DKK3 (dickkopf WNT signaling pathway inhibitor 3) - Rat Genome Database

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Gene: DKK3 (dickkopf WNT signaling pathway inhibitor 3) Canis lupus familiaris
Analyze
Symbol: DKK3
Name: dickkopf WNT signaling pathway inhibitor 3
RGD ID: 12370716
Description: INVOLVED IN adrenal gland development (inferred); negative regulation of aldosterone biosynthetic process (inferred); negative regulation of canonical Wnt signaling pathway (inferred); ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); intellectual disability (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dickkopf 3 homolog; dickkopf homolog 3; dickkopf-related protein 3; REIC/Dkk-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12135,032,501 - 35,074,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2135,899,250 - 35,950,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:23732075   PMID:28599655  


Genomics

Comparative Map Data
DKK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12135,032,501 - 35,074,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2135,899,250 - 35,950,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBIUU_Cfam_GSD_1.0
DKK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,963,036 - 12,009,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1111,956,207 - 12,009,769 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,984,583 - 12,030,883 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,941,119 - 11,987,493 (-)NCBINCBI36Build 36hg18NCBI36
Build 341111,941,228 - 11,987,205NCBI
Celera1112,109,802 - 12,156,171 (-)NCBICelera
Cytogenetic Map11p15.3NCBI
HuRef1111,660,573 - 11,706,919 (-)NCBIHuRef
CHM1_11111,983,471 - 12,029,827 (-)NCBICHM1_1
T2T-CHM13v2.01112,054,919 - 12,101,206 (-)NCBIT2T-CHM13v2.0
Dkk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397111,715,226 - 111,758,689 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7111,715,224 - 111,758,264 (-)EnsemblGRCm39 Ensembl
GRCm387112,116,019 - 112,159,482 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7112,116,017 - 112,159,057 (-)EnsemblGRCm38mm10GRCm38
MGSCv377119,259,533 - 119,302,571 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367111,907,200 - 111,950,238 (-)NCBIMGSCv36mm8
Celera7112,091,357 - 112,134,444 (-)NCBICelera
Cytogenetic Map7F1NCBI
Dkk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21166,237,969 - 166,281,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,238,238 - 166,280,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1174,573,298 - 174,615,607 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01181,759,295 - 181,801,602 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01174,459,245 - 174,501,581 (-)NCBIRnor_WKY
Rnor_6.01176,940,424 - 176,983,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1176,940,693 - 176,983,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,919,812 - 183,962,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,924,617 - 169,964,692 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,043,564 - 170,084,626 (-)NCBI
Celera1164,115,480 - 164,157,817 (-)NCBICelera
Cytogenetic Map1q33NCBI
Dkk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541427,456,770 - 27,508,109 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541427,466,636 - 27,507,186 (-)NCBIChiLan1.0ChiLan1.0
DKK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11111,824,955 - 11,871,139 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1111,824,955 - 11,871,139 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01112,131,306 - 12,177,906 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Dkk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494750,394,918 - 50,443,027 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365286,428,824 - 6,477,007 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl247,385,192 - 47,444,660 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1247,385,244 - 47,444,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2250,699,247 - 50,758,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1152,823,415 - 52,868,804 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl152,824,176 - 52,868,885 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038150,424,876 - 150,470,271 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dkk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247664,041,816 - 4,085,209 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247664,042,307 - 4,085,613 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 2 16 3 6 12 8 10 5
Low 1 3 6 6 3 6 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012527   ⟹   ENSCAFP00000011598
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030630   ⟹   ENSCAFP00845024032
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2135,899,250 - 35,950,171 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030743   ⟹   ENSCAFP00845024110
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2135,907,935 - 35,950,691 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030795   ⟹   ENSCAFP00845024145
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2135,907,935 - 35,950,171 (-)Ensembl
RefSeq Acc Id: NM_001284475   ⟹   NP_001271404
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12135,033,878 - 35,074,664 (-)NCBI
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBI
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBI
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBI
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBI
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001271404 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAN37426 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001271404   ⟸   NM_001284475
- Peptide Label: precursor
- UniProtKB: W0RY37 (UniProtKB/TrEMBL),   A0A8C0T1J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000011598   ⟸   ENSCAFT00000012527
RefSeq Acc Id: ENSCAFP00845024032   ⟸   ENSCAFT00845030630
RefSeq Acc Id: ENSCAFP00845024110   ⟸   ENSCAFT00845030743
RefSeq Acc Id: ENSCAFP00845024145   ⟸   ENSCAFT00845030795
Protein Domains
Dickkopf_N

Promoters
RGD ID:13687251
Promoter ID:EPDNEW_C5319
Type:multiple initiation site
Name:DKK3_1
Description:Canis lupus familiaris dickkopf WNT signaling pathway inhibitor3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12135,074,705 - 35,074,765EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007845 Ensembl
  ENSCAFG00030026085 UniProtKB/TrEMBL
  ENSCAFG00040017516 UniProtKB/TrEMBL
  ENSCAFG00845017299 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030042229.1 UniProtKB/TrEMBL
  ENSCAFP00040028148 UniProtKB/TrEMBL
  ENSCAFP00845024032.1 UniProtKB/TrEMBL
  ENSCAFP00845024110.1 UniProtKB/TrEMBL
  ENSCAFP00845024145 ENTREZGENE
  ENSCAFP00845024145.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030048263.1 UniProtKB/TrEMBL
  ENSCAFT00040032362 UniProtKB/TrEMBL
  ENSCAFT00845030630.1 UniProtKB/TrEMBL
  ENSCAFT00845030743.1 UniProtKB/TrEMBL
  ENSCAFT00845030795 ENTREZGENE
  ENSCAFT00845030795.1 UniProtKB/TrEMBL
InterPro Dickkopf_N UniProtKB/TrEMBL
  DKK-like UniProtKB/TrEMBL
KEGG Report cfa:476857 UniProtKB/TrEMBL
NCBI Gene DKK3 ENTREZGENE
PANTHER PTHR12113 UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/TrEMBL
UniProt A0A8C0T1J9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P0C0_CANLF UniProtKB/TrEMBL
  A0A8I3S2K3_CANLF UniProtKB/TrEMBL
  W0RY37 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39971 ENTREZGENE