DKK3 (dickkopf WNT signaling pathway inhibitor 3) - Rat Genome Database

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Gene: DKK3 (dickkopf WNT signaling pathway inhibitor 3) Canis lupus familiaris
Analyze
Symbol: DKK3
Name: dickkopf WNT signaling pathway inhibitor 3
RGD ID: 12370716
Description: INVOLVED IN adrenal gland development (ortholog); negative regulation of aldosterone biosynthetic process (ortholog); negative regulation of canonical Wnt signaling pathway (ortholog); ASSOCIATED WITH intellectual disability (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dickkopf 3 homolog; dickkopf homolog 3; dickkopf-related protein 3; REIC/Dkk-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12135,032,501 - 35,074,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBI
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBI
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBI
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBI
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:23732075   PMID:28599655  


Genomics

Comparative Map Data
DKK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12135,032,501 - 35,074,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBI
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBI
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBI
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBI
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBI
DKK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1111,956,207 - 12,009,769 (-)EnsemblGRCh38hg38GRCh38
GRCh381111,963,036 - 12,009,827 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371111,984,583 - 12,030,883 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,941,119 - 11,987,493 (-)NCBINCBI36hg18NCBI36
Build 341111,941,228 - 11,987,205NCBI
Celera1112,109,802 - 12,156,171 (-)NCBI
Cytogenetic Map11p15.3NCBI
HuRef1111,660,573 - 11,706,919 (-)NCBIHuRef
CHM1_11111,983,471 - 12,029,827 (-)NCBICHM1_1
Dkk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397111,715,226 - 111,758,689 (-)NCBIGRCm39mm39
GRCm39 Ensembl7111,715,224 - 111,758,264 (-)Ensembl
GRCm387112,116,019 - 112,159,482 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7112,116,017 - 112,159,057 (-)EnsemblGRCm38mm10GRCm38
MGSCv377119,259,533 - 119,302,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv367111,907,200 - 111,950,238 (-)NCBImm8
Celera7112,091,357 - 112,134,444 (-)NCBICelera
Cytogenetic Map7F1NCBI
Dkk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21166,237,969 - 166,281,271 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1166,238,238 - 166,280,590 (-)Ensembl
Rnor_6.01176,940,424 - 176,983,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1176,940,693 - 176,983,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,919,812 - 183,962,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,924,617 - 169,964,692 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,043,564 - 170,084,626 (-)NCBI
Celera1164,115,480 - 164,157,817 (-)NCBICelera
Cytogenetic Map1q33NCBI
Dkk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541427,456,770 - 27,508,109 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541427,466,636 - 27,507,186 (-)NCBIChiLan1.0ChiLan1.0
DKK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11111,824,955 - 11,871,139 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1111,824,955 - 11,871,139 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01112,131,306 - 12,177,906 (-)NCBIMhudiblu_PPA_v0panPan3
Dkk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494750,394,918 - 50,443,027 (+)NCBI
SpeTri2.0NW_0049365286,428,824 - 6,477,007 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl247,385,191 - 47,446,538 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1247,385,244 - 47,444,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2250,699,247 - 50,758,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1152,823,415 - 52,868,804 (+)NCBI
ChlSab1.1 Ensembl152,824,176 - 52,868,885 (+)Ensembl
Vero_WHO_p1.0NW_023666038150,424,876 - 150,470,271 (+)NCBI
Dkk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247664,042,307 - 4,085,613 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 2 16 3 6 12 8 10 5
Low 1 3 6 6 3 6 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012527   ⟹   ENSCAFP00000011598
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)Ensembl
RefSeq Acc Id: NM_001284475   ⟹   NP_001271404
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12135,033,878 - 35,074,664 (-)NCBI
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBI
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBI
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBI
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBI
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014122426   ⟹   XP_013977901
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12135,032,501 - 35,069,863 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001271404 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAN37426 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013977901   ⟸   XM_014122426
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001271404   ⟸   NM_001284475
- Peptide Label: precursor
- UniProtKB: W0RY37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000011598   ⟸   ENSCAFT00000012527

Promoters
RGD ID:13687251
Promoter ID:EPDNEW_C5319
Type:multiple initiation site
Name:DKK3_1
Description:Canis lupus familiaris dickkopf WNT signaling pathway inhibitor3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12135,074,705 - 35,074,765EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007845 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000011598 ENTREZGENE
Ensembl Transcript ENSCAFT00000012527 ENTREZGENE
NCBI Gene DKK3 ENTREZGENE
UniProt W0RY37 ENTREZGENE
VGNC ID VGNC:39971 ENTREZGENE