PPIH (peptidylprolyl isomerase H) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PPIH (peptidylprolyl isomerase H) Canis lupus familiaris
Analyze
Symbol: PPIH
Name: peptidylprolyl isomerase H
RGD ID: 12371114
Description: ENCODES a protein that exhibits cyclosporin A binding (inferred); peptidyl-prolyl cis-trans isomerase activity (inferred); ribonucleoprotein complex binding (inferred); INVOLVED IN positive regulation of viral genome replication (inferred); protein folding (inferred); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); intracellular membrane-bounded organelle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peptidyl-prolyl cis-trans isomerase H
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115671,323 - 689,627 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15671,324 - 689,544 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha15926,045 - 944,371 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.015752,681 - 771,039 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl15752,682 - 770,962 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115662,128 - 680,381 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.015723,569 - 741,836 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015738,714 - 757,011 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PPIH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115671,323 - 689,627 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15671,324 - 689,544 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha15926,045 - 944,371 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.015752,681 - 771,039 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl15752,682 - 770,962 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115662,128 - 680,381 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.015723,569 - 741,836 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015738,714 - 757,011 (-)NCBIUU_Cfam_GSD_1.0
PPIH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38142,658,423 - 42,681,654 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl142,658,335 - 42,676,758 (+)EnsemblGRCh38hg38GRCh38
GRCh37143,124,094 - 43,142,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36142,896,635 - 42,915,016 (+)NCBINCBI36Build 36hg18NCBI36
Build 34142,793,140 - 42,811,521NCBI
Celera141,405,975 - 41,424,356 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,244,218 - 41,262,600 (+)NCBIHuRef
CHM1_1143,240,906 - 43,259,287 (+)NCBICHM1_1
T2T-CHM13v2.0142,528,918 - 42,552,149 (+)NCBIT2T-CHM13v2.0
Ppih
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394119,157,207 - 119,177,720 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4119,157,207 - 119,177,743 (-)EnsemblGRCm39 Ensembl
GRCm384119,300,010 - 119,320,523 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,300,010 - 119,320,546 (-)EnsemblGRCm38mm10GRCm38
MGSCv374118,972,615 - 118,993,128 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364118,797,947 - 118,818,411 (-)NCBIMGSCv36mm8
Celera4118,027,842 - 118,048,366 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.34NCBI
Ppih
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,191,624 - 138,209,625 (-)NCBIGRCr8
mRatBN7.25132,906,324 - 132,924,341 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5132,906,328 - 132,924,267 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5135,633,875 - 135,652,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,390,334 - 137,409,153 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,410,930 - 137,429,749 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,343,934 - 138,361,743 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,352,916 - 138,361,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05142,160,007 - 142,178,024 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45139,959,365 - 139,969,320 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5131,431,800 - 131,449,612 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ppih
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,211,410 - 2,230,452 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,211,566 - 2,229,444 (+)NCBIChiLan1.0ChiLan1.0
PPIH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21184,130,421 - 184,153,502 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11183,272,085 - 183,295,157 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,958,260 - 41,981,598 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1143,336,039 - 43,354,609 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl143,336,039 - 43,353,898 (+)Ensemblpanpan1.1panPan2
Ppih
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,179,131 - 58,200,103 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647424,003,827 - 24,024,922 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647424,003,963 - 24,024,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPIH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6168,742,005 - 168,760,286 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16168,741,999 - 168,760,350 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26156,223,015 - 156,241,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPIH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12090,250,959 - 90,275,275 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2090,256,081 - 90,274,751 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603326,635,055 - 26,659,466 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppih
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248921,916,912 - 1,935,875 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248921,916,873 - 1,935,458 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPIH
106 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 15 4 6 12 6 9 6
Low 5 7 6 2 6 6 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000004012   ⟹   ENSCAFP00000003706
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl15671,450 - 689,544 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000093306   ⟹   ENSCAFP00000049301
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl15671,324 - 688,799 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845029124   ⟹   ENSCAFP00845022906
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl15752,682 - 770,654 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845029204   ⟹   ENSCAFP00845022970
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl15752,682 - 770,217 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845029246   ⟹   ENSCAFP00845023002
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl15752,808 - 770,962 (-)Ensembl
RefSeq Acc Id: XM_038495318   ⟹   XP_038351246
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.115662,128 - 680,380 (-)NCBI
RefSeq Acc Id: XM_038557663   ⟹   XP_038413591
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.015738,714 - 757,010 (-)NCBI
RefSeq Acc Id: XM_038621556   ⟹   XP_038477484
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.015723,569 - 741,835 (-)NCBI
RefSeq Acc Id: XM_038687325   ⟹   XP_038543253
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.015752,681 - 771,038 (-)NCBI
RefSeq Acc Id: XM_843144   ⟹   XP_848237
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.115671,323 - 689,627 (-)NCBI
Dog10K_Boxer_Tasha15926,045 - 944,370 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005336248
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.115662,128 - 680,381 (-)NCBI
RefSeq Acc Id: XR_005370055
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.015738,714 - 757,011 (-)NCBI
RefSeq Acc Id: XR_005404313
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.015723,569 - 741,836 (-)NCBI
RefSeq Acc Id: XR_005437793
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.015752,681 - 771,039 (-)NCBI
RefSeq Acc Id: XR_294098
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.115671,323 - 689,627 (-)NCBI
Dog10K_Boxer_Tasha15926,045 - 944,371 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_848237   ⟸   XM_843144
- UniProtKB: A0A8C0JRM9 (UniProtKB/TrEMBL),   A0A8C0P8H4 (UniProtKB/TrEMBL),   A0A8I3P2F4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000003706   ⟸   ENSCAFT00000004012
RefSeq Acc Id: ENSCAFP00000049301   ⟸   ENSCAFT00000093306
RefSeq Acc Id: XP_038351246   ⟸   XM_038495318
RefSeq Acc Id: XP_038477484   ⟸   XM_038621556
RefSeq Acc Id: XP_038543253   ⟸   XM_038687325
- UniProtKB: A0A8C0JRM9 (UniProtKB/TrEMBL),   A0A8C0P8H4 (UniProtKB/TrEMBL),   A0A8I3P2F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038413591   ⟸   XM_038557663
- UniProtKB: A0A8C0JRM9 (UniProtKB/TrEMBL),   A0A8C0P8H4 (UniProtKB/TrEMBL),   A0A8I3P2F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845022970   ⟸   ENSCAFT00845029204
RefSeq Acc Id: ENSCAFP00845022906   ⟸   ENSCAFT00845029124
RefSeq Acc Id: ENSCAFP00845023002   ⟸   ENSCAFT00845029246
Protein Domains
PPIase cyclophilin-type

Promoters
RGD ID:13685836
Promoter ID:EPDNEW_C3904
Type:multiple initiation site
Name:PPIH_1
Description:peptidylprolyl isomerase H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.115689,555 - 689,615EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002544 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023625 UniProtKB/TrEMBL
  ENSCAFG00040009526 UniProtKB/TrEMBL
  ENSCAFG00845016259 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004012.4 UniProtKB/TrEMBL
  ENSCAFT00000093306.2 UniProtKB/TrEMBL
  ENSCAFT00030043463.1 UniProtKB/TrEMBL
  ENSCAFT00030043495.1 UniProtKB/TrEMBL
  ENSCAFT00040017803.1 UniProtKB/TrEMBL
  ENSCAFT00040017851.1 UniProtKB/TrEMBL
  ENSCAFT00845029124 ENTREZGENE
  ENSCAFT00845029124.1 UniProtKB/TrEMBL
  ENSCAFT00845029204.1 UniProtKB/TrEMBL
  ENSCAFT00845029246 ENTREZGENE
  ENSCAFT00845029246.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.100.10 UniProtKB/TrEMBL
InterPro Cyclophilin-like_dom_sf UniProtKB/TrEMBL
  Cyclophilin-type_PPIase UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_CS UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_dom UniProtKB/TrEMBL
KEGG Report cfa:606899 UniProtKB/TrEMBL
NCBI Gene PPIH ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED UniProtKB/TrEMBL
Pfam Pro_isomerase UniProtKB/TrEMBL
PIRSF Peptidylpro_ismrse UniProtKB/TrEMBL
PRINTS CSAPPISMRASE UniProtKB/TrEMBL
PROSITE CSA_PPIASE_1 UniProtKB/TrEMBL
  CSA_PPIASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF50891 UniProtKB/TrEMBL
UniProt A0A8C0JRM9 ENTREZGENE
  A0A8C0P8H4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S3T3_CANLF UniProtKB/TrEMBL
  A0A8I3P2B6_CANLF UniProtKB/TrEMBL
  A0A8I3P2F4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RZB4_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:44854 ENTREZGENE