MYOZ2 (myozenin 2) - Rat Genome Database

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Pathways
Gene: MYOZ2 (myozenin 2) Canis lupus familiaris
Analyze
Symbol: MYOZ2
Name: myozenin 2
RGD ID: 12365071
Description: ENCODES a protein that exhibits actin binding (inferred); telethonin binding (inferred); INVOLVED IN negative regulation of calcineurin-NFAT signaling cascade (inferred); negative regulation of transcription by RNA polymerase II (inferred); sarcomere organization (inferred); ASSOCIATED WITH cardiomyopathy (ortholog); familial hypertrophic cardiomyopathy (ortholog); hypertrophic cardiomyopathy (ortholog); FOUND IN actin cytoskeleton (inferred); Z disc (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myozenin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13238,088,505 - 38,132,265 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3238,088,527 - 38,132,285 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha323,942,865 - 3,986,606 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03238,309,363 - 38,353,519 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3238,309,379 - 38,353,519 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13238,332,252 - 38,375,974 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03238,055,661 - 38,099,376 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0321,699,831 - 1,743,560 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IBA,IEA)
Z disc  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MYOZ2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13238,088,505 - 38,132,265 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3238,088,527 - 38,132,285 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha323,942,865 - 3,986,606 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03238,309,363 - 38,353,519 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3238,309,379 - 38,353,519 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13238,332,252 - 38,375,974 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03238,055,661 - 38,099,376 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0321,699,831 - 1,743,560 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MYOZ2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384119,135,832 - 119,187,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4119,135,832 - 119,187,789 (+)Ensemblhg38GRCh38
GRCh374120,056,987 - 120,108,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364120,276,469 - 120,328,385 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344120,414,623 - 120,466,538NCBI
Celera4117,418,487 - 117,470,527 (+)NCBICelera
Cytogenetic Map4q26NCBI
HuRef4115,778,656 - 115,830,665 (+)NCBIHuRef
CHM1_14120,033,387 - 120,085,416 (+)NCBICHM1_1
T2T-CHM13v2.04122,438,583 - 122,492,858 (+)NCBIT2T-CHM13v2.0
Myoz2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,799,855 - 122,828,649 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3122,799,855 - 122,828,664 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383123,006,206 - 123,035,003 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3123,006,206 - 123,035,015 (-)Ensemblmm10GRCm38
MGSCv373122,709,124 - 122,737,905 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363122,998,230 - 123,026,971 (-)NCBIMGSCv36mm8
Celera3129,417,952 - 129,446,276 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map353.78NCBI
Myoz2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82213,826,052 - 213,852,778 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2213,826,052 - 213,852,914 (-)EnsemblGRCr8
mRatBN7.22211,141,463 - 211,168,187 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2211,141,463 - 211,168,221 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2218,819,268 - 218,846,003 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02216,727,055 - 216,753,793 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02211,573,388 - 211,600,124 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02227,180,887 - 227,207,629 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2227,180,886 - 227,207,635 (-)Ensemblrn6Rnor6.0
Rnor_5.02246,542,267 - 246,569,008 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42219,702,470 - 219,729,176 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2203,570,719 - 203,596,880 (-)NCBICelera
RGSC_v3.12219,665,531 - 219,692,235 (-)NCBI
Cytogenetic Map2q42NCBI
Myoz2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542821,052,137 - 21,101,795 (-)Ensembl
ChiLan1.0NW_00495542821,052,352 - 21,088,468 (-)NCBIChiLan1.0ChiLan1.0
MYOZ2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23116,919,064 - 116,971,033 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14117,216,005 - 117,267,938 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04111,330,427 - 111,382,323 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14121,880,721 - 121,932,652 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4121,880,721 - 121,931,558 (+)EnsemblpanPan2panpan1.1
Myoz2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530167,379,247 - 67,418,873 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936869244,591 - 284,194 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936869244,599 - 284,228 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOZ2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8104,577,790 - 104,609,328 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18104,578,942 - 104,609,367 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28112,235,080 - 112,247,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYOZ2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1766,615,254 - 66,666,060 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl766,616,084 - 66,666,263 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603745,475,897 - 45,526,858 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myoz2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248675,947,521 - 5,989,426 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248675,947,671 - 5,987,804 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in MYOZ2
405 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 20 14 4 6 4 6 31 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000019736   ⟹   ENSCAFP00000018306
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3238,088,527 - 38,132,285 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845053160   ⟹   ENSCAFP00845041737
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3238,309,379 - 38,353,519 (+)Ensembl
RefSeq Acc Id: XM_038444521   ⟹   XP_038300449
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03238,309,363 - 38,353,519 (+)NCBI
RefSeq Acc Id: XM_038518918   ⟹   XP_038374846
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13238,332,252 - 38,375,974 (+)NCBI
RefSeq Acc Id: XM_038581759   ⟹   XP_038437687
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0321,699,831 - 1,743,560 (-)NCBI
RefSeq Acc Id: XM_038646861   ⟹   XP_038502789
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03238,055,661 - 38,099,376 (+)NCBI
RefSeq Acc Id: XM_535703   ⟹   XP_535703
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13238,088,505 - 38,132,265 (+)NCBI
Dog10K_Boxer_Tasha323,942,865 - 3,986,606 (-)NCBI
Sequence:
RefSeq Acc Id: XP_535703   ⟸   XM_535703
- UniProtKB: A0A8C0T799 (UniProtKB/TrEMBL),   A0A8C0R320 (UniProtKB/TrEMBL),   A0A8I3Q871 (UniProtKB/TrEMBL),   A0A8P0PG17 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000018306   ⟸   ENSCAFT00000019736
RefSeq Acc Id: XP_038374846   ⟸   XM_038518918
RefSeq Acc Id: XP_038502789   ⟸   XM_038646861
RefSeq Acc Id: XP_038300449   ⟸   XM_038444521
- UniProtKB: A0A8C0T799 (UniProtKB/TrEMBL),   A0A8C0R320 (UniProtKB/TrEMBL),   A0A8I3Q871 (UniProtKB/TrEMBL),   A0A8P0PG17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038437687   ⟸   XM_038581759
- UniProtKB: A0A8C0R320 (UniProtKB/TrEMBL),   A0A8C0T799 (UniProtKB/TrEMBL),   A0A8I3Q871 (UniProtKB/TrEMBL),   A0A8P0PG17 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845041737   ⟸   ENSCAFT00845053160


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012432 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014689 UniProtKB/TrEMBL
  ENSCAFG00040018965 UniProtKB/TrEMBL
  ENSCAFG00845030005 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019736.5 UniProtKB/TrEMBL
  ENSCAFT00000107073.1 UniProtKB/TrEMBL
  ENSCAFT00030027126.1 UniProtKB/TrEMBL
  ENSCAFT00040035064.1 UniProtKB/TrEMBL
  ENSCAFT00040035078.1 UniProtKB/TrEMBL
  ENSCAFT00845053160 ENTREZGENE
  ENSCAFT00845053160.1 UniProtKB/TrEMBL
InterPro MYOZ UniProtKB/TrEMBL
KEGG Report cfa:478524 UniProtKB/TrEMBL
NCBI Gene MYOZ2 ENTREZGENE
PANTHER MYOZENIN-2 UniProtKB/TrEMBL
  PTHR15941 UniProtKB/TrEMBL
Pfam Calsarcin UniProtKB/TrEMBL
UniProt A0A8C0R320 ENTREZGENE
  A0A8C0T260_CANLF UniProtKB/TrEMBL
  A0A8C0T799 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q871 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PG17 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43584 ENTREZGENE