ETF1 (eukaryotic translation termination factor 1) - Rat Genome Database

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Gene: ETF1 (eukaryotic translation termination factor 1) Canis lupus familiaris
Analyze
Symbol: ETF1
Name: eukaryotic translation termination factor 1
RGD ID: 12361415
Description: ENCODES a protein that exhibits aminoacyl-tRNA hydrolase activity (inferred); sequence-specific mRNA binding (inferred); translation release factor activity (inferred); INVOLVED IN translational termination (ortholog); PARTICIPATES IN translation termination pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 31 (ortholog); familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); FOUND IN cytosolic ribosome (ortholog); nucleus (ortholog); translation release factor complex (ortholog)
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: eukaryotic peptide chain release factor subunit 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC474696  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,078,611 - 26,110,805 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,080,478 - 26,110,894 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,849,760 - 24,879,852 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,934,917 - 26,967,373 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,934,919 - 26,967,344 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,643,833 - 25,674,484 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,466,681 - 25,497,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,130,745 - 26,160,981 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ETF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,078,611 - 26,110,805 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,080,478 - 26,110,894 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,849,760 - 24,879,852 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,934,917 - 26,967,373 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,934,919 - 26,967,344 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,643,833 - 25,674,484 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,466,681 - 25,497,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,130,745 - 26,160,981 (-)NCBIUU_Cfam_GSD_1.0
ETF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,506,095 - 138,543,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,506,095 - 138,543,236 (-)EnsemblGRCh38hg38GRCh38
GRCh375137,841,784 - 137,878,925 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,869,687 - 137,906,802 (-)NCBINCBI36Build 36hg18NCBI36
Build 345137,869,686 - 137,906,802NCBI
Celera5133,963,667 - 134,000,818 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5133,032,353 - 133,069,485 (-)NCBIHuRef
CHM1_15137,274,606 - 137,311,379 (-)NCBICHM1_1
T2T-CHM13v2.05139,032,342 - 139,069,467 (-)NCBIT2T-CHM13v2.0
Etf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391835,035,838 - 35,065,060 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1835,035,838 - 35,065,060 (-)EnsemblGRCm39 Ensembl
GRCm381834,902,785 - 34,932,008 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,902,785 - 34,932,007 (-)EnsemblGRCm38mm10GRCm38
MGSCv371835,062,439 - 35,091,657 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361835,029,893 - 35,057,927 (-)NCBIMGSCv36mm8
Celera1835,357,083 - 35,386,323 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.78NCBI
Etf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,776,518 - 26,804,857 (-)NCBIGRCr8
mRatBN7.21826,502,413 - 26,530,753 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,504,080 - 26,530,810 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,631,118 - 26,658,118 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,394,786 - 27,421,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,729,671 - 26,756,759 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,698,693 - 27,725,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,698,695 - 27,725,694 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,409,448 - 27,436,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,386,539 - 27,413,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,413,186 - 27,440,191 (-)NCBI
Celera1826,240,446 - 26,267,428 (-)NCBICelera
Cytogenetic Map18p12NCBI
Etf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554181,943,233 - 1,974,241 (+)NCBIChiLan1.0ChiLan1.0
ETF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,781,540 - 133,818,141 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,921,094 - 131,957,688 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,886,074 - 133,922,682 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15140,015,518 - 140,052,063 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5140,015,518 - 140,051,974 (-)Ensemblpanpan1.1panPan2
Etf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,917,982 - 153,947,623 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,663,882 - 7,693,549 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,665,246 - 7,693,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ETF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,469,306 - 140,504,287 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,471,931 - 140,504,381 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,186,588 - 146,219,180 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ETF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,180,547 - 41,219,125 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603436,667,090 - 36,706,807 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Etf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474331,280,547 - 31,313,086 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ETF1
315 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 4 5 19 3 6 3 6 5 12 8 10 6
Below cutoff 1 3 3 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001252146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005626427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014117666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014117667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM536990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GR893029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GR898023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000001987   ⟹   ENSCAFP00000001835
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1126,080,478 - 26,110,894 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845038677   ⟹   ENSCAFP00845030285
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1126,934,919 - 26,967,344 (-)Ensembl
RefSeq Acc Id: NM_001252146   ⟹   NP_001239075
RefSeq Status: INFERRED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11126,080,478 - 26,110,481 (-)NCBI
Dog10K_Boxer_Tasha1124,849,760 - 24,879,852 (-)NCBI
ROS_Cfam_1.01126,936,784 - 26,967,034 (-)NCBI
UMICH_Zoey_3.11125,643,833 - 25,674,484 (-)NCBI
UNSW_CanFamBas_1.01125,466,681 - 25,497,013 (-)NCBI
UU_Cfam_GSD_1.01126,130,745 - 26,160,981 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038680986   ⟹   XP_038536914
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01126,934,917 - 26,967,373 (-)NCBI
RefSeq Acc Id: XM_038680987   ⟹   XP_038536915
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01126,936,297 - 26,967,373 (-)NCBI
RefSeq Acc Id: XM_038680988   ⟹   XP_038536916
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01126,936,297 - 26,953,969 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001239075   ⟸   NM_001252146
- UniProtKB: A0A8C0T289 (UniProtKB/TrEMBL),   A0A8P0PGY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001835   ⟸   ENSCAFT00000001987
RefSeq Acc Id: XP_038536914   ⟸   XM_038680986
- Peptide Label: isoform X1
- UniProtKB: A0A8C0T289 (UniProtKB/TrEMBL),   A0A8P0PGY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038536915   ⟸   XM_038680987
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SPX7 (UniProtKB/TrEMBL),   A0A8C0KDH9 (UniProtKB/TrEMBL),   A0A8I3PCV3 (UniProtKB/TrEMBL),   A0A8C0T289 (UniProtKB/TrEMBL),   A0A8P0PGY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038536916   ⟸   XM_038680988
- Peptide Label: isoform X3
- UniProtKB: A0A8C0T289 (UniProtKB/TrEMBL),   A0A8P0PGY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845030285   ⟸   ENSCAFT00845038677
Protein Domains
eRF1

Promoters
RGD ID:13685190
Promoter ID:EPDNEW_C3259
Type:single initiation site
Name:ETF1_1
Description:eukaryotic peptide chain release factor subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11126,110,492 - 26,110,552EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001282 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00000054253 UniProtKB/TrEMBL
  ENSCAFG00030004166 UniProtKB/TrEMBL
  ENSCAFG00040015171 UniProtKB/TrEMBL
  ENSCAFG00040018178 UniProtKB/TrEMBL
  ENSCAFG00845021909 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001987.6 UniProtKB/TrEMBL
  ENSCAFT00000100545.1 UniProtKB/TrEMBL
  ENSCAFT00030007747.1 UniProtKB/TrEMBL
  ENSCAFT00040027961.1 UniProtKB/TrEMBL
  ENSCAFT00040033542.1 UniProtKB/TrEMBL
  ENSCAFT00845038677 ENTREZGENE
  ENSCAFT00845038677.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/TrEMBL
  3.30.420.60 UniProtKB/TrEMBL
  3.30.960.10 UniProtKB/TrEMBL
InterPro eFR1_2_sf UniProtKB/TrEMBL
  eRF1_1_Pelota UniProtKB/TrEMBL
  eRF1_1_sf UniProtKB/TrEMBL
  eRF1_2 UniProtKB/TrEMBL
  eRF1_3 UniProtKB/TrEMBL
  L30e-like UniProtKB/TrEMBL
  Peptide_chain-rel_eRF1/aRF1 UniProtKB/TrEMBL
NCBI Gene ETF1 ENTREZGENE
PANTHER EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 UniProtKB/TrEMBL
  PTHR10113 UniProtKB/TrEMBL
Pfam eRF1_1 UniProtKB/TrEMBL
  eRF1_2 UniProtKB/TrEMBL
  eRF1_3 UniProtKB/TrEMBL
SMART eRF1_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF55315 UniProtKB/TrEMBL
  SSF55481 UniProtKB/TrEMBL
  Translational machinery components UniProtKB/TrEMBL
UniProt A0A8C0KDH9 ENTREZGENE
  A0A8C0SPX7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T289 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PCV3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PGY7 ENTREZGENE
UniProt Secondary A0A8P0PGY7 UniProtKB/TrEMBL