127 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,243,260 - 149,264,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,231,360 - 149,253,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,746,284 - 150,775,675 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,754,021 - 150,775,672 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,414,542 - 154,443,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,565,687 - 152,587,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15152,575,728 - 152,597,381 (-)NCBI
Celera5143,199,712 - 143,221,168 (+)NCBICelera
Cytogenetic Map5q36NCBI
Ptafr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,311,901 - 7,312,929 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,309,854 - 7,345,579 (-)NCBIChiLan1.0ChiLan1.0
PTAFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,678,044 - 198,707,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,792,619 - 197,829,135 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,405,880 - 27,436,184 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,447,178 - 28,474,623 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,447,833 - 28,448,861 (-)Ensemblpanpan1.1panPan2
Ptafr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,509,123 - 46,540,460 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,336,071 - 12,337,099 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,333,905 - 12,337,140 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTAFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,235,394 - 85,261,760 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,235,390 - 85,272,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2684,789,514 - 84,851,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTAFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,627,591 - 104,658,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,657,179 - 104,658,207 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603311,819,318 - 11,850,460 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptafr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,998,657 - 11,999,685 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476411,996,454 - 12,025,751 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTAFR
361 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1
Low 5 21 6 6 6 6 11 9 6
Below cutoff 5 1 6 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000018894   ⟹   ENSCAFP00000037334
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl272,225,386 - 72,256,352 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845019079   ⟹   ENSCAFP00845014905
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl272,785,522 - 72,816,261 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845019098   ⟹   ENSCAFP00845014919
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl272,804,570 - 72,815,309 (+)Ensembl
RefSeq Acc Id: NM_001287047   ⟹   NP_001273976
RefSeq Status: INFERRED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1272,225,386 - 72,256,352 (+)NCBI
Dog10K_Boxer_Tasha268,803,234 - 68,834,141 (+)NCBI
ROS_Cfam_1.0272,785,522 - 72,816,261 (+)NCBI
UMICH_Zoey_3.1269,612,919 - 69,643,905 (+)NCBI
UNSW_CanFamBas_1.0270,622,939 - 70,654,206 (+)NCBI
UU_Cfam_GSD_1.0271,619,611 - 71,650,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038657828   ⟹   XP_038513756
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0272,795,266 - 72,816,260 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001273976 (Get FASTA)   NCBI Sequence Viewer  
  XP_038513756 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF01435 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000037334.1
  ENSCAFP00030015779.1
  ENSCAFP00040004430.1
  ENSCAFP00845014905
  ENSCAFP00845014905.1
  ENSCAFP00845014919.1
Reference Protein Sequences
RefSeq Acc Id: NP_001273976   ⟸   NM_001287047
- UniProtKB: A0A8C0Q1F4 (UniProtKB/TrEMBL),   A0A8C0R6K4 (UniProtKB/TrEMBL),   A0A8I3NSH0 (UniProtKB/TrEMBL),   A0A8I3RY80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000037334   ⟸   ENSCAFT00000018894
RefSeq Acc Id: XP_038513756   ⟸   XM_038657828
- Peptide Label: isoform X1
- UniProtKB: A0A8C0Q1F4 (UniProtKB/TrEMBL),   A0A8C0R6K4 (UniProtKB/TrEMBL),   A0A8I3NSH0 (UniProtKB/TrEMBL),   A0A8I3RY80 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845014905   ⟸   ENSCAFT00845019079
RefSeq Acc Id: ENSCAFP00845014919   ⟸   ENSCAFT00845019098
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011895 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009752 UniProtKB/TrEMBL
  ENSCAFG00040002707 UniProtKB/TrEMBL
  ENSCAFG00845010815 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018894.5 UniProtKB/TrEMBL
  ENSCAFT00030018069.1 UniProtKB/TrEMBL
  ENSCAFT00040005149.1 UniProtKB/TrEMBL
  ENSCAFT00845019079 ENTREZGENE
  ENSCAFT00845019079.1 UniProtKB/TrEMBL
  ENSCAFT00845019098.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  PAF_rcpt UniProtKB/TrEMBL
KEGG Report cfa:487336 UniProtKB/TrEMBL
NCBI Gene PTAFR ENTREZGENE
PANTHER P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PLATELET-ACTIVATING FACTOR RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PAFRECEPTOR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C0Q1F4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R6K4 ENTREZGENE
  A0A8I3NSH0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RY80 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45129 ENTREZGENE