TTLL4 (tubulin tyrosine ligase like 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: TTLL4 (tubulin tyrosine ligase like 4) Canis lupus familiaris
Analyze
Symbol: TTLL4
Name: tubulin tyrosine ligase like 4
RGD ID: 12369689
Description: ENCODES a protein that exhibits protein-glutamic acid ligase activity (inferred); tubulin binding (inferred); tubulin-glutamic acid ligase activity (inferred); INVOLVED IN regulation of blastocyst development (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); cerebrotendinous xanthomatosis (ortholog); genetic disease (ortholog); FOUND IN 9+0 non-motile cilium (inferred); ciliary basal body (inferred); cilium (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tubulin polyglutamylase TTLL4; tubulin tyrosine ligase-like family, member 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,303,818 - 25,341,315 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,273,110 - 25,340,512 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,123,846 - 26,160,606 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,319,791 - 25,356,071 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,319,910 - 25,356,002 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,224,607 - 25,260,995 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,158,861 - 25,195,634 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,179,670 - 25,216,226 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TTLL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,303,818 - 25,341,315 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,273,110 - 25,340,512 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,123,846 - 26,160,606 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,319,791 - 25,356,071 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,319,910 - 25,356,002 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,224,607 - 25,260,995 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,158,861 - 25,195,634 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,179,670 - 25,216,226 (+)NCBIUU_Cfam_GSD_1.0
TTLL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,710,835 - 218,759,724 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,710,835 - 218,755,416 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,575,558 - 219,620,139 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,283,887 - 219,327,652 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,401,147 - 219,444,913NCBI
Celera2213,343,326 - 213,387,891 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,428,803 - 211,473,377 (+)NCBIHuRef
CHM1_12219,582,524 - 219,627,056 (+)NCBICHM1_1
T2T-CHM13v2.02219,197,391 - 219,244,038 (+)NCBIT2T-CHM13v2.0
Ttll4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,700,804 - 74,740,991 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,700,904 - 74,742,889 (+)EnsemblGRCm39 Ensembl
GRCm38174,661,645 - 74,701,832 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,661,745 - 74,703,730 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,708,328 - 74,744,547 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,594,961 - 74,631,180 (+)NCBIMGSCv36mm8
Celera175,216,789 - 75,252,776 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.54NCBI
Ttll4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,670,788 - 83,706,891 (+)NCBIGRCr8
mRatBN7.2976,221,659 - 76,258,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,221,796 - 76,251,301 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0981,925,363 - 81,961,882 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,940,630 - 81,954,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,687,817 - 81,724,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,011,065 - 74,025,699 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera973,794,152 - 73,830,671 (+)NCBICelera
Cytogenetic Map9q33NCBI
Ttll4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545314,679,945 - 14,720,025 (-)NCBIChiLan1.0ChiLan1.0
TTLL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,339,077 - 121,388,881 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,356,017 - 121,403,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,968,840 - 106,016,034 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,563,626 - 224,610,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,563,691 - 224,610,431 (+)Ensemblpanpan1.1panPan2
Ttll4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,810,537 - 174,859,089 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,153,447 - 1,194,269 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,153,376 - 1,201,704 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTLL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,773,185 - 120,793,194 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,748,537 - 120,791,825 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,817,235 - 133,820,673 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTLL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,612,946 - 104,656,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,613,026 - 104,656,622 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,745,779 - 94,790,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttll4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,310,738 - 6,352,333 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,314,177 - 6,352,236 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TTLL4
487 total Variants

Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005640664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005640665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038447958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038447959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038447960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038463830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038585750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038585751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038585752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038650130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038650131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_545645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00845049685   ⟹   ENSCAFP00845038967
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3725,319,910 - 25,356,002 (+)Ensembl
RefSeq Acc Id: XM_038447958   ⟹   XP_038303886
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03725,319,791 - 25,356,071 (+)NCBI
RefSeq Acc Id: XM_038447959   ⟹   XP_038303887
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03725,319,865 - 25,356,071 (+)NCBI
RefSeq Acc Id: XM_038447960   ⟹   XP_038303888
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03725,319,865 - 25,356,071 (+)NCBI
RefSeq Acc Id: XM_038463830   ⟹   XP_038319758
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3726,137,273 - 26,160,606 (+)NCBI
RefSeq Acc Id: XM_038521945   ⟹   XP_038377873
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13725,224,607 - 25,260,995 (+)NCBI
RefSeq Acc Id: XM_038521946   ⟹   XP_038377874
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13725,224,681 - 25,260,995 (+)NCBI
RefSeq Acc Id: XM_038521947   ⟹   XP_038377875
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13725,224,681 - 25,260,995 (+)NCBI
RefSeq Acc Id: XM_038585750   ⟹   XP_038441678
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03725,179,670 - 25,216,226 (+)NCBI
RefSeq Acc Id: XM_038585751   ⟹   XP_038441679
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03725,179,744 - 25,216,226 (+)NCBI
RefSeq Acc Id: XM_038585752   ⟹   XP_038441680
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03725,179,744 - 25,216,226 (+)NCBI
RefSeq Acc Id: XM_038650130   ⟹   XP_038506058
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03725,158,861 - 25,195,634 (+)NCBI
RefSeq Acc Id: XM_038650131   ⟹   XP_038506059
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03725,172,295 - 25,195,634 (+)NCBI
RefSeq Acc Id: XM_545645   ⟹   XP_545645
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13725,303,818 - 25,341,315 (+)NCBI
Dog10K_Boxer_Tasha3726,123,846 - 26,160,606 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_545645   ⟸   XM_545645
- UniProtKB: A0A8P0NGF7 (UniProtKB/TrEMBL),   A0A8C0MPS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038377873   ⟸   XM_038521945
RefSeq Acc Id: XP_038377874   ⟸   XM_038521946
RefSeq Acc Id: XP_038377875   ⟸   XM_038521947
RefSeq Acc Id: XP_038506058   ⟸   XM_038650130
RefSeq Acc Id: XP_038506059   ⟸   XM_038650131
RefSeq Acc Id: XP_038303886   ⟸   XM_038447958
- UniProtKB: A0A8I3PZY0 (UniProtKB/TrEMBL),   A0A8C0MPS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038303887   ⟸   XM_038447959
- UniProtKB: A0A8I3PZY0 (UniProtKB/TrEMBL),   A0A8C0MPS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038303888   ⟸   XM_038447960
- UniProtKB: A0A8I3PZY0 (UniProtKB/TrEMBL),   A0A8C0MPS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038319758   ⟸   XM_038463830
- UniProtKB: A0A8P0NGF7 (UniProtKB/TrEMBL),   A0A8C0MPS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441678   ⟸   XM_038585750
- UniProtKB: A0A8C0LNF9 (UniProtKB/TrEMBL),   A0A8C0MPS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441679   ⟸   XM_038585751
- UniProtKB: A0A8C0LNF9 (UniProtKB/TrEMBL),   A0A8C0MPS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441680   ⟸   XM_038585752
- UniProtKB: A0A8C0LNF9 (UniProtKB/TrEMBL),   A0A8C0MPS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845038967   ⟸   ENSCAFT00845049685


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014919 Ensembl
  ENSCAFG00000058182 UniProtKB/TrEMBL
  ENSCAFG00030007175 UniProtKB/TrEMBL
  ENSCAFG00040023709 UniProtKB/TrEMBL
  ENSCAFG00845028151 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023705.5 UniProtKB/TrEMBL
  ENSCAFT00030013988.1 UniProtKB/TrEMBL
  ENSCAFT00040044305.1 UniProtKB/TrEMBL
  ENSCAFT00845049685 ENTREZGENE
  ENSCAFT00845049685.1 UniProtKB/TrEMBL
Gene3D-CATH ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro TTL/TTLL_fam UniProtKB/TrEMBL
NCBI Gene TTLL4 ENTREZGENE
PANTHER TUBULIN POLYGLUTAMYLASE UniProtKB/TrEMBL
  TUBULIN POLYGLUTAMYLASE TTLL4 UniProtKB/TrEMBL
Pfam TTL UniProtKB/TrEMBL
PROSITE TTL UniProtKB/TrEMBL
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/TrEMBL
UniProt A0A8C0LNF9 ENTREZGENE
  A0A8C0MPS2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PZY0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NGF7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54382 ENTREZGENE